Iron metabolism in placenta (Homo sapiens)

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8, 163, 5, 13Ferritinclathrin-coated early endosome signal ? foetal livermithocondrion84, 6, 112, 15ApicalpH 6-7basolateral?TFR1SLC40A1TFHAMPfoetal HAMP?HEPHSTEAP386148FeIIIFeIIITFR1TFFeIIIFeIIITFR11TFFeIIISTEAP3late endosome TFR1TFFeIIISTEAP3lysosomeTFR1TFFeIIpH 5-6FeIIH+FeII?SLC11A2MCOLN1FeII10H+FeIIMCOLN110SLC11A2FeIII6, 9?12foetal TFFeIIIFeIIIFeIIIFeIIFeIIIFeIIIFeIIITFR27TFFeIIIFeIIImaternal liverTFFeIIIFeIII


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Bibliography

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  1. Georgieff MK, Berry SA, Wobken JD, Leibold EA; ''Increased placental iron regulatory protein-1 expression in diabetic pregnancies complicated by fetal iron deficiency.''; Placenta, 1999 PubMed Europe PMC Scholia
  2. Stys A, Galy B, Starzynski RR, Smuda E, Drapier JC, Lipinski P, Bouton C; ''Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  3. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA; ''Cloning and characterization of a mammalian proton-coupled metal-ion transporter.''; Nature, 1997 PubMed Europe PMC Scholia
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  5. Dong XP, Cheng X, Mills E, Delling M, Wang F, Kurz T, Xu H; ''The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel.''; Nature, 2008 PubMed Europe PMC Scholia
  6. Chen H, Attieh ZK, Syed BA, Kuo YM, Stevens V, Fuqua BK, Andersen HS, Naylor CE, Evans RW, Gambling L, Danzeisen R, Bacouri-Haidar M, Usta J, Vulpe CD, McArdle HJ; ''Identification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, and characterization in rodents and human cells.''; J Nutr, 2010 PubMed Europe PMC Scholia
  7. Gambling L, Lang C, McArdle HJ; ''Fetal regulation of iron transport during pregnancy.''; Am J Clin Nutr, 2011 PubMed Europe PMC Scholia
  8. Ohgami RS, Campagna DR, Greer EL, Antiochos B, McDonald A, Chen J, Sharp JJ, Fujiwara Y, Barker JE, Fleming MD; ''Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells.''; Nat Genet, 2005 PubMed Europe PMC Scholia
  9. Ganz T; ''Hepcidin and iron regulation, 10 years later.''; Blood, 2011 PubMed Europe PMC Scholia
  10. Habtemichael EN, Brewer PD, Romenskaia I, Mastick CC; ''Kinetic evidence that Glut4 follows different endocytic pathways than the receptors for transferrin and alpha2-macroglobulin.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  11. Baraibar MA, Muhoberac BB, Garringer HJ, Hurley TD, Vidal R; ''Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  12. Bou-Abdallah F, Santambrogio P, Levi S, Arosio P, Chasteen ND; ''Unique iron binding and oxidation properties of human mitochondrial ferritin: a comparative analysis with Human H-chain ferritin.''; J Mol Biol, 2005 PubMed Europe PMC Scholia
  13. Steere AN, Byrne SL, Chasteen ND, Mason AB; ''Kinetics of iron release from transferrin bound to the transferrin receptor at endosomal pH.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
  14. Chen J, Wang J, Meyers KR, Enns CA; ''Transferrin-directed internalization and cycling of transferrin receptor 2.''; Traffic, 2009 PubMed Europe PMC Scholia
  15. Zoller H, Theurl I, Koch R, Kaser A, Weiss G; ''Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1.''; Blood Cells Mol Dis, 2002 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
106626view20:53, 12 September 2019Khanspersfixed unconnected
106625view20:51, 12 September 2019KhanspersModified description
105632view05:04, 10 August 2019KhanspersModified description
97386view04:23, 14 May 2018Khansperswork on interactions
