Integrin-mediated cell adhesion (Bos taurus)

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1signaling systemPAKcell maintenanceRAFcell maintenanceF-actinPAKC3GMEKCAPNIntegrin betaITGACAPNcell motilityERKECMIntegrin alphaPI3Kp130 Cascell proliferationPhosphatidylinositiolITGBF-actinMAP2K1ITGADSRCITGA9SORBS1AKT2LOC100140050CAPN10RHOMYOPAK4CAPN2MAPK7ITGB5CAPN6CDC42ROCK1VAV2CAPN9LOC100138102PXNPTK2ITGA11BCAR1RAF1CSKITGALACTNMYO-PCAV1ITGAXCRKMAPK4PIK3R2CAPN1RAC2ILKMAP2K5TLN1CAV3CAPN5ITGB8VAV3LOC100137872RAPGEF1CAPN11ITGA2BZYXMAP2K2ITGAVROCK2CAPN7PAK2MAPK1ITGA5CAV2ITGB2BRAFMAP2K3ITGA3ARHGEF7GIT2SHC1ITGAMPTK2MAP2K6ITGA7ITGB6VASPSEPP1CAPN3HRASMAPK6CAPNS1RAP1AITGA4ITGA6RAP1BRAC1ITGA10ARAFPAK6GRB2PAK1SHC3ITGA8DOCK1ITGB1ITGB7FYNp110MAPK10MYLK2ITGA1SRCITGA2AKT1PAK3VCLRAC3SOS1ITGB4MAPK12PI5KTNS1ITGB3


Description

Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP185(r21067) with a 83% conversion rate.

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Ontology Terms

 

