Cell cycle (Danio rerio)

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1+p+uORC (OriginRecognition complex)epathwayGrowth Factor withdrawalR-point(Start)S-phase proteinsUbiquitin+pHistone DeacetylaseseG1DNA-pG2p27,57SHDAC-pMSecurinMAPKTranscription Factor E2F+pCondensinSeparinp21DNA biosynthesis+uApoptosis+up16,15,18,19+pproteolysis+p+pe+p+p+p+pe+pDNA damage checkpointGrowth Factor+pDNA+u+pmediated+u+p+psignalinge+p+pMCM (Mini-ChromosomeMaintenance) complexsb:cb730CDKN1Asi:ch211-195d17.2cdk2mcm4ccnb1rb1skp2MPEG1CDKN2Aorc3lCDC25Ctp53cdkn1bCDC25Amdm2ARFzgc:163016zgc:174506ccna1rb1ASKrbl1ccne2ORC2Lccnb2rb1cdc25SCFhdac6HDAC2LOC100006682zgc:85772LOC557486wu:fl55e11GADD45Accneskp2LOC794566CDH1LOC566767chek1LOC100000720orc5lPTTG1cdc2APC/Cwee1cdc20PTTG3CCND3BUB3mcm5cdc45lcdk214-3-3mcm2mcm7ATRLOC100150936DKEY-168J9.1HDAC7Acdc14be2f4hdac8hdac3MCMccnhmad2l1smad3bhdac4UBE2Fchek2zgc:162280E2F2ccna2gsk3bcdc2rbl1TGFB1mcm6E2FORCorc6lplk1zgc:101602ccna2SCFpcnaep300accna1GeneProductwu:fa96e12smc1aAPC/CYWHAGE2F3E2F5orc1lcdk2zgc:153726CH1073-192F24.1MAD2L2mcm3MENmad1l1zgc:153369hdac1PTTG2LOC567485LOC559111


Description

(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.

