Platelet homeostasis (Homo sapiens)

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116, 179, 10254, 531823222926, 272429220, 2111, 126-813-151928302531endoplasmic reticulum lumencytosolplatelet dense tubular network lumenG-protein beta-gamma complexLDL:p-ApoER2:FGRGDPCyclic GMP-dependent protein kinases (PKGs)ADPsodium ionGMPSHP1CationscPLA23',5'-Cyclic GMPLDL:ApoER2H+Sarco/endoplasmic reticulum Ca2+ ATPases (SERCAs)Activated cGMP-dependent protein kinase (PKGs)Heterotrimeric G-protein Gs (inactive)SHP2BK channelProstacyclinNa+/Ca2+ exchanger proteinsDAG-activated TRPC3/6/7p-PECAM:PP2APhospho-MAP kinase p38 alphaCalciumNADPHOxygenIP receptorGuanylate cyclase:NOGuanylate cyclase, solublesodium ionpyrophosphateATPNitric oxideProstacyclin:prostacyclin receptor:Gs (inactive)IRAG:IP3 receptor type 1ATPProstacyclin:prostacyclin receptor:G-protein Gs (active)L-ArginineATPCRAC channelATPStromal interaction molecule 1MAP kinase p38 alphaPECAM-1:SHP-2 complexBK channel, phophorylatedFGRLDLOrai1 dimerGTPP2X purinoceptor 1P2X1 purinoreceptor bound to ATPphospho-cPLA2phosphorylated PECAM-1Nitric oxide synthaseCationsPP2AIP receptor:ProstacyclinH+cGMP phosphodiesterasesCalciumPhosphorylated IRAG:IP3 receptor type 1NADP+L-CitrullineG-protein alpha (s):GTPIP3 receptor bound to IP3 and Ca++ApoER2Plasma membrane Ca2+ ATPasesPECAM-1:SHP-1 complexGTPCalcium


Description

Cyclooxygenase-2 (COX-2) and endothelial nitric oxide synthase (eNOS) are primarily expressed in endothelial cells and are considered as important regulators of vascular function. Under normal conditions, laminar flow induces vascular endothelial COX-2 expression and synthesis of Prostacyclin (PGI2) which in turn stimulates endothelial Nitric Oxide Synthase (eNOS) activity. PGI2 and NO both oppose platelet activation and aggregation, as does the CD39 ecto-ADPase (not annotated here) which decreases platelet activation and recruitment by metabolizing platelet-released ADP.

