TNF-alpha signaling (Homo sapiens)

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Arachidonic acidROSCytochrome CCa2+PLA2CYProcaspase 3/7Cytochrome CHydroperoxidesTNF alpha Signaling PathwayCeramideApoptosisNUCYNecrosisROSNURFFLDIABLOFBXW11MAPK8SOS1BIDMAP3K14CASP7MAP2K3BIRC2RELAMAPK9HSP90AA1PYGLAPAF1FADDTNFRSF1BRAC1IKBKBIKBKGTNFGLULMAP3K8CYBACASP8TRADD IL6TNFRSF1BKSR1TNFRFKTRAP1BIRC3PPP2CATNFTNFRSF1BRAF1SMPD2CREBBPPro-CASP8BCL2L1TRADDTRAF2CASP9DIABLOTAB3TNFRSF1ACASP3TNFCFLARMAP3K7TAB1MAP3K5BADNFKB1MAPK3MAP3K1PRKCZTNFBAXKSR2RELTNFRELMAP2K7NOX1PSMD2MAPK8RIPK1NFKB2MAP4K2OTUD7BTRAF2CDC37SKP1MAP2K4TNFRSF1APLK1MAP2K6NFKB2NOXO1BTRCNFKBIETXNNFKBIBMAPK1NSMAFCUL1RIPK1CCL2TRAF1TANKNFKB1MADDTBK1RIPK3GRB2TNFAIP3MAPK9JUNCHUKCSNK2A1RELANFKBIABIRC3BCL2L1TAB2RASSELETNFRSF1ABIRC2AKT1MAP3K3PPPPPPCPPPPPUbUbPPPNUCYCYMTCYMTProteinReceptorProteinProteinmRNASmall moleculeLigandInduced activationEnzyme complexInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMoleculeProtein-protein dissociation


