Insulin signaling (Bos taurus)

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1, 3Glucose TransportPDK/Akt SignalingTranscriptional Regulators & Immediate Early GenesMetabolic RegulationTor SignalingPI 3-Kinase isoformsp90 Rsk KinasesModulators of Insulin ActionRas-MAPK SignalingMEK/MAP KinasesCell GrowthDifferentiationp70 S6 KinasesTranslation RegulationInsulin Receptor SubstratesVesicular TraffickingPIK3C3SORBS1MAPK8SGK2INPPL1MAPK7FOXO1MAP2K1FOXO3GRB10MYO1CMAPK13PRKCQGRB2PIK3C2AIKBKBCBLIGF1RLIPEPFKMPTPN1ENPP1PRKCAMAPK4SLC2A4FLOT2MAP3K8MAP3K12VAMP2SGK1PRKCDEIF4ERHOQMAPK1MAPK3GYS2PDPK1TSC2RAC1EHD2MAP3K3TSC1LOC100138767MAP3K1SLC2A1RPS6KB1EHD1PIK3R2RHEBMAP2K2PTPMAP2K5STXBP3RPS6KA3ARF6HRASPRKCIPIK3CBSTXBP1CYTH3PRKCBRAPGEF1MAPK8GSK3APIK3C2GCBLCSNAP23MAPK6TBC1D4PRKAA2MAP4K1MAP3K5GAB1RRADKIF3AFOSPRKAA1SOS1RPS6KB2RPS6KA2SNAP25PIK3R3SHC3IRS3MAP3K4EIF4EBP1IRS4MAP4K3TRIB3CRKMAP2K6GYG1MAPK9SRFPRKCHARF4CAP1MAPK10MTORMAP3K9INPP4APRKCZRPS6KA4PIK3CGPTPN11MINK1SOCS3FLOT1STX4MAP3K14MAP3K13MAP2K7SHC1PIK3R4MAP3K7SOS2PIK3R1MAP2K4MAP4K4MAPK12ELK1STXBP4XBP1PPP1R3ARPS6KA6MAP3K6MAP3K2AKT1RPS6KA5AKT2RHOJIRS2SH2B2RAF1PTPRFPFKLSOCS1GYS1MAPK14RPS6KA1IRS1GSK3BMAP3K11PIK3MAPK11CBLBIRS1STXBP2KIF5BPIK3CARAC2EGR1INSRMAP3K10PIK3CDSHC2MAP2K3RAB4ASGKLPTENJUNMAP4K2MAP4K5GRB142


Description

Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentation.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP481(r45380) with a 94% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism.''; Nature, 2001 PubMed Europe PMC Scholia
  2. Quon MJ, Campfield LA; ''A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation.''; J Theor Biol, 1991 PubMed Europe PMC Scholia
  3. Bevan P; ''Insulin signalling.''; J Cell Sci, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116790view09:59, 14 May 2021EweitzModified title
95776view14:28, 19 January 2018MkutmonHomology conversion update
80882view15:29, 30 June 2015Mkutmonhomology conversion
78838view23:00, 4 February 2015ZariModified title
78837view22:58, 4 February 2015ZariPeriodical save, work in progress
71280view04:14, 17 October 2013MaintBotRemoved buggy complexes
63393view00:04, 10 May 2013MaintBotUpdated to 2013 gpml schema
48134view05:52, 9 May 2012MaintBotUpdating from human to fix xref duplication
40566view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
33804view00:18, 9 December 2009MaintBotAutomatic update of empty xrefs
33615view10:00, 1 December 2009MaintBotRemoved group label
31628view22:21, 13 August 2009MaintBotFixed text labels
30535view21:54, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct280991 (Entrez Gene)
AKT2GeneProduct534923 (Entrez Gene)
ARF4GeneProduct282601 (Entrez Gene)
ARF6GeneProduct100294979 (Entrez Gene)
CAP1GeneProduct504519 (Entrez Gene)
CBLGeneProduct527418 (Entrez Gene)
CBLBGeneProduct525906 (Entrez Gene)
CBLCGeneProduct615866 (Entrez Gene)
