Retinoblastoma gene in cancer (Homo sapiens)

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132MYCCCNE2TFAMMCM6CDK2POLA1BRCA1KIF4AMCM3CCND1ABL1mitotic cell cycleRAF1MCM7CDK1CDK1RABIFHLTFTTKBARD1CKS1BRPA1MSH6PCNACDC25BCCNE1PRIM1E2F1SMARCA2RBBP4SMC1ACCDC6PLK4MAPK13HDAC1E2F1Rb-E2F complexTYMSDNA replicationCDC25AG2/M transition of mitotic cell cycleSMC2MDM2DHFRDCKTOP2ACCNA2RBP1DNMT1RFC3FANCGJUNSMC3ABL1MCM7CDK1G1/S transition of mitotic cell cycleCDKN1BPRKDChistone H3-K9 methylationRPA3CDK1CDKN1BJNK cascadeCHEK1RRM1CCNB1RRM2HMGB1CCNB2NPATcell cycle checkpointSP1RFC5CDC7POLE2RPA2CDC45CBX5LY6EMCM4CCNA1CDT1GTPBP1DNA repairTFDP2GeneProductH2AFZregulation of cyclin-dependent protein kinase activityRPA1CCNE1POLD3CCND3DNA damage response, signal transduction resulting in induction of apoptosisPOLEM/G1 transition of mitotic cell cycleRFC4STMN1FAF1G1/S transition of mitotic cell cycleANLNTLX2SKP2DNA replication checkpointSUV39H1RAF1TP53MDM2CCNE1HMGB2CDKN1AORC1RB1TFDP1CCNA2PRMT2MASP1WEE1RB1RB1TFDP1E2F1RB1SKP2RB1TFDP1E2F1TFDP1E2F2TFDP1E2F3RB1RB1ZNF655RB1RB1MDM2TFDP1E2F1MDM2RBP1HDAC1TFDP1E2F1RB1RB1TFDP1E2F1RB1RB1RB1RB1SP1RB1RB1JUNTP53E2F1E2F3E2F2SKP2E2F3TFDP1G1/S transition of mitotic cell cycleG1/S transition of mitotic cell cycleHDAC1TFDP1E2F1TFDP1E2F1Rb-E2F complexTFDP1E2F2TFDP1E2F3regulation of cyclin-dependent protein kinase activitymitotic spindle organizationHDAC1TFDP1E2F2HDAC1TFDP1E2F3TFDP2E2F1TFDP2E2F2TFDP2E2F3HDAC1TFDP2E2F1HDAC1TFDP2E2F2HDAC1TFDP2E2F3


Description

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Ontology Terms

 

