Cell surface interactions at the vascular wall (Homo sapiens)

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1-64, 37-394, 35462, 634, 5166, 671464, 657928, 321917, 259, 59, 6071617869775, 504, 3422, 237052, 5317, 185457, 5880-82754, 40-426918, 2124197226-2955, 5618, 2048, 498330, 3112, 13683318, 2118, 22, 2345-47734, 43, 446074764, 36plasma membraneplasma membraneGolgi lumenGolgi membranecytosolMERTK ligandsMonocarboxylate Transporter Set (MCT)JAM2ADPCyP60 complexed with BasiginpTie2:Ang-1VLA-4SOS-1 bound to Tie2:Grb2Integrin alpha5beta1Collagen IGrb2 bound to Tie2Basigin:Mannose-carrying cell recognition moleculesP-selectin glycoprotein ligand 1 precursorTie2/Ang1 dimerPeptidyl-prolyl cis-trans isomerase like 2p21 RAS:GTPGTPMannose-carrying cell recognition moleculesOxidized low-density lipoprotein receptor 1Heparan SulphateAngiopoietin-4Integrin alphaMbeta2:JAM3Complex of Tie2:Ang2Son of sevenless protein homolog 1Basigin:CD98hc complexp85 bound to Tie2ADPP-selectin bound to its ligandPI3KCD98hc complexGrb14Ligand to TREM-1 on the platelet membraneTie2 and Grb14 complexGPVI:FceRI gamma:FYN:LYN:Collagen IAngiopoietin 1 receptor precursorpTie2 and SHP2 complexCD47Integrin alphaVbeta3:PECAM-1SHIP1activated thrombin:thrombomodulinIntegrin alphaXbeta2Tie2:Grb7 complexphosphorylated PECAM-1Basigin:MMP1LFA-1:JAM-ABasigin bound to MCTsBasigin bound to CyPAcaveolin-1Angiopoietin-1SHC1VLA-4: JAM-BCD84 HomodimerTie2 and Dok-2 complexJAM3Coxsackievirus and adenovirus receptorATPAngiopoietin-2Integrin alpha5beta1:FibronectinCD84Junctional adhesion molecule-like precursorTriggering receptor expressed on myeloid cells 1 precursorpTie2:SHC1 complexATPManganeseCD48 bound to CD244Neutrophil CEACAMs affecting integrin binding to fibronectinJAM-C homodimerSrc family tyrosine kinasesPhosphorylated Tie2 in Tie2/Akt dimerPECAM-1:SHP-2 complexPECAM-1:PECAM-1Caveolin-1 bound to BasiginTREM-1 bound to its ligandPECAM-1:PLC gamma1 complexGRB2JAM-A HomodimerGrb7CEACAM heterodimerPECAM-1:SHIP1 complexBasigin bound to CD43activated protein CCXADR bound to JAMLMERTK bound to its ligandLeukosialin precursorIntegrin alphaXbeta2:JAMLprotein C heavy chain activation peptidePECAM-1 bound to CD177PECAM-1:SHP-1 complexLDLMatrix metalloproteinase-1Platelet Factor 4JAM-AGDPIntegrin alphaVbeta3SHP1CD58 bound to CD2Basigin-binding integrinsPhospholipase C gamma 1B-lymphocyte activation marker BLAST-1 precursorSelectinDocking protein 2protein CT-cell surface antigen CD2 precursorPECAM-1CD47-binding SIRPsGPVI:FceRI gamma:FYN:LYNSHP2Proto-oncogene tyrosine-protein kinase MER precursorNatural killer cell receptor 2B4 precursorCD47 bound to its ligandJunctional adhesion molecule-like (JAML)Lymphocyte function-associated antigen 3 precursorIntegrin alphaMbeta2CypA proteinJAM-B homodimerBasigin homodimerTie2 and Ang4 complexp-PECAM1:p-PECAM1CD177 antigen precursorFibronectin dimerBasigin precursorOLR1 bound to oxidized LDLComplex of Tie2:Ang-1JAM-B bound to JAM-Cp21 RAS:GDPBasigin precursorBasigin bound to integrinsIntegrin alphaLbeta2 (LFA-1)10, 111598141610-1279131610-12


Description

Leukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are required for leukocytes to withstand local flow at the vessel wall is a multistep process mediated by different adhesion molecules. Platelets adhered to injured vessel walls form strong adhesive substrates for leukocytes. For instance, the initial tethering and rolling of leukocytes over the site of injury are mediated by reversible binding of selectins to their cognate cell-surface glycoconjugates.

