Non-homologous end joining (Mus musculus)

From WikiPathways

Revision as of 20:53, 21 February 2013 by MaintBot (Talk | contribs)
Jump to: navigation, search
Xrcc5PrkdcXrcc6Xrcc5Xrcc5Ligase VXrcc6Xrcc6Xrcc6Rad50Xrcc4Xrcc6Xrcc5Xrcc6Nbs1 ?Xrcc6PrkdcXrcc4Xrcc5PrkdcXrcc6Xrcc5Nhej1PrkdcXrcc6PrkdcXrcc6Xrcc5Ligase VXrcc5PrkdcXrcc5Mre11aPrkdcXrcc5PrkdcNhej1


Description

(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP438(r29612) with a 91% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
69140view18:16, 8 July 2013MaintBotUpdated to 2013 gpml schema
67513view11:19, 26 June 2013DdiglesOntology Term : 'non-homologous end joining pathway of double-strand break repair' added !
59048view20:53, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41329view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35403view09:55, 12 February 2010MartijnVanIerselModified description
31847view12:31, 14 August 2009MaintBotFixed group labels
30822view23:58, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Ligase VGeneProduct
Mre11aGeneProductENSMUSG00000031928 (Ensembl)
Nbs1 ?GeneProduct
Nhej1GeneProduct75570 (Entrez Gene)
Nhej1GeneProductENSMUSG00000026162 (Ensembl)
PrkdcGeneProductENSMUSG00000022672 (Ensembl)
Rad50GeneProductENSMUSG00000020380 (Ensembl)
Xrcc4GeneProductENSMUSG00000021615 (Ensembl)
Xrcc5GeneProductENSMUSG00000026187 (Ensembl)
Xrcc6GeneProductENSMUSG00000022471 (Ensembl)

Annotated Interactions

No annotated interactions
Personal tools