Wnt signaling pathway (Canis familiaris)

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MTDEndoplasmic reticulumPM->CYActivationNU(Protein-protein interaction)PMComplex formationEnzyme ComplexProteolytic cleavageMolecular AssociationDeacetylationUbiquitinationAcetylationDephosphorylationPlasma membraneCY->NUCY->PMEndosomeCY->NUCY->PMReceptorCY->PMENInhibitionGolgi apparatusDDProteins in a complex interactionCY->PMRecruitmentDeubiquitinationDPalmitoylationNU->CYECTranslocationGlycosylationDemethylationDLigandControlDNucleusCY->NUCYMethylationPhosphorylationGOGene SymbolCY->NUSumoylationMitochondrionAutophosphorylationReaction through unknowm mechanisms/moleculesAccession Number: NetPath_8; cellmap:8DExtracellularERMolecule in the pathwayDCY->NUDesumoylationCytoplasmDCTNNB1FRAT1RUNX2CTNNBIP1LRP6FRAT2AKT1TCF3CSNK2A1CSNK2A1WNT7ACDH1BRD7AKT1ARRB2SFRP2LRP1APCSFRP1MARK2MAP3K7MAPK8MAPK8IP1WNT1WNT3PIN1WNT1RHOATFAP2AAXIN1FZD4APCPAX2LOC482772CAMK2DCDC25CDLG2PRKCACRYBB2TCF4JUNCSNK1ERUVBL1CCND1FZD6RAC1FHL2ARRB2FZD1MAPK1MYBFZD9CUL1LEF1SENP2FZD1DAAM1NR5A1CAMK2GDVL1CTBP1SOX9MAGI3PRKCBFZD1GSK3BWNT1SALL1BTRCDAB2TBPNLKSUMO2WNT5ACSNK1A1SKP1LRP6PRKCGLEF1CAMK2BAPCPPP2CACSNK2A2WNT3AFZD1BTRCLRP5WNT2CAMK2ACDC2WNT1SMAD3APCFZD2CSNK2A2EP300ARRB1APCTAX1BP3MAP1BDVL1GSK3BDVL2FZD7CDC2CSNK2BCTNNB1FZD4PIAS4CXXC4WNT4CSNK1DAXIN1VANGL2DVL2AXIN1SOX1RAF1WNT4NKD1CTBP2UBL1DLG1WNT1SMAD4MAPK3DVL1MAPK9DKK1FZD5JUPWNT3AFZD8WNT2MAP3K7CTNNB1DVL3BCL9AXIN2ANKRD6DLG4ROR2


Description

Wnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Binding of Wnt to its receptors leads to activation of at least 3 distinct pathways: i) the canonical beta catenin pathway, ii) the planar cell polarity pathway, and, iii) the calcium pathway. In the canonical beta catenin pathway, binding of Wnt to its receptors leads to stabilization of beta catenin in the cytosol followed by its translocation into the nucleus where it activates the transcription factor Tcf/Lef leading to upregulation of target genes. The non canonical planar cell polarity pathway involves activation of Dishevelled, small G proteins (Rho/Rac) and JNK. The non canonical calcium pathway involves activation of calcium sensitive kinases, PKC and CAMKII by Dishevelled. The Wnt signaling pathway is similar to the Hedgehog pathway in many respects. Abnormalities in the Wnt signaling pathway are associated with a large variety of human malignancies including tumors of breast, colon, pancreas, liver and bone.

Source: NethPath

Additional comments:

This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP363(r28127) with a 88% conversion rate.

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Ontology Terms

 

