Oxidation by cytochrome P450 (Danio rerio)
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Cytochrome P450 genes
Substrate
NAD+
cyp51
CYP2J2
CYP3A5
LOC570455
CYP3A4
dia1
Fe3+
A9JRH5_DANRE
Fe2+
cyp4
CYP2A13
cyb5a
LOC793249
cyp24a1l
Fe2+
cyb5a
cyp51
cyp4
Fe3+
cyp1a
CYP4F2
cyb5b
CYP4F2
CYP
CYP4F2
cyp4
Substrate-OH
CYP2D6
CYP2C8
CYP2C18
zgc:112177
CYP19A1
CYP2A7
Substrate
cyb5r3
zgc:63920
cyp11b2
cyp11b2
cyp2u1
Fe3+
cyp4
POR
activated O2
H2O
cyp4v2
Fe2+
CYP46A1
CYP2G1P
cyb5b
CYP4F2
zgc:174342
CYP2E1
NADH
cyp11a1
Fe2+
CYP27B1
CYP2F1
CYP2C9
Substrate
CYP2W1
CYP
cyb5b
Substrate
si:dkey-69h9.1
CYP2C19
cyp26b1
CYP3A43
cyp4
cyp27c1
Substrate
O2
CYP
CYP
CYP4F2
cyp1a
NADP+
cyp1b1
cyb5a
CYP3A7
O2
CYP2S1
zgc:63986
NADPH
CYP2A6
cyp26c1
CYP27A1
zgc:153291
Fe3+
cyp17a1
CYP4F2
CYP2B6
cyp26a1
CYP
Description
Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP43(r29608)
with a 56% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Niesink, R.J.M, Vries, de, J., Hollinger, M.A.; ''Toxicology; Principles and Applications''; , 1996
History
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Compare
Revision
Action
Time
User
Comment
118187
view
10:51, 25 May 2021
Eweitz
Modified title
107100
view
14:18, 17 September 2019
MaintBot
ChEBI identifier normalization
106084
view
11:59, 16 August 2019
MaintBot
HMDB identifier normalization
88275
view
14:35, 1 August 2016
Fehrhart
Ontology Term : 'hepatocyte' added !
88274
view
14:35, 1 August 2016
Fehrhart
Ontology Term : 'phase I biotransformation pathway via cytochrome P450' added !
88273
view
14:35, 1 August 2016
Fehrhart
Ontology Term : 'xenobiotics biodegradation pathway' added !
73520
view
23:32, 29 January 2014
Khanspers
Modified title
71931
view
20:48, 23 October 2013
Egonw
Fixed the PubChem-compound data source.
68671
view
05:29, 6 July 2013
MaintBot
Updated to 2013 gpml schema
58797
view
22:46, 20 February 2013
MaintBot
Updated Ensembl and UniProt data source
48312
view
04:37, 18 May 2012
Khanspers
Updating PubChem xrefs
46428
view
20:47, 27 January 2012
MaintBot
Automatic update of PubChem xrefs
40844
view
22:19, 1 March 2011
MaintBot
Removed redundant pathway information and comments
34226
view
21:36, 9 December 2009
MaintBot
Automatic update of empty xrefs
31966
view
13:06, 14 August 2009
MaintBot
Fixed group labels
31102
view
01:42, 30 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
A9JRH5_DANRE
GeneProduct
ENSDARG00000056587 (Ensembl Zebrafish)
CYP
GeneProduct
CYP19A1
GeneProduct
CYP27A1
GeneProduct
CYP27B1
GeneProduct
ENSDARG00000045015 (Ensembl Zebrafish)
CYP2A13
GeneProduct
CYP2A6
GeneProduct
CYP2A7
GeneProduct
CYP2B6
GeneProduct
CYP2C18
GeneProduct
CYP2C19
GeneProduct
CYP2C8
GeneProduct
CYP2C9
GeneProduct
CYP2D6
GeneProduct
CYP2E1
GeneProduct
CYP2F1
GeneProduct
CYP2G1P
GeneProduct
CYP2J2
GeneProduct
CYP2S1
GeneProduct
CYP2W1
GeneProduct
CYP3A4
GeneProduct
CYP3A43
GeneProduct
CYP3A5
GeneProduct
CYP3A7
GeneProduct
CYP46A1
GeneProduct
553543 (Entrez Gene)
CYP4F2
GeneProduct
ENSDARG00000053530 (Ensembl Zebrafish)
Fe2+
Metabolite
29033 (ChEBI)
Fe3+
Metabolite
29034 (ChEBI)
H2O
Metabolite
LOC570455
GeneProduct
ENSDARG00000008858 (Ensembl Zebrafish)
LOC793249
GeneProduct
ENSDARG00000037550 (Ensembl Zebrafish)
NAD+
Metabolite
15846 (ChEBI)
NADH
Metabolite
16908 (ChEBI)
NADP+
Metabolite
18009 (ChEBI)
NADPH
Metabolite
16474 (ChEBI)
O2
Metabolite
HMDB01377 (HMDB)
POR
GeneProduct
568202 (Entrez Gene)
Substrate
GeneProduct
Substrate-OH
GeneProduct
activated O2
Metabolite
cyb5a
GeneProduct
ENSDARG00000055643 (Ensembl Zebrafish)
cyb5b
GeneProduct
ENSDARG00000053954 (Ensembl Zebrafish)
cyb5r3
GeneProduct
ENSDARG00000005891 (Ensembl Zebrafish)
cyp11a1
GeneProduct
ENSDARG00000002347 (Ensembl Zebrafish)
cyp11b2
GeneProduct
ENSDARG00000042014 (Ensembl Zebrafish)
cyp17a1
GeneProduct
ENSDARG00000033566 (Ensembl Zebrafish)
cyp1a
GeneProduct
ENSDARG00000026039 (Ensembl Zebrafish)
cyp1b1
GeneProduct
ENSDARG00000068934 (Ensembl Zebrafish)
cyp24a1l
GeneProduct
ENSDARG00000070420 (Ensembl Zebrafish)
cyp26a1
GeneProduct
ENSDARG00000033999 (Ensembl Zebrafish)
cyp26b1
GeneProduct
ENSDARG00000077121 (Ensembl Zebrafish)
cyp26c1
GeneProduct
ENSDARG00000056029 (Ensembl Zebrafish)
cyp27c1
GeneProduct
ENSDARG00000058439 (Ensembl Zebrafish)
cyp2u1
GeneProduct
ENSDARG00000026548 (Ensembl Zebrafish)
cyp4
GeneProduct
ENSDARG00000004964 (Ensembl Zebrafish)
cyp4v2
GeneProduct
ENSDARG00000062132 (Ensembl Zebrafish)
cyp51
GeneProduct
ENSDARG00000042641 (Ensembl Zebrafish)
dia1
GeneProduct
ENSDARG00000018966 (Ensembl Zebrafish)
si:dkey-69h9.1
GeneProduct
ENSDARG00000017982 (Ensembl Zebrafish)
zgc:112177
GeneProduct
ENSDARG00000020898 (Ensembl Zebrafish)
zgc:153291
GeneProduct
ENSDARG00000051925 (Ensembl Zebrafish)
zgc:174342
GeneProduct
ENSDARG00000053068 (Ensembl Zebrafish)
zgc:63920
GeneProduct
ENSDARG00000069018 (Ensembl Zebrafish)
zgc:63986
GeneProduct
ENSDARG00000006040 (Ensembl Zebrafish)
Annotated Interactions
No annotated interactions
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DataNodes
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No annotated interactions