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Bibliography

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  1. Antl M, von Brühl ML, Eiglsperger C, Werner M, Konrad I, Kocher T, Wilm M, Hofmann F, Massberg S, Schlossmann J.; ''IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.''; PubMed Europe PMC Scholia
  2. Kramer RM, Roberts EF, Um SL, Börsch-Haubold AG, Watson SP, Fisher MJ, Jakubowski JA.; ''p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2.''; PubMed Europe PMC Scholia
  3. Hua CT, Gamble JR, Vadas MA, Jackson DE.; ''Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates.''; PubMed Europe PMC Scholia
  4. Thévenin AF, Monillas ES, Winget JM, Czymmek K, Bahnson BJ.; ''Trafficking of platelet-activating factor acetylhydrolase type II in response to oxidative stress.''; PubMed Europe PMC Scholia
  5. Zhang L, Wu J, Ruan KH.; ''Solution structure of the first intracellular loop of prostacyclin receptor and implication of its interaction with the C-terminal segment of G alpha s protein.''; PubMed Europe PMC Scholia
  6. Bokkala S, el-Daher SS, Kakkar VV, Wuytack F, Authi KS.; ''Localization and identification of Ca2+ATPases in highly purified human platelet plasma and intracellular membranes. Evidence that the monoclonal antibody PL/IM 430 recognizes the SERCA 3 Ca2+ATPase in human platelets.''; PubMed Europe PMC Scholia
  7. Wieland T, Michel MC.; ''Can a GDP-liganded G-protein be active?''; PubMed Europe PMC Scholia
  8. Lambert NA.; ''Dissociation of heterotrimeric g proteins in cells.''; PubMed Europe PMC Scholia
  9. Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K.; ''Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases.''; PubMed Europe PMC Scholia
  10. Fumagalli L, Zhang H, Baruzzi A, Lowell CA, Berton G.; ''The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine.''; PubMed Europe PMC Scholia
  11. Gabellini N, Bortoluzzi S, Danieli GA, Carafoli E.; ''The human SLC8A3 gene and the tissue-specific Na+/Ca2+ exchanger 3 isoforms.''; PubMed Europe PMC Scholia
  12. Park CY, Hoover PJ, Mullins FM, Bachhawat P, Covington ED, Raunser S, Walz T, Garcia KC, Dolmetsch RE, Lewis RS.; ''STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1.''; PubMed Europe PMC Scholia
  13. Komuro I, Wenninger KE, Philipson KD, Izumo S.; ''Molecular cloning and characterization of the human cardiac Na+/Ca2+ exchanger cDNA.''; PubMed Europe PMC Scholia
  14. Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E, Birnbaumer L.; ''trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.''; PubMed Europe PMC Scholia
  15. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G.; ''Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.''; PubMed Europe PMC Scholia
  16. Relou IA, Gorter G, Ferreira IA, van Rijn HJ, Akkerman JW.; ''Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits low density lipoprotein-induced signaling in platelets.''; PubMed Europe PMC Scholia
  17. Korporaal SJ, Relou IA, van Eck M, Strasser V, Bezemer M, Gorter G, van Berkel TJ, Nimpf J, Akkerman JW, Lenting PJ.; ''Binding of low density lipoprotein to platelet apolipoprotein E receptor 2' results in phosphorylation of p38MAPK.''; PubMed Europe PMC Scholia
  18. DeHaven WI, Smyth JT, Boyles RR, Putney JW.; ''Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels.''; PubMed Europe PMC Scholia
  19. Stitham J, Stojanovic A, Merenick BL, O'Hara KA, Hwa J.; ''The unique ligand-binding pocket for the human prostacyclin receptor. Site-directed mutagenesis and molecular modeling.''; PubMed Europe PMC Scholia
  20. Ransnäs LA, Insel PA.; ''Subunit dissociation is the mechanism for hormonal activation of the Gs protein in native membranes.''; PubMed Europe PMC Scholia
  21. Armstrong RA, Lawrence RA, Jones RL, Wilson NH, Collier A.; ''Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors.''; PubMed Europe PMC Scholia
  22. Sun B, Li J, Okahara K, Kambayashi J.; ''P2X1 purinoceptor in human platelets. Molecular cloning and functional characterization after heterologous expression.''; PubMed Europe PMC Scholia
  23. Becker BF, Heindl B, Kupatt C, Zahler S.; ''Endothelial function and hemostasis.''; PubMed Europe PMC Scholia
  24. Zschauer A, van Breemen C, Bühler FR, Nelson MT.; ''Calcium channels in thrombin-activated human platelet membrane.''; PubMed Europe PMC Scholia
  25. Vial C, Pitt SJ, Roberts J, Rolf MG, Mahaut-Smith MP, Evans RJ.; ''Lack of evidence for functional ADP-activated human P2X1 receptors supports a role for ATP during hemostasis and thrombosis.''; PubMed Europe PMC Scholia
  26. Li Z, Matsuoka S, Hryshko LV, Nicoll DA, Bersohn MM, Burke EP, Lifton RP, Philipson KD.; ''Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger.''; PubMed Europe PMC Scholia
  27. Riccio A, Mattei C, Kelsell RE, Medhurst AD, Calver AR, Randall AD, Davis JB, Benham CD, Pangalos MN.; ''Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx.''; PubMed Europe PMC Scholia
  28. Spamer C, Heilmann C, Gerok W.; ''Ca2+-activated ATPase in microsomes from human liver.''; PubMed Europe PMC Scholia
  29. Mócsai A, Jakus Z, Vántus T, Berton G, Lowell CA, Ligeti E.; ''Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases.''; PubMed Europe PMC Scholia
  30. Jackson DE, Ward CM, Wang R, Newman PJ.; ''The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1- and integrin-mediated cellular signaling.''; PubMed Europe PMC Scholia
  31. Monillas ES, Caplan JL, Thévenin AF, Bahnson BJ.; ''Oligomeric state regulated trafficking of human platelet-activating factor acetylhydrolase type-II.''; PubMed Europe PMC Scholia
  32. Katsuyama M, Sugimoto Y, Namba T, Irie A, Negishi M, Narumiya S, Ichikawa A.; ''Cloning and expression of a cDNA for the human prostacyclin receptor.''; PubMed Europe PMC Scholia
  33. Verma AK, Filoteo AG, Stanford DR, Wieben ED, Penniston JT, Strehler EE, Fischer R, Heim R, Vogel G, Mathews S.; ''Complete primary structure of a human plasma membrane Ca2+ pump.''; PubMed Europe PMC Scholia
  34. Rice SQ, Southan C, Boyd HF, Terrett JA, MacPhee CH, Moores K, Gloger IS, Tew DG.; ''Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor.''; PubMed Europe PMC Scholia
  35. Muik M, Frischauf I, Derler I, Fahrner M, Bergsmann J, Eder P, Schindl R, Hesch C, Polzinger B, Fritsch R, Kahr H, Madl J, Gruber H, Groschner K, Romanin C.; ''Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.''; PubMed Europe PMC Scholia
  36. Chou AC, Ju YT, Pan CY.; ''Calmodulin Interacts with the Sodium/Calcium Exchanger NCX1 to Regulate Activity.''; PubMed Europe PMC Scholia
  37. Luik RM, Wang B, Prakriya M, Wu MM, Lewis RS.; ''Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation.''; PubMed Europe PMC Scholia
  38. Derbyshire ER, Marletta MA.; ''Biochemistry of soluble guanylate cyclase.''; PubMed Europe PMC Scholia
  39. Ding S, Sachs F.; ''Single channel properties of P2X2 purinoceptors.''; PubMed Europe PMC Scholia
  40. Boie Y, Rushmore TH, Darmon-Goodwin A, Grygorczyk R, Slipetz DM, Metters KM, Abramovitz M.; ''Cloning and expression of a cDNA for the human prostanoid IP receptor.''; PubMed Europe PMC Scholia
  41. Zamparelli C, Macquaide N, Colotti G, Verzili D, Seidler T, Smith GL, Chiancone E.; ''Activation of the cardiac Na(+)-Ca(2+) exchanger by sorcin via the interaction of the respective Ca(2+)-binding domains.''; PubMed Europe PMC Scholia
  42. Schwaner I, Offermanns S, Spicher K, Seifert R, Schultz G.; ''Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL.''; PubMed Europe PMC Scholia
  43. Mahaut-Smith MP, Sage SO, Rink TJ.; ''Receptor-activated single channels in intact human platelets.''; PubMed Europe PMC Scholia
  44. Schatzmann HJ.; ''ATP-dependent Ca++-extrusion from human red cells.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114759view16:24, 25 January 2021ReactomeTeamReactome version 75
113203view11:27, 2 November 2020ReactomeTeamReactome version 74
112428view15:37, 9 October 2020ReactomeTeamReactome version 73
101332view11:22, 1 November 2018ReactomeTeamreactome version 66
100870view20:55, 31 October 2018ReactomeTeamreactome version 65
100411view19:28, 31 October 2018ReactomeTeamreactome version 64
99960view16:13, 31 October 2018ReactomeTeamreactome version 63
99515view14:46, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99157view12:41, 31 October 2018ReactomeTeamreactome version 62
93869view13:42, 16 August 2017ReactomeTeamreactome version 61
93435view11:23, 9 August 2017ReactomeTeamreactome version 61
88100view09:31, 26 July 2016RyanmillerOntology Term : 'homeostasis pathway' added !
88099view09:30, 26 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
86527view09:20, 11 July 2016ReactomeTeamreactome version 56
83192view10:19, 18 November 2015ReactomeTeamVersion54
81566view13:06, 21 August 2015ReactomeTeamVersion53
77031view08:33, 17 July 2014ReactomeTeamFixed remaining interactions
76736view12:09, 16 July 2014ReactomeTeamFixed remaining interactions
76061view10:12, 11 June 2014ReactomeTeamRe-fixing comment source
75771view11:28, 10 June 2014ReactomeTeamReactome 48 Update
75121view14:07, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74768view08:51, 30 April 2014ReactomeTeamReactome46
72011view12:23, 24 October 2013EgonwMore Uniprot-TrEMBL data source fixes.
72010view12:21, 24 October 2013EgonwFixed the Uniprot-TrEMBL data source.
42101view21:57, 4 March 2011MaintBotAutomatic update
39911view05:56, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3',5'-Cyclic GMP Metabolite16356 (ChEBI)
ADP Metabolite16761 (ChEBI)
ATP Metabolite15422 (ChEBI)
Activated cGMP-

