DNA replication (Gallus gallus)

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1, 2Mcm2Mcm7Orc complexOrc3Cdc6Orc5Mcm4Mcm10Mcm5Mcm7Cdt1Ubiquitinated Cdc6DNA polymerase alpha:primase: origin complexCdc6Mcm3Orc3RFC37Cdt1RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimer1. Assembly of the pre-replicative complexRFC40Cdc6PrimaseDNAPolymerase AUbiquitinOriginGemininMcm3Ubiquitinated Orc1Cdt1Processive complexCdt12. Activation of the pre-replicative complexUbiquitinRFC38Mcm6Mcm10RNA primer-DNA primerPhosphorylation ofMcm 2-7 complexOrc2RNA Primerp49Mcm 4,6,7 trimer forms andassociates with the replication fork4. Switching of origins to post-replicative statep70Orc3Orc complexp180RNA primer-DNA primer:origin duplex:PCNAOrc complexOrc2Mcm6Mcm5Orc3Phosphorylated Cdc6Orc2Orc5Degraded by proteasome in cytosolOrc4Mcm2RNA primer-DNA primerPhosphorylated Orc1Pre-replicative complexRFC36Orc complexOrc4Orc complexp58Cdt1Orc23. DNA replication initiationDNA polymerase alpha:primase: origin complexPre-replicative complexOrc55. Leading/lagging strand synthesisRFC140Cdc6Degraded byproteasomein cytosolMcm4RFC Heteropentamer:RNA primer-DNA primerOrc1MCM6dCTPCDT1PCNAATPORC3LCDC7ATPdATPRFC1UBCPRIM1PRIM2DBF4RCJMB04_6d17UTPPOLD3ORC5LADPdGTPMCM5MCM4ORC2LRFC4RFC5POLERFC2POLA2MCM10GMNNCDC45LORC1LMCM3RPA4RPA3dUTPPOLD4GTPCDC6ORC6LATPADPCDK2ATPORC4LPOLA1RPA1POLD2MCM7MCM2UBA52POLD1POLE2CTPRFC3


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 54% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117195view10:32, 18 May 2021EweitzModified title
68859view17:20, 8 July 2013MaintBotUpdated to 2013 gpml schema
68762view15:29, 7 July 2013EgonwRemoved data source where no ID was given.
67165view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40997view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
35218view15:49, 11 February 2010Thomasadded literature
35210view15:44, 11 February 2010ThomasModified description
35204view15:41, 11 February 2010ThomasModified description
33918view18:06, 9 December 2009MaintBotAutomatic update of empty xrefs
33442view14:58, 30 November 2009MaintBotRemoved group label
31499view21:32, 13 August 2009MaintBotFixed text labels
30326view20:45, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ATPMetabolite
CDC45LGeneProduct416776 (Entrez Gene)
CDC6GeneProduct
CDC7GeneProduct424507 (Entrez Gene)
CDK2GeneProduct
CDT1GeneProduct426254 (Entrez Gene)
CTPMetabolite
DBF4GeneProduct420536 (Entrez Gene)
GMNNGeneProduct421004 (Entrez Gene)
GTPMetabolite
MCM10GeneProduct429525 (Entrez Gene)
MCM2GeneProduct416027 (Entrez Gene)
MCM3GeneProduct422043 (Entrez Gene)
MCM4GeneProduct426764 (Entrez Gene)
MCM5GeneProduct418058 (Entrez Gene)
MCM6GeneProduct424295 (Entrez Gene)
MCM7GeneProduct
ORC1LGeneProduct424640 (Entrez Gene)
ORC2LGeneProduct424077 (Entrez Gene)
ORC3LGeneProduct421822 (Entrez Gene)
ORC4LGeneProduct424307 (Entrez Gene)
ORC5LGeneProduct417714 (Entrez Gene)
ORC6LGeneProduct415749 (Entrez Gene)
PCNAGeneProduct373984 (Entrez Gene)
POLA1GeneProduct418593 (Entrez Gene)
POLA2GeneProduct
POLD1GeneProduct
POLD2GeneProduct
POLD3GeneProduct419053 (Entrez Gene)
POLD4GeneProduct
POLE2GeneProduct423567 (Entrez Gene)
POLEGeneProduct416997 (Entrez Gene)
PRIM1GeneProduct426646 (Entrez Gene)
PRIM2GeneProduct421878 (Entrez Gene)
RCJMB04_6d17GeneProduct419566 (Entrez Gene)
RFC1GeneProduct422788 (Entrez Gene)
RFC2GeneProduct396542 (Entrez Gene)
RFC3GeneProduct418907 (Entrez Gene)
RFC4GeneProduct424958 (Entrez Gene)
RFC5GeneProduct
RPA1GeneProduct417563 (Entrez Gene)
RPA3GeneProduct420578 (Entrez Gene)
RPA4GeneProduct
UBA52GeneProduct395958 (Entrez Gene)
UBCGeneProduct396425 (Entrez Gene)
UTPMetabolite
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite

Annotated Interactions

No annotated interactions
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