Insulin signaling (Danio rerio)

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1PI 3-Kinasep70 S6 KinasesVesicular TraffickingMetabolic Regulationp90 Rsk KinasesGlucose TransportTor SignalingRas-MAPK SignalingTranslation RegulationInsulin Receptor SubstratesPDK/Akt SignalingMEK/MAP KinasesModulators of Insulin ActionTranscriptional Regulators & Immediate Early Genespik3c3zgc:172250si:ch211-142e24.2LOC567895crkMAP4K1im:7148788zgc:86905sgk2arf1LOC560913RPS6KB2stxbp1LOC563727map2k1LOC561737LOC100149498zgc:76966ehd1map3k5LOC567916STX4Asrfrps6kb1map3k3rab4acblbCBLCrac1stxbp3snap25atsc1aLOC571285MAP3K14ehd2zgc:194486LOC572074si:dkey-94n12.3ARF6MAPK12SOCS3LOC570106MAP3K6sgk1gys2IRS2SOS1prkaa1CH211-259K16.4IGF1RLOC568412inpp4afosmapk6foxo5mapk3gab1zgc:77033mapk1LOC100149671zgc:172124PTPRFLOC558321MAP2K3PRKCQIRS3rps6ka3bLOC558498rps6kalDKEY-273O13.5zgc:172209LOC559249zgc:153787wu:fb92a07kif5baprkciMAP4K2junptenbegr1IRS4rac2LOC100002190CH211-67F24.8GSK3Asgk3pik3r3map4k5zgc:56072PFKMFLOT2mapk10LOC557176rhebLOC792354LOC100005183zgc:172209rps6ka3astxbp2im:7136778PRKCDLOC565173vamp2SNX26LOC100149273mapk4HRASLOC563639map3k12frap1tsc2LIPEFLOT1mapk14araf1cap1map3k7ptpn11mapk7rhoqzgc:101581xbp1pik3r2rradLOC100007176ptp1bMINK1zgc:172137LOC562032map2k6GYGSLC2A4MAP3K11wu:fc58a04socs1CH211-238G23.2cblslc2a1LOC564899LOC100002756rhojpik3cdprkcb1FOXO1ALOC560525LOC554439gsk3bakt2LOC566459si:dkey-24l11.7LOC100001260grb2MAP4K4INSRLOC559281ikbkbwu:fc83c01kif3aprkczCH211-127H20.2zgc:64137


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP481(r28132) with a 80% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Quon MJ, Campfield LA; ''A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation.''; J Theor Biol, 1991 PubMed Europe PMC Scholia
  2. Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism.''; Nature, 2001 PubMed Europe PMC Scholia
  3. Bevan P; ''Insulin signalling.''; J Cell Sci, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116791view09:59, 14 May 2021EweitzModified title
95773view14:28, 19 January 2018MkutmonHomology conversion update
86952view13:13, 15 July 2016MkutmonOntology Term : 'insulin signaling pathway' added !