Bibliography

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  1. Welch PJ, Wang JY; ''A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.''; Cell, 1993 PubMed Europe PMC Scholia
  2. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM; ''MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.''; Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  3. Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, Andreeff M, Croce CM; ''MicroRNA 29b functions in acute myeloid leukemia.''; Blood, 2009 PubMed Europe PMC Scholia
  4. Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, Zhu L; ''An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  5. Welch PJ, Wang JY; ''Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms.''; Mol Cell Biol, 1995 PubMed Europe PMC Scholia
  6. Domínguez R, Famulari A, Vila J; ''[Leukoencephalopathy: the frontier between what is reversible and what is persistent].''; Rev Neurol, 1997 PubMed Europe PMC Scholia
  7. Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM; ''MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116593view16:31, 8 May 2021EweitzModified title
113796view11:10, 24 November 2020Finterlysmall graphical update
108145view10:34, 29 November 2019FehrhartOntology Term : 'cancer' added !
108144view10:34, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106493view21:43, 4 September 2019KhanspersModified description
105447view04:57, 8 August 2019KhanspersModified description
102997view14:43, 31 January 2019Mkutmonupdated outdated ensembl ids
98748view01:20, 4 October 2018AlexanderPicoModified title
98747view01:20, 4 October 2018AlexanderPicoModified title
98354view05:35, 24 August 2018EgonwUpdated the MIR21 identifier.
87639view08:54, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
84651view22:24, 10 March 2016KhanspersQuick edit to datanode annotation or property
80443view05:49, 23 June 2015KhanspersAdded mir29b targeting of CDK6
80434view20:26, 22 June 2015KhanspersAdded mir21 targeting of MSH6
80433view20:17, 22 June 2015KhanspersAdded mir21 targetinf of E2F1
80430view20:00, 22 June 2015KhanspersAdded mir21 targeting of CDC25A
80174view11:06, 16 May 2015EveloModified title
80173view11:01, 16 May 2015EveloModified description
80172view10:44, 16 May 2015EveloModified description
80171view10:40, 16 May 2015EveloModified description
78573view14:50, 7 January 2015MaintBotadded missing graphIds
76353view18:32, 3 July 2014EgonwRemoved database names when no identifier was given.
76335view22:48, 2 July 2014MaintBotchanged pathway node Xrefs
72248view22:23, 29 October 2013MaintBotchanged xrefs from Gene Ontology to WikiPathways
71096view14:30, 4 October 2013Mkutmonconnected lines
70977view04:49, 19 September 2013JYoungrenSpecify description
70976view04:40, 19 September 2013JYoungrenPeriodical save, work in progress
70975view04:30, 19 September 2013JYoungrenPeriodical save, work in progress
70974view04:18, 19 September 2013JYoungrenSpecify description
70973view00:58, 19 September 2013JYoungrenSpecify description
70972view00:56, 19 September 2013JYoungrenPeriodical save, work in progress
70971view00:32, 19 September 2013JYoungrenSpecify description
70970view00:25, 19 September 2013JYoungrenPeriodical save, work in progress
70969view00:15, 19 September 2013JYoungrenPeriodical save, work in progress
70968view23:23, 18 September 2013JYoungrenPeriodical save, work in progress
70967view21:49, 18 September 2013JYoungrenPeriodical save, work in progress
70966view21:39, 18 September 2013JYoungrenPeriodical save, work in progress
70965view21:29, 18 September 2013JYoungrenPeriodical save, work in progress
70964view21:19, 18 September 2013JYoungrenPeriodical save, work in progress
70963view18:46, 18 September 2013JYoungrenSpecify description
70962view18:34, 18 September 2013JYoungrenPeriodical save, work in progress
70961view18:23, 18 September 2013JYoungrenPeriodical save, work in progress
70954view20:11, 17 September 2013JYoungrenPeriodical save, work in progress
70953view20:00, 17 September 2013JYoungrenPeriodical save, work in progress
70952view19:30, 17 September 2013JYoungrenSpecify description
70934view23:18, 15 September 2013JYoungrenSpecify description
70933view22:39, 15 September 2013JYoungrenPeriodical save, work in progress
