Quercetin and Nf-kB/ AP-1 induced cell apoptosis-delete (Homo sapiens)

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AP-1 transcription factor complexPhosphorylationE-boxIKBKBFOSACOX2NFKB1IKBA_HUMANPhosphorylationIKBA_HUMANNf-kBNOS1VEGFAAngiogenesisCarcinogenesisNFKB1JUNAP-1ACOX2MMP1MetastasisGene boxE-boxGene box444644AREROSApoptosis6induces malformation4inhibits dimerization6inhibition of ubiquitination34DNA damageCYP2A6carcinogenic metaboliteNFE2L2KEAP1NFE2L2NFE2L2small MAFPhase 2 enzymeCell cycle arrestMalignancy6(Causes vasodilation;inhibits platelet aggregation)6732, 32, 332, 32, 33331, 33Phospholipase A2 (PLA2)2, 3Cox1/Cox2PGH2PGI2TXA2Arachidonic acid (AA)(Causes vasoconstriction;promotes platelet aggregation)PGG2QuercetinCell membrane phospholipids(Increasesvasoconstriction)PGF2aPGD2PGE2(Induces vasoconstrictionand secretion of IL-1 and IL-2)INFLAMMATION


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography


History

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CompareRevisionActionTimeUserComment
59128view22:32, 21 February 2013MaintBotDeleted pathway: tutorial
57890view19:40, 4 February 2013MaintBotModified title
56310view19:45, 5 January 2013BeanthaPeriodical save, work in progress
56309view18:26, 5 January 2013BeanthaPeriodical save, work in progress
56306view18:00, 5 January 2013Beanthaquercetin zonder inflammation
56305view17:57, 5 January 2013BeanthaPeriodical save, work in progress
56304view17:47, 5 January 2013BeanthaPeriodical save, work in progress
56301view17:37, 5 January 2013BeanthaPeriodical save, work in progress
56296view16:20, 5 January 2013BeanthaQuercetin pathway
56294view16:16, 5 January 2013BeanthaPeriodical save, work in progress
56290view16:06, 5 January 2013BeanthaPeriodical save, work in progress
56288view15:55, 5 January 2013BeanthaPeriodical save, work in progress
56282view15:45, 5 January 2013BeanthaPeriodical save, work in progress
56279view15:35, 5 January 2013BeanthaPeriodical save, work in progress
56276view15:24, 5 January 2013BeanthaPeriodical save, work in progress
55527view14:29, 17 December 2012Cboye21fina final�pathway
55526view14:23, 17 December 2012Cboye21Periodical save, work in progress
55523view14:13, 17 December 2012Cboye21Periodical save, work in progress
55517view14:03, 17 December 2012Cboye21Periodical save, work in progress
55516view13:52, 17 December 2012Cboye21final version
55515view13:31, 17 December 2012Cboye21Periodical save, work in progress
55351view17:11, 13 December 2012Cboye21final pathway
55350view17:07, 13 December 2012Cboye21Periodical save, work in progress
55347view16:47, 13 December 2012Cboye21Periodical save, work in progress
55346view16:46, 13 December 2012Cboye21Almost finalized
55344view16:27, 13 December 2012Cboye21Periodical save, work in progress
55339view16:18, 13 December 2012Cboye21All pathways included
55337view16:15, 13 December 2012Cboye21extra pathway
55327view15:49, 13 December 2012Cboye21Periodical save, work in progress
55317view15:29, 13 December 2012Cboye21Periodical save, work in progress
55312view15:19, 13 December 2012Cboye21Periodical save, work in progress
55305view15:09, 13 December 2012Cboye21Periodical save, work in progress
55296view14:59, 13 December 2012Cboye21Periodical save, work in progress
55291view14:48, 13 December 2012Cboye21Periodical save, work in progress
55283view14:38, 13 December 2012Cboye21Periodical save, work in progress
55267view14:18, 13 December 2012Cboye21Periodical save, work in progress
55262view14:08, 13 December 2012Cboye21Periodical save, work in progress
55255view13:57, 13 December 2012Cboye21New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
(Causes vasoconstriction; promotes platelet aggregation)
(Causes vasodilation; inhibits platelet aggregation)
(Increases vasoconstriction)
(Induces vasoconstriction and secretion of IL-1 and IL-2)
ACOX2GeneProductENSG00000168306 (Ensembl Human)
AngiogenesisPathway
Arachidonic acid (AA)
CYP2A6GeneProductENSG00000255974 (Ensembl Human)
CarcinogenesisPathway
Cell membrane phospholipids
DNA damage
FOSGeneProductENSG00000170345 (Ensembl Human)
IKBA_HUMANProteinP25963 (Uniprot/TrEMBL)
IKBKBGeneProductENSG00000104365 (Ensembl Human)
INFLAMMATION
JUNGeneProductENSG00000177606 (Ensembl Human)
KEAP1GeneProductENSG00000079999 (Ensembl Human)
MMP1GeneProductENSG00000196611 (Ensembl Human)
MetastasisPathway
NFE2L2GeneProductENSG00000116044 (Ensembl Human)
NFKB1GeneProductENSG00000109320 (Ensembl Human)
NOS1GeneProductENSG00000089250 (Ensembl Human)
PGD2MetaboliteGO:0016404 (GeneOntology)
PGE2MetaboliteGO:0031867 (GeneOntology)
PGF2aMetabolite
PGG2 Metabolite
PGH2 Metabolite
PGI2GeneProduct
Phase 2 enzyme Protein
Quercetin
TXA2Metabolite
VEGFAGeneProductENSG00000112715 (Ensembl Human)
carcinogenic metaboliteMetabolite
small MAFProtein

Annotated Interactions

No annotated interactions

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