Retinoblastoma gene in cancer (Homo sapiens)

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132CCDC6DNA replication factor A complexCDKN1BRBBP4CDKN1AJUNSUV39H1CCND1histone H3-K9 methylationCCNE1SKP2ABL1SP1ABL1G1/S transition of mitotic cell cycleMCM7PRMT2CDC25ARAF1MYCCCNA2CDK2CCNB1E2F1CCND3CKS1BCCNA2MAPK13RBP1DBF4CCNA1CCNA1CCNE1CCDC7HDAC1PathwayCDK1E2F1MDM2CCNE1CCNA1CDKN1BDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestG1/S transition of mitotic cell cycleTP53RAF1DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisRB1SKP1PLK4CDK1NPATCCNE2MDM2CDK1JNK cascadeDNA damage response, signal transduction resulting in induction of apoptosisCCNB2BRCA1CBX5TFDP1TFDP2DNA replicationDNMT1RB1RB1TFDP1E2F1RB1SKP2RB1TFDP1E2F1TFDP1E2F2TFDP1E2F3RB1RB1C9JNK1_HUMANRB1RB1MDM2TFDP1E2F1MDM2RBP1HDAC1TFDP1E2F1RB1RB1TFDP1E2F1RB1RB1RB1RB1SP1RB1RB1JUNTP53E2F1E2F3E2F2SKP2E2F2E2F3TFDP1


Description

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Bibliography

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  1. Welch PJ, Wang JY; ''A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.''; Cell, 1993 PubMed Europe PMC Scholia
  2. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM; ''MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.''; Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  3. Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, Andreeff M, Croce CM; ''MicroRNA 29b functions in acute myeloid leukemia.''; Blood, 2009 PubMed Europe PMC Scholia
  4. Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, Zhu L; ''An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  5. Welch PJ, Wang JY; ''Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms.''; Mol Cell Biol, 1995 PubMed Europe PMC Scholia
  6. Domínguez R, Famulari A, Vila J; ''[Leukoencephalopathy: the frontier between what is reversible and what is persistent].''; Rev Neurol, 1997 PubMed Europe PMC Scholia
  7. Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM; ''MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116593view16:31, 8 May 2021EweitzModified title
113796view11:10, 24 November 2020Finterlysmall graphical update
108145view10:34, 29 November 2019FehrhartOntology Term : 'cancer' added !
108144view10:34, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106493view21:43, 4 September 2019KhanspersModified description
105447view04:57, 8 August 2019KhanspersModified description
102997view14:43, 31 January 2019Mkutmonupdated outdated ensembl ids
98748view01:20, 4 October 2018AlexanderPicoModified title
98747view01:20, 4 October 2018AlexanderPicoModified title
98354view05:35, 24 August 2018EgonwUpdated the MIR21 identifier.
87639view08:54, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
84651view22:24, 10 March 2016KhanspersQuick edit to datanode annotation or property
80443view05:49, 23 June 2015KhanspersAdded mir29b targeting of CDK6
80434view20:26, 22 June 2015KhanspersAdded mir21 targeting of MSH6
80433view20:17, 22 June 2015KhanspersAdded mir21 targetinf of E2F1
80430view20:00, 22 June 2015KhanspersAdded mir21 targeting of CDC25A
80174view11:06, 16 May 2015EveloModified title
80173view11:01, 16 May 2015EveloModified description
80172view10:44, 16 May 2015EveloModified description
80171view10:40, 16 May 2015EveloModified description
78573view14:50, 7 January 2015MaintBotadded missing graphIds
76353view18:32, 3 July 2014EgonwRemoved database names when no identifier was given.
76335view22:48, 2 July 2014MaintBotchanged pathway node Xrefs
72248view22:23, 29 October 2013MaintBotchanged xrefs from Gene Ontology to WikiPathways
71096view14:30, 4 October 2013Mkutmonconnected lines
70977view04:49, 19 September 2013JYoungrenSpecify description
70976view04:40, 19 September 2013JYoungrenPeriodical save, work in progress
70975view04:30, 19 September 2013JYoungrenPeriodical save, work in progress
70974view04:18, 19 September 2013JYoungrenSpecify description
70973view00:58, 19 September 2013JYoungrenSpecify description
70972view00:56, 19 September 2013JYoungrenPeriodical save, work in progress
70971view00:32, 19 September 2013JYoungrenSpecify description
70970view00:25, 19 September 2013JYoungrenPeriodical save, work in progress
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70963view18:46, 18 September 2013JYoungrenSpecify description
70962view18:34, 18 September 2013JYoungrenPeriodical save, work in progress
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70952view19:30, 17 September 2013JYoungrenSpecify description
70934view23:18, 15 September 2013JYoungrenSpecify description
70933view22:39, 15 September 2013JYoungrenPeriodical save, work in progress
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70931view22:18, 15 September 2013JYoungrenPeriodical save, work in progress
70930view22:08, 15 September 2013JYoungrenPeriodical save, work in progress

External references

DataNodes

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NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene)
BRCA1GeneProduct672 (Entrez Gene)
C9JNK1_HUMANProteinC9JNK1 (Uniprot/TrEMBL)
CBX5GeneProduct23468 (Entrez Gene)
CCDC6GeneProduct8030 (Entrez Gene)
CCDC7GeneProduct221016 (Entrez Gene)
CCNA1GeneProduct8900 (Entrez Gene)
CCNA2GeneProduct890 (Entrez Gene)
CCNB1GeneProduct891 (Entrez Gene)
CCNB2GeneProduct9133 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CCNE2GeneProduct9134 (Entrez Gene)
CDC25AGeneProduct993 (Entrez Gene)
CDK1GeneProduct983 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CKS1BGeneProduct1163 (Entrez Gene)
DBF4GeneProduct10926 (Entrez Gene)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestPathwayGO:0006977 (GeneOntology)
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisPathwayGO:0042771 (GeneOntology)
DNA damage response, signal transduction resulting in induction of apoptosisPathwayGO:0008630 (GeneOntology)
DNA replication factor A complexProteinGO:0005662 (GeneOntology)
DNA replicationPathwayGO:0006260 (GeneOntology)
DNMT1GeneProduct1786 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
E2F2GeneProduct1870 (Entrez Gene)
E2F3GeneProduct1871 (Entrez Gene)
G1/S transition of mitotic cell cyclePathwayGO:0000082 (GeneOntology)
HDAC1GeneProduct3065 (Entrez Gene)
JNK cascadePathwayGO:0007254 (GeneOntology)
JUNGeneProduct3725 (Entrez Gene)
MAPK13GeneProduct5603 (Entrez Gene)
MCM7GeneProduct4176 (Entrez Gene)
MDM2GeneProduct4193 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
NPATGeneProduct4863 (Entrez Gene)
PLK4GeneProduct10733 (Entrez Gene)
PRMT2GeneProduct3275 (Entrez Gene)
PathwayPathway
RAF1GeneProduct5894 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RBBP4GeneProduct5928 (Entrez Gene)
RBP1GeneProduct5947 (Entrez Gene)
SKP1GeneProduct6500 (Entrez Gene)
SKP2GeneProduct6502 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
SUV39H1GeneProduct6839 (Entrez Gene)
TFDP1GeneProduct7027 (Entrez Gene)
TFDP2GeneProduct7029 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
histone H3-K9 methylationPathwayGO:0051567 (GeneOntology)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2446"
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