CRKGeneProduct512841 (Entrez Gene)
CYTH3GeneProduct618488 (Entrez Gene)
EGR1GeneProduct407125 (Entrez Gene)
EHD1GeneProduct511908 (Entrez Gene)
EHD2GeneProduct538348 (Entrez Gene)
EIF4EGeneProduct281751 (Entrez Gene)
EIF4EBP1GeneProduct509613 (Entrez Gene)
ELK1GeneProduct786886 (Entrez Gene)
ENPP1GeneProduct615535 (Entrez Gene)
FLOT1GeneProduct532573 (Entrez Gene)
FLOT2GeneProduct615679 (Entrez Gene)
FOSGeneProduct280795 (Entrez Gene)
FOXO1GeneProduct506618 (Entrez Gene)
FOXO3GeneProduct535530 (Entrez Gene)
GAB1GeneProduct540085 (Entrez Gene)
GRB10GeneProduct407210 (Entrez Gene)
GRB14GeneProduct497029 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
GSK3AGeneProduct536561 (Entrez Gene)
GSK3BGeneProduct790875 (Entrez Gene)
GYG1GeneProduct280812 (Entrez Gene)
GYS1GeneProduct786335 (Entrez Gene)
GYS2GeneProduct537451 (Entrez Gene)
HRASGeneProduct100298939 (Entrez Gene)
IGF1RGeneProduct281848 (Entrez Gene)
IKBKBGeneProduct281854 (Entrez Gene)
INPP4AGeneProduct535487 (Entrez Gene)
INPPL1GeneProduct783833 (Entrez Gene)
INSRGeneProduct408017 (Entrez Gene)
IRS1GeneProduct538598 (Entrez Gene)
IRS2GeneProduct
IRS3GeneProduct
IRS4GeneProduct514607 (Entrez Gene)
JUNGeneProduct280831 (Entrez Gene)
KIF3AGeneProduct541246 (Entrez Gene)
KIF5BGeneProduct514261 (Entrez Gene)
LIPEGeneProduct286879 (Entrez Gene)
LOC100138767GeneProduct100138767 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAP2K3GeneProduct516039 (Entrez Gene)
MAP2K4GeneProduct526469 (Entrez Gene)
MAP2K5GeneProduct100295732 (Entrez Gene)
MAP2K6GeneProduct286883 (Entrez Gene)
MAP2K7GeneProduct787278 (Entrez Gene)
MAP3K10GeneProduct
MAP3K11GeneProduct514210 (Entrez Gene)
MAP3K12GeneProduct505427 (Entrez Gene)
MAP3K13GeneProduct505369 (Entrez Gene)
MAP3K14GeneProduct508367 (Entrez Gene)
MAP3K1GeneProduct523962 (Entrez Gene)
MAP3K2GeneProduct504592 (Entrez Gene)
MAP3K3GeneProduct508943 (Entrez Gene)
MAP3K4GeneProduct511779 (Entrez Gene)
MAP3K5GeneProduct537380 (Entrez Gene)
MAP3K6GeneProduct614598 (Entrez Gene)
MAP3K7GeneProduct529146 (Entrez Gene)
MAP3K8GeneProduct535622 (Entrez Gene)
MAP3K9GeneProduct538340 (Entrez Gene)
MAP4K1GeneProduct522002 (Entrez Gene)
MAP4K2GeneProduct520058 (Entrez Gene)
MAP4K3GeneProduct507624 (Entrez Gene)
MAP4K4GeneProduct
MAP4K5GeneProduct781335 (Entrez Gene)
MAPK10GeneProduct537631 (Entrez Gene)
MAPK11GeneProduct618906 (Entrez Gene)
MAPK12GeneProduct512943 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK13GeneProduct535327 (Entrez Gene)
MAPK14GeneProduct534492 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MAPK4GeneProduct
MAPK6GeneProduct538094 (Entrez Gene)
MAPK7GeneProduct537703 (Entrez Gene)
MAPK8GeneProduct539941 (Entrez Gene)
MAPK9GeneProduct534125 (Entrez Gene)
MINK1GeneProduct519558 (Entrez Gene)
MTORGeneProduct100139219 (Entrez Gene)
MYO1CGeneProduct281937 (Entrez Gene)