Description

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Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
129710view01:30, 22 May 2024EweitzModified title
124583view05:13, 13 November 2022EgonwRemoved outdated license info: all CCZero now
124582view05:11, 13 November 2022EgonwConverted a label ("ROS") to a metabolite node with identifier
120699view13:12, 23 December 2021EweitzStandardize font, weight, case
116472view10:16, 7 May 2021EweitzModified title
111053view14:57, 3 July 2020L DupuisConverted interactions to graphical lines in legend
105836view23:09, 15 August 2019KhanspersModified description
89895view13:10, 6 October 2016EgonwModified description
81070view19:14, 19 July 2015EgonwAdded three missing ChEBI metabolite IDs.
79942view08:40, 28 April 2015Zariadded annotation for RAS
79280view22:53, 19 March 2015ZariAdded Identifier for SELE,CCL2 and NOXO1
78500view10:28, 7 January 2015MaintBotadded missing graphIds
72093view21:34, 24 October 2013Mkutmonadded datasource to "TNF"
71708view20:00, 17 October 2013MaintBotremoved data source from nodes without identifier
70103view18:53, 12 July 2013MaintBotupdated to 2013 schema
67700view11:51, 26 June 2013DdiglesOntology Term : 'tumor necrosis factor mediated signaling pathway' added !
47978view14:38, 23 April 2012NetPathModified description
44640view18:30, 22 September 2011Khanspersadded description
44639view18:29, 22 September 2011KhanspersModified categories
44638view18:29, 22 September 2011KhanspersUpdating content to NetSlim
41210view23:44, 1 March 2011MaintBotRemoved redundant pathway information and comments
36762view19:39, 29 April 2010Khansperstest
35303view23:33, 11 February 2010NsalomonisModified description
32365view13:44, 15 August 2009MaintBotFixed text labels
32004view13:18, 14 August 2009MaintBotFixed group labels
28972view11:00, 19 March 2009EveloSpecify description
28971view10:54, 19 March 2009EveloJus alignments
28970view10:42, 19 March 2009Evelocleaned up a bit
28911view08:09, 12 March 2009AlexanderPicoconnecting edges
28908view07:04, 12 March 2009AlexanderPicoconnecting edges
28907view06:23, 12 March 2009AlexanderPicoconnecting edges
28906view05:04, 12 March 2009Burakconnected the edges
28905view04:54, 12 March 2009BurakPeriodical save, work in progress
21163view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:WP231]]: Moved to stable identifier
8446view13:46, 7 January 2008MaintBot[[Pathway:Human:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:Homo sapiens:TNF-alpha-NF-kB NetPath 9]]: Renaming species
7839view16:21, 18 December 2007MaintBotfixed category names
7307view12:42, 4 November 2007MaintBotAdded categories to GPML
6399view22:18, 22 May 2007A.Pandeygpml file for [[Human:TNF-alpha-NF-kB_NetPath_9]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
IL6Rna3569 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
APAF1Protein317 (Entrez Gene)
BADProtein572 (Entrez Gene)
BAXProtein581 (Entrez Gene)
BCL2L1Protein598 (Entrez Gene)
BIDProtein637 (Entrez Gene)
BIRC2Rna329 (Entrez Gene)
BIRC3Rna330 (Entrez Gene)
BTRCProtein8945 (Entrez Gene)
CASP3Protein836 (Entrez Gene)
CASP7Protein840 (Entrez Gene)
CASP8Protein841 (Entrez Gene)
CASP9Protein842 (Entrez Gene)
CCL2Rna
CDC37Protein11140 (Entrez Gene)
CFLARProtein8837 (Entrez Gene)
CHUKProtein1147 (Entrez Gene)
CREBBPProtein1387 (Entrez Gene)
CSNK2A1Protein1457 (Entrez Gene)
CUL1Protein8454 (Entrez Gene)
CYBAProtein1535 (Entrez Gene)
DIABLOProtein56616 (Entrez Gene)
FADDProtein8772 (Entrez Gene)
FBXW11Protein23291 (Entrez Gene)
GLULProtein2752 (Entrez Gene)
GRB2Protein2885 (Entrez Gene)
HSP90AA1Protein3320 (Entrez Gene)
IKBKBProtein3551 (Entrez Gene)
IKBKGProtein8517 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
KSR1Protein8844 (Entrez Gene)
KSR2Protein283455 (Entrez Gene)
MADDProtein8567 (Entrez Gene)
MAP2K3Protein5606 (Entrez Gene)
MAP2K4Protein6416 (Entrez Gene)
MAP2K6Protein5608 (Entrez Gene)
MAP2K7Protein5609 (Entrez Gene)
MAP3K1Protein4214 (Entrez Gene)
MAP3K14Protein9020 (Entrez Gene)
MAP3K3Protein4215 (Entrez Gene)
MAP3K5Protein4217 (Entrez Gene)
MAP3K7Protein6885 (Entrez Gene)
MAP3K8Protein1326 (Entrez Gene)
MAP4K2Protein5871 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKB2Protein4791 (Entrez Gene)
NFKBIAProtein4792 (Entrez Gene)
NFKBIBProtein4793 (Entrez Gene)
NFKBIEProtein4794 (Entrez Gene)
NOX1Protein27035 (Entrez Gene)
NOXO1ProteinSH3 domain of NOXO1 interacts with TRADD in mouse embryonic fibroblasts and 293 cells.
NSMAFProtein8439 (Entrez Gene)
OTUD7BProtein56957 (Entrez Gene)
PLK1Protein5347 (Entrez Gene)
PPP2CAProtein5515 (Entrez Gene)
PRKCZProtein5590 (Entrez Gene)
PSMD2Protein5708 (Entrez Gene)
PYGLProtein5836 (Entrez Gene)
Pro-CASP8Protein541 (Entrez Gene)
RAC1Protein5879 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RASProtein
RELProtein5966 (Entrez Gene)
RELAProtein5790 (Entrez Gene)
RELAProtein5966 (Entrez Gene)
RFFLProtein117584 (Entrez Gene)
RFKProtein55312 (Entrez Gene)
RIPK1Protein8737 (Entrez Gene)
RIPK3Protein11035 (Entrez Gene)
SELERna
SKP1Protein6500 (Entrez Gene)
SMPD2Protein6610 (Entrez Gene)
SOS1Protein6654 (Entrez Gene)
TAB1Protein10454 (Entrez Gene)
TAB2Protein23118 (Entrez Gene)
TAB3Protein257397 (Entrez Gene)
TANKProtein10010 (Entrez Gene)
TBK1Protein29110 (Entrez Gene)
TNFProtein7124
TNFProtein7124 (Entrez Gene)
TNFAIP3Protein7128 (Entrez Gene)
TNFRSF1AProtein7132 (Entrez Gene)
TNFRSF1BProtein7133 (Entrez Gene)
TRADDProtein8717 (Entrez Gene)
TRAF1Protein7185 (Entrez Gene)
TRAF2Protein7186 (Entrez Gene)
TRAP1Protein10131 (Entrez Gene)
TXNProtein7295 (Entrez Gene)

Annotated Interactions

No annotated interactions

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