Angiogenesis (Homo sapiens)
From WikiPathways
Description
This pathway is a concise and simplified version of the basic proteins involved in angiogenesis. The proces is regulated by hyopoxia, which results in the transcription of eg. VEGF1, FGF2, PDGFbeta, MMP9, MMP2 and Ang1. These proteins bind to their receptors and by doing this they initiate different pathways that result in vesselformation.
Quality Tags
Ontology Terms
Bibliography
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- Hellberg C, Ostman A, Heldin CH; ''PDGF and vessel maturation.''; Recent Results Cancer Res, 2010 PubMed Europe PMC Scholia
- Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D; ''Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis.''; Nat Cell Biol, 2000 PubMed Europe PMC Scholia
- ; ''Angiogenesis Pathway''; http://www.cst.neb.com/reference/pathway/Angiogenesis.html, 2008
- Novotny NM, Lahm T, Markel TA, Crisostomo PR, Wang M, Wang Y, Tan J, Meldrum DR; ''Angiopoietin-1 in the treatment of ischemia and sepsis.''; Shock, 2009 PubMed Europe PMC Scholia
- Burbridge MF, Coge F, Galizzi JP, Boutin JA, West DC, Tucker GC; ''The role of the matrix metalloproteinases during in vitro vessel formation.''; Angiogenesis, 2002 PubMed Europe PMC Scholia
- Madeddu P; ''Therapeutic angiogenesis and vasculogenesis for tissue regeneration.''; Exp Physiol, 2005 PubMed Europe PMC Scholia
- Kutryk MJ, Stewart DJ; ''Angiogenesis of the heart.''; Microsc Res Tech, 2003 PubMed Europe PMC Scholia
- Koblizek TI, Weiss C, Yancopoulos GD, Deutsch U, Risau W; ''Angiopoietin-1 induces sprouting angiogenesis in vitro.''; Curr Biol, 1998 PubMed Europe PMC Scholia
- Renault MA, Losordo DW; ''The matrix revolutions: matrix metalloproteinase, vasculogenesis, and ischemic tissue repair.''; Circ Res, 2007 PubMed Europe PMC Scholia
- Li J, Wei Y, Liu K, Yuan C, Tang Y, Quan Q, Chen P, Wang W, Hu H, Yang L; ''Synergistic effects of FGF-2 and PDGF-BB on angiogenesis and muscle regeneration in rabbit hindlimb ischemia model.''; Microvasc Res, 2010 PubMed Europe PMC Scholia
- Tomanek RJ, Sandra A, Zheng W, Brock T, Bjercke RJ, Holifield JS; ''Vascular endothelial growth factor and basic fibroblast growth factor differentially modulate early postnatal coronary angiogenesis.''; Circ Res, 2001 PubMed Europe PMC Scholia
- Millauer B, Wizigmann-Voos S, Schnuerch H, Martinez R, Moller NP, Risau W, Ullrich A; ''High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.''; Cell, 1993 PubMed Europe PMC Scholia
- Tomanek RJ, Zheng W, Yue X; ''Growth factor activation in myocardial vascularization: therapeutic implications.''; Mol Cell Biochem, 2004 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
AKT1 | GeneProduct | ENSG00000142208 (Ensembl Human) | |
ARNT | GeneProduct | 405 (Entrez Gene) | |
Ang 1 | GeneProduct | Q15389 (Uniprot/TrEMBL) | |
CBP | GeneProduct | 1387 (Entrez Gene) | |
FAK | GeneProduct | Q05397 (Uniprot/TrEMBL) | |
FGF2 | GeneProduct | ENSG00000138685 (Ensembl Human) | |
FGFR2 | GeneProduct | 2263 (Entrez Gene) | |
FLT1 | GeneProduct | ENSG00000102755 (Ensembl Human) | |
HIF1A | GeneProduct | 3091 (Entrez Gene) | |
MAPK1 | GeneProduct | ENSG00000100030 (Ensembl Human) | |
MMP2 | GeneProduct | ENSG00000100985 (Ensembl Human) | |
MMP9 | GeneProduct | ENSG00000100985 (Ensembl Human) | |
NOS | GeneProduct | ENSG00000164867 (Ensembl Human) | |
PDGFB | GeneProduct | ENSG00000100311 (Ensembl Human) | |
PDGFRA | GeneProduct | P16234 (Uniprot/TrEMBL) | |
PI3K | GeneProduct | 5290 (Entrez Gene) | |
PLCG1 | GeneProduct | ENSG00000124181 (Ensembl Human) | |
SMAD1 | GeneProduct | ENSG00000170365 (Ensembl Human) | |
SRC | GeneProduct | ENSG00000197122 (Ensembl Human) | |
TIE2 | GeneProduct | 7010 (Entrez Gene) | |
TIMP2 | GeneProduct | ENSG00000035862 (Ensembl Human) | |
TIMP3 | Protein | ENSG00000100234 (Ensembl Human) | |
VEGFA | GeneProduct | P15692 (Uniprot/TrEMBL) | |
VEGFR2 | GeneProduct | 3791 (Entrez Gene) | |
p38 MAPK | GeneProduct | 42866 (Entrez Gene) | |
sTIE2 | GeneProduct | 7010 (Entrez Gene) |
Annotated Interactions
No annotated interactions