Aflatoxin B1 metabolism (Mus musculus)

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2, 3, 5-101, 41, 4nonenzymaticDNA adductsnonenzymatic(pH-dependent)Aflatoxin B1 C8-monoalcoholAflatoxin B1 C6-monoaldehydeAflatoxin B1 C8-monoaldehydeCYP3A4Cyp1a2AKR7A3Aflatoxin B1-6,8-dialcoholGstt1Akr7a5aflatoxin B1Aflatoxin B1 dialdehydeCYP2A13CYP3A4Cyp1a2Ephx1Aflatoxin M1Aflatoxin B1 8,9-dihydrodiolAflatoxin B1 exo-8,9-epoxideAflatoxin Q1Aflatoxin M1 epoxideAflatoxin-endo-B1-8,9-epoxideCyp1a2CYP2A13Aflatoxin B1 exo-8,9-epoxide-GSHAflatoxin B1 C6-monoalcoholGstm1


Description

Aflatoxins are naturally occurring mycotoxins that are produced by many species of Aspergillus, a fungus, most notably Aspergillus flavus and Aspergillus parasiticus. After entering the body, aflatoxins are metabolized by the liver to a reactive intermediate, aflatoxin M1, an epoxide. Aflatoxin B1 is considered the most toxic and is produced by both Aspergillus flavus and Aspergillus parasiticus. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP699(r30253) with a 50% conversion rate.

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Ontology Terms

 

Bibliography

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  1. Guengerich FP; ''Cytochrome P450s and other enzymes in drug metabolism and toxicity.''; AAPS J, 2006 PubMed Europe PMC Scholia
  2. Zhu LR, Thomas PE, Lu G, Reuhl KR, Yang GY, Wang LD, Wang SL, Yang CS, He XY, Hong JY; ''CYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody.''; Drug Metab Dispos, 2006 PubMed Europe PMC Scholia
  3. Stewart RK, Smith GB, Donnelly PJ, Reid KR, Petsikas D, Conlan AA, Massey TE; ''Glutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B(1) in human lung: differential cellular distribution and lack of significance of the GSTM1 genetic polymorphism.''; Carcinogenesis, 1999 PubMed Europe PMC Scholia
  4. Tiemersma EW, Omer RE, Bunschoten A, van't Veer P, Kok FJ, Idris MO, Kadaru AM, Fedail SS, Kampman E; ''Role of genetic polymorphism of glutathione-S-transferase T1 and microsomal epoxide hydrolase in aflatoxin-associated hepatocellular carcinoma.''; Cancer Epidemiol Biomarkers Prev, 2001 PubMed Europe PMC Scholia
  5. Guengerich FP, Cai H, McMahon M, Hayes JD, Sutter TR, Groopman JD, Deng Z, Harris TM; ''Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.''; Chem Res Toxicol, 2001 PubMed Europe PMC Scholia
  6. Kensler TW, Qian GS, Chen JG, Groopman JD; ''Translational strategies for cancer prevention in liver.''; Nat Rev Cancer, 2003 PubMed Europe PMC Scholia
  7. He XY, Tang L, Wang SL, Cai QS, Wang JS, Hong JY; ''Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract.''; Int J Cancer, 2006 PubMed Europe PMC Scholia
  8. Guengerich FP, Arneson KO, Williams KM, Deng Z, Harris TM; ''Reaction of aflatoxin B(1) oxidation products with lysine.''; Chem Res Toxicol, 2002 PubMed Europe PMC Scholia
  9. Jin Y, Penning TM; ''Aldo-keto reductases and bioactivation/detoxication.''; Annu Rev Pharmacol Toxicol, 2007 PubMed Europe PMC Scholia
  10. Barski OA, Tipparaju SM, Bhatnagar A; ''The aldo-keto reductase superfamily and its role in drug metabolism and detoxification.''; Drug Metab Rev, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
106843view13:32, 17 September 2019MaintBotHMDB identifier normalization
89962view18:13, 6 October 2016Mkutmonfix unconnected lines
69179view18:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
67030view09:56, 26 June 2013Christine ChichesterOntology Term : 'aflatoxin metabolic pathway' added !
59068view21:22, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
48257view21:49, 17 May 2012KhanspersUpdating PubChem xrefs
48231view05:32, 17 May 2012MaintBotAutomatic update of PubChem xrefs
41368view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
35017view08:26, 11 February 2010ThomasModified description
32836view19:19, 14 September 2009MaintBotadded xrefs
32296view13:13, 15 August 2009MaintBotFixed text labels
31864view12:35, 14 August 2009MaintBotFixed group labels
31325view20:19, 13 August 2009MaintBotFixed text labels
30878view00:15, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKR7A3GeneProduct
Aflatoxin B1 8,9-dihydrodiolMetabolite
Aflatoxin B1 C6-monoalcoholMetabolite
Aflatoxin B1 C6-monoaldehydeMetabolite
Aflatoxin B1 C8-monoalcoholMetabolite
Aflatoxin B1 C8-monoaldehydeMetabolite
Aflatoxin B1 dialdehydeMetabolite
Aflatoxin B1 exo-8,9-epoxide-GSHMetabolite5460816 (PubChem-compound)
Aflatoxin B1 exo-8,9-epoxideMetaboliteHMDB06558 (HMDB)
Aflatoxin B1-6,8-dialcoholMetabolite
Aflatoxin M1 epoxideMetabolite
Aflatoxin M1Metabolite15558498 (PubChem-compound)
Aflatoxin Q1Metabolite104757 (PubChem-compound)
Aflatoxin-endo-B1-8,9-epoxideMetabolite
Akr7a5GeneProductENSMUSG00000028743 (Ensembl)
CYP2A13GeneProduct
CYP3A4GeneProduct
Cyp1a2GeneProductENSMUSG00000032310 (Ensembl)
Ephx1GeneProductENSMUSG00000038776 (Ensembl)
Gstm1GeneProduct14862 (Entrez Gene)
Gstt1GeneProductENSMUSG00000001663 (Ensembl)
aflatoxin B1MetaboliteHMDB06552 (HMDB)

Annotated Interactions

No annotated interactions
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