70932view22:28, 15 September 2013JYoungrenPeriodical save, work in progress
70931view22:18, 15 September 2013JYoungrenPeriodical save, work in progress
70930view22:08, 15 September 2013JYoungrenPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene)
ANLNGeneProduct54443 (Entrez Gene)
BARD1GeneProduct580 (Entrez Gene)
BRCA1GeneProduct672 (Entrez Gene)
CBX5GeneProduct23468 (Entrez Gene)
CCDC6GeneProduct8030 (Entrez Gene)
CCNA1GeneProduct8900 (Entrez Gene)
CCNA2GeneProduct890 (Entrez Gene)
CCNB1GeneProduct891 (Entrez Gene)
CCNB2GeneProduct9133 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CCNE2GeneProduct9134 (Entrez Gene)
CDC25AGeneProduct993 (Entrez Gene)
CDC25BGeneProduct994 (Entrez Gene)
CDC45GeneProduct8318 (Entrez Gene)
CDC7GeneProduct8317 (Entrez Gene)
CDK1GeneProduct983 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CDT1GeneProduct81620 (Entrez Gene)
CHEK1GeneProduct1111 (Entrez Gene)
CKS1BGeneProduct1163 (Entrez Gene)
DCKGeneProduct1633 (Entrez Gene)
DHFRGeneProduct1719 (Entrez Gene)
DNA damage response, signal transduction resulting in induction of apoptosisPathwayGO:0008630 (GeneOntology)
DNA repairPathwayGO:0006281 (GeneOntology)
DNA replication checkpointPathwayGO:0000076 (GeneOntology)
DNA replicationPathwayGO:0006260 (GeneOntology)
DNMT1GeneProduct1786 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
E2F2GeneProduct1870 (Entrez Gene)
E2F3GeneProduct1869 (Entrez Gene)
E2F3GeneProduct1871 (Entrez Gene)
FAF1GeneProduct11124 (Entrez Gene)
FANCGGeneProduct2189 (Entrez Gene)
G1/S transition of mitotic cell cyclePathwayGO:0000082 (GeneOntology)
G2/M transition of mitotic cell cyclePathwayGO:0000086 (GeneOntology)
GTPBP1GeneProduct9567 (Entrez Gene)
GeneProductGeneProduct
H2AFZGeneProduct3015 (Entrez Gene)
HDAC1GeneProduct3065 (Entrez Gene)
HLTFGeneProduct6596 (Entrez Gene)
HMGB1GeneProduct3146 (Entrez Gene)
HMGB2GeneProduct3148 (Entrez Gene)
JNK cascadePathwayGO:0007254 (GeneOntology)
JUNGeneProduct3725 (Entrez Gene)
KIF4AGeneProduct24137 (Entrez Gene)
LY6EGeneProduct4061 (Entrez Gene)
M/G1 transition of mitotic cell cyclePathwayGO:0000216 (GeneOntology)
MAPK13GeneProduct5603 (Entrez Gene)
MASP1GeneProduct5648 (Entrez Gene)
MCM3GeneProduct4172 (Entrez Gene)
MCM4GeneProduct4173 (Entrez Gene)
MCM6GeneProduct4175 (Entrez Gene)
MCM7GeneProduct4176 (Entrez Gene)
MDM2GeneProduct4193 (Entrez Gene)
MSH6GeneProduct2956 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
NPATGeneProduct4863 (Entrez Gene)
ORC1GeneProduct4998 (Entrez Gene)
PCNAGeneProduct5111 (Entrez Gene)
PLK4GeneProduct10733 (Entrez Gene)
POLA1GeneProduct5422 (Entrez Gene)
POLD3GeneProduct10714 (Entrez Gene)
POLE2GeneProduct5427 (Entrez Gene)
POLEGeneProduct5426 (Entrez Gene)
PRIM1GeneProduct5557 (Entrez Gene)
PRKDCGeneProduct5591 (Entrez Gene)
PRMT2GeneProduct3275 (Entrez Gene)
RABIFGeneProduct5877 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RBBP4GeneProduct5928 (Entrez Gene)
RBP1GeneProduct5947 (Entrez Gene)
RFC3GeneProduct5983 (Entrez Gene)
RFC4GeneProduct5984 (Entrez Gene)
RFC5GeneProduct5985 (Entrez Gene)
RPA1GeneProduct6117 (Entrez Gene)
RPA2Protein6118 (Entrez Gene)
RPA3Protein6119 (Entrez Gene)
RRM1GeneProduct6240 (Entrez Gene)
RRM2GeneProduct6241 (Entrez Gene)
Rb-E2F complexPathwayGO:0035189 (GeneOntology)
SKP2GeneProduct6502 (Entrez Gene)
SMARCA2GeneProduct6595 (Entrez Gene)
SMC1AGeneProduct8243 (Entrez Gene)
SMC2GeneProduct10592 (Entrez Gene)
SMC3GeneProduct9126 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
STMN1GeneProduct3925 (Entrez Gene)
SUV39H1GeneProduct6839 (Entrez Gene)
TFAMGeneProduct7019 (Entrez Gene)
TFDP1GeneProduct7027 (Entrez Gene)
TFDP2GeneProduct7029 (Entrez Gene)
TLX2GeneProduct3196 (Entrez Gene)
TOP2AGeneProduct7153 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
TTKGeneProduct7272 (Entrez Gene)
TYMSGeneProduct7298 (Entrez Gene)
WEE1GeneProduct7465 (Entrez Gene)
ZNF655Protein79027 (Entrez Gene)
cell cycle checkpointPathwayGO:0000075 (GeneOntology)
histone H3-K9 methylationPathwayGO:0051567 (GeneOntology)
mitotic cell cyclePathwayGO:0000278 (GeneOntology)
mitotic spindle organizationPathwayGO:0007052 (GeneOntology)
regulation of cyclin-dependent protein kinase activityPathwayGO:0000079 (GeneOntology)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2446"
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