Kit receptor signaling pathway (Bos taurus)

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CY->PMAcetylationGene SymbolMolecule in the pathwayPalmitoylationENDesumoylationECUbiquitinationEndosome(Protein-protein interaction)InhibitionMolecular associationAutophosphorlationLigandExtracellularReaction through unknown mechanisms/moleculesERTranslocationEnzyme complexAccession Number: NetPath 6; cellmap:6ActivationCYGOReceptorMethylationGolgi apparatusDephosphorylationPMCytoplasmDemethylationMitochondrionDeacetylationDeubiquitinationProteolytic cleavageDMTDPhosphorylationNucleusRecruitmentp85 complexEndoplasmic reticulumControlProteins in a complex interactionGlycosylationPlasma MembraneNUSumoylationFGRCBLBCRKHCKPRKCBPRKCAMATKSTAT5BSTAT1SOCS4PIK3R1PTPN6DOK1PIK3R2SHC1CBLMPDZEPORTRAILR1PIK3CGYES1VAV1FYNMITFJAK2SOCS1KITLGGRAPMAP2K1TECSH2B2CLTCBADRPS6KA1STAT5ASPRED1GRB2Grb10SPRED2KITMAPK1SOCS5CSF2RBBTKPLCG1GRB7HRASEP300SH3KBP1KITAKT1RAF1LYNRASA1ABL1SOCS6INPP5DCISHDOK1CRKLVAV2STAT3FESPLCE1STAP1SRCPTPN11SOS1KITLGPTPRU


Description

Kit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets among others. Binding of Kit receptor to stem cell factor leads to an intracellular cascade of events that includes activation of PI 3-kinase, Src family kinases and PLC gamma. Activating mutations in the Kit receptor are associated with several human malignancies include leukemias, gastrointestinal stromal tumors and mastocytomas. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_6

Comments

GenMAPP notes 
NetPath 6; cellmap:6 - Kit Receptor Signaling Pathway. The Kit Receptor signaling pathway was kindly reviewed by Imke Ehlers in Peter Besmer’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP304(r21319) with a 88% conversion rate.

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Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
115956view08:22, 22 March 2021EgonwCopied the NetPath paper into the literature list
115946view07:11, 22 March 2021EgonwModified description
80716view15:23, 30 June 2015Mkutmonhomology conversion
67423view10:59, 26 June 2013DdiglesOntology Term : 'Stem Cell Factor signaling pathway' added !
63453view17:14, 10 May 2013MaintBotUpdated to 2013 gpml schema
40587view19:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
35758view00:04, 13 February 2010AlexanderPico
33825view00:26, 9 December 2009MaintBotAutomatic update of empty xrefs
32485view12:44, 17 August 2009MaintBotFixed text labels
31183view19:28, 13 August 2009MaintBotFixed text labels
30573view22:06, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProduct540876 (Entrez Gene)
AKT1GeneProduct280991 (Entrez Gene)
BADGeneProduct615013 (Entrez Gene)
BTKGeneProduct533459 (Entrez Gene)
CBLGeneProduct527418 (Entrez Gene)
CBLBGeneProduct525906 (Entrez Gene)
CISHGeneProduct616753 (Entrez Gene)
CLTCGeneProduct281080 (Entrez Gene)
CRKGeneProduct512841 (Entrez Gene)
CRKLGeneProduct
CSF2RBGeneProduct528530 (Entrez Gene)
DOK1GeneProduct514962 (Entrez Gene)
EP300GeneProduct
EPORGeneProduct281144 (Entrez Gene)
FESGeneProduct507304 (Entrez Gene)
FGRGeneProduct516133 (Entrez Gene)
FYNGeneProduct527263 (Entrez Gene)
GRAPGeneProduct534491 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
GRB7GeneProduct508847 (Entrez Gene)
Grb10GeneProduct407210 (Entrez Gene)
HCKGeneProduct280814 (Entrez Gene)
HRASGeneProduct513012 (Entrez Gene)
INPP5DGeneProduct507329 (Entrez Gene)
JAK2GeneProduct525246 (Entrez Gene)
KITGeneProduct280832 (Entrez Gene)
KITLGGeneProduct281885 (Entrez Gene)
LYNGeneProduct534996 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MATKGeneProduct504668 (Entrez Gene)
MITFGeneProduct407219 (Entrez Gene)
MPDZGeneProduct536863 (Entrez Gene)
PIK3CGGeneProduct530001 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PIK3R2GeneProduct282308 (Entrez Gene)
PLCE1GeneProduct519037 (Entrez Gene)
PLCG1GeneProduct281987 (Entrez Gene)
PRKCAGeneProduct282001 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PTPN11GeneProduct533590 (Entrez Gene)
PTPN6GeneProduct512312 (Entrez Gene)
PTPRUGeneProduct535675 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RASA1GeneProduct282032 (Entrez Gene)
RPS6KA1GeneProduct533908 (Entrez Gene)
SH2B2GeneProduct617840 (Entrez Gene)
SH3KBP1GeneProduct510489 (Entrez Gene)
SHC1GeneProduct507196 (Entrez Gene)
SOCS1GeneProduct518795 (Entrez Gene)
SOCS4GeneProduct540412 (Entrez Gene)
SOCS5GeneProduct514773 (Entrez Gene)
SOCS6GeneProduct
SOS1GeneProduct537682 (Entrez Gene)
SPRED1GeneProduct519882 (Entrez Gene)
SPRED2GeneProduct519081 (Entrez Gene)
SRCGeneProduct535742 (Entrez Gene)
STAP1GeneProduct507296 (Entrez Gene)
STAT1GeneProduct510814 (Entrez Gene)
STAT3GeneProduct508541 (Entrez Gene)
STAT5AGeneProduct282375 (Entrez Gene)
STAT5BGeneProduct282376 (Entrez Gene)
TECGeneProduct504733 (Entrez Gene)
TRAILR1GeneProduct
VAV1GeneProduct617345 (Entrez Gene)
VAV2GeneProduct
YES1GeneProduct507632 (Entrez Gene)

Annotated Interactions

No annotated interactions
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