EGFR1 signaling pathway (Mus musculus)

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1CYNUNUMACYPMReceptorPMNUPMPMCYCYPMMAPMMACYPhosphorylationExtracellularProteins in a complex interactionCYCYPMPMDAutophosphorylationEndoplasmic reticulumActivationPlasma membraneNUPMCYCYEnzyme complexCYPMTranslocationMAPMPMCYMACYCYCYDephosphorylationNUUbiquitinationPMMTPMGene SymbolCYPMCYPMAcetylationECNUProteolytic cleavageENCYPMMANUMAReaction through unknown mechanisms/moleculesPMCYCYDesumoylationMAMAMADeubiquitinationNucleusMethylationCYDMACYNUNUERMACYCYNUNUAccession Number : NetPath 4; cellmap:4PMCYCytoplasmNUMACYControlEndosomeENDemethylationNUGONUGlycosylationMANUDeacetylationPMCYNU(Protein-protein interaction)PMPMPalmitoylationInhibitionENMolecule in the pathwayMANUCYNUAutodephosphorylationNUDSumoylationCYMACYCYMACYCYGolgi apparatusCYMolecular associationCYMAMitochondrionMALigandMANUMARecruitmentCYPtpn6Mapk7Spry2Pld1Krt1-17Pik3r2YwhabCamk2aPtpn5Ptk6Dip3bPik3r3HdhKrt2-8Stat1Pkn2Grb10Pik3cbStat5bAp2a1Cdc42Usp6nlPik3cdPlcg2Sh3bgrlArf4SncaSrcStat3Mapk1Ddef1Tieg3Dip3bSmad2Smad3Jak1Dusp1Stxbp1Stxbp1Rbbp7Cav2Arf4FosGrb14EgfrEps8EgfrGrb7Sh2d3cMapk14EgfrEps15Sos1Sos2Krt1-18Socs1Mta2Socs3PrkcaPik3caHip1Pik3c2bStat1Sh3gl2EPPK1Map2k3TgifRalbZfp259Sh3kbp1Mapk3Gab1Nck1Smad2PrkcmPebp1MAP3K1Jund1Hras1Gab1Raf1Ctnnd1CrklPtpn11PRKCGBcar1Casp9Rps6ka3Map2k5Plscr1Jak2Arf4EgfKrt2-7Pld1Mapk1Snrpd2Ceacam1Stat3Pld2Eef1a1Rab5aGab2Stat5aVav3Eps15Dnm1Map2k7CblcRaf1Ptpn12Rasa1EgfrDusp1Reps2PrkczArafAkt1Map3k142900057D21RikErrfi1RfxankPak1Elk1JunShc1Sh2d3cMap2k1LOC382523Map3k2Elf3PrkciGit1CblPlcg1Sp1Hdac1Plcg1Reps1Shoc2WaslPik3cgPIK3R1Elf3Vav22900057D21RikFoxo1Map3k4Mapk8ItchRps6ka2PtprrSh3gl3Vav1Creb1Eef1a1Wnk1ABI1Map2k1Epn1Hat1Rps6ka3KrasNck2RalgdsGja1Map2k2Spry2Plec1Zfp259CrkMcf2Tnip1CebpaStat5aMycBcar1CblbNras2900057D21RikPlcg2Grb2Cav1EgfRps6ka1Smad3Stat2CebpbFoxo1PxnRipk1Rgs16Ptpn6CskNdufa13Ralbp1PitpnaElk4Dok2Shc1EgfStat2Prkar1aRps6ka5Rac1Tnk2Eps15l1Stat1Inppl1Sin3aSh3gl2Prkcb1PrkcaMap3k3Ptk2bATF1Map3k2Stat3


