TNF-alpha signaling pathway (Bos taurus)

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CY ->NUDeubiquitinationDephosphorylationMitochondrionAutophosphorylationPalmitoylationUbiquitinationSumoylationActivationLigandPhosphorylationCY ->NUAcetylationNUDemethylationMolecular associationPlasma membraneMethylation(Protein-protein interaction)CY ->NUControlAccession Number: NetPath 9; cellmap:9DesumoylationNucleusERCYEndosomeEndoplasmic reticulumPMInhibitionDeacetylationProteins in a complex interactionGlycosylationDCY ->NUGolgi apparatusRecruitmentReaction through unknown mechanisms/moleculesCytoplasmCY ->NUEnzyme complexECGOProteolytic cleavageTranslocationENReceptorMTExtracellularMolecule in the pathwayTANKRIPK3TBK1PAPOLAPOLR1BTNFSMARCA4RELACASP3PPP2CATRAF5HDAC2TNFPEG3MCM5RELBUBE2D2SUMO1IKBKAPNKIRAS2GLG1HSP90AB1PSMC3TNFRSF1APTK2NFKB1CASP2TRAF1POLR1CCASP8AP2CAPN3UBCH5CTNFRSF8GeneNKIRAS1TNFAIP3CD3EAPNFKB2RPL6MAP3K2TNFRSF1BMAP3K7IP2TRAIPRPS6KA5POLR2LFBLTNFRSF1APSMD7BCL7ARPL30POLR2HTRAF2NFKBIEPSMD6TNIP2CREBBPTNFFANCD2CHUKPSMD1TRADDNALP4HDAC6RNF25CSNK2A2YWHAHFADDRELACSNK2BMTIF2PSMC1POLR1DRELARELALOC511264HIST3H3CYLDACTL6ATRAF2PTPN11RIPK1NFKB1MGC143170KCNQ1GeneDDX3XUSP2AKAP8PRKACABIRC2PEBP1NFKBIACDC37MAP3K3NFKB1TNFTXLNAIQGAP2MAP3K7IP1MAP3K8GeneYWHAGNR2C2AKT2NR2C2PSMD13PRKCZRELBCAV1KPNA2IKBKBSMARCB1BAG4MAP3K14CSNK2A1RELCRADDTNFRSF1BRPL8IKBKECASP10RPL4TRPC4APAKT1BTRCCHUKHSPCATRAF4TRADDTRAF3CDC34Gene SymbolPSMB5CASP7TNFRSF1AIKBKGKIAA1967ZFAND5RIPK1HSPB1LOC509995MAP3K1YWHABGAB1FKBP5TNFRSF11AUBE2IMAP2K5NFKBIZLOC100138545RPS13NFKBIBWDR68RIPK2RNF216MCM7PSMC2DPF2YWHAETRAF6SMARCE1BIRC3RPS6KB1YWHAZNSMAFMCCYWHAQKPNA3PSMD12SRCBIRC2PIAS3PDCD2TNFRSF1BCASP8PKN1USP11PFDN2LOC790559EIF4A3TRAF1RASAL2PPP1R13LCOPS3FLNABIRC3IKBKGNFKBIABCL3GeneUNC5CLSMARCC2ALPLRELSTAT1KPNA6LOC522045G3BP2TRAF4KTN1GSK3BCUL1TNFRPS11FBXW11TBK1GTF2IMAP3K3CFLARCOMMD1TNIP1AZI2TRAF2POLR1EMARK2PSMD3HDAC1GNB2L1TNFNFKBIADAPPOLR1AFAF1