Bibliography

  1. Hermeking H; ''The miR-34 family in cancer and apoptosis.''; Cell Death Differ, 2010 PubMed Europe PMC Scholia
  2. Sepulveda JL, Gkretsi V, Wu C; ''Assembly and signaling of adhesion complexes.''; Curr Top Dev Biol, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117549view11:17, 21 May 2021EweitzModified title
80667view15:21, 30 June 2015Mkutmonhomology conversion
71411view19:01, 17 October 2013MaintBotAutomated update of data sources
67399view10:56, 26 June 2013DdiglesOntology Term : 'integrin mediated signaling pathway' added !
63354view22:22, 9 May 2013MaintBotUpdated to 2013 gpml schema
62704view23:17, 1 May 2013MaintBotUpdated UniProt data source
40528view19:30, 1 March 2011MaintBotRemoved redundant pathway information and comments
35601view15:45, 12 February 2010ThomasModified description
35594view15:42, 12 February 2010Thomasadded literature
33770view00:06, 9 December 2009MaintBotAutomatic update of empty xrefs
31701view11:50, 14 August 2009MaintBotFixed group labels
30638view22:28, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACTNGeneProduct
AKT1GeneProduct280991 (Entrez Gene) AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
AKT2GeneProduct534923 (Entrez Gene) AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
ARAFGeneProduct540421 (Entrez Gene) ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
ARHGEF7GeneProduct524352 (Entrez Gene) ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
BCAR1GeneProduct527550 (Entrez Gene) BCAR1; breast cancer anti-estrogen resistance 1
BRAFGeneProduct536051 (Entrez Gene) BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
CAPN10GeneProduct789674 (Entrez Gene) CAPN10; calpain 10 [EC:3.4.22.17
CAPN11GeneProduct527966 (Entrez Gene) CAPN11; calpain 11 [EC:3.4.22.17]
CAPN1GeneProduct281661 (Entrez Gene) CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17]
CAPN2GeneProduct281662 (Entrez Gene) CAPN2; calpain 2 (m/II) large subunit [EC:3.4.22.17]
CAPN3GeneProduct281663 (Entrez Gene) CAPN3; calpain 3 (p94) [EC:3.4.22.17]
CAPN5GeneProduct536988 (Entrez Gene) CAPN5; calpain
CAPN6GeneProduct539360 (Entrez Gene) CAPN6; calpain 6 [EC:3.4.22.17]
CAPN7GeneProduct618048 (Entrez Gene) CAPN7; calpain 7 [EC:3.4.22.17
CAPN9GeneProductCAPN9; calpain 9 (nCL-4) [EC:3.4.22.17
CAPNS1GeneProduct281664 (Entrez Gene) CAPNS1; calpain small subunit 1 [EC:3.4.22.17]
CAV1GeneProduct281040 (Entrez Gene) CAV1; caveolin 1 caveolae protein 22kD
CAV2GeneProduct493642 (Entrez Gene) CAV2; caveolin 2
CAV3GeneProduct615310 (Entrez Gene) CAV3; caveolin 3
CDC42GeneProduct532712 (Entrez Gene) CDC42; cell division cycle 42 (GTP binding protein 25kD)
CRKGeneProduct512841 (Entrez Gene) CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
CSKGeneProduct509246 (Entrez Gene) CSK; c-src tyrosine kinase [EC:2.7.1.112]
DOCK1GeneProduct537203 (Entrez Gene) DOCK1; dedicator of cyto-kinesis
FYNGeneProduct527263 (Entrez Gene) FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
GIT2GeneProduct516048 (Entrez Gene) GIT2; G protein-coupled receptor kinase-interactor 2
GRB2GeneProduct535298 (Entrez Gene) GRB2; growth factor receptor-bound protein 2
HRASGeneProduct513012 (Entrez Gene)
ILKGeneProduct540207 (Entrez Gene) ILK; integrin-linked kinase [EC:2.7.1.-]
ITGA10GeneProduct506526 (Entrez Gene)
ITGA11GeneProduct523755 (Entrez Gene)
ITGA1GeneProduct535951 (Entrez Gene)
ITGA2GeneProduct281872 (Entrez Gene)
ITGA2BGeneProduct515011 (Entrez Gene)
ITGA3GeneProduct508490 (Entrez Gene)
ITGA4GeneProduct282882 (Entrez Gene)
ITGA5GeneProduct281873 (Entrez Gene)
ITGA6GeneProduct535043 (Entrez Gene)
ITGA7GeneProduct506953 (Entrez Gene)
ITGA8GeneProduct
ITGA9GeneProduct532127 (Entrez Gene)
ITGADGeneProduct514056 (Entrez Gene)
ITGALGeneProduct281874 (Entrez Gene)
ITGAMGeneProduct407124 (Entrez Gene)
ITGAVGeneProduct281875 (Entrez Gene)
ITGAXGeneProduct
ITGB1GeneProduct281876 (Entrez Gene)
ITGB2GeneProduct281877 (Entrez Gene)
ITGB3GeneProduct282642 (Entrez Gene)
ITGB4GeneProduct506995 (Entrez Gene)
ITGB5GeneProduct282564 (Entrez Gene)
ITGB6GeneProduct282644 (Entrez Gene)
ITGB7GeneProduct514031 (Entrez Gene)
ITGB8GeneProduct536286 (Entrez Gene)
LOC100137872GeneProduct100137872 (Entrez Gene) AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
LOC100138102GeneProduct100138102 (Entrez Gene) PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37]
LOC100140050GeneProduct100140050 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene) MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
MAP2K2GeneProduct510434 (Entrez Gene) MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
MAP2K3GeneProduct516039 (Entrez Gene) MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
MAP2K5GeneProductMAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
MAP2K6GeneProduct286883 (Entrez Gene) MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
MAPK10GeneProduct537631 (Entrez Gene)
MAPK12GeneProduct512943 (Entrez Gene) MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
MAPK1GeneProduct327672 (Entrez Gene) MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
MAPK4GeneProduct529183 (Entrez Gene) MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
MAPK6GeneProduct538094 (Entrez Gene) MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
MAPK7GeneProduct537703 (Entrez Gene) MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
MYLK2GeneProduct533378 (Entrez Gene) MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117
MYO-PGeneProduct
MYOGeneProduct
PAK1GeneProduct533729 (Entrez Gene) PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
PAK2GeneProductPAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
PAK3GeneProduct534526 (Entrez Gene) PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
PAK4GeneProduct539742 (Entrez Gene) PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
PAK6GeneProduct539224 (Entrez Gene) PAK6; p21(CDKN1A)-activated kinase
PI5KGeneProduct
PIK3R2GeneProduct282308 (Entrez Gene) PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
PTK2GeneProduct506270 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
PXNGeneProduct517456 (Entrez Gene) PXN; paxillin
RAC1GeneProduct281440 (Entrez Gene) RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
RAC2GeneProduct327671 (Entrez Gene) RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
RAC3GeneProduct619066 (Entrez Gene) RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
RAF1GeneProduct521196 (Entrez Gene) RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
RAP1AGeneProduct282031 (Entrez Gene) RAP1A; RAP1A member of RAS oncogene family
RAP1BGeneProduct327708 (Entrez Gene) RAP1B; RAP1B member of RAS oncogene family
RAPGEF1GeneProduct520454 (Entrez Gene) GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
RHOGeneProduct509933 (Entrez Gene) RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
ROCK1GeneProduct785911 (Entrez Gene) ROCK1; Rho-associated coiled-coil containing protein kinase
ROCK2GeneProduct282041 (Entrez Gene) ROCK2; Rho-associated coiled-coil containing protein kinase
SEPP1GeneProduct282066 (Entrez Gene) SEPP1; selenoprotein P plasma
SHC1GeneProduct507196 (Entrez Gene) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SHC3GeneProduct512696 (Entrez Gene) SHC3; neuronal Sh
SORBS1GeneProduct504625 (Entrez Gene) SH3D5; SH3-domain protein 5 (ponsin
SOS1GeneProduct537682 (Entrez Gene) SOS1; son of sevenless homolog 1 (Drosophila)
SRCGeneProduct535742 (Entrez Gene) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
TLN1GeneProduct783470 (Entrez Gene) TLN1; talin 1
TNS1GeneProduct286798 (Entrez Gene) TNS; tensi
VASPGeneProduct514902 (Entrez Gene) VASP; vasodilator-stimulated phosphoprotein
VAV2GeneProductVAV2; vav 2 oncogene
VAV3GeneProduct521961 (Entrez Gene) VAV3; vav 3 oncogene
VCLGeneProduct783645 (Entrez Gene) VCL; vinculin
ZYXGeneProduct768226 (Entrez Gene) ZYX; zyxin
p110GeneProduct

Annotated Interactions

No annotated interactions
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