Angiogenesis overview (Homo sapiens)
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FAK
MT1-MMP
Ca2+
VEGF
Cdc42
P110
Stem Cell
DAG
eloC
transcription of angiogenesis-related genes
Ang1
Proteosome
TK
P85-PI3K
Dok-R
Tie2
Integrins
Nox4
ROS
MT-MMP
GF
Pak
MEKK
Shb
Akt / PKB
PLC-gamma
Filopodia and
Lamellopodia
p38 MAPK
PI3K
FAK
NO
urokinase-plasminogen activator
Survival
Shc
HIF2-alpha
Raf
Shp2
Breakdown of extracellular
tissue like collagen
PIP2
Robo4
Slit2
MMP12
TIMP4
Raf
BAD
MMP2
STAT3
Grb2
Migration
Ras GAP
Ras
Elk1
IP2
FGFR1
VHL
ATF2
Plexin D1
PLD
PKC
Angiogenesis
IQGAP
Neuropillin
Semaphorin 3A
Grb2
NADPH oxidase 2
OH
Ca2+ - release
Survival
MEK
hypoxia
PDKs
Sos
eNOS
PIP3
TIMP2
Paxillin
MMP9
MKK3/6
1/2 ERK MAPK
Dia1
Bmx
APC
SEK
Thrombin
Filipodia and
lamellopodia
Ras
JNK
Rac
Crk
Migration
PHD
Migration
AKT
Ras
WASP
Permeability
SHP-2
Nck
CDC42
VEGFR2
FGF1
STAT5
MEK
ERK 1/2 MAPK
PKC
Proliferation
Grb14
Slit2
Pla2
Robo1
Robo1
p38 MAPK
Src
MMPs
IP3
PLC-gamma
PIP2
Semaphorin4A
FRS-2
Crk
DAG1
Tor
Robo4
HIF2-alpha
HIF2-alpha
OH
pUb
eloB
Grb2
SOS1
Grb7
Slit2
Stem Cell
Stem Cell
Description
No description
Comments
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Bibliography
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History
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Compare
Revision
Action
Time
User
Comment
126081
view
09:00, 1 April 2023
Egonw
Removed unclear "GF" comment
126080
view
08:50, 1 April 2023
Egonw
Added a few datanode types (guessed a few, because no IDs were given)
110975
view
14:21, 25 June 2020
L Dupuis
Connected lines
106214
view
12:11, 16 August 2019
MaintBot
HMDB identifier normalization
85555
view
08:32, 29 May 2016
Egonw
Replaced a mim-conversion with Arrow.
71385
view
18:41, 17 October 2013
MaintBot
Automated update of data sources
71268
view
21:58, 16 October 2013
MaintBot
Automated update of data sources
69001
view
17:45, 8 July 2013
MaintBot
Updated to 2013 gpml schema
59192
view
19:07, 22 February 2013
MaintBot
Updated Ensembl and UniProt data source
58505
view
19:00, 14 February 2013
MaintBot
Modified title
44954
view
12:37, 6 October 2011
MartijnVanIersel
Ontology Term : 'growth factor signaling pathway' added !
44820
view
13:30, 5 October 2011
Susan
Modified description
44464
view
18:42, 14 September 2011
MaintBot
Modified categories
44462
view
14:33, 14 September 2011
Helix
angiogenesis overview
44393
view
10:35, 8 September 2011
Helix
angiogenesis overviuew
44392
view
10:26, 8 September 2011
Helix
Periodical save, work in progress
44389
view
10:15, 8 September 2011
Helix
Periodical save, work in progress
43912
view
12:37, 16 August 2011
Helix
angiogensisi overview
43911
view
12:29, 16 August 2011
Helix
Periodical save, work in progress
43909
view
12:19, 16 August 2011
Helix
Periodical save, work in progress
43908
view
11:54, 16 August 2011
Helix
Periodical save, work in progress
43907
view
11:43, 16 August 2011
Helix
Periodical save, work in progress
43906
view
11:31, 16 August 2011
Helix
angiogenesis overview
43905
view
11:11, 16 August 2011
Helix
Periodical save, work in progress
43902
view
11:48, 15 August 2011
Helix
angiogenesis overview
43901
view
11:46, 15 August 2011
Helix
Periodical save, work in progress
43900
view
11:36, 15 August 2011
Helix
Periodical save, work in progress
43899
view
11:26, 15 August 2011
Helix
Periodical save, work in progress
43898
view
