Quercetin and Nf-kB/ AP-1 induced cell apoptosis-delete (Homo sapiens)

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1, 677E-box4PhosphorylatedAP-1 transcription factor complexit was not possbile to add a further article without pubmed idFOSPGH2ACOX2IKBKBIKBA_HUMANNFKB1PhosphorylatedIKBA_HUMANNf-kBNOS1VEGFAAngiogenesisCarcinogenesisNFKB1JUNAP-1MMP1MetastasisGene boxE-boxGene box22272277AREROSApoptosis7induces malformation2inhibits dimerization7inhibition of ubiquitination82DNA damageCYP2A6carcinogenic metaboliteNFE2L2KEAP1NFE2L2NFE2L2small MAFPhase 2 enzymeCell cycle arrest7Malignancy(Causes vasodilation;inhibits platelet aggregation)741, 61, 661, 66663, 66Phospholipase A2 (PLA2)1, 6Cox1/Cox2Prostaglandin I2Thromboxane A2Arachidonic acid (AA)(Causes vasoconstriction;promotes platelet aggregation)PGG2QuercetinCell membrane phospholipids(Increasesvasoconstriction)Prostaglandin F2aProstaglandin D2Prostaglandin E2(Induces vasoconstrictionand secretion of IL-1 and IL-2)INFLAMMATION444444444446


Description

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Quality Tags

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Bibliography


History

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CompareRevisionActionTimeUserComment
59128view22:32, 21 February 2013MaintBotDeleted pathway: tutorial
57890view19:40, 4 February 2013MaintBotModified title
56310view19:45, 5 January 2013BeanthaPeriodical save, work in progress
56309view18:26, 5 January 2013BeanthaPeriodical save, work in progress
56306view18:00, 5 January 2013Beanthaquercetin zonder inflammation
56305view17:57, 5 January 2013BeanthaPeriodical save, work in progress
56304view17:47, 5 January 2013BeanthaPeriodical save, work in progress
56301view17:37, 5 January 2013BeanthaPeriodical save, work in progress
56296view16:20, 5 January 2013BeanthaQuercetin pathway
56294view16:16, 5 January 2013BeanthaPeriodical save, work in progress
56290view16:06, 5 January 2013BeanthaPeriodical save, work in progress
56288view15:55, 5 January 2013BeanthaPeriodical save, work in progress
56282view15:45, 5 January 2013BeanthaPeriodical save, work in progress
56279view15:35, 5 January 2013BeanthaPeriodical save, work in progress
56276view15:24, 5 January 2013BeanthaPeriodical save, work in progress
55527view14:29, 17 December 2012Cboye21fina final�pathway
55526view14:23, 17 December 2012Cboye21Periodical save, work in progress
55523view14:13, 17 December 2012Cboye21Periodical save, work in progress
55517view14:03, 17 December 2012Cboye21Periodical save, work in progress
55516view13:52, 17 December 2012Cboye21final version
55515view13:31, 17 December 2012Cboye21Periodical save, work in progress
55351view17:11, 13 December 2012Cboye21final pathway
55350view17:07, 13 December 2012Cboye21Periodical save, work in progress
55347view16:47, 13 December 2012Cboye21Periodical save, work in progress
55346view16:46, 13 December 2012Cboye21Almost finalized
55344view16:27, 13 December 2012Cboye21Periodical save, work in progress
55339view16:18, 13 December 2012Cboye21All pathways included
55337view16:15, 13 December 2012Cboye21extra pathway
55327view15:49, 13 December 2012Cboye21Periodical save, work in progress
55317view15:29, 13 December 2012Cboye21Periodical save, work in progress
55312view15:19, 13 December 2012Cboye21Periodical save, work in progress
55305view15:09, 13 December 2012Cboye21Periodical save, work in progress
55296view14:59, 13 December 2012Cboye21Periodical save, work in progress
55291view14:48, 13 December 2012Cboye21Periodical save, work in progress
55283view14:38, 13 December 2012Cboye21Periodical save, work in progress
55267view14:18, 13 December 2012Cboye21Periodical save, work in progress
55262view14:08, 13 December 2012Cboye21Periodical save, work in progress
55255view13:57, 13 December 2012Cboye21New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
(Causes vasoconstriction; promotes platelet aggregation)
(Causes vasodilation; inhibits platelet aggregation)
(Increases vasoconstriction)
(Induces vasoconstriction and secretion of IL-1 and IL-2)
ACOX2GeneProductENSG00000168306 (Ensembl Human)
AngiogenesisPathway
Arachidonic acid (AA)
CYP2A6GeneProductENSG00000255974 (Ensembl Human) one of several possible phase 1 enzymes
CarcinogenesisPathway
Cell membrane phospholipids
DNA damage
FOSGeneProductENSG00000170345 (Ensembl Human)
IKBA_HUMANProteinP25963 (Uniprot/TrEMBL)
IKBKBGeneProductENSG00000104365 (Ensembl Human)
INFLAMMATION
JUNGeneProductENSG00000177606 (Ensembl Human)
KEAP1GeneProductENSG00000079999 (Ensembl Human)
MMP1GeneProductENSG00000196611 (Ensembl Human)
MetastasisPathway
NFE2L2GeneProductENSG00000116044 (Ensembl Human)
NFKB1GeneProductENSG00000109320 (Ensembl Human)
NOS1GeneProductENSG00000089250 (Ensembl Human)
PGG2 Metabolite
PGH2Metabolite
Phase 2 enzyme Protein
Prostaglandin D2MetaboliteHMDB01403 (HMDB)
Prostaglandin E2MetaboliteHMDB01220 (HMDB)
Prostaglandin F2aMetaboliteHMDB01139 (HMDB)
Prostaglandin I2MetaboliteHMDB01335 (HMDB)
Quercetin
Thromboxane A2MetaboliteHMDB01452 (HMDB)
VEGFAGeneProductENSG00000112715 (Ensembl Human)
carcinogenic metaboliteMetabolite
small MAFProtein

Annotated Interactions

No annotated interactions

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