DNA replication (Saccharomyces cerevisiae)

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1-3Cdt1UbiquitinMcm2Cdt1Mcm4Degraded by proteasome in cytosolOrc ComplexMcm 4,6,7 trimer forms and associatesOrc2RNA primer-DNA primerMcm3Mcm5RNA primer-DNA primer:origin duplex:PCNAHOMOLOGY MAPPMcm5Orc2Orc2Ubiquitinated Cdc6Orc complexProcessive complexRFC38Orc1Mcm6Orc35. Leading/lagging strand synthesisDegraded by proteasome in cytosol2. Activation of the pre-replicative complexDNA Polymerasep70Cdc6Pre-replicative complexOrc5RFC Heteropentamer:RNA primer-DNA primer:with the replication forkPhosphorylation of Mcm 2-7 complexMcm6DNA polymerase alpha: primase: origin complexCdc6UbiquitinCdt1Phosphorylated Orc1Orc4Ubiquitinated Orc1RFC40RNA PrimerCdc6Orc complexp491. Assembly of the pre-replicative complexCdt1DNA polymerase alpha: primase: origin complexOrc complex3. DNA replication initiationOrc5Orc3Pre-replicative complexap180Cdc6Mcm7RFC140Mcm2RFC374. Switching of origins to post-replicative stateOrc2GemininOrc complexOrc3RFC Heteropentamer:RNA primer-DNA primerdUTPMcm3Orc3Mcm4PCNA homotrimerCdt1Orc4RNA primer-DNA primerp58UTPCTPMcm10RFC36Mcm7Orc5PrimasePhosphorylated Cdc6OriginPOLD4dCTPORC4LRFC3PRI2ADPCDC2RFC2dGTPMCM2RFC4GTPMCM3CDC7ORC1LATPPOLD3CDC45PRI1ATPdATPMCM6ASKCDC46POL12UBI4RPA3CDC47RFA2ORC2ATPPOL30ORC3LGMNNRFC1ORC6LHYS2DPB2POL1ORC5LATPRPL40APOL2CDC6CDK2CDC54ADPRFA1RPA4CDT1RFC5MCM10


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [wikipedia:DNA_replication|Wikipedia]

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Marahrens Y, Stillman B; ''A yeast chromosomal origin of DNA replication defined by multiple functional elements.''; Science, 1992 PubMed Europe PMC Scholia
  3. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117289view10:58, 20 May 2021EweitzModified title
102295view19:29, 17 December 2018KhanspersModified description
78398view10:25, 7 January 2015MaintBotadded missing graphIds
76275view21:24, 25 June 2014KhanspersModified description
76274view21:24, 25 June 2014Khanspersremoved genmapp comments
76273view21:22, 25 June 2014Khanspersoverhaul
71354view18:03, 17 October 2013MaintBotAutomated update of data sources
69761view11:05, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69672view20:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
67159view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41916view04:54, 2 March 2011MaintBotRemoved redundant pathway information and comments
35199view15:38, 11 February 2010ThomasModified description
35198view15:38, 11 February 2010ThomasModified description
35197view15:37, 11 February 2010Thomasadded literature
34367view22:36, 9 December 2009MaintBotAutomatic update of empty xrefs
20699view11:29, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:DNA replication Reactome]] moved to [[Pathway:WP13]]: Moved to stable identifier
12692view07:58, 17 May 2008MaintBotautomated metabolite conversion
8540view14:02, 7 January 2008MaintBotAdded to category $category
19420view14:02, 7 January 2008D.KorenUploaded new pathway
8538view14:02, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADP58-64-0 (CAS)
ASKGeneProduct
ATP1927-31-7 (CAS)
CDC2GeneProduct851456 (Entrez Gene)
CDC45GeneProduct850793 (Entrez Gene)
CDC46GeneProduct850980 (Entrez Gene)
CDC47GeneProduct852501 (Entrez Gene)
CDC54GeneProduct856130 (Entrez Gene)
CDC6GeneProduct853244 (Entrez Gene)
CDC7GeneProduct851545 (Entrez Gene)
CDK2GeneProduct
CDT1GeneProduct
DPB2GeneProduct856305 (Entrez Gene)
GMNNGeneProduct
GTP2564-35-4 (CAS)
HYS2GeneProduct853462 (Entrez Gene)
MCM10GeneProduct854656 (Entrez Gene)
MCM2GeneProduct852258 (Entrez Gene)
MCM3GeneProduct856680 (Entrez Gene)
MCM6GeneProduct852673 (Entrez Gene)
ORC1LGeneProduct
ORC2GeneProduct852352 (Entrez Gene)
ORC3LGeneProduct
ORC4LGeneProduct
ORC5LGeneProduct
ORC6LGeneProduct
POL12GeneProduct852245 (Entrez Gene)
POL1GeneProduct855621 (Entrez Gene)
POL2GeneProduct855459 (Entrez Gene)
POL30GeneProduct852385 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
PRI1GeneProduct854825 (Entrez Gene)
PRI2GeneProduct853821 (Entrez Gene)
RFA1GeneProduct851266 (Entrez Gene)
RFA2GeneProduct855404 (Entrez Gene)
RFC1GeneProduct854392 (Entrez Gene)
RFC2GeneProduct853531 (Entrez Gene)
RFC3GeneProduct855426 (Entrez Gene)
RFC4GeneProduct854059 (Entrez Gene)
RFC5GeneProduct852383 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RPL40AGeneProduct854658 (Entrez Gene)
UBI4GeneProduct850620 (Entrez Gene)
dATP1927-31-7 (CAS)
dCTP2056-98-6 (CAS)
dGTP2564-35-4 (CAS)

Annotated Interactions

No annotated interactions
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