71528view19:23, 17 October 2013MaintBotAutomated update of data sources
68661view05:18, 6 July 2013MaintBotUpdated to 2013 gpml schema
47923view22:21, 18 April 2012Khanspersupdated xrefs
40832view22:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
34218view21:34, 9 December 2009MaintBotAutomatic update of empty xrefs
32315view13:23, 15 August 2009MaintBotFixed text labels
31910view12:49, 14 August 2009MaintBotFixed group labels
31344view20:28, 13 August 2009MaintBotFixed text labels
31023view01:10, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARF6GeneProduct
CBLCGeneProduct
CH211-127H20.2GeneProduct558635 (Entrez Gene)
CH211-238G23.2GeneProduct560932 (Entrez Gene)
CH211-259K16.4GeneProduct560639 (Entrez Gene)
CH211-67F24.8GeneProduct561670 (Entrez Gene)
DKEY-273O13.5GeneProduct561959 (Entrez Gene)
FLOT1GeneProduct561345 (Entrez Gene)
FLOT2GeneProduct
FOXO1AGeneProduct768121 (Entrez Gene)
GSK3AGeneProduct30664 (Entrez Gene)
GYGGeneProduct
HRASGeneProduct550286 (Entrez Gene)
IGF1RGeneProduct
INSRGeneProduct
IRS2GeneProduct
IRS3GeneProduct
IRS4GeneProduct
LIPEGeneProduct
LOC100001260GeneProduct100001260 (Entrez Gene)
LOC100002190GeneProduct100002190 (Entrez Gene)
LOC100002756GeneProduct100002756 (Entrez Gene)
LOC100005183GeneProduct100005183 (Entrez Gene)
LOC100007176GeneProduct100007176 (Entrez Gene)
LOC100149273GeneProduct100149273 (Entrez Gene)
LOC100149498GeneProduct100149498 (Entrez Gene)
LOC100149671GeneProduct100149671 (Entrez Gene)
LOC554439GeneProduct554439 (Entrez Gene)
LOC557176GeneProduct557176 (Entrez Gene)
LOC558321GeneProduct558321 (Entrez Gene)
LOC558498GeneProduct558498 (Entrez Gene)
LOC559249GeneProduct559249 (Entrez Gene)
LOC559281GeneProduct559281 (Entrez Gene)
LOC560525GeneProduct560525 (Entrez Gene)
LOC560913GeneProduct560913 (Entrez Gene)
LOC561737GeneProduct561737 (Entrez Gene)
LOC562032GeneProduct562032 (Entrez Gene)
LOC563639GeneProduct563639 (Entrez Gene)
LOC563727GeneProduct563727 (Entrez Gene)
LOC564899GeneProduct564899 (Entrez Gene)
LOC565173GeneProduct565173 (Entrez Gene)
LOC566459GeneProduct566459 (Entrez Gene)
LOC567895GeneProduct567895 (Entrez Gene)
LOC567916GeneProduct567916 (Entrez Gene)
LOC568412GeneProduct568412 (Entrez Gene)
LOC570106GeneProduct570106 (Entrez Gene)
LOC571285GeneProduct571285 (Entrez Gene)
LOC572074GeneProduct572074 (Entrez Gene)
LOC792354GeneProduct792354 (Entrez Gene)
MAP2K3GeneProduct
MAP3K11GeneProduct
MAP3K14GeneProduct
MAP3K6GeneProduct
MAP4K1GeneProduct
MAP4K2GeneProduct
MAP4K4GeneProduct
MAPK12GeneProduct30681 (Entrez Gene)
MINK1GeneProduct100038799 (Entrez Gene)
PFKMGeneProduct
PRKCDGeneProduct334571 (Entrez Gene)
PRKCQGeneProduct555521 (Entrez Gene)
PTPRFGeneProduct140819 (Entrez Gene)
RPS6KB2GeneProduct
SLC2A4GeneProduct
SNX26GeneProduct
SOCS3GeneProduct
SOS1GeneProduct
STX4AGeneProduct
akt2GeneProduct378972 (Entrez Gene)
arf1GeneProduct114428 (Entrez Gene)
cap1GeneProduct334527 (Entrez Gene)
cblGeneProduct492364 (Entrez Gene)
cblbGeneProduct556277 (Entrez Gene)
crkGeneProduct445234 (Entrez Gene)
egr1GeneProduct30498 (Entrez Gene)
ehd1GeneProduct447839 (Entrez Gene)
ehd2GeneProduct337401 (Entrez Gene)
fosGeneProduct394198 (Entrez Gene)
foxo5GeneProduct30296 (Entrez Gene)
frap1GeneProduct324254 (Entrez Gene)