Endothelial cells are tightly connected through various proteins, which regulate the organization of the junctional complex and bind to cytoskeletal proteins or cytoplasmic interaction partners that allow the transfer of intracellular signals. An important role for these junctional proteins in governing the transendothelial migration of leukocytes under normal or inflammatory conditions has been established.<p>

This pathway describes some of the key interactions that assist in the process of platelet and leukocyte interaction with the endothelium, in response to injury.</div>

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History

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112591view15:56, 9 October 2020ReactomeTeamReactome version 73
101507view11:37, 1 November 2018ReactomeTeamreactome version 66
101043view21:18, 31 October 2018ReactomeTeamreactome version 65
100574view19:51, 31 October 2018ReactomeTeamreactome version 64
100123view16:37, 31 October 2018ReactomeTeamreactome version 63
99673view15:07, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99268view12:45, 31 October 2018ReactomeTeamreactome version 62
94057view13:54, 16 August 2017ReactomeTeamreactome version 61
93737view13:25, 16 August 2017ReactomeTeamreactome version 61
93686view11:31, 9 August 2017ReactomeTeamreactome version 61
87157view19:14, 18 July 2016MkutmonOntology Term : 'hemostasis pathway' added !
86809view09:27, 11 July 2016ReactomeTeamreactome version 56
83824view13:10, 13 December 2015EgonwMarked heparan sulfate (HS) as a metabolite.
83200view10:21, 18 November 2015ReactomeTeamVersion54
81579view13:07, 21 August 2015ReactomeTeamVersion53
77039view08:33, 17 July 2014ReactomeTeamFixed remaining interactions
76744view12:10, 16 July 2014ReactomeTeamFixed remaining interactions
76069view10:13, 11 June 2014ReactomeTeamRe-fixing comment source
75779view11:29, 10 June 2014ReactomeTeamReactome 48 Update
75129view14:07, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74859view15:22, 2 May 2014EgonwMarked a metabolite as a DataNode type="Metabolite"...
74776view08:51, 30 April 2014ReactomeTeamReactome46
42017view21:50, 4 March 2011MaintBotAutomatic update
39820view05:51, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADP Metabolite16761 (ChEBI)
ATP Metabolite15422 (ChEBI)
Angiopoietin 1

receptor precursor

ProteinQ02763 (UniProt)
Angiopoietin-1 ProteinQ15389 (UniProt)
Angiopoietin-2 ProteinO15123 (UniProt)
Angiopoietin-4 ProteinQ9Y264 (UniProt)
B-lymphocyte

activation marker BLAST-1 precursor

ProteinP09326 (UniProt)
Basigin bound to

CD43

ComplexREACT_18170 (Reactome)
Basigin bound to

CyPA

ComplexREACT_12714 (Reactome)
Basigin bound to

MCTs

ComplexREACT_15052 (Reactome)
Basigin bound to

integrins

ComplexREACT_14081 (Reactome)
Basigin homodimer ComplexREACT_13277 (Reactome)
Basigin precursor ProteinP35613 (UniProt)
Basigin-binding

integrins

ComplexREACT_14484 (Reactome)
Basigin:CD98hc

complex

ComplexREACT_17413 (Reactome)
Basigin:MMP1 ComplexREACT_17528 (Reactome)
Basigin:Mannose-

carrying cell recognition molecules

ComplexREACT_18084 (Reactome)
CD177 antigen

precursor

ProteinQ8N6Q3 (UniProt)
CD47 ProteinQ08722 (UniProt)
CD47 bound to its

ligand

ComplexREACT_12217 (Reactome)
CD47-binding SIRPs ProteinREACT_12311 (Reactome)
CD48 bound to