dependent protein kinase (PKGs)

ComplexREACT_24034 (Reactome)
ApoER2 ProteinQ14114 (UniProt)
BK channel ComplexREACT_24118 (Reactome) BK channels (also called Maxi-K or slo1) are potassium ion channels. They are activated by changes in membrane electrical potential and increases in intracellular [Ca2+]. Opening of BK channels results in cell membrane hyperpolarization. BK channels are tetramers of dimer subunits formed by the association of a pore-forming alpha subunit, always derived from the same gene KCNMA1, and a modulatory beta subunit, dervied from one of 4 human genes KCNMB11-4. Intracellular calcium regulates the physical association between the alpha and beta subunits.
BK channel,

phophorylated

ComplexREACT_24816 (Reactome) BK channels (also called Maxi-K or slo1) are potassium ion channels. They are activated by changes in membrane electrical potential and increases in intracellular [Ca2+]. Opening of BK channels results in cell membrane hyperpolarization. BK channels are tetramers of dimer subunits formed by the association of a pore-forming alpha subunit, always derived from the same gene KCNMA1, and a modulatory beta subunit, dervied from one of 4 human genes KCNMB11-4. Intracellular calcium regulates the physical association between the alpha and beta subunits.
CRAC channel ComplexREACT_24443 (Reactome)
Calcium Metabolite29108 (ChEBI)
Cations MetaboliteREACT_24030 (Reactome)
Cations MetaboliteREACT_24868 (Reactome)
Cyclic GMP-dependent

protein kinases (PKGs)