gab1GeneProduct406666 (Entrez Gene)
grb2GeneProduct406308 (Entrez Gene)
gsk3bGeneProduct30654 (Entrez Gene)
gys2GeneProduct373082 (Entrez Gene)
ikbkbGeneProduct563560 (Entrez Gene)
im:7136778GeneProduct100002318 (Entrez Gene)
im:7148788GeneProduct564088 (Entrez Gene)
inpp4aGeneProduct664741 (Entrez Gene)
junGeneProduct335916 (Entrez Gene)
kif3aGeneProduct550267 (Entrez Gene)
kif5baGeneProduct563459 (Entrez Gene)
map2k1GeneProduct406728 (Entrez Gene)
map2k6GeneProduct65239 (Entrez Gene)
map3k12GeneProduct404626 (Entrez Gene)
map3k3GeneProduct560211 (Entrez Gene)
map3k5GeneProduct555703 (Entrez Gene)
map3k7GeneProduct553788 (Entrez Gene)
map4k5GeneProduct334565 (Entrez Gene)
mapk10GeneProduct569698 (Entrez Gene)
mapk1GeneProduct360144 (Entrez Gene)
mapk14aGeneProduct65237 (Entrez Gene)
mapk3GeneProduct399480 (Entrez Gene)
mapk4GeneProduct406782 (Entrez Gene)
mapk6GeneProduct565830 (Entrez Gene)
mapk7GeneProduct541323 (Entrez Gene)
pik3c3GeneProduct548346 (Entrez Gene)
pik3cdGeneProduct394174 (Entrez Gene)
pik3r2GeneProduct404211 (Entrez Gene)
pik3r3GeneProduct100000252 (Entrez Gene)
prkaa1GeneProduct100001198 (Entrez Gene)
prkcb1GeneProduct393953 (Entrez Gene)
prkciGeneProduct117507 (Entrez Gene)
prkczGeneProduct555737 (Entrez Gene)
ptenbGeneProduct368415 (Entrez Gene)
ptp1bGeneProduct30081 (Entrez Gene)
ptpn11GeneProduct333979 (Entrez Gene)
rab4aGeneProduct403031 (Entrez Gene)
rac1GeneProduct327204 (Entrez Gene)
rac2GeneProduct415151 (Entrez Gene)
raf1GeneProduct30716 (Entrez Gene)
rhebGeneProduct767781 (Entrez Gene)
rhojGeneProduct556371 (Entrez Gene)
rhoqGeneProduct327510 (Entrez Gene)
rps6ka3aGeneProduct338219 (Entrez Gene)
rps6ka3bGeneProduct100009657 (Entrez Gene)
rps6kalGeneProduct337670 (Entrez Gene)
rps6kb1GeneProduct406349 (Entrez Gene)
rradGeneProduct327396 (Entrez Gene)
sgk1GeneProduct324140 (Entrez Gene)
sgk2GeneProduct570956 (Entrez Gene)
sgk3GeneProduct564523 (Entrez Gene)
si:ch211-142e24.2GeneProduct562399 (Entrez Gene)
si:dkey-24l11.7GeneProduct571356 (Entrez Gene)
si:dkey-94n12.3GeneProduct562011 (Entrez Gene)
slc2a1GeneProduct555778 (Entrez Gene)
snap25aGeneProduct30712 (Entrez Gene)
socs1GeneProduct445073 (Entrez Gene)
srfGeneProduct30431 (Entrez Gene)
stxbp1GeneProduct574003 (Entrez Gene)
stxbp2GeneProduct406578 (Entrez Gene)
stxbp3GeneProduct406780 (Entrez Gene)
tsc1aGeneProduct337167 (Entrez Gene)
tsc2GeneProduct567524 (Entrez Gene)
vamp2GeneProduct336281 (Entrez Gene)
wu:fb92a07GeneProduct100002263 (Entrez Gene)
wu:fc58a04GeneProduct325179 (Entrez Gene)
wu:fc83c01GeneProduct325488 (Entrez Gene)
xbp1GeneProduct140614 (Entrez Gene)
zgc:101581GeneProduct493617 (Entrez Gene)
zgc:153787GeneProduct768202 (Entrez Gene)
zgc:172124GeneProduct100144561 (Entrez Gene)
zgc:172137GeneProduct100007679 (Entrez Gene)
zgc:172209GeneProduct562720 (Entrez Gene)
zgc:172250GeneProduct100002225 (Entrez Gene)
zgc:194486GeneProduct568951 (Entrez Gene)
zgc:56072GeneProduct393159 (Entrez Gene)
zgc:64137GeneProduct799566 (Entrez Gene)
zgc:76966GeneProduct405805 (Entrez Gene)
zgc:77033GeneProduct406598 (Entrez Gene)
zgc:86905GeneProduct415185 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1313"
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