CD244

ComplexREACT_12345 (Reactome)
CD58 bound to CD2 ComplexREACT_12230 (Reactome)
CD84 ProteinQ9UIB8-1 (UniProt)
CD84 Homodimer ComplexREACT_12135 (Reactome)
CD98hc complex ComplexREACT_18154 (Reactome)
CEACAM

heterodimer

ComplexREACT_12134 (Reactome)
CXADR bound to

JAML

ComplexREACT_11619 (Reactome)
Caveolin-1 bound to

Basigin

ComplexREACT_13130 (Reactome)
Collagen I ComplexREACT_2739 (Reactome)
Complex of Tie2:

Ang-1

ComplexREACT_12688 (Reactome)
Complex of Tie2:

Ang2

ComplexREACT_12895 (Reactome)
Coxsackievirus and

adenovirus receptor

ProteinP78310 (UniProt)
CyP60 complexed

with Basigin

ComplexREACT_12835 (Reactome)
CypA protein ProteinP62937 (UniProt)
Docking protein 2 ProteinO60496 (UniProt)
Fibronectin dimer ComplexREACT_14040 (Reactome)
GDP Metabolite17552 (ChEBI)
GPVI:FceRI

gamma:FYN:LYN

ComplexREACT_20322 (Reactome)
GPVI:FceRI gamma:

FYN:LYN:Collagen I

ComplexREACT_20373 (Reactome)
GRB2 ProteinP62993-1 (UniProt)
GTP Metabolite15996 (ChEBI)
Grb14 ProteinQ14449 (UniProt)
Grb2 bound to Tie2 ComplexREACT_12659 (Reactome)
Grb7 ProteinQ14451 (UniProt)
Heparan Sulphate Unknown35721 (ChEBI)
Integrin

alphaLbeta2 (LFA-1)

ComplexREACT_11837 (Reactome)
Integrin

alphaMbeta2

ComplexREACT_12291 (Reactome)
Integrin

alphaMbeta2: JAM3

ComplexREACT_12228 (Reactome)
Integrin

alphaVbeta3

ComplexREACT_13287 (Reactome)
Integrin

alphaVbeta3: PECAM-1

ComplexREACT_13361 (Reactome)
Integrin

alphaXbeta2

ComplexREACT_12091 (Reactome)
Integrin alpha5beta1 ComplexREACT_12335 (Reactome)
Integrin alpha5beta1:

Fibronectin

ComplexREACT_12353 (Reactome)
Integrin alphaXbeta2:

JAML

ComplexREACT_12224 (Reactome)
JAM-A ProteinQ9Y624 (UniProt)
JAM-A Homodimer ComplexREACT_12319 (Reactome)
JAM-B bound to

JAM-C

ComplexREACT_12255 (Reactome)
JAM-B homodimer ComplexREACT_12209 (Reactome)
JAM-C homodimer ComplexREACT_12100 (Reactome)
JAM2 ProteinP57087 (UniProt)
JAM3 ProteinQ9BX67 (UniProt)
Junctional adhesion

molecule-like precursor

ProteinQ86YT9-1 (UniProt)
Junctional adhesion

molecule-like (JAML)

ProteinQ86YT9 (UniProt)
LDL ComplexREACT_7774 (Reactome) LDL (low density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipids. LDL complexes contain single molecules of apoB-100, but their content of lipids is variable (Chapman et al. 1988; Mateu et al. 1972; Tardieu et al. 1976). High levels of LDL in the blood are strongly correlated with increased risk of atherosclerosis, and recent studies have raised the possibility that this risk is further increased in individuals whose blood LDL population is enriched in high-density (low lipid content) LDL complexes (Rizzo and Berneis 2006). The LDL complex annotated here contains an average lipid composition.
LFA-1:JAM-A ComplexREACT_12182 (Reactome)
Leukosialin

precursor

ProteinP16150 (UniProt)
Ligand to TREM-1

on the platelet membrane

UnknownREACT_12176 (Reactome)
Lymphocyte function-

associated antigen 3 precursor

ProteinP19256 (UniProt)
MERTK bound to its

ligand

ComplexREACT_12164 (Reactome)
MERTK ligands ProteinREACT_12235 (Reactome)
Manganese Metabolite18291 (ChEBI)
Mannose-carrying

cell recognition molecules

ComplexREACT_18192 (Reactome)
Matrix

metalloproteinase-1

ProteinP03956 (UniProt)
Monocarboxylate

Transporter Set (MCT)

