Cell cycle (Pan troglodytes)

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1mediated+pS-phase proteinsG2Histone DeacetylasesS+pep27,57(Start)+pDNA damage checkpoint+p+pSecurin+u+pApoptosisGrowth Factor+p+pMR-point+peMCM (Mini-ChromosomeMaintenance) complexproteolysis+uHDACp21G1+u+pSeparinDNA+pTranscription Factor E2Fesignaling+u+ppathway+pUbiquitin-p-p+p+pGrowth Factor withdrawalORC (OriginRecognition complex)DNA biosynthesis+u+pp16,15,18,19DNA+pMAPKCondensineeBUB1BESPL1TP53RB1ORC3LGSK3BSMAD3SMAD4HDAC4CDH1BUB1CCNE2CCNB3E2F6CDC14BLOC464259CDKN1BARFMCMEP300MDM2ORC6LUBE2FLOC738624SCFE2F5CDC25BMCM2CHEK2YWHAGMCM4MPEG1CDC14AMCM6SMC1L1CDC6CDC7SCFORC5LMAD2L214-3-3CDKN2ACDK2CCND2ATRCDKN1ALOC454721ORC2LCDK4E2F1PTTG1ORCCHEK1CDC2E2FLOC466968DBF4HDAC6APC/CCCNA1ORC1LE2F2CDC20MAD2L1SKP2CCNA2CCNE1APC/CABL1PKMYT1TGFB1MCM3PCNARB1CCNB2CDC25ASKP2GADD45AORC4LLOC465712CCNB1MAD1L1TBC1D8CCNA2CDK2BUB3CCNA1CCNHPTTG2E2F4RB1E2F3ATMCDK2CDC25CMCM5CDK6CDC45LGeneProductWEE1RBL1PRKDCPTTG3CCND3CDC2PLK1LOC462950RBL1TFDP1MENMCM7


Description

(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.