11:15, 15 August 2011
Helix
Periodical save, work in progress
43896
view
11:04, 15 August 2011
Helix
angiogenesis overview
43605
view
09:00, 7 July 2011
Helix
angiopgenesis overview
43604
view
08:57, 7 July 2011
Helix
Periodical save, work in progress
43603
view
08:46, 7 July 2011
Helix
Periodical save, work in progress
43602
view
08:36, 7 July 2011
Helix
Periodical save, work in progress
43596
view
09:28, 6 July 2011
Helix
angiogenesis overview
43146
view
13:05, 3 June 2011
Helix
angiogenesis overview
43145
view
12:58, 3 June 2011
Helix
Periodical save, work in progress
43144
view
12:48, 3 June 2011
Helix
Periodical save, work in progress
43143
view
12:37, 3 June 2011
Helix
Periodical save, work in progress
43142
view
12:27, 3 June 2011
Helix
Periodical save, work in progress
43141
view
12:17, 3 June 2011
Helix
Periodical save, work in progress
43140
view
11:38, 3 June 2011
Helix
Periodical save, work in progress
43139
view
11:28, 3 June 2011
Helix
Periodical save, work in progress
43138
view
11:17, 3 June 2011
Helix
Periodical save, work in progress
43137
view
11:07, 3 June 2011
Helix
Periodical save, work in progress
43136
view
10:43, 3 June 2011
Helix
Periodical save, work in progress
43135
view
10:40, 3 June 2011
Helix
angiogenesis overview
43134
view
10:33, 3 June 2011
Helix
Periodical save, work in progress
43133
view
10:23, 3 June 2011
Helix
Periodical save, work in progress
43132
view
10:13, 3 June 2011
Helix
Periodical save, work in progress
External references
DataNodes
View all...
Name
Type
Database reference
Comment
1/2 ERK MAPK
Protein
AKT
Protein
APC
Protein
ATF2
Protein
Akt / PKB
Protein
Angiogenesis
Pathway
BAD
Protein
Bmx
Protein
Breakdown of extracellular tissue like collagen
Pathway
CDC42
GeneProduct
ENSG00000070831 (Ensembl Human)
Ca2+ - release
Pathway
Crk
Protein
DAG1
GeneProduct
ENSG00000173402 (Ensembl Human)
Dia1
Protein
ERK 1/2 MAPK
Protein
Elk1
Protein
FAK
Protein
FGF1
GeneProduct
ENSG00000113578 (Ensembl Human)
FGFR1
GeneProduct
ENSG00000077782 (Ensembl Human)
FRS-2
Protein
Filipodia and lamellopodia
Protein
Filopodia and Lamellopodia
Protein
Grb14
Protein
Grb2
Protein
Grb7
Protein
HIF2-alpha
Protein
IP2
Protein
IP3
Protein
IQGAP
Protein
JNK
Protein
MEK
Protein
MKK3/6
Protein
MMP12
Protein
MMP2
Protein
MMP9
Protein
MMPs
Protein
Migration
Pathway
NADPH oxidase 2
Protein
NO
Protein
Nck
Protein
Neuropillin
Protein
OH
PDKs
Protein
PHD
Protein
PI3K
Protein
PIP2
Protein
PIP2
Metabolite
HMDB10032 (HMDB)
PIP3
Protein
PKC
PLC-gamma
Protein
PLC-gamma
GeneProduct
5335 (Entrez Gene)
PLD
Protein
Paxillin
Protein
Permeability
Pathway
Pla2
Protein
Plexin D1
Protein
Proliferation
Pathway
Rac
Protein
Raf
Protein
Ras
Protein
Ras GAP
Protein
Robo1
Protein
Robo4
Protein
SEK
Protein
SHP-2
Protein
SOS1
GeneProduct
ENSG00000115904 (Ensembl Human)
STAT3
Protein
STAT5
Protein
Semaphorin 3A
Protein
Semaphorin4A
Protein
Shc
Protein
Shp2
Protein
Slit2
Sos
Protein
Src
Protein
Survival
Pathway
TIMP2
Protein
TIMP4
Protein
Thrombin
Protein
Tor
Protein
VEGFR2
VHL
GeneProduct
ENSG00000134086 (Ensembl Human)
WASP
Protein
eNOS
Protein
hypoxia
p38 MAPK
Protein
p38 MAPK
GeneProduct
ENSG00000185386 (Ensembl Human)
p38 MAPK
pUb
urokinase-plasminogen activator
Protein
Annotated Interactions
No annotated interactions
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External references
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