ProteinREACT_24186 (Reactome)
DAG-activated

TRPC3/6/7

ComplexREACT_24061 (Reactome)
FGR ProteinP09769 (UniProt)
G-protein alpha

(s):GTP

ComplexREACT_5470 (Reactome)
G-protein beta-

gamma complex

ComplexREACT_15674 (Reactome)
GDP Metabolite17552 (ChEBI)
GMP Metabolite17345 (ChEBI)
GTP Metabolite15996 (ChEBI)
Guanylate cyclase,

soluble

ComplexREACT_24123 (Reactome)
Guanylate cyclase:NO ComplexREACT_24768 (Reactome)
H+ Metabolite15378 (ChEBI)
Heterotrimeric G-

protein Gs (inactive)

ComplexREACT_18222 (Reactome)
IP receptor ProteinP43119 (UniProt)
IP receptor:

Prostacyclin

ComplexREACT_17421 (Reactome)
IP3 receptor bound

to IP3 and Ca++

ComplexREACT_4346 (Reactome)
IRAG:IP3 receptor

type 1

ComplexREACT_24389 (Reactome)
L-Arginine Metabolite16467 (ChEBI)
L-Citrulline Metabolite16349 (ChEBI)
LDL ComplexREACT_7774 (Reactome) LDL (low density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipids. LDL complexes contain single molecules of apoB-100, but their content of lipids is variable (Chapman et al. 1988; Mateu et al. 1972; Tardieu et al. 1976). High levels of LDL in the blood are strongly correlated with increased risk of atherosclerosis, and recent studies have raised the possibility that this risk is further increased in individuals whose blood LDL population is enriched in high-density (low lipid content) LDL complexes (Rizzo and Berneis 2006). The LDL complex annotated here contains an average lipid composition.
LDL:ApoER2 ComplexREACT_24595 (Reactome)
LDL:p-ApoER2:FGR ComplexREACT_24077 (Reactome)
MAP kinase p38 alpha ProteinQ16539 (UniProt)
NADP+ Metabolite18009 (ChEBI)
NADPH Metabolite16474 (ChEBI)
Na+/Ca2+

exchanger proteins

ProteinREACT_20277 (Reactome)
Nitric oxide Metabolite16480 (ChEBI)
Nitric oxide synthase ProteinREACT_24417 (Reactome)
Orai1

dimer

ComplexREACT_24301 (Reactome)
Oxygen Metabolite15379 (ChEBI)
P2X purinoceptor

1

ProteinP51575 (UniProt)
P2X1

purinoreceptor bound to ATP

ComplexREACT_3044 (Reactome) P2X1 protein readily forms stable trimers and hexamers, suggesting that the intact receptor is a multimer of three or six subunits in heterologous expression systems. However,assembly in native cells may be influenced significantly by associated proteins that are not present in heterologous expression systems.
PECAM-1:SHP-1

complex

ComplexREACT_13228 (Reactome)
PECAM-1:SHP-2

complex

ComplexREACT_13041 (Reactome)
PP2A ComplexREACT_10628 (Reactome)
Phospho-MAP kinase

p38 alpha

ProteinQ16539 (UniProt)
Phosphorylated

IRAG:IP3 receptor type 1

ComplexREACT_24181 (Reactome)
Plasma membrane

Ca2+ ATPases

ProteinREACT_24662 (Reactome)
Prostacyclin Metabolite15552 (ChEBI)
Prostacyclin:

prostacyclin receptor:G-protein Gs (active)

ComplexREACT_24753 (Reactome)
Prostacyclin:

prostacyclin receptor:Gs (inactive)

ComplexREACT_24060 (Reactome)
SHP1 ProteinP29350 (UniProt)
SHP2 ProteinQ06124 (UniProt)
Sarco/endoplasmic

reticulum Ca2+ ATPases (SERCAs)

ProteinREACT_24286 (Reactome)
Stromal interaction

molecule 1

ProteinQ13586 (UniProt)
cGMP

phosphodiesterases

ProteinREACT_24101 (Reactome)
cPLA2 ProteinP47712 (UniProt)
p-PECAM:PP2A ComplexREACT_24470 (Reactome)
phospho-cPLA2 ProteinP47712 (UniProt)
phosphorylated

PECAM-1

ProteinP16284 (UniProt)
pyrophosphate Metabolite29888 (ChEBI)
sodium ion Metabolite29101 (ChEBI)

Annotated Interactions

No annotated interactions

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