Comments

GenMAPP notes 
Adapted from: http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP179(r30295) with a 68% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
111031view21:40, 1 July 2020L DupuisConverted interactions to graphical lines in outlines
91983view09:20, 11 April 2017LWackersUpdated annotations.
86992view14:38, 15 July 2016MkutmonOntology Term : 'cell cycle pathway' added !
71498view19:20, 17 October 2013MaintBotAutomated update of data sources
68614view03:56, 6 July 2013MaintBotUpdated to 2013 gpml schema
62730view03:21, 2 May 2013MaintBotUpdated UniProt data source
40775view22:14, 1 March 2011MaintBotRemoved redundant pathway information and comments
35388view09:30, 12 February 2010MartijnVanIerselModified description
34167view21:16, 9 December 2009MaintBotAutomatic update of empty xrefs
32346view13:36, 15 August 2009MaintBotFixed text labels
31969view13:07, 14 August 2009MaintBotFixed group labels
31393view20:46, 13 August 2009MaintBotFixed text labels
31105view01:43, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
14-3-3GeneProduct
APC/CGeneProduct
ARFGeneProduct
ASKGeneProductASK; activator of S phase kinas
ATRGeneProductATR; ataxia telangiectasia and Rad3 related
BUB3GeneProduct403012 (Entrez Gene) BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
CCND3GeneProductCCND3; cyclin D3
CDC25AGeneProductCDC25A; cell division cycle 25A [EC:3.1.3.48]
CDC25CGeneProductCDC25C; cell division cycle 25C [EC:3.1.3.48]
CDH1GeneProduct114424 (Entrez Gene)
CDKN1AGeneProduct100151416 (Entrez Gene)
CDKN2AGeneProduct
CH1073-192F24.1GeneProduct567071 (Entrez Gene) BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
DKEY-168J9.1GeneProduct565969 (Entrez Gene) CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
E2FGeneProduct
E2F2GeneProductE2F2; E2F transcription factor 2
E2F3GeneProductE2F3; E2F transcription factor 3
E2F5GeneProduct373090 (Entrez Gene) E2F5; E2F transcription factor 5 p130-binding
GADD45AGeneProduct431763 (Entrez Gene)
GeneProductGeneProduct
HDAC2GeneProductHDAC2; histone deacetylase 2
HDAC7AGeneProductHDAC7A; histone deacetylase 7
LOC100000720GeneProduct100000720 (Entrez Gene) ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
LOC100006682GeneProduct100006682 (Entrez Gene) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
LOC100150936GeneProduct100150936 (Entrez Gene) TFDP1; transcription factor Dp-1
LOC557486GeneProduct557486 (Entrez Gene) HDAC5; histone deacetylase 5
LOC559111GeneProduct559111 (Entrez Gene) MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
LOC566767GeneProduct566767 (Entrez Gene)
LOC567485GeneProduct567485 (Entrez Gene) E2F1; E2F transcription factor 1
LOC794566GeneProduct794566 (Entrez Gene) ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
MAD2L2GeneProductMAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
MCMGeneProduct
MENGeneProduct
MPEG1GeneProduct335407 (Entrez Gene)
ORCGeneProduct
ORC2LGeneProductORC2L; origin recognition complex subunit 2-like (yeast)
PTTG1GeneProductPTTG1; pituitary tumor-transforming
PTTG2GeneProductPTTG2; pituitary tumor-transforming
PTTG3GeneProductPTTG3; pituitary tumor-transforming
SCFGeneProduct
TGFB1GeneProduct359834 (Entrez Gene)
UBE2FGeneProductUBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
YWHAGGeneProductYWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
ccna1GeneProduct404206 (Entrez Gene) CCNA1; cyclin A1
ccna2GeneProduct192295 (Entrez Gene) CCNA2; cyclin A2
ccnb1GeneProduct58025 (Entrez Gene) CCNB1; cyclin B1
ccnb2GeneProduct368316 (Entrez Gene) CCNB2; cyclin B2
ccne2GeneProduct415165 (Entrez Gene) CCNE2; cyclin E
ccneGeneProduct30188 (Entrez Gene) CCNE1; cyclin E
ccnhGeneProduct541325 (Entrez Gene) CCNH; cyclin H
cdc14bGeneProduct393148 (Entrez Gene) CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
cdc20GeneProduct406353 (Entrez Gene) CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
cdc25GeneProduct57925 (Entrez Gene) CDC25B; cell division cycle 25B [EC:3.1.3.48]
cdc2GeneProduct80973 (Entrez Gene) CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
cdc45lGeneProduct406695 (Entrez Gene) CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
cdk2GeneProduct406715 (Entrez Gene) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
cdkn1bGeneProduct368329 (Entrez Gene) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
chek1GeneProduct393162 (Entrez Gene) CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
chek2GeneProduct336998 (Entrez Gene) CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
e2f4GeneProduct406741 (Entrez Gene) E2F4; E2F transcription factor 4 p107/p130-binding
ep300aGeneProduct559273 (Entrez Gene) EP300; E1A binding protein p300
gsk3bGeneProduct30654 (Entrez Gene) GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
hdac1GeneProduct192302 (Entrez Gene) HDAC1; histone deacetylase 1
hdac3GeneProduct393965 (Entrez Gene) HDAC3; histone deacetylase 3
hdac4GeneProduct568877 (Entrez Gene) HDAC4; histone deacetylase 4
hdac6GeneProduct565482 (Entrez Gene) HDAC6; histone deacetylase 6
hdac8GeneProduct406740 (Entrez Gene) HDAC8; histone deacetylase
mad1l1GeneProduct393886 (Entrez Gene) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
mad2l1GeneProduct550434 (Entrez Gene) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
mcm2GeneProduct192338 (Entrez Gene) MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
mcm3GeneProduct192323 (Entrez Gene) MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
mcm4GeneProduct337598 (Entrez Gene) MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
mcm5GeneProduct286747 (Entrez Gene) MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
mcm6GeneProduct566409 (Entrez Gene) MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
mcm7GeneProduct192333 (Entrez Gene) MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
mdm2GeneProduct30637 (Entrez Gene) MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
orc1lGeneProduct554509 (Entrez Gene) ORC1L; origin recognition complex subunit 1-like (yeast)
orc3lGeneProduct334315 (Entrez Gene) ORC3L; origin recognition complex subunit 3-like (yeast)
orc5lGeneProduct406479 (Entrez Gene) ORC5L; origin recognition complex subunit 5-like (yeast)
orc6lGeneProduct324256 (Entrez Gene) ORC6L; origin recognition complex subunit 6-like (yeast)
pcnaGeneProduct30678 (Entrez Gene) PCNA; proliferating cell nuclear antigen
plk1GeneProduct280649 (Entrez Gene) PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
rb1GeneProduct777733 (Entrez Gene) RB1; retinoblastoma 1 (including osteosarcoma)
rbl1GeneProduct795522 (Entrez Gene) RBL1; retinoblastoma-like 1 (p107)
sb:cb730GeneProduct567006 (Entrez Gene) BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
si:ch211-195d17.2GeneProduct560495 (Entrez Gene) E2F6; E2F transcription factor 6
skp2GeneProduct563708 (Entrez Gene) SKP2; S-phase kinase-associated protein 2 (p45
smad3bGeneProduct326283 (Entrez Gene) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
smc1aGeneProduct559665 (Entrez Gene) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
tp53GeneProduct30590 (Entrez Gene)
wee1GeneProduct327060 (Entrez Gene) WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
wu:fa96e12GeneProduct562283 (Entrez Gene) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
wu:fl55e11GeneProduct797406 (Entrez Gene) ESPL1; extra spindle poles like 1 (S. cerevisiae
zgc:101602GeneProduct492768 (Entrez Gene) CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
zgc:153369GeneProduct767751 (Entrez Gene) CCNB3; cyclin B
zgc:153726GeneProduct777730 (Entrez Gene) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
zgc:162280GeneProduct799608 (Entrez Gene) CCND2; cyclin D2
zgc:163016GeneProduct100049158 (Entrez Gene) PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
zgc:174506GeneProduct402825 (Entrez Gene) CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
zgc:85772GeneProduct406462 (Entrez Gene) ORC4L; origin recognition complex subunit 4-like (yeast)

Annotated Interactions

No annotated interactions
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