Kinesins (Homo sapiens)

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1-45-722, 2326, 272514-1612, 20245, 8-132117-19cytosolCENP-E dimerKinesin-like protein KIFC1Kinesin-3 dimersKinesin-3 monomersKinesin-associated protein 3KIF15 dimerKinesinsKinesin-14ADPKinesin-6microtubuleKinesin-13 monomersKinesin-1 heavy chainKinesin-like protein KIF9KIF3A partnersKinesin-like protein KIF3AChromokinesin dimersKinesin-5 homotetramerKinesin-2ATPChromokinesin monomersKIF18AKinesin-like protein KIF15CentralspindlinRACGAP1Kinesin-1 light chainsKinesin-13 dimersKinesin-1KIF18A dimerKIF9 dimerCENP-EKinesins:microtubuleKinesin-5


Description

Kinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 families of kinesins, all reprsented in humans. A standardized nomenclature was published in 2004 (Lawrence et al.).

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Bibliography

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  1. Endow SA, Kull FJ, Liu H.; ''Kinesins at a glance.''; PubMed Europe PMC Scholia
  2. Nangaku M, Sato-Yoshitake R, Okada Y, Noda Y, Takemura R, Yamazaki H, Hirokawa N.; ''KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria.''; PubMed Europe PMC Scholia
  3. Nislow C, Lombillo VA, Kuriyama R, McIntosh JR.; ''A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles.''; PubMed Europe PMC Scholia
  4. Mayr MI, Hümmer S, Bormann J, Grüner T, Adio S, Woehlke G, Mayer TU.; ''The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression.''; PubMed Europe PMC Scholia
  5. Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, Yonemura S, Tsukita S, Inoue J, Yamamota T.; ''Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle.''; PubMed Europe PMC Scholia
  6. Sekine Y, Okada Y, Noda Y, Kondo S, Aizawa H, Takemura R, Hirokawa N.; ''A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally.''; PubMed Europe PMC Scholia
  7. Mazumdar M, Sundareshan S, Misteli T.; ''Human chromokinesin KIF4A functions in chromosome condensation and segregation.''; PubMed Europe PMC Scholia
  8. Cai S, Weaver LN, Ems-McClung SC, Walczak CE.; ''Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules.''; PubMed Europe PMC Scholia
  9. Navone F, Niclas J, Hom-Booher N, Sparks L, Bernstein HD, McCaffrey G, Vale RD.; ''Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells.''; PubMed Europe PMC Scholia
  10. Vale RD, Funatsu T, Pierce DW, Romberg L, Harada Y, Yanagida T.; ''Direct observation of single kinesin molecules moving along microtubules.''; PubMed Europe PMC Scholia
  11. Sindelar CV, Budny MJ, Rice S, Naber N, Fletterick R, Cooke R.; ''Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy.''; PubMed Europe PMC Scholia
  12. Okada Y, Yamazaki H, Sekine-Aizawa Y, Hirokawa N.; ''The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors.''; PubMed Europe PMC Scholia
  13. Espeut J, Gaussen A, Bieling P, Morin V, Prieto S, Fesquet D, Surrey T, Abrieu A.; ''Phosphorylation relieves autoinhibition of the kinetochore motor Cenp-E.''; PubMed Europe PMC Scholia
  14. Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA.; ''The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.''; PubMed Europe PMC Scholia
  15. Brown CL, Maier KC, Stauber T, Ginkel LM, Wordeman L, Vernos I, Schroer TA.; ''Kinesin-2 is a motor for late endosomes and lysosomes.''; PubMed Europe PMC Scholia
  16. Hirokawa N, Noda Y.; ''Intracellular transport