Bibliography

  1. Nusse R; ''Wnt signaling in disease and in development.''; Cell Res, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118616view08:53, 31 May 2021FinterlyPrevious edit, Changed "Entrez" to "Entrez Gene" for TCF-1/LEF and LDLR
118615view08:51, 31 May 2021FinterlyChanged
117464view10:56, 21 May 2021EweitzModified title
79839view08:06, 18 April 2015EgonwAdded two missing gene identifiers.
79430view23:44, 21 March 2015Khanspersupdate schema
79429view23:44, 21 March 2015KhanspersReverted to version '11:58, 26 June 2013' by Khanspers
68563view22:48, 5 July 2013MaintBotUpdated to 2013 gpml schema
67748view11:58, 26 June 2013DdiglesOntology Term : 'Wnt signaling pathway' added !
40721view21:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
35129view13:40, 11 February 2010Thomasconnected line
35121view13:25, 11 February 2010Thomasadded literature
35111view13:17, 11 February 2010ThomasModified description
34000view18:38, 9 December 2009MaintBotAutomatic update of empty xrefs
32565view13:10, 17 August 2009MaintBotFixed text labels
32244view12:53, 15 August 2009MaintBotFixed text labels
31756view12:04, 14 August 2009MaintBotFixed group labels
31263view19:56, 13 August 2009MaintBotFixed text labels
30704view22:50, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct490878 (Entrez Gene)
ANKRD6GeneProduct481919 (Entrez Gene)
APCGeneProduct479139 (Entrez Gene)
ARRB1GeneProduct485189 (Entrez Gene)
ARRB2GeneProduct607262 (Entrez Gene)
AXIN1GeneProduct490099 (Entrez Gene)
AXIN2GeneProduct490903 (Entrez Gene)
BCL9GeneProduct483154 (Entrez Gene)
BRD7GeneProduct478130 (Entrez Gene)
BTRCGeneProduct486851 (Entrez Gene)
CAMK2AGeneProduct612941 (Entrez Gene)
CAMK2BGeneProduct
CAMK2DGeneProduct610764 (Entrez Gene)
CAMK2GGeneProduct489050 (Entrez Gene)
CCND1GeneProduct449028 (Entrez Gene)
CDC2GeneProduct488997 (Entrez Gene)
CDC25CGeneProduct610456 (Entrez Gene)
CDH1GeneProduct442858 (Entrez Gene)
CRYBB2GeneProduct486326 (Entrez Gene)
CSNK1A1GeneProduct479331 (Entrez Gene)
CSNK1DGeneProduct475928 (Entrez Gene)
CSNK1EGeneProduct474510 (Entrez Gene)
CSNK2A1GeneProduct477185 (Entrez Gene)
CSNK2A2GeneProduct478108 (Entrez Gene)
CSNK2BGeneProduct474844 (Entrez Gene)
CTBP1GeneProduct612240 (Entrez Gene)
CTBP2GeneProduct
CTNNB1GeneProduct477032 (Entrez Gene)
CTNNBIP1GeneProduct608589 (Entrez Gene)
CUL1GeneProduct475512 (Entrez Gene)
CXXC4GeneProduct610189 (Entrez Gene)
DAAM1GeneProduct490714 (Entrez Gene)
DAB2GeneProduct479353 (Entrez Gene)
DKK1GeneProduct609600 (Entrez Gene)
DLG1GeneProduct488036 (Entrez Gene)
DLG2GeneProduct485158 (Entrez Gene)
DLG4GeneProduct489462 (Entrez Gene)
DVL1GeneProduct489593 (Entrez Gene)
DVL2GeneProduct489464 (Entrez Gene)
DVL3GeneProduct478650 (Entrez Gene)
EP300GeneProduct
FHL2GeneProduct474544 (Entrez Gene)
FRAT1GeneProduct
FRAT2GeneProduct
FZD1GeneProduct482294 (Entrez Gene)
FZD2GeneProduct490937 (Entrez Gene)
FZD4GeneProduct485149 (Entrez Gene)
FZD5GeneProduct488493 (Entrez Gene)
FZD6GeneProduct403610 (Entrez Gene)
FZD7GeneProduct488478 (Entrez Gene)
FZD8GeneProduct
FZD9GeneProduct489809 (Entrez Gene)
GSK3BGeneProduct478575 (Entrez Gene)
JUNGeneProduct609429 (Entrez Gene)
JUPGeneProduct480522 (Entrez Gene)
LEF1GeneProduct478507 (Entrez Gene)
LOC482772GeneProduct482772 (Entrez Gene)
LRP1GeneProduct481124 (Entrez Gene)
LRP5GeneProduct100306933 (Entrez Gene)
LRP6GeneProduct477692 (Entrez Gene)
MAGI3GeneProduct483214 (Entrez Gene)
MAP1BGeneProduct478092 (Entrez Gene)
MAP3K7GeneProduct474996 (Entrez Gene)
MAPK1GeneProduct477575 (Entrez Gene)
MAPK3GeneProduct486758 (Entrez Gene)
MAPK8GeneProduct477746 (Entrez Gene)
MAPK8IP1GeneProduct483640 (Entrez Gene)
MAPK9GeneProduct474652 (Entrez Gene)
MARK2GeneProduct483769 (Entrez Gene)
MYBGeneProduct483995 (Entrez Gene)
NKD1GeneProduct487288 (Entrez Gene)
NLKGeneProduct491160 (Entrez Gene)
NR5A1GeneProduct609642 (Entrez Gene)
PAX2GeneProduct609228 (Entrez Gene)
PIAS4GeneProduct485049 (Entrez Gene)
PIN1GeneProduct484963 (Entrez Gene)
PPP2CAGeneProduct403608 (Entrez Gene)
PRKCAGeneProduct490904 (Entrez Gene)
PRKCBGeneProduct489968 (Entrez Gene)
PRKCGGeneProduct484316 (Entrez Gene)
RAC1GeneProduct403955 (Entrez Gene)
RAF1GeneProduct484648 (Entrez Gene)
RHOAGeneProduct403954 (Entrez Gene)
ROR2GeneProduct484193 (Entrez Gene)
RUNX2GeneProduct449531 (Entrez Gene)
RUVBL1GeneProduct476512 (Entrez Gene)
SALL1GeneProduct487284 (Entrez Gene)
SENP2GeneProduct478661 (Entrez Gene)
SFRP1GeneProduct
SFRP2GeneProduct475471 (Entrez Gene)
SKP1GeneProduct474682 (Entrez Gene)
SMAD3GeneProduct610902 (Entrez Gene)
SMAD4GeneProduct476196 (Entrez Gene)
SOX1GeneProduct607464 (Entrez Gene)
SOX9GeneProduct403464 (Entrez Gene)
SUMO2GeneProduct474963 (Entrez Gene)
TAX1BP3GeneProduct491221 (Entrez Gene)
TBPGeneProduct611193 (Entrez Gene)
TCF3GeneProduct485079 (Entrez Gene)
TCF4GeneProduct403949 (Entrez Gene)
TFAP2AGeneProduct488213 (Entrez Gene)
UBL1GeneProduct
VANGL2GeneProduct
WNT1GeneProduct486560 (Entrez Gene)
WNT2GeneProduct612141 (Entrez Gene)
WNT3GeneProduct609107 (Entrez Gene)
WNT3AGeneProduct482208 (Entrez Gene)
WNT4GeneProduct612367 (Entrez Gene)
WNT5AGeneProduct484721 (Entrez Gene)
WNT7AGeneProduct607180 (Entrez Gene)

Annotated Interactions

No annotated interactions
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