Cholesterol biosynthesis (Bos taurus)

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1-7Fatty Acid DegradationDHCR7Squalenefarnesyl pyrophosphateCYP51Geranyl-PPLathosterolMVKMevalonic acidMevalonic acid-5PSC4MOLMevalonic acid 5-pyrophosphateSQLEHMG-CoAIDI1HMGCRCholesterolDimethylallylpyrophosphateSC5DLNSDHLFDPSisopentenyl pyrophosphateMVDAcetyl-CoALSS7-DehydrocholesterolPMVKFDPS(S)-2,3-EpoxysqualeneFDFT1HMGCS1Lanosterin


Description

Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP197(r21093) with a 82% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
118367view13:46, 27 May 2021EweitzOntology Term : 'cholesterol biosynthetic pathway' added !
117487view11:01, 21 May 2021EweitzModified title
105958view11:48, 16 August 2019MaintBotHMDB identifier normalization
101765view13:47, 7 November 2018EgonwReplaced a wrong CAS number of with right ChEBI identifier.
85039view07:05, 10 April 2016EgonwReverted to version '15:24, 30 June 2015' by Egonw
85038view03:21, 10 April 2016KhanspersQuick edit to datanode annotation or property
80735view15:24, 30 June 2015Mkutmonhomology conversion
71427view19:03, 17 October 2013MaintBotAutomated update of data sources
67110view10:07, 26 June 2013Christine ChichesterOntology Term : 'cholesterol biosynthetic pathway' added !
63450view17:14, 10 May 2013MaintBotUpdated to 2013 gpml schema
40584view19:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
35152view14:22, 11 February 2010ThomasModified description
35151view14:21, 11 February 2010Thomasmoved literature from genmapp comments to bibliography
33822view00:25, 9 December 2009MaintBotAutomatic update of empty xrefs
31703view11:50, 14 August 2009MaintBotFixed group labels
30639view22:29, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(S)-2,3-EpoxysqualeneMetabolite9029-62-3 (CAS)
7-DehydrocholesterolMetabolite434-16-2 (CAS)
Acetyl-CoAMetabolite
CYP51GeneProduct505060 (Entrez Gene)
CholesterolMetabolite57-88-5 (CAS)
DHCR7GeneProduct514745 (Entrez Gene)
DimethylallylpyrophosphateMetabolite358-72-5 (CAS)
FDFT1GeneProduct281767 (Entrez Gene)
FDPSGeneProduct281156 (Entrez Gene)
Geranyl-PPMetabolite6699-20-3 (CAS)
HMG-CoAMetabolite
HMGCRGeneProduct407159 (Entrez Gene)
HMGCS1GeneProduct783184 (Entrez Gene)
IDI1GeneProduct514293 (Entrez Gene)
LSSGeneProduct615906 (Entrez Gene)
LanosterinMetabolite79-63-0 (CAS)
LathosterolMetabolite80-99-9 (CAS)
MVDGeneProduct509958 (Entrez Gene)
MVKGeneProduct505792 (Entrez Gene)
Mevalonic acid 5-pyrophosphateMetabolite1492-08-6 (CAS)
Mevalonic acid-5PMetabolite73566-35-5 (CAS)
Mevalonic acidMetabolite150-97-0 (CAS)
NSDHLGeneProduct616694 (Entrez Gene) NAD(P) dependent steroid dehydrogenase-like
PMVKGeneProduct513533 (Entrez Gene)
SC4MOLGeneProduct504481 (Entrez Gene)
SC5DLGeneProduct525154 (Entrez Gene)
SQLEGeneProduct526535 (Entrez Gene)
SqualeneMetabolite111-02-4 (CAS)
farnesyl pyrophosphateMetabolite13058-04-3 (CAS)
isopentenyl pyrophosphateMetabolite358-71-4 (CAS)

Annotated Interactions

No annotated interactions
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