Hypothetical network for drug addiction (Rattus norvegicus)

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1GnRH Signal pathwayStrong depolarizationNMDARLocal TranslationGonadotropins gene expression & secretionGap junctionRegulation of gap junctionLong-term potentiationMAPK signaling pathwaymGluRAMPARNeuroactive ligand-receptorinteractionRegulation of actin cytoskeletonGria2NischAdcy1Drd4GRIA1Ppa1Grm5Gria4connexinCamk4Adcy8PrkacaActa1Terf2ipCa++PrkacaGrin2dGria3PrkceDrd1aGrm1Map2k2Creb1Zhx2Map2k1Cyclic AMPDrd2Krit1Grin1GsMapk1connexinGrin2aGrin2bAdcy1GiCamk2bGrin2cMapk3D-Glutamate


Description

Adapted from figure 2 in Li et al..

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP666(r29740) with a 86% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Li CY, Mao X, Wei L; ''Genes and (common) pathways underlying drug addiction.''; PLoS Comput Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116979view10:43, 16 May 2021EweitzModified title
107230view14:32, 17 September 2019MaintBotChEBI identifier normalization
102278view08:36, 17 December 2018EgonwReplaced the ChEBI idea of Ca(0) with that of Ca2++
69367view18:54, 8 July 2013MaintBotUpdated to 2013 gpml schema
67353view10:41, 26 June 2013Christine ChichesterOntology Term : 'substance dependence disease pathway' added !
41681view02:36, 2 March 2011MaintBotRemoved redundant pathway information and comments
34071view19:10, 9 December 2009MaintBotAutomatic update of empty xrefs
32302view13:17, 15 August 2009MaintBotFixed text labels
31881view12:41, 14 August 2009MaintBotFixed group labels
31331view20:22, 13 August 2009MaintBotFixed text labels
30937view00:39, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Acta1GeneProduct29437 (Entrez Gene)
Adcy1GeneProduct305509 (Entrez Gene)
Adcy8GeneProduct29241 (Entrez Gene)
Ca++Metabolite29320 (ChEBI)
Camk2bGeneProduct24245 (Entrez Gene)
Camk4GeneProduct25050 (Entrez Gene)
Creb1GeneProduct81646 (Entrez Gene)
Cyclic AMPMetabolite17489 (ChEBI)
D-GlutamateMetabolite15966 (ChEBI)
Drd1aGeneProduct24316 (Entrez Gene)
Drd2GeneProduct24318 (Entrez Gene)
Drd4GeneProduct25432 (Entrez Gene)
GRIA1GeneProduct50592 (Entrez Gene)
GiGeneProduct
Gria2GeneProduct29627 (Entrez Gene)
Gria3GeneProduct29628 (Entrez Gene)
Gria4GeneProduct29629 (Entrez Gene)
Grin1GeneProduct24408 (Entrez Gene)
Grin2aGeneProduct24409 (Entrez Gene)
Grin2bGeneProduct24410 (Entrez Gene)
Grin2cGeneProduct24411 (Entrez Gene)
Grin2dGeneProduct24412 (Entrez Gene)
Grm1GeneProduct24414 (Entrez Gene)
Grm5GeneProduct24418 (Entrez Gene)
GsGeneProduct
Krit1GeneProduct362317 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene)
Map2k2GeneProduct58960 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk3GeneProduct50689 (Entrez Gene)
NischGeneProduct306255 (Entrez Gene)
Ppa1GeneProduct294504 (Entrez Gene)
PrkacaGeneProduct25636 (Entrez Gene)
PrkceGeneProduct29340 (Entrez Gene)
Terf2ipGeneProduct307861 (Entrez Gene)
Zhx2GeneProduct314988 (Entrez Gene)
connexinGeneProduct

Annotated Interactions

No annotated interactions
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