Description

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV; ''Control of MAPK signalling: from complexity to what really matters.''; Oncogene, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117874view10:19, 23 May 2021EweitzModified title
82883view12:40, 11 November 2015JmeliusCorrect outdated id
71756view20:20, 17 October 2013MaintBotAutomated update of data sources
69206view18:24, 8 July 2013MaintBotUpdated to 2013 gpml schema
67178view10:16, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
41396view00:29, 2 March 2011MaintBotRemoved redundant pathway information and comments
35717view23:28, 12 February 2010AlexanderPico
35440view11:37, 12 February 2010MichielAdded ref
34429view23:24, 9 December 2009MaintBotAutomatic update of empty xrefs
32711view22:49, 2 September 2009MaintBotReverted to version '11:32, 14 November 2008' by MaintBot
32710view22:45, 2 September 2009MaintBotadded xrefs
30821view23:58, 29 July 2009MaintBotConverted from Homo sapiens
21884view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:EGFR1 NetPath 4]] moved to [[Pathway:WP572]]: Moved to stable identifier
7998view13:46, 7 January 2008MaintBot[[Pathway:Mouse:EGFR1 NetPath 4]] moved to [[Pathway:Mus musculus:EGFR1 NetPath 4]]: Renaming species
7622view16:05, 18 December 2007MaintBotfixed category names
7216view12:33, 4 November 2007MaintBotAdded categories to GPML
6432view22:18, 22 May 2007A.Pandeygpml file for [[Mouse:EGFR1_NetPath_4]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2900057D21RikGeneProduct72993 (Entrez Gene)
ABI1GeneProduct11308 (Entrez Gene)
ATF1GeneProduct11908 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
Ap2a1GeneProduct11771 (Entrez Gene)
ArafGeneProduct11836 (Entrez Gene)
Arf4GeneProduct11843 (Entrez Gene)
Bcar1GeneProduct12927 (Entrez Gene)
Camk2aGeneProduct12322 (Entrez Gene)
Casp9GeneProduct12371 (Entrez Gene)
Cav1GeneProduct12389 (Entrez Gene)
Cav2GeneProduct12390 (Entrez Gene)
CblGeneProduct12402 (Entrez Gene)
CblbGeneProduct208650 (Entrez Gene)
CblcGeneProduct80794 (Entrez Gene)
Cdc42GeneProduct12540 (Entrez Gene)
Ceacam1GeneProduct26365 (Entrez Gene)
CebpaGeneProduct12606 (Entrez Gene)
CebpbGeneProduct12608 (Entrez Gene)
Creb1GeneProduct12912 (Entrez Gene)
CrkGeneProduct12928 (Entrez Gene)
CrklGeneProduct12929 (Entrez Gene)
CskGeneProduct12988 (Entrez Gene)
Ctnnd1GeneProduct12388 (Entrez Gene)
Ddef1GeneProduct13196 (Entrez Gene)
Dip3bGeneProduct216190 (Entrez Gene)
Dnm1GeneProduct13429 (Entrez Gene)
Dok2GeneProduct13449 (Entrez Gene)
Dusp1GeneProduct19252 (Entrez Gene)
EPPK1GeneProduct223650 (Entrez Gene)
Eef1a1GeneProduct13627 (Entrez Gene)
EgfGeneProduct13645 (Entrez Gene)
EgfrGeneProduct13649 (Entrez Gene)
Elf3GeneProduct13710 (Entrez Gene)
Elk1GeneProduct13712 (Entrez Gene)
Elk4GeneProduct13714 (Entrez Gene)
Epn1GeneProduct13854 (Entrez Gene)
Eps15GeneProduct13858 (Entrez Gene)
Eps15l1GeneProduct13859 (Entrez Gene)
Eps8GeneProduct13860 (Entrez Gene)
Errfi1GeneProduct74155 (Entrez Gene)
FosGeneProduct14281 (Entrez Gene)
Foxo1GeneProduct56458 (Entrez Gene)
Gab1GeneProduct14388 (Entrez Gene)
Gab2GeneProduct14389 (Entrez Gene)
Git1GeneProduct216963 (Entrez Gene)
Gja1GeneProduct14609 (Entrez Gene)
Grb10GeneProduct14783 (Entrez Gene)
Grb14GeneProduct50915 (Entrez Gene)
Grb2GeneProduct14784 (Entrez Gene)
Grb7GeneProduct14786 (Entrez Gene)
Hat1GeneProduct107435 (Entrez Gene)
Hdac1GeneProduct433759 (Entrez Gene)
HdhGeneProduct15194 (Entrez Gene)
Hip1GeneProduct215114 (Entrez Gene)
Hras1GeneProduct15461 (Entrez Gene)
Inppl1GeneProduct16332 (Entrez Gene)
ItchGeneProduct16396 (Entrez Gene)
Jak1GeneProduct16451 (Entrez Gene)
Jak2GeneProduct16452 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
Jund1GeneProduct16478 (Entrez Gene)
KrasGeneProduct16653 (Entrez Gene)
Krt1-17GeneProduct16667 (Entrez Gene)
Krt1-18GeneProduct16668 (Entrez Gene)
Krt2-7GeneProduct110310 (Entrez Gene)
Krt2-8GeneProduct16691 (Entrez Gene)
LOC382523GeneProduct382523 (Entrez Gene)