97317view14:18, 9 May 2018AMTanRectified interactions where possible, converted some lines to graphical lines if they were between a target and the actual interaction line.
69751view10:40, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
67414view10:58, 26 June 2013DdiglesOntology Term : 'iron homeostasis pathway' added !
63226view21:03, 8 May 2013MaintBotUpdating gpml version
59188view18:57, 22 February 2013MaintBotUpdated Ensembl data source
58506view19:06, 14 February 2013MaintBotModified title
45568view07:39, 17 October 2011Evelotype in mitochondrion
44879view10:03, 6 October 2011MartijnVanIerselOntology Term : 'PW:0000590' removed !
44878view10:03, 6 October 2011MartijnVanIerselOntology Term : 'iron transport pathway' added !
44877view10:03, 6 October 2011MartijnVanIerselOntology Term : 'iron homeostasis pathway' added !
44272view18:02, 30 August 2011KhanspersModified categories
44268view14:37, 30 August 2011JcompaiPeriodical save, work in progress
44265view14:16, 30 August 2011JcompaiSpecify description
44264view14:15, 30 August 2011JcompaiPeriodical save, work in progress
44254view11:11, 30 August 2011JcompaiIRP1/ferritin interaction
44237view09:02, 29 August 2011JcompaiWIP
44136view10:36, 25 August 2011JcompaiPeriodical save, work in progress
43924view13:30, 17 August 2011JcompaiWIP
43897view11:06, 15 August 2011JcompaiPeriodical save, work in progress
43895view10:56, 15 August 2011JcompaiPeriodical save, work in progress
43885view13:31, 11 August 2011JcompaiWIP
43884view11:23, 11 August 2011JcompaiPeriodical save, work in progress
43883view11:13, 11 August 2011JcompaiPeriodical save, work in progress
43818view08:25, 4 August 2011JcompaiWIP
43806view11:14, 29 July 2011JcompaiWIP
43805view09:09, 29 July 2011JcompaiModified description
43797view11:10, 28 July 2011JcompaiWIP
43796view10:58, 28 July 2011JcompaiPeriodical save, work in progress
43795view08:21, 28 July 2011JcompaiWIP
43779view14:48, 27 July 2011JcompaiWIP
43778view14:35, 27 July 2011JcompaiPeriodical save, work in progress
43777view12:47, 27 July 2011JcompaiWIP
43776view12:42, 27 July 2011JcompaiPeriodical save, work in progress
43775view12:31, 27 July 2011JcompaiPeriodical save, work in progress
43743view11:04, 21 July 2011JcompaiPeriodical save, work in progress
43737view10:26, 21 July 2011JcompaiWIP
43734view10:19, 21 July 2011JcompaiPeriodical save, work in progress
43733view10:08, 21 July 2011JcompaiPeriodical save, work in progress
43732view09:31, 21 July 2011JcompaiPeriodical save, work in progress
43722view11:41, 20 July 2011JcompaiWIP
43721view11:34, 20 July 2011Jcompai
43720view11:28, 20 July 2011JcompaiPeriodical save, work in progress
43688view12:06, 14 July 2011JcompaiPeriodical save, work in progress
43687view11:52, 14 July 2011JcompaiPeriodical save, work in progress
43686view11:42, 14 July 2011JcompaiPeriodical save, work in progress
43685view11:32, 14 July 2011JcompaiPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
HAMPProteinENSG00000105697 (Ensembl Human)
HEPHGeneProductENSG00000089472 (Ensembl Human)
MCOLN1GeneProductENSG00000090674 (Ensembl Human)
SLC11A2GeneProductENSG00000110911 (Ensembl Human)
SLC40A1GeneProductENSG00000138449 (Ensembl Human)
STEAP3GeneProductENSG00000115107 (Ensembl Human)
TFProteinENSG00000091513 (Ensembl Human) Transferrin
TFR1ProteinENSG00000072274 (Ensembl Human) Transferrin receptor
TFR2GeneProductENSG00000106327 (Ensembl Human) Transferrin receptor
foetal HAMP?ProteinENSG00000105697 (Ensembl Human) HAMP
foetal TFProteinENSG00000091513 (Ensembl Human) Transferrin

Annotated Interactions

No annotated interactions

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