Keap1-Nrf2 (Canis familiaris)
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1
S-P
Phase II enzymes
CCAAT/XRE
S-P
T-P
Nucleus
ARE
T-P
Sulforaphane
MAF
GSTA2
C/EBP-beta
NFE2L2
Caffeic acid phenethyl ester
GCLC
GCLM
KEAP1
PIK3CA
MAPK8
HMOX1
NFE2L2
NQO1
C/EBP-beta
Curcumin
KEAP1
NFE2L2
PRKCA
6-HITC
EPHB2
AIMP2
Description
Based on
Surh, 2003, figure 4
.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP3(r29720)
with a 77% conversion rate.
Try the New WikiPathways
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the new wikipathways.org
.
Quality Tags
Ontology Terms
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Bibliography
Surh YJ; ''Cancer chemoprevention with dietary phytochemicals.''; Nat Rev Cancer, 2003
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
106034
view
11:56, 16 August 2019
MaintBot
HMDB identifier normalization
88679
view
15:44, 12 August 2016
Jmelius
Ontology Term : 'nuclear factor, erythroid derived 2, like 2 signaling pathway' added !
88678
view
15:44, 12 August 2016
Jmelius
Ontology Term : 'oxidative stress response pathway' added !
74169
view
14:50, 2 April 2014
Egonw
Updated the PubChem-compound data source.
71464
view
19:17, 17 October 2013
MaintBot
Automated update of data sources
68534
view
22:19, 5 July 2013
MaintBot
Updated to 2013 gpml schema
40690
view
21:50, 1 March 2011
MaintBot
Removed redundant pathway information and comments
31731
view
11:57, 14 August 2009
MaintBot
Fixed group labels
30675
view
22:41, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
6-HITC
Metabolite
Full name: 6-(Methylsulfinyl)hexylisothiocyanate, or Japanese horseradish wasabi
AIMP2
GeneProduct
479752 (Entrez Gene)
C/EBP-beta
GeneProduct
Caffeic acid phenethyl ester
Metabolite
Curcumin
Metabolite
HMDB02269 (HMDB)
EPHB2
GeneProduct
487380 (Entrez Gene)
GCLC
GeneProduct
609822 (Entrez Gene)
GCLM
GeneProduct
612283 (Entrez Gene)
GSTA2
GeneProduct
HMOX1
GeneProduct
442987 (Entrez Gene)
KEAP1
GeneProduct
476713 (Entrez Gene)
MAF
GeneProduct
MAPK8
GeneProduct
477746 (Entrez Gene)
NFE2L2
GeneProduct
478813 (Entrez Gene)
NQO1
GeneProduct
610935 (Entrez Gene)
PIK3CA
GeneProduct
488084 (Entrez Gene)
PRKCA
GeneProduct
490904 (Entrez Gene)
Sulforaphane
Metabolite
5350 (PubChem)
Annotated Interactions
No annotated interactions
Views
Pathway
Discussion
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View approved pathways at the new wikipathways.org.Quality Tags
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Annotated Interactions
No annotated interactions