Neurotransmitter clearance (Homo sapiens)

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23541, 6cytosolmitochondrial matrixH2O5-hydroxytryptamine N-methyl conjugateDopaminesodium ion5-hydroxyindole acetaldehydeOxygenAcetylcholinesteraseNAD+S-adenosylmethionineNoradrenaline uptake transporterS-adenosylhomocysteineSodium dependent Serotonin transporterCholinesodium ionNH3sodium ionNH35-Hydroxytryptaminesodium ionS-adenosylmethionineAcetateNoradrenalineSerotoninDopamine5-Hydroxyindole acetic acidH2O2H2OCatechol O-methyltransferase1-chloro-2,4-dinitrobenzeneHomocysteine5-hydroxytryptamine N-methyl conjugateH+MAOA-FAD complexaldehyde dehydrogenase, mitochondrial, tetramerOxygenNoradrenalineSodium dpendent Dopamine transporterO-acetylcholineNADH


Description

Neurotransmitter released in the synaptic cleft binds to specific receptors on the post-synaptic cell and the excess of the neurotransmitter is cleared to prevent over activation of the post-synaptic cell. The neurotransmitter is cleared by either re-uptake by the pre-synaptic neuron, diffusion in the perisynaptic area, uptake by astrocytes surrounding the synaptic cleft or enzymatic degradation of the neurotransmitter.
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Bibliography

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  4. Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melén K, Julkunen I, Taskinen J.; ''Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme.''; PubMed Europe PMC Scholia
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History

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CompareRevisionActionTimeUserComment
114635view16:09, 25 January 2021ReactomeTeamReactome version 75
113083view11:14, 2 November 2020ReactomeTeamReactome version 74
112317view15:23, 9 October 2020ReactomeTeamReactome version 73
101216view11:11, 1 November 2018ReactomeTeamreactome version 66
100754view20:36, 31 October 2018ReactomeTeamreactome version 65
100298view19:13, 31 October 2018ReactomeTeamreactome version 64
99844view15:57, 31 October 2018ReactomeTeamreactome version 63
99401view14:34, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99092view12:39, 31 October 2018ReactomeTeamreactome version 62
94498view09:04, 14 September 2017Mkutmonreactome version 61
87768view10:01, 25 July 2016RyanmillerOntology Term : 'signaling pathway' added !
87767view10:00, 25 July 2016RyanmillerOntology Term : 'signaling pathway pertinent to the brain and nervous system' added !
86397view09:17, 11 July 2016ReactomeTeamreactome version 56
83079view09:53, 18 November 2015ReactomeTeamVersion54
81400view12:55, 21 August 2015ReactomeTeamVersion53
76869view08:14, 17 July 2014ReactomeTeamFixed remaining interactions
76574view11:55, 16 July 2014ReactomeTeamFixed remaining interactions
75907view09:56, 11 June 2014ReactomeTeamRe-fixing comment source
75607view10:46, 10 June 2014ReactomeTeamReactome 48 Update
74962view13:48, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74606view08:39, 30 April 2014ReactomeTeamReactome46
58006view22:02, 5 February 2013AriuttaPeriodical save, work in progress
42088view21:56, 4 March 2011MaintBotAutomatic update
39896view05:55, 21 January 2011MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
1-chloro-2,4-

dinitrobenzene

MetaboliteREACT_7022 (Reactome)
5-Hydroxyindole

acetic acid

MetaboliteREACT_17511 (Reactome)
5-Hydroxytryptamine Metabolite28790 (ChEBI)
5-hydroxyindole

acetaldehyde

MetaboliteREACT_17970 (Reactome)
5-hydroxytryptamine

N-methyl conjugate

MetaboliteREACT_15971 (Reactome)
Acetate Metabolite15366 (ChEBI)
Acetylcholinesterase ProteinP22303 (UniProt)
Catechol O-

methyltransferase

ProteinP21964 (UniProt)
Choline Metabolite15354 (ChEBI)
Dopamine Metabolite18243 (ChEBI)
H+ Metabolite15378 (ChEBI)
H2O Metabolite15377 (ChEBI)
H2O2 Metabolite16240 (ChEBI)
Homocysteine Metabolite17230 (ChEBI)
MAOA-FAD complex ComplexREACT_5113 (Reactome)
NAD+ Metabolite15846 (ChEBI)
NADH Metabolite16908 (ChEBI)
NH3 Metabolite16134 (ChEBI)
Noradrenaline Metabolite18357 (ChEBI)
Noradrenaline

uptake transporter

ProteinO15244 (UniProt)
O-acetylcholine Metabolite15355 (ChEBI)
Oxygen Metabolite15379 (ChEBI)
S-

adenosylhomocysteine

Metabolite16680 (ChEBI)
S-adenosylmethionine Metabolite15414 (ChEBI)
Serotonin Metabolite28790 (ChEBI)
Sodium dependent

Serotonin transporter

REACT_15766 (Reactome)
Sodium dpendent

Dopamine transporter

ProteinQ01959 (UniProt)
aldehyde

dehydrogenase, mitochondrial, tetramer

ComplexREACT_2466 (Reactome)
sodium ion Metabolite29101 (ChEBI)

Annotated Interactions

No annotated interactions

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