Statin pathway (Bos taurus)

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1Liver cellCell MembraneLegendRepressesActivatesPlasmaTissuesHDLAcetyl-CoATriglycerideVLDLAPOEPhospholipidABCA1LIPCHMGCRSCARB1LRP1LDLRStatinCholesterolCholesterol esterAPOA1CETPAPOA4Fatty acidIDLDGAT1APOC1LOC510507Cholic AcidCholesterolApoC3PLTPSOAT1LPLTRNPAPOC2LDLLCAT


Description

What are statins? See Wikipedia at: http://en.wikipedia.org/wiki/Statin More about this pathway and statins: https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP430(r29996) with a 69% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Chen H, Ikeda U, Shimpo M, Shimada K; ''Direct effects of statins on cells primarily involved in atherosclerosis.''; Hypertens Res, 2000 PubMed Europe PMC Scholia
  2. Wetterau JR, Lin MC, Jamil H; ''Microsomal triglyceride transfer protein.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129529view01:24, 9 May 2024EweitzOntology Term : '' added !
117611view11:39, 21 May 2021EweitzModified title
106004view11:53, 16 August 2019MaintBotHMDB identifier normalization
103263view07:46, 20 February 2019EgonwMore specific ChEBI identifier.
82697view18:42, 22 October 2015EgonwMore specific ChEBI identifiers.
80853view15:28, 30 June 2015Mkutmonhomology conversion
71420view19:02, 17 October 2013MaintBotAutomated update of data sources
67658view11:45, 26 June 2013DdiglesOntology Term : 'statin drug pathway' added !
63383view23:07, 9 May 2013MaintBotUpdated to 2013 gpml schema
40555view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
38712view19:31, 23 September 2010AlexanderPico
35546view14:20, 12 February 2010Thomasadded literature, cosmetic change
33794view00:14, 9 December 2009MaintBotAutomatic update of empty xrefs
31678view11:43, 14 August 2009MaintBotFixed group labels
30610view22:18, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCA1GeneProduct535379 (Entrez Gene)
APOA1GeneProduct281631 (Entrez Gene)
APOA4GeneProduct537301 (Entrez Gene)
APOC1GeneProduct281633 (Entrez Gene)
APOC2GeneProduct618039 (Entrez Gene)
APOEGeneProduct281004 (Entrez Gene)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
ApoC3GeneProduct408009 (Entrez Gene)
CETPGeneProduct
Cholesterol esterMetaboliteC02530 (Kegg Compound)
CholesterolMetabolite
Cholic AcidMetabolite
DGAT1GeneProduct282609 (Entrez Gene)
Fatty acidMetaboliteC00162 (Kegg Compound)
HDLMetaboliteC01834 (Kegg Compound)
HMGCRGeneProduct407159 (Entrez Gene)
IDLMetaboliteC01834 (Kegg Compound)
LCATGeneProduct510960 (Entrez Gene)
LDLMetaboliteC01834 (Kegg Compound)
LDLRGeneProduct281276 (Entrez Gene)
LIPCGeneProduct535192 (Entrez Gene)
LOC510507GeneProduct510507 (Entrez Gene)
LPLGeneProduct280843 (Entrez Gene)
LRP1GeneProduct
PLTPGeneProduct505640 (Entrez Gene)
PhospholipidMetaboliteC00865 (Kegg Compound)
SCARB1GeneProduct282346 (Entrez Gene)
SOAT1GeneProduct504287 (Entrez Gene)
StatinMetabolite
TRNPGeneProduct
TriglycerideMetaboliteC00422 (Kegg Compound)
VLDLMetaboliteC01834 (Kegg Compound)

Annotated Interactions

No annotated interactions
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