MAP3K1GeneProduct26401 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k2GeneProduct26396 (Entrez Gene)
Map2k3GeneProduct26397 (Entrez Gene)
Map2k5GeneProduct23938 (Entrez Gene)
Map2k7GeneProduct26400 (Entrez Gene)
Map3k14GeneProduct53859 (Entrez Gene)
Map3k2GeneProduct26405 (Entrez Gene)
Map3k3GeneProduct26406 (Entrez Gene)
Map3k4GeneProduct26407 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk14GeneProduct26416 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
Mapk7GeneProduct23939 (Entrez Gene)
Mapk8GeneProduct26419 (Entrez Gene)
Mcf2GeneProduct109904 (Entrez Gene)
Mta2GeneProduct23942 (Entrez Gene)
MycGeneProduct17869 (Entrez Gene)
Nck1GeneProduct17973 (Entrez Gene)
Nck2GeneProduct17974 (Entrez Gene)
Ndufa13GeneProduct67184 (Entrez Gene)
NrasGeneProduct18176 (Entrez Gene)
PIK3R1GeneProduct18708 (Entrez Gene)
PRKCGGeneProduct
Pak1GeneProduct18479 (Entrez Gene)
Pebp1GeneProduct23980 (Entrez Gene)
Pik3c2bGeneProduct240752 (Entrez Gene)
Pik3caGeneProduct18706 (Entrez Gene)
Pik3cbGeneProduct74769 (Entrez Gene)
Pik3cdGeneProduct18707 (Entrez Gene)
Pik3cgGeneProduct30955 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
Pik3r3GeneProduct18710 (Entrez Gene)
PitpnaGeneProduct18738 (Entrez Gene)
Pkn2GeneProduct109333 (Entrez Gene)
Plcg1GeneProduct18803 (Entrez Gene)
Plcg2GeneProduct234779 (Entrez Gene)
Pld1GeneProduct18805 (Entrez Gene)
Pld2GeneProduct18806 (Entrez Gene)
Plec1GeneProduct18810 (Entrez Gene)
Plscr1GeneProduct22038 (Entrez Gene)
Prkar1aGeneProduct19084 (Entrez Gene)
PrkcaGeneProduct18750 (Entrez Gene)
Prkcb1GeneProduct18751 (Entrez Gene)
PrkciGeneProduct18759 (Entrez Gene)
PrkcmGeneProduct18760 (Entrez Gene)
PrkczGeneProduct18762 (Entrez Gene)
Ptk2bGeneProduct19229 (Entrez Gene)
Ptk6GeneProduct20459 (Entrez Gene)
Ptpn11GeneProduct19247 (Entrez Gene)
Ptpn12GeneProduct19248 (Entrez Gene)
Ptpn5GeneProduct19259 (Entrez Gene)
Ptpn6GeneProduct15170 (Entrez Gene)
PtprrGeneProduct19279 (Entrez Gene)
PxnGeneProduct19303 (Entrez Gene)
Rab5aGeneProduct271457 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
Raf1GeneProduct110157 (Entrez Gene)
RalbGeneProduct64143 (Entrez Gene)
Ralbp1GeneProduct19765 (Entrez Gene)
RalgdsGeneProduct19730 (Entrez Gene)
Rasa1GeneProduct218397 (Entrez Gene)
Rbbp7GeneProduct245688 (Entrez Gene)
Reps1GeneProduct19707 (Entrez Gene)
Reps2GeneProduct194590 (Entrez Gene)
RfxankGeneProduct19727 (Entrez Gene)
Rgs16GeneProduct19734 (Entrez Gene)
Ripk1GeneProduct19766 (Entrez Gene)
Rps6ka1GeneProduct20111 (Entrez Gene)
Rps6ka2GeneProduct20112 (Entrez Gene)
Rps6ka3GeneProduct110651 (Entrez Gene)
Rps6ka5GeneProduct73086 (Entrez Gene)
Sh2d3cGeneProduct27387 (Entrez Gene)
Sh3bgrlGeneProduct56726 (Entrez Gene)
Sh3gl2GeneProduct20404 (Entrez Gene)
Sh3gl3GeneProduct20408 (Entrez Gene)
Sh3kbp1GeneProduct58194 (Entrez Gene)
Shc1GeneProduct20416 (Entrez Gene)
Shoc2GeneProduct56392 (Entrez Gene)
Sin3aGeneProduct20466 (Entrez Gene)
Smad2GeneProduct17126 (Entrez Gene)
Smad3GeneProduct17127 (Entrez Gene)
SncaGeneProduct20617 (Entrez Gene)
Snrpd2GeneProduct107686 (Entrez Gene)
Socs1GeneProduct12703 (Entrez Gene)
Socs3GeneProduct12702 (Entrez Gene)
Sos1GeneProduct20662 (Entrez Gene)
Sos2GeneProduct20663 (Entrez Gene)
Sp1GeneProduct20683 (Entrez Gene)
Spry2GeneProduct24064 (Entrez Gene)
SrcGeneProduct20779 (Entrez Gene)
Stat1GeneProduct20846 (Entrez Gene)
Stat2GeneProduct20847 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)
Stat5aGeneProduct20850 (Entrez Gene)
Stat5bGeneProduct20851 (Entrez Gene)
Stxbp1GeneProduct20910 (Entrez Gene)
TgifGeneProduct21815 (Entrez Gene)
Tieg3GeneProduct194655 (Entrez Gene)
Tnip1GeneProduct57783 (Entrez Gene)
Tnk2GeneProduct51789 (Entrez Gene)
Usp6nlGeneProduct98910 (Entrez Gene)
Vav1GeneProduct22324 (Entrez Gene)
Vav2GeneProduct22325 (Entrez Gene)
Vav3GeneProduct57257 (Entrez Gene)
WaslGeneProduct73178 (Entrez Gene)
Wnk1GeneProduct232341 (Entrez Gene)
YwhabGeneProduct54401 (Entrez Gene)
Zfp259GeneProduct22687 (Entrez Gene)

Annotated Interactions

No annotated interactions
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