PDPK1GeneProduct100138102 (Entrez Gene)
PFKLGeneProduct508683 (Entrez Gene)
PFKMGeneProduct506544 (Entrez Gene)
PIK3GeneProduct
PIK3C2AGeneProduct537790 (Entrez Gene)
PIK3C2GGeneProduct513301 (Entrez Gene)
PIK3C3GeneProduct534815 (Entrez Gene)
PIK3CAGeneProduct282306 (Entrez Gene)
PIK3CBGeneProduct517948 (Entrez Gene)
PIK3CDGeneProduct504531 (Entrez Gene)
PIK3CGGeneProduct530001 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PIK3R2GeneProduct282308 (Entrez Gene)
PIK3R3GeneProduct286865 (Entrez Gene)
PIK3R4GeneProduct507414 (Entrez Gene)
PPP1R3AGeneProduct784877 (Entrez Gene)
PRKAA1GeneProduct540404 (Entrez Gene)
PRKAA2GeneProduct538954 (Entrez Gene)
PRKCAGeneProduct282001 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PRKCDGeneProduct505708 (Entrez Gene)
PRKCHGeneProduct518542 (Entrez Gene)
PRKCIGeneProduct528478 (Entrez Gene)
PRKCQGeneProduct505901 (Entrez Gene)
PRKCZGeneProduct286877 (Entrez Gene)
PTENGeneProduct540786 (Entrez Gene)
PTPGeneProduct
PTPN11GeneProduct533590 (Entrez Gene)
PTPN1GeneProduct508658 (Entrez Gene)
PTPRFGeneProduct512072 (Entrez Gene)
RAB4AGeneProduct615849 (Entrez Gene)
RAC1GeneProduct281440 (Entrez Gene)
RAC2GeneProduct327671 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RAPGEF1GeneProduct520454 (Entrez Gene)
RHEBGeneProduct528204 (Entrez Gene)
RHOJGeneProduct540619 (Entrez Gene)
RHOQGeneProduct100139988 (Entrez Gene)
RPS6KA1GeneProduct533908 (Entrez Gene)
RPS6KA2GeneProduct517953 (Entrez Gene)
RPS6KA3GeneProduct511190 (Entrez Gene)
RPS6KA4GeneProduct523746 (Entrez Gene)
RPS6KA5GeneProduct504408 (Entrez Gene)
RPS6KA6GeneProduct526227 (Entrez Gene)
RPS6KB1GeneProduct404181 (Entrez Gene)
RPS6KB2GeneProduct506083 (Entrez Gene)
RRADGeneProduct505165 (Entrez Gene)
SGK1GeneProduct515854 (Entrez Gene)
SGK2GeneProduct517909 (Entrez Gene)
SGKLGeneProduct
SH2B2GeneProduct617840 (Entrez Gene)
SHC1GeneProduct507196 (Entrez Gene)
SHC2GeneProduct533455 (Entrez Gene)
SHC3GeneProduct
SLC2A1GeneProduct282356 (Entrez Gene)
SLC2A4GeneProduct282359 (Entrez Gene)
SNAP23GeneProduct522423 (Entrez Gene)
SNAP25GeneProduct540853 (Entrez Gene)
SOCS1GeneProduct518795 (Entrez Gene)
SOCS3GeneProduct282081 (Entrez Gene)
SORBS1GeneProduct504625 (Entrez Gene)
SOS1GeneProduct537682 (Entrez Gene)
SOS2GeneProduct100138040 (Entrez Gene)
SRFGeneProduct533039 (Entrez Gene)
STX4GeneProduct508675 (Entrez Gene)
STXBP1GeneProduct282378 (Entrez Gene)
STXBP2GeneProduct515618 (Entrez Gene)
STXBP3GeneProduct512490 (Entrez Gene)
STXBP4GeneProduct537963 (Entrez Gene)
TBC1D4GeneProduct534649 (Entrez Gene)
TRIB3GeneProduct538465 (Entrez Gene)
TSC1GeneProduct533440 (Entrez Gene)
TSC2GeneProduct504985 (Entrez Gene)
VAMP2GeneProduct282116 (Entrez Gene)
XBP1GeneProduct541236 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP966"
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