Methylation (Rattus norvegicus)

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1, 2N-methylationO-methylationS-methylationSAM synthesis (co-substrate)PhosphateS-methylated substrateTpmtATPMat1aS-AdenosylhomocysteineHnmtPhosphateMAT2BS-AdenosylmethionineComtS-AdenosylhomocysteineSubstrateS-AdenosylmethionineNP_001100289.1PNMTL-MethionineS-AdenosylmethionineS-AdenosylhomocysteineN-methylated substrateRGD1560523_predictedNP_001102492.1O-methylated substrate


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP704(r30265) with a 77% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008 PubMed Europe PMC Scholia
  2. Weinshilboum RM; ''Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.''; Cell Mol Neurobiol, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106950view13:41, 17 September 2019MaintBotHMDB identifier normalization
69452view19:06, 8 July 2013MaintBotUpdated to 2013 gpml schema
67462view11:05, 26 June 2013DdiglesOntology Term : 'protein modification pathway' added !
58975view18:45, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
58520view20:15, 14 February 2013MaintBotModified title
41781view02:42, 2 March 2011MaintBotRemoved redundant pathway information and comments
34149view19:35, 9 December 2009MaintBotAutomatic update of empty xrefs
31882view12:41, 14 August 2009MaintBotFixed group labels
30939view00:40, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetaboliteHMDB00538 (HMDB)
ComtGeneProductENSRNOG00000001889 (Ensembl Rat)
HnmtGeneProductENSRNOG00000005223 (Ensembl Rat)
L-MethionineMetaboliteHMDB00696 (HMDB)
MAT2BGeneProduct689330 (Entrez Gene)
Mat1aGeneProductENSRNOG00000011351 (Ensembl Rat)
N-methylated substrateMetabolite
NP_001100289.1GeneProductENSRNOG00000005930 (Ensembl Rat)
NP_001102492.1GeneProductENSRNOG00000011250 (Ensembl Rat)
O-methylated substrateMetabolite
PNMTGeneProduct24661 (Entrez Gene)
PhosphateMetaboliteHMDB01429 (HMDB)
RGD1560523_predictedGeneProductENSRNOG00000013520 (Ensembl Rat)
S-AdenosylhomocysteineMetaboliteHMDB00939 (HMDB)
S-AdenosylmethionineMetaboliteHMDB01185 (HMDB)
S-methylated substrateMetabolite
SubstrateMetabolite
TpmtGeneProductENSRNOG00000016468 (Ensembl Rat)

Annotated Interactions

No annotated interactions
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