Description

No description

Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 87% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
116471view10:15, 7 May 2021EweitzModified title
89903view13:20, 6 October 2016EgonwModified description
80680view15:21, 30 June 2015Mkutmonhomology conversion
63380view23:07, 9 May 2013MaintBotUpdated to 2013 gpml schema
40552view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
33791view00:12, 9 December 2009MaintBotAutomatic update of empty xrefs
32512view12:52, 17 August 2009MaintBotFixed text labels
32200view12:38, 15 August 2009MaintBotFixed text labels
31682view11:44, 14 August 2009MaintBotFixed group labels
31210view19:36, 13 August 2009MaintBotFixed text labels
30616view22:20, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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AKAP8GeneProduct522905 (Entrez Gene)
AKT1GeneProduct280991 (Entrez Gene)
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BAG4GeneProduct516353 (Entrez Gene)
BCL3GeneProduct531942 (Entrez Gene)
BCL7AGeneProduct616240 (Entrez Gene)
BIRC2GeneProduct
BIRC3GeneProduct514386 (Entrez Gene)
BTRCGeneProduct534072 (Entrez Gene)
CAPN3GeneProduct281663 (Entrez Gene)
CASP10GeneProduct
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CASP7GeneProduct526279 (Entrez Gene)
CASP8GeneProduct507481 (Entrez Gene)
CASP8AP2GeneProduct505138 (Entrez Gene)
CAV1GeneProduct281040 (Entrez Gene)
CD3EAPGeneProduct617937 (Entrez Gene)
CDC34GeneProduct616156 (Entrez Gene)
CDC37GeneProduct520883 (Entrez Gene)
CFLARGeneProduct497199 (Entrez Gene)
CHUKGeneProduct281073 (Entrez Gene)
COMMD1GeneProduct534683 (Entrez Gene)
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CRADDGeneProduct615788 (Entrez Gene)
CREBBPGeneProduct505453 (Entrez Gene)
CSNK2A1GeneProduct282419 (Entrez Gene)
CSNK2A2GeneProduct282420 (Entrez Gene)
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DDX3XGeneProduct510093 (Entrez Gene)
DPF2GeneProduct513235 (Entrez Gene)
EIF4A3GeneProduct515145 (Entrez Gene)
FADDGeneProduct493720 (Entrez Gene)
FAF1GeneProduct531770 (Entrez Gene)
FANCD2GeneProduct515845 (Entrez Gene)
FBLGeneProduct538548 (Entrez Gene)
FBXW11GeneProduct540642 (Entrez Gene)
FKBP5GeneProduct535704 (Entrez Gene)
FLNAGeneProduct281165 (Entrez Gene)
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GSK3BGeneProduct790875 (Entrez Gene)
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GeneGeneProduct
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HIST3H3GeneProduct
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MTIF2GeneProduct281923 (Entrez Gene)
NALP4GeneProduct
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PSMD6GeneProduct538625 (Entrez Gene)
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PTK2GeneProduct506270 (Entrez Gene)
PTPN11GeneProduct533590 (Entrez Gene)
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RELGeneProduct509135 (Entrez Gene)
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RIPK3GeneProduct507427 (Entrez Gene)
RNF216GeneProduct534455 (Entrez Gene)
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RPL30GeneProduct513031 (Entrez Gene)
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RPL6GeneProduct511051 (Entrez Gene)
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RPS13GeneProduct535668 (Entrez Gene)
RPS6KA5GeneProduct504408 (Entrez Gene)
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SUMO1GeneProduct788060 (Entrez Gene)
TANKGeneProduct539513 (Entrez Gene)
TBK1GeneProduct533141 (Entrez Gene)
TNFGeneProduct280943 (Entrez Gene)
TNFAIP3GeneProduct508105 (Entrez Gene)
TNFRSF11AGeneProduct530884 (Entrez Gene)
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TNFRSF1BGeneProduct338033 (Entrez Gene)
TNFRSF8GeneProduct614780 (Entrez Gene)
TNIP1GeneProduct526103 (Entrez Gene)
TNIP2GeneProduct617265 (Entrez Gene)
TRADDGeneProduct504707 (Entrez Gene)
TRAF1GeneProduct540944 (Entrez Gene)
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UBCH5CGeneProduct
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YWHABGeneProduct286863 (Entrez Gene)
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YWHAHGeneProduct282126 (Entrez Gene)
YWHAQGeneProduct768311 (Entrez Gene)
YWHAZGeneProduct287022 (Entrez Gene)
ZFAND5GeneProduct404110 (Entrez Gene)

Annotated Interactions

No annotated interactions
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