Programmed cell death (Caenorhabditis elegans)

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34, 11PCD Signal: germlinedevelopmentPCD Signal:Somatic development9-1-1 complexPCD Signal:DNA damageProgrammedCell Deathegl-1ced-3ape-1hpr-9mrt-2ced-9clk-2cep-1pax-2abl-1egl-38ced-4ced-13hus-1gld-3gld-1akt-1fsn-165892127, 101


Description

Programmed Cell Death pathway. Based on conference notes, european worm meeting 2004

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Gartner A, Boag PR, Blackwell TK; ''Germline survival and apoptosis.''; WormBook, 2008 PubMed Europe PMC Scholia
  2. Gartner A, Milstein S, Ahmed S, Hodgkin J, Hengartner MO; ''A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans.''; Mol Cell, 2000 PubMed Europe PMC Scholia
  3. Hofmann ER, Milstein S, Boulton SJ, Ye M, Hofmann JJ, Stergiou L, Gartner A, Vidal M, Hengartner MO; ''Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis.''; Curr Biol, 2002 PubMed Europe PMC Scholia
  4. Derry WB, Putzke AP, Rothman JH; ''Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance.''; Science, 2001 PubMed Europe PMC Scholia
  5. Schumacher B, Hofmann K, Boulton S, Gartner A; ''The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis.''; Curr Biol, 2001 PubMed Europe PMC Scholia
  6. Schumacher B, Schertel C, Wittenburg N, Tuck S, Mitani S, Gartner A, Conradt B, Shaham S; ''C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage.''; Cell Death Differ, 2005 PubMed Europe PMC Scholia
  7. Schumacher B, Hanazawa M, Lee MH, Nayak S, Volkmann K, Hofmann ER, Hengartner M, Schedl T, Gartner A; ''Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis.''; Cell, 2005 PubMed Europe PMC Scholia
  8. Ahmed S, Alpi A, Hengartner MO, Gartner A; ''C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein.''; Curr Biol, 2001 PubMed Europe PMC Scholia
  9. Quevedo C, Kaplan DR, Derry WB; ''AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans.''; Curr Biol, 2007 PubMed Europe PMC Scholia
  10. Deng X, Hofmann ER, Villanueva A, Hobert O, Capodieci P, Veach DR, Yin X, Campodonico L, Glekas A, Cordon-Cardo C, Clarkson B, Bornmann WG, Fuks Z, Hengartner MO, Kolesnick R; ''Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation.''; Nat Genet, 2004 PubMed Europe PMC Scholia
  11. Gao MX, Liao EH, Yu B, Wang Y, Zhen M, Derry WB; ''The SCF FSN-1 ubiquitin ligase controls germline apoptosis through CEP-1/p53 in C. elegans.''; Cell Death Differ, 2008 PubMed Europe PMC Scholia
  12. Bergamaschi D, Samuels Y, O'Neil NJ, Trigiante G, Crook T, Hsieh JK, O'Connor DJ, Zhong S, Campargue I, Tomlinson ML, Kuwabara PE, Lu X; ''iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.''; Nat Genet, 2003 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135390view12:14, 3 September 2024EgonwConverted to use Ensembl identifiers
118158view10:41, 25 May 2021EweitzModified title
68478view20:43, 5 July 2013MaintBotUpdated to 2013 gpml schema
67605view11:32, 26 June 2013DdiglesOntology Term : 'apoptotic cell death pathway' added !
40631view19:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
32410view17:05, 15 August 2009MaintBotFixed text labels
32066view13:35, 14 August 2009MaintBotFixed group labels
29816view22:47, 2 June 2009Khansperschanges gene symbols to IDs
21447view11:31, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:Programmed Cell Death]] moved to [[Pathway:WP367]]: Moved to stable identifier
19607view11:43, 9 October 2008MartijnVanIerselConnected lines to boxes
19605view11:41, 9 October 2008MartijnVanIerselpax genes, influence cell death in germline according to wormbook
19603view11:39, 9 October 2008MartijnVanIerselPeriodical save, work in progress
19140view10:59, 19 September 2008MartijnVanIerselModified categories
17683view05:07, 26 July 2008MartijnVanIerseladded a few missing wormbase links
17680view20:28, 25 July 2008WBDerryPeriodical save, work in progress
17678view20:18, 25 July 2008WBDerryPeriodical save, work in progress
17676view20:07, 25 July 2008WBDerryPeriodical save, work in progress
17674view19:57, 25 July 2008WBDerryPeriodical save, work in progress
17423view16:24, 22 July 2008WBDerryadded new genes
16666view20:46, 25 June 2008MartijnVanIerselModified description
16663view20:42, 25 June 2008MartijnVanIerselNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
abl-1GeneProductM79.1 (WormBase)
akt-1GeneProductC12D8.10 (WormBase)
ape-1GeneProductF46F3.4 (WormBase)
ced-13GeneProductR09F10.9 (WormBase)
ced-3GeneProductC48D1.2 (WormBase)
ced-4GeneProductC35D10.9 (WormBase)
ced-9GeneProductT07C4.8 (WormBase)
cep-1GeneProductF52B5.5 (WormBase)
clk-2GeneProductC07H6.6 (WormBase)
egl-1GeneProductF23B12.9 (WormBase)
egl-38GeneProductC04G2.7 (WormBase)
fsn-1GeneProductC26E6.5 (WormBase)
gld-1GeneProductT23G11.3 (WormBase)
gld-3GeneProductT07F8.3 (WormBase)
hpr-9GeneProductY39A1A.23 (WormBase)
hus-1GeneProductH26D21.1 (WormBase)
mrt-2GeneProductY41C4A.14 (WormBase)
pax-2GeneProductK06B9.5 (WormBase)

Annotated Interactions

No annotated interactions

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