Metastatic brain tumor (Homo sapiens)

Revision as of 20:05, 4 February 2013 by MaintBot (Talk | contribs)

Description

Interaction between microRNAs (miRNAs) and abnormal methylation to control metastasis.

Tumor growth and metastasis formation through down regulation of their oncogenic targets such as MYC ,E2F3 and cyclin –dependent kinase(CDK6).

View approved pathways at the new wikipathways.org.

Park SY, Lee JH, Ha M, Nam JW, Kim VN; ''miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia
Christoffersen NR, Shalgi R, Frankel LB, Leucci E, Lees M, Klausen M, Pilpel Y, Nielsen FC, Oren M, Lund AH; ''p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC.''; Cell Death Differ, 2010 PubMed Europe PMC Scholia
Hermeking H; ''The miR-34 family in cancer and apoptosis.''; Cell Death Differ, 2010 PubMed Europe PMC Scholia
Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M Jr, Jungkamp AC, Munschauer M, Ulrich A, Wardle GS, Dewell S, Zavolan M, Tuschl T; ''Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.''; Cell, 2010 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
107453	view	17:25, 10 October 2019	Khanspers	Modified description
106644	view	21:05, 12 September 2019	Khanspers	Modified description
105647	view	05:11, 10 August 2019	Khanspers	Modified description
102998	view	14:47, 31 January 2019	Mkutmon	updated outdated ensembl ids
89836	view	12:10, 6 October 2016	Mkutmon	Modified description
87807	view	11:28, 25 July 2016	Elisa	Ontology Term : 'disease of cellular proliferation' added !
87806	view	11:27, 25 July 2016	Elisa	Ontology Term : 'disease pathway' added !
84646	view	21:18, 10 March 2016	Khanspers	Quick edit to datanode annotation or property
84484	view	22:57, 25 February 2016	Khanspers	Quick edit to datanode annotation or property
84483	view	22:56, 25 February 2016	Khanspers	Quick edit to datanode annotation or property
80457	view	21:47, 24 June 2015	Khanspers	Added some literature references for miRNA targeting
76471	view	22:11, 9 July 2014	Khanspers	Added data nodes, fixed layout and interactions
73839	view	00:10, 26 February 2014	MaintBot	updated schema
58199	view	21:39, 9 February 2013	Egonw	Connected dots.
57902	view	20:05, 4 February 2013	MaintBot	Modified categories
49794	view	11:02, 26 July 2012	Devi	Modified description
49677	view	09:47, 24 July 2012	Devi	metastatic brain tumor
49671	view	05:53, 24 July 2012	Devi	New pathway