Eukaryotic transcription initiation (Mus musculus)

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1, 2Primary RNA transcriptTFIIA(recognize surface DNA geometry)TFIIE5'3'TFIIE3'TATATFIIATFIIBTFIIF3'TFIIH3'(mRNA, snRNPs)3'TATASteps 1) TBP binds TATA boxdsDNA5'3'Transcription Initiation Factors (TIFs)RNA polymerase IITFIIB5'3'(small stable RNAs)TFIIF5'(large ribosomal RNAs)TFIID5'TATA Box binding5'3'RNA polymerase IIIcell growth5'TFIID5'Gene Regulatory Proteins5'TATAproteinSteps 5) RNA elongation with CDT phosphorylationSteps 2) Association of TIFs and RNA polymeraseRNA polymerase I5'Steps 3) DNA melting by association with TFIIHTFIIH3'Steps 4) Transcription elongation by NTPsRNA pol IITaf13Gtf2h4Polr2eGtf2h1Polr2kErcc3Taf7Polr2aPolr2fGtf2h2Polr2cGtf2f2Rpo1-3Rpo1-2Gtf2bTaf6Polr2jErcc2Polr3hPolr3dCcnhGtf2e1Polr2gCdk7IlkRpo1-1Polr3bTaf9Mnat1Gtf2h3Gtf2a2Polr3eGtf2e2TbpPolr2bRpo1-4Taf12Polr2hPolr2iTaf5Polr3kTFIIF


Description

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: Wikipedia

Comments

GenMAPP notes 
Reference: http://www.web-books.com/MoBio/Free/Ch4E.htm

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Bibliography

  1. Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998 PubMed Europe PMC Scholia
  2. Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117881view10:21, 23 May 2021EweitzModified title
89957view18:07, 6 October 2016Mkutmonfix unconnected lines
69915view19:37, 11 July 2013Mkutmonfixed unconnected lines
69137view18:16, 8 July 2013MaintBotUpdated to 2013 gpml schema
67216view10:22, 26 June 2013Christine ChichesterOntology Term : 'transcription pathway' added !
41326view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35533view14:04, 12 February 2010Thomasadded literature
35522view13:53, 12 February 2010ThomasModified description
34504view23:33, 16 December 2009KhanspersAdded connectors
26591view18:28, 10 December 2008AlexanderPico
21874view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:RNA transcription Reactome]] moved to [[Pathway:WP567]]: Moved to stable identifier
8368view13:46, 7 January 2008MaintBot[[Pathway:Mouse:RNA transcription Reactome]] moved to [[Pathway:Mus musculus:RNA transcription Reactome]]: Renaming species
7802view16:18, 18 December 2007MaintBotfixed category names
7287view12:41, 4 November 2007MaintBotAdded categories to GPML
6489view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:RNA_transcription_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CcnhGeneProduct66671 (Entrez Gene)
Cdk7GeneProduct12572 (Entrez Gene)
Ercc2GeneProduct13871 (Entrez Gene)
Ercc3GeneProduct13872 (Entrez Gene)
Gtf2a2GeneProduct235459 (Entrez Gene)
Gtf2bGeneProduct229906 (Entrez Gene)
Gtf2e1GeneProduct74197 (Entrez Gene)
Gtf2e2GeneProduct68153 (Entrez Gene)
Gtf2f2GeneProduct68705 (Entrez Gene)
Gtf2h1GeneProduct14884 (Entrez Gene)
Gtf2h2GeneProduct23894 (Entrez Gene)
Gtf2h3GeneProduct209357 (Entrez Gene)
Gtf2h4GeneProduct14885 (Entrez Gene)
IlkGeneProduct16202 (Entrez Gene)
Mnat1GeneProduct17420 (Entrez Gene)
Polr2aGeneProduct20020 (Entrez Gene)
Polr2bGeneProduct231329 (Entrez Gene)
Polr2cGeneProduct20021 (Entrez Gene)
Polr2eGeneProduct66420 (Entrez Gene)
Polr2fGeneProduct110812 (Entrez Gene)
Polr2gGeneProduct67710 (Entrez Gene)
Polr2hGeneProduct245841 (Entrez Gene)
Polr2iGeneProduct69920 (Entrez Gene)
Polr2jGeneProduct20022 (Entrez Gene)
Polr2kGeneProduct17749 (Entrez Gene)
Polr3bGeneProduct70428 (Entrez Gene)
Polr3dGeneProduct67065 (Entrez Gene)
Polr3eGeneProduct26939 (Entrez Gene)
Polr3hGeneProduct78929 (Entrez Gene)
Polr3kGeneProduct67005 (Entrez Gene)
Rpo1-1GeneProduct20016 (Entrez Gene)
Rpo1-2GeneProduct20017 (Entrez Gene)
Rpo1-3GeneProduct20018 (Entrez Gene)
Rpo1-4GeneProduct20019 (Entrez Gene)
Taf12GeneProduct66464 (Entrez Gene)
Taf13GeneProduct99730 (Entrez Gene)
Taf5GeneProduct226182 (Entrez Gene)
Taf6GeneProduct21343 (Entrez Gene)
Taf7GeneProduct24074 (Entrez Gene)
Taf9GeneProduct108143 (Entrez Gene)
TbpGeneProduct21374 (Entrez Gene)

Annotated Interactions

No annotated interactions
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