Eicosanoid synthesis (Danio rerio)

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115-Hydroperoxy Eicosatetraenoic AcidCell MembraneThromboxane A312-Hydroperoxy Eicosatetraenoic Acid6-Keto-Prostaglandin F2-alphaProstaglandin E2IPLA2(GAMMA)Leukotriene D4Prostaglandin F2aptgs2bArachidonic acidPGD2 11-ketoreducLeukotriene E4Peroxidase?12-HETEptges5-HPETEPGE2 9-ketoreducProstaglandin D2ALOX15ALOX15Leukotriene B4Prostaglandin I2GGT1LOC567284PLA2G2ALeukotriene C4Thromboxane A2Peroxidase?DKEY-194N13.2Leukotriene A45-HETEptgeslPeroxidase?15-HETEalox12pla2g6PTGDSDKEY-194N13.2pla2g6ALOX15BLOC791800ptgisllta4hptgs1zgc:153024tbxas1Thromboxane B2Prostaglandin H2LOC791800


Description

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP167(r21031) with a 51% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116859view10:55, 14 May 2021EweitzModified title
106066view11:58, 16 August 2019MaintBotHMDB identifier normalization
89463view13:13, 15 September 2016Mkutmonremove space in ontology term id
71523view19:22, 17 October 2013MaintBotAutomated update of data sources
68658view05:14, 6 July 2013MaintBotUpdated to 2013 gpml schema
67183view10:17, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
62791view16:33, 2 May 2013MaintBotUpdated UniProt data source
40827view22:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
35479view12:14, 12 February 2010Thomasadded literature
35474view12:13, 12 February 2010ThomasModified description
34213view21:32, 9 December 2009MaintBotAutomatic update of empty xrefs
31914view12:51, 14 August 2009MaintBotFixed group labels
31028view01:12, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
12-HETEMetabolite
15-HETEMetabolite
5-HETEMetabolite
5-HPETEMetaboliteHMDB01193 (HMDB)
ALOX15GeneProduct
ALOX15BGeneProduct
Arachidonic acidMetaboliteHMDB01043 (HMDB)
DKEY-194N13.2GeneProduct567204 (Entrez Gene)
GGT1GeneProduct393387 (Entrez Gene)
IPLA2(GAMMA)GeneProduct
LOC567284GeneProduct567284 (Entrez Gene)
LOC791800GeneProduct791800 (Entrez Gene)
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene E4MetaboliteHMDB02200 (HMDB)
PGD2 11-ketoreducGeneProduct
PGE2 9-ketoreducGeneProduct
PLA2G2AGeneProduct
PTGDSGeneProduct336492 (Entrez Gene)
Peroxidase?GeneProduct
Prostaglandin D2MetaboliteHMDB01403 (HMDB)
Prostaglandin F2aMetaboliteHMDB01139 (HMDB)
Prostaglandin H2MetaboliteHMDB01381 (HMDB)
Prostaglandin I2MetaboliteHMDB01335 (HMDB)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)
alox12GeneProduct322732 (Entrez Gene)
lta4hGeneProduct406575 (Entrez Gene)
pla2g6GeneProduct406370 (Entrez Gene)
ptgesGeneProduct544666 (Entrez Gene)
ptgeslGeneProduct799964 (Entrez Gene)
ptgislGeneProduct559148 (Entrez Gene)
ptgs1GeneProduct246226 (Entrez Gene)
ptgs2bGeneProduct559020 (Entrez Gene)
tbxas1GeneProduct792041 (Entrez Gene)
zgc:153024GeneProduct768195 (Entrez Gene)

Annotated Interactions

No annotated interactions
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