MAPK signaling pathway (Saccharomyces cerevisiae)

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1High osmolarity+p+p+pMAPKKCell Cycle ArrestCell Wall remodelingMAPKMAPKKK+p+p+p+pCell Cycle+p+p+pPheromone+pStarvation+p+p+pHypotonic shock+p+pSynthesis+p+p+p+pPolarityMatingFilamentation+p+p+pOsmolyteGDPSte5GPA1Msg5Mcm1Ste7Mlp1Glo1Hog1Mcm1Sho1Wsc1,2,3Rlm1Mid2Bni1Fus1Ste12Bem1Slt2Cdc24Ssk1Ras2GDPSte2Swi4Bkc1Rho1Dig1,2Sho1Ste1Ste20Tec1Cdc42GTPSln1Far1Fus1GTPCdc42Mkk1GDPSte18Ste11Msn2Ste20Kss1Ste11GDPPkc1GTPSte11MATaCtt1Ypd1Ssk2Fks1Ste20MATalphaGTPPbs2Fks2Ste3Ste4Dig1Ste7


Description

The MAPK/ERK pathway is a signal transduction pathway that couples intracellular responses to the binding of growth factors to cell surface receptors. In many cell types, activation of this pathway promotes cell division.

Comments

GenMAPP notes 
Adapted from: http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=sce&mapno=04010

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Quality Tags

Ontology Terms

 

Bibliography

  1. Chen RE, Thorner J; ''Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.''; Biochim Biophys Acta, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117311view11:19, 20 May 2021EweitzModified title
113908view20:01, 8 December 2020Finterlysmall graphical update
78392view10:25, 7 January 2015MaintBotadded missing graphIds
78105view03:07, 3 December 2014AlexanderPicochanged nucleus font
78104view03:06, 3 December 2014AlexanderPicochanged nucleus font
78103view03:05, 3 December 2014AlexanderPicochanged nucleus font
78101view20:28, 2 December 2014KhanspersAdded Cell Cycle pathway node
78100view20:22, 2 December 2014KhanspersModified description
78099view20:22, 2 December 2014Khanspersremoved GenMAPP notes
78098view20:20, 2 December 2014Khanspers
78097view19:36, 2 December 2014KhanspersAdded cell and nucleus
78096view19:27, 2 December 2014KhanspersAdded states, changed layout
78063view01:06, 25 November 2014KhanspersAdded phosphorylations, scaffold etc
76250view22:11, 23 June 2014MaintBotconnected lines and updated to graphical lines where appropriate
74856view10:34, 2 May 2014Nunoconnected some unconnected lines
69938view20:11, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69666view20:40, 8 July 2013MaintBotUpdated to 2013 gpml schema
67445view11:02, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
41908view04:54, 2 March 2011MaintBotRemoved redundant pathway information and comments
35484view12:23, 12 February 2010MichielModified description
35483view12:21, 12 February 2010MichielAdded ref
34716view13:02, 13 January 2010Thomasconnected remaining unconnected lines
34715view13:02, 13 January 2010Thomasconnected remaining unconnected lines
34672view06:16, 10 January 2010Shigetaconnecting lines
21752view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:MAPK Signaling KEGG]] moved to [[Pathway:WP510]]: Moved to stable identifier
12778view08:02, 17 May 2008MaintBotautomated metabolite conversion
8543view14:02, 7 January 2008MaintBotAdded to category $category
19508view14:02, 7 January 2008BruceConklinUploaded new pathway
8541view14:02, 7 January 2008NsalomonisUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Bem1GeneProductS000000404 (SGD)
Bkc1GeneProductS000003631 (SGD)
Bni1GeneProductS000005215 (SGD)
Cdc24GeneProductS000000039 (SGD)
Cdc42GeneProductS000004219 (SGD)
Ctt1GeneProductS000003320 (SGD)
Dig1,2GeneProductS000005970 (SGD)
Dig1GeneProductS000005970 (SGD)
Far1GeneProductS000003693 (SGD)
Fks1GeneProductS000004334 (SGD)
Fks2GeneProductS000003264 (SGD)
Fus1GeneProductS000000532 (SGD)
GDPMetabolite146-91-8 (CAS)
GPA1GeneProductS000001047 (SGD)
GTPMetabolite2564-35-4 (CAS)
Glo1GeneProductS000004463 (SGD)
Hog1GeneProductS000004103 (SGD)
Kss1GeneProductS000003272 (SGD)
MATaGeneProductS000002869 (SGD)
MATalphaGeneProductS000006108 (SGD)
Mcm1GeneProductS000004646 (SGD)
Mid2GeneProductS000004324 (SGD)
Mkk1GeneProductS000005757 (SGD)
Mlp1GeneProductS000001803 (SGD)
Msg5GeneProductS000004998 (SGD)
Msn2GeneProductS000004640 (SGD)
Pbs2GeneProductS000003664 (SGD)
Pkc1GeneProductS000000201 (SGD)
Ras2GeneProductS000005042 (SGD)
Rho1GeneProductS000006369 (SGD)
Rlm1GeneProductS000006010 (SGD)
Sho1GeneProductS000000920 (SGD)
Sln1GeneProductS000001409 (SGD)
Slt2GeneProductS000001072 (SGD)
Ssk1GeneProductS000003996 (SGD)
Ssk2GeneProductS000005314 (SGD)
Ste11GeneProductS000004354 (SGD)
Ste12GeneProductS000001126 (SGD)
Ste18GeneProductS000003846 (SGD)
Ste1GeneProductS000001126 (SGD)
Ste20GeneProductS000000999 (SGD)
Ste2GeneProductS000001868 (SGD)
Ste3GeneProductS000001661 (SGD)
Ste4GeneProductS000005738 (SGD)
Ste5GeneProductS000002510 (SGD)
Ste7GeneProductS000002318 (SGD)
Swi4GeneProductS000000913 (SGD)
Tec1GeneProductS000000287 (SGD)
Wsc1,2,3GeneProductS000005534 (SGD)
Ypd1GeneProductS000002394 (SGD)

Annotated Interactions

No annotated interactions
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