ProteinREACT_17955 (Reactome)
Natural killer cell

receptor 2B4 precursor

ProteinQ9BZW8 (UniProt)
Neutrophil CEACAMs

affecting integrin binding to fibronectin

ProteinREACT_12292 (Reactome)
OLR1 bound to

oxidized LDL

ComplexREACT_12181 (Reactome)
Oxidized low-density

lipoprotein receptor 1

ProteinP78380 (UniProt)
P-selectin

glycoprotein ligand 1 precursor

ProteinQ14242 (UniProt)
P-selectin bound to

its ligand

ComplexREACT_12193 (Reactome)
PECAM-1 ProteinP16284 (UniProt)
PECAM-1 bound to

CD177

ComplexREACT_12173 (Reactome)
PECAM-1:PECAM-1 ComplexREACT_13059 (Reactome)
PECAM-1:PLC

gamma1 complex

ComplexREACT_13045 (Reactome)
PECAM-1:SHIP1

complex

ComplexREACT_13027 (Reactome)
PECAM-1:SHP-1

complex

ComplexREACT_13228 (Reactome)
PECAM-1:SHP-2

complex

ComplexREACT_13041 (Reactome)
PI3K ComplexREACT_4240 (Reactome)
Peptidyl-prolyl cis-

trans isomerase like 2

ProteinQ13356 (UniProt)
Phospholipase C

gamma 1

ProteinP19174 (UniProt)
Phosphorylated

Tie2 in Tie2/Akt dimer

ComplexREACT_13046 (Reactome)
Platelet Factor 4 UnknownREACT_12205 (Reactome)
Proto-oncogene

tyrosine-protein kinase MER precursor

ProteinQ12866 (UniProt)
SHC1 ProteinP29353 (UniProt)
SHIP1 ProteinQ92835 (UniProt)
SHP1 ProteinP29350 (UniProt)
SHP2 ProteinQ06124 (UniProt)
SOS-1 bound to

Tie2:Grb2

ComplexREACT_13320 (Reactome)
Selectin ProteinREACT_12297 (Reactome)
Son of sevenless

protein homolog 1

ProteinQ07889 (UniProt)
Src family tyrosine

kinases

UnknownREACT_13328 (Reactome)
T-cell surface

antigen CD2 precursor

ProteinP06729 (UniProt)
TREM-1 bound to its

ligand

ComplexREACT_12367 (Reactome)
Tie2 and Ang4

complex

ComplexREACT_12703 (Reactome)
Tie2 and Dok-2

complex

ComplexREACT_13019 (Reactome)
Tie2 and Grb14

complex

ComplexREACT_18185 (Reactome)
Tie2/Ang1 dimer ComplexREACT_13336 (Reactome)
Tie2:Grb7 complex ComplexREACT_18058 (Reactome)
Triggering receptor

expressed on myeloid cells 1 precursor

ProteinQ9NP99 (UniProt)
VLA-4 ComplexREACT_11798 (Reactome)
VLA-4: JAM-B ComplexREACT_12179 (Reactome)
activated protein C ComplexREACT_2599 (Reactome)
activated thrombin:

thrombomodulin

ComplexREACT_5904 (Reactome)
caveolin-1 ProteinQ03135 (UniProt)
p-PECAM1:p-

PECAM1

ComplexREACT_12801 (Reactome)
p21 RAS:GDP ComplexREACT_2657 (Reactome)
p21 RAS:GTP ComplexREACT_4782 (Reactome)
p85 bound to Tie2 ComplexREACT_13298 (Reactome)
pTie2 and SHP2

complex

ComplexREACT_17975 (Reactome)
pTie2:Ang-1 ComplexREACT_13342 (Reactome)
pTie2:SHC1

complex

ComplexREACT_12988 (Reactome)
phosphorylated

PECAM-1

ProteinP16284 (UniProt)
protein C ComplexREACT_4912 (Reactome)
protein C heavy

chain activation peptide

ProteinP04070 (UniProt)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1794"
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