Selenium micronutrient network (Rattus norvegicus)

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TransportREACTIONPLASMAINTRACELULARInfluence on expression Negative effect Unspecified interactions GENERIC ENZYMEGENERIC BINDING PROTEININORGANIC IONBindingPositive effect Transformation METABOLITELeukotriene E4FADLipoxin A4RNSAA (n-6)DHA (n-3)PGF2aa-tocopherolAscorbic acidGlutathioneEPA (n-3)TBROSMthfrThioredoxinThromboxane B2TTTHomocysteineNADPHemePGG3Ascorbic acidMethionine SeleniumBMtr15-HETECopperTRXR 3BZincTRXR 2iPF2-alphaVitamin B12ManganeseUric acidBALA (n-3)ZincGlutathioneTbxas1PtgesXanthineglutathione disulfideLipoic acidCysteineXdhLA (n-6)5-HPETELeukotriene D4O2Alox5BBTNCatTNPGH3SelkBALA (n-3)Gpx3Tromboxane A2PGFSBNADPHBBPGD2TRXR 1Fads2BGpx1d4 desaturaseGpx2IEPGE2DHA (n-3)BF2-IsoprostaneKmoIronBSepp1H20LA (n-6)CysteineSod1TBBBBGpx6Leukotriene D4C22:5 (n-6)IEHypoxanthineTPtgdsPGI2Folic acidNADPHIronFads1Leukotriene B4NADPTRiboflavinCOX2Gpx4Methionine sulfoxideGsrPtgisPGE3Folic acid15-HETEBBTryptophanBPGH2BMethioninePGE2Leukotriene C4PNPOPGG2Lipoxin A4Lipoxin B4Pyrodoxal 5'-phosphateNiacinCopperEndoperoxidaseCOX1Pyridoxal 5'-phosphateLeukotriene F4AA (n-6)Uric AcidLeukotriene B4H2O2BLeukotriene C4Vitamin B12BTPGI2Ba-TocopherolBSelRPGF2aPGD2HomocysteineSeleniumHypoxanthine EPA (n-3)SelWLeukotrieneE4C22:5 (n-6)BLeukotriene A4TThromboxane A2FMN12