Comments

GenMAPP notes 
Adapted from: http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP179(r30295) with a 80% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
111047view12:30, 3 July 2020L DupuisConverted interactions to graphical lines
86990view14:37, 15 July 2016MkutmonOntology Term : 'cell cycle pathway' added !
71659view19:39, 17 October 2013MaintBotAutomated update of data sources
69225view18:33, 8 July 2013MaintBotUpdated to 2013 gpml schema
62736view03:33, 2 May 2013MaintBotUpdated UniProt data source
41528view01:57, 2 March 2011MaintBotRemoved redundant pathway information and comments
35370view09:15, 12 February 2010MartijnVanIerselModified description
34265view21:52, 9 December 2009MaintBotAutomatic update of empty xrefs
33613view10:00, 1 December 2009MaintBotRemoved group label
31626view22:20, 13 August 2009MaintBotFixed text labels
30533view21:54, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
14-3-3GeneProduct
ABL1GeneProduct464802 (Entrez Gene) ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
APC/CGeneProduct
ARFGeneProduct
ATMGeneProduct451530 (Entrez Gene) ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
ATRGeneProduct460745 (Entrez Gene) ATR; ataxia telangiectasia and Rad3 related
BUB1GeneProduct459484 (Entrez Gene) BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
BUB1BGeneProduct453324 (Entrez Gene) BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
BUB3GeneProduct450800 (Entrez Gene) BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
CCNA1GeneProduct467260 (Entrez Gene) CCNA1; cyclin A1
CCNA2GeneProduct461467 (Entrez Gene) CCNA2; cyclin A2
CCNB1GeneProduct461835 (Entrez Gene) CCNB1; cyclin B1
CCNB2GeneProduct453478 (Entrez Gene) CCNB2; cyclin B2
CCNB3GeneProduct465635 (Entrez Gene) CCNB3; cyclin B
CCND2GeneProduct747123 (Entrez Gene) CCND2; cyclin D2
CCND3GeneProduct462689 (Entrez Gene) CCND3; cyclin D3
CCNE1GeneProduct455914 (Entrez Gene) CCNE1; cyclin E
CCNE2GeneProduct464292 (Entrez Gene) CCNE2; cyclin E
CCNHGeneProduct739351 (Entrez Gene) CCNH; cyclin H
CDC14AGeneProduct457058 (Entrez Gene) CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
CDC14BGeneProduct465251 (Entrez Gene) CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
CDC20GeneProduct456819 (Entrez Gene) CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
CDC2GeneProduct450481 (Entrez Gene) CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
CDC25AGeneProduct460341 (Entrez Gene) CDC25A; cell division cycle 25A [EC:3.1.3.48]
CDC25BGeneProduct458064 (Entrez Gene) CDC25B; cell division cycle 25B [EC:3.1.3.48]
CDC25CGeneProduct746151 (Entrez Gene) CDC25C; cell division cycle 25C [EC:3.1.3.48]
CDC45LGeneProduct458651 (Entrez Gene) CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
CDC6GeneProduct468234 (Entrez Gene) CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
CDC7GeneProduct469380 (Entrez Gene) CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
CDH1GeneProduct468009 (Entrez Gene)
CDK2GeneProduct467032 (Entrez Gene) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDK4GeneProduct452025 (Entrez Gene) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CDK6GeneProduct746968 (Entrez Gene) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CDKN1AGeneProduct747442 (Entrez Gene)
CDKN1BGeneProduct466947 (Entrez Gene) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN2AGeneProduct465021 (Entrez Gene)
CHEK1GeneProduct739836 (Entrez Gene) CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
CHEK2GeneProduct458733 (Entrez Gene) CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
DBF4GeneProduct472668 (Entrez Gene) ASK; activator of S phase kinas
E2FGeneProduct
E2F1GeneProductE2F1; E2F transcription factor 1
E2F2GeneProduct469153 (Entrez Gene) E2F2; E2F transcription factor 2
E2F3GeneProductE2F3; E2F transcription factor 3
E2F4GeneProduct454158 (Entrez Gene) E2F4; E2F transcription factor 4 p107/p130-binding
E2F5GeneProduct747256 (Entrez Gene) E2F5; E2F transcription factor 5 p130-binding
E2F6GeneProduct470148 (Entrez Gene) E2F6; E2F transcription factor 6
EP300GeneProduct458862 (Entrez Gene) EP300; E1A binding protein p300
ESPL1GeneProductESPL1; extra spindle poles like 1 (S. cerevisiae
GADD45AGeneProduct456929 (Entrez Gene)
GSK3BGeneProduct470896 (Entrez Gene) GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
GeneProductGeneProduct
HDAC4GeneProductHDAC4; histone deacetylase 4
HDAC6GeneProductHDAC6; histone deacetylase 6
LOC454721GeneProduct454721 (Entrez Gene) HDAC5; histone deacetylase 5
LOC462950GeneProduct462950 (Entrez Gene) HDAC2; histone deacetylase 2
LOC464259GeneProduct464259 (Entrez Gene) HDAC1; histone deacetylase 1
LOC465712GeneProduct465712 (Entrez Gene) HDAC8; histone deacetylase
LOC466968GeneProduct466968 (Entrez Gene) HDAC7A; histone deacetylase 7
LOC738624GeneProduct738624 (Entrez Gene) HDAC3; histone deacetylase 3
MAD1L1GeneProduct463223 (Entrez Gene) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
MAD2L1GeneProduct461661 (Entrez Gene) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
MAD2L2GeneProduct457953 (Entrez Gene) MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
MCMGeneProduct
MCM2GeneProduct460668 (Entrez Gene) MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
MCM3GeneProduct462763 (Entrez Gene) MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
MCM4GeneProduct472757 (Entrez Gene) MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
MCM5GeneProduct458790 (Entrez Gene) MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
MCM6GeneProduct741695 (Entrez Gene) MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
MCM7GeneProduct472460 (Entrez Gene) MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
MDM2GeneProduct742141 (Entrez Gene) MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
MENGeneProduct
MPEG1GeneProduct451211 (Entrez Gene)
ORCGeneProduct
ORC1LGeneProduct456857 (Entrez Gene) ORC1L; origin recognition complex subunit 1-like (yeast)
ORC2LGeneProduct459868 (Entrez Gene) ORC2L; origin recognition complex subunit 2-like (yeast)
ORC3LGeneProduct462876 (Entrez Gene) ORC3L; origin recognition complex subunit 3-like (yeast)
ORC4LGeneProduct459647 (Entrez Gene) ORC4L; origin recognition complex subunit 4-like (yeast)
ORC5LGeneProduct463636 (Entrez Gene) ORC5L; origin recognition complex subunit 5-like (yeast)
ORC6LGeneProduct465140 (Entrez Gene) ORC6L; origin recognition complex subunit 6-like (yeast)
PCNAGeneProduct458081 (Entrez Gene) PCNA; proliferating cell nuclear antigen
PKMYT1GeneProduct467880 (Entrez Gene) PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
PLK1GeneProduct453991 (Entrez Gene) PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
PRKDCGeneProduct464165 (Entrez Gene) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
PTTG1GeneProduct462238 (Entrez Gene) PTTG1; pituitary tumor-transforming
PTTG2GeneProduct736475 (Entrez Gene) PTTG2; pituitary tumor-transforming
PTTG3GeneProductPTTG3; pituitary tumor-transforming
RB1GeneProduct452715 (Entrez Gene) RB1; retinoblastoma 1 (including osteosarcoma)
RBL1GeneProduct735916 (Entrez Gene) RBL1; retinoblastoma-like 1 (p107)
SCFGeneProduct
SKP2GeneProduct471570 (Entrez Gene) SKP2; S-phase kinase-associated protein 2 (p45
SMAD3GeneProduct748161 (Entrez Gene) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
SMAD4GeneProduct468537 (Entrez Gene) MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
SMC1L1GeneProductSMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
TBC1D8GeneProduct459451 (Entrez Gene)
TFDP1GeneProduct465967 (Entrez Gene) TFDP1; transcription factor Dp-1
TGFB1GeneProduct456060 (Entrez Gene)
TP53GeneProduct455214 (Entrez Gene)
UBE2FGeneProduct460054 (Entrez Gene) UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
WEE1GeneProduct466440 (Entrez Gene) WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
YWHAGGeneProduct463489 (Entrez Gene) YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid

Annotated Interactions

No annotated interactions
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