Description

The selenium-centred micronutrient biological network. The most relevant biochemical processes related to selenium in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the selenium centred plasma metabolome. A selenoprotein database exists at: http://www.selenodb.org.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP15(r29615) with a 55% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Guzik TJ, Korbut R, Adamek-Guzik T.; ''Nitric oxide and superoxide in inflammation and immune regulation.''; J Physiol Pharmacol., 2003 PubMed Europe PMC Scholia
  2. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone.''; Prostaglandins., 1982 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120918view06:30, 31 January 2022EgonwReplaced an old HMDB identifier with the current one
117013view11:23, 16 May 2021EweitzModified title
106962view13:42, 17 September 2019MaintBotHMDB identifier normalization
91818view06:29, 31 March 2017EgonwROS is a metabolite, and better annotated with the matching Wikidata ID.
87652view08:54, 25 July 2016LindarieswijkOntology Term : 'selenoamino acid metabolic pathway' added !
82693view18:05, 22 October 2015EgonwFixed a typo.
73553view18:32, 30 January 2014EgonwH2O not H20....
71774view20:30, 17 October 2013MaintBotAutomated update of data sources
69346view18:52, 8 July 2013MaintBotUpdated to 2013 gpml schema
69078view18:09, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
68388view10:11, 4 July 2013EgonwMade the link to Wikipedia machine readable.
68387view10:08, 4 July 2013EgonwFixed a number of DataNode types.
66317view17:34, 17 June 2013MaintBotModified title
58922view05:10, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
58521view20:15, 14 February 2013MaintBotModified title
41659view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
34057view19:04, 9 December 2009MaintBotAutomatic update of empty xrefs
31907view12:48, 14 August 2009MaintBotFixed group labels
31015view01:06, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
15-HETEMetaboliteHMDB11134 (HMDB)
5-HPETEMetaboliteHMDB01193 (HMDB)
AA (n-6)MetaboliteHMDB01043 (HMDB)
ALA (n-3)MetaboliteHMDB01388 (HMDB)
Alox5Protein25290 (Entrez Gene)
Ascorbic acidMetaboliteHMDB00044 (HMDB)
BMetabolite
C22:5 (n-6)MetaboliteHMDB01976 (HMDB)
COX1Protein26195 (Entrez Gene)
COX2Protein26198 (Entrez Gene)
CatProtein24248 (Entrez Gene)
CopperMetaboliteHMDB00657 (HMDB)
CysteineMetaboliteHMDB00574 (HMDB)
DHA (n-3)MetaboliteHMDB02183 (HMDB)
EPA (n-3)MetaboliteHMDB01999 (HMDB)
EndoperoxidaseProtein
F2-IsoprostaneMetaboliteHMDB04659 (HMDB)
FADMetaboliteHMDB01248 (HMDB)
FMNGeneProduct342184 (Entrez Gene)
Fads1Protein84575 (Entrez Gene)
Fads2Protein83512 (Entrez Gene)
Folic acidMetaboliteHMDB00121 (HMDB)
GlutathioneMetaboliteHMDB00125 (HMDB)
Gpx1Protein24404 (Entrez Gene)
Gpx2Protein29326 (Entrez Gene)
Gpx3Protein64317 (Entrez Gene)
Gpx4Protein29328 (Entrez Gene)
Gpx6Protein259233 (Entrez Gene)
GsrProteinENSRNOG00000014915 (Ensembl)
H20MetaboliteHMDB02111 (HMDB)
H2O2MetaboliteHMDB03125 (HMDB)
HemeMetaboliteHMDB03178 (HMDB)
HomocysteineMetaboliteHMDB00742 (HMDB)
Hypoxanthine MetaboliteHMDB00157 (HMDB)
HypoxanthineMetaboliteHMDB00157 (HMDB)
IEMetabolite
IronMetaboliteHMDB00692 (HMDB)
KmoProtein59113 (Entrez Gene)
LA (n-6)MetaboliteHMDB00673 (HMDB)
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene E4MetaboliteHMDB02200 (HMDB)
Leukotriene F4MetaboliteHMDB06465 (HMDB)
LeukotrieneE4MetaboliteHMDB02200 (HMDB)
Lipoic acidMetabolite
Lipoic acidMetaboliteHMDB01451 (HMDB)
Lipoxin A4MetaboliteHMDB04385 (HMDB)
Lipoxin B4MetaboliteHMDB05082 (HMDB)
ManganeseMetaboliteHMDB01333 (HMDB)
Methionine MetaboliteHMDB00696 (HMDB)
Methionine sulfoxideMetaboliteHMDB02005 (HMDB)
MethionineMetaboliteHMDB00696 (HMDB)
MthfrProtein362657 (Entrez Gene)
MtrProtein81522 (Entrez Gene)
NADPHMetaboliteHMDB00221 (HMDB)
NADPMetaboliteHMDB00217 (HMDB)
NiacinMetaboliteHMDB01406 (HMDB)
O2MetaboliteHMDB01377 (HMDB)
PGD2MetaboliteHMDB01403 (HMDB)
PGE2Metabolite
PGE3MetaboliteHMDB02664 (HMDB)
PGF2aMetaboliteHMDB01139 (HMDB)
PGFSProtein
PGG2MetaboliteHMDB03235 (HMDB)
PGG3Metabolite
PGH2MetaboliteHMDB01381 (HMDB)
PGH3Metabolite
PGI2MetaboliteHMDB01335 (HMDB)
PNPOProtein64533 (Entrez Gene)
PtgdsProtein25526 (Entrez Gene)
PtgesProtein59103 (Entrez Gene)
PtgisProtein25527 (Entrez Gene)
Pyridoxal 5'-phosphateMetaboliteHMDB01491 (HMDB)
Pyrodoxal 5'-phosphateMetaboliteHMDB01491 (HMDB)
RNSMetabolite
ROSProteinReactive Oxygen Species (Wikipedia) http://en.wikipedia.org/wiki/Reactive_Oxygen_Species
RiboflavinMetaboliteHMDB00244 (HMDB)
SelRGeneProduct51734 (Entrez Gene)
SelWGeneProduct6415 (Entrez Gene)
SeleniumMetaboliteHMDB01349 (HMDB)
SelkProtein290549 (Entrez Gene)
Sepp1Protein29360 (Entrez Gene)
Sod1Protein24786 (Entrez Gene)
TMetabolite
TGeneProduct292301 (Entrez Gene)
TNMetabolite
TRXR 1GeneProduct7296 (Entrez Gene)
TRXR 2GeneProduct10587 (Entrez Gene)
TRXR 3GeneProduct114112 (Entrez Gene)
Tbxas1Protein24886 (Entrez Gene)
ThioredoxinProtein7295 (Entrez Gene)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)
Tromboxane A2MetaboliteHMDB01452 (HMDB)
TryptophanMetaboliteHMDB00929 (HMDB)
Uric AcidMetaboliteHMDB00289 (HMDB)
Uric acidMetabolite
Vitamin B12MetaboliteHMDB02174 (HMDB)
XanthineMetaboliteHMDB00292 (HMDB)
XdhProtein497811 (Entrez Gene)
ZincMetaboliteHMDB01303 (HMDB)
a-TocopherolMetaboliteHMDB01893 (HMDB)
a-tocopherolMetaboliteHMDB01893 (HMDB)
d4 desaturaseProtein
glutathione disulfideMetaboliteHMDB00656 (HMDB)
iPF2-alphaMetaboliteHMDB04659 (HMDB)

Annotated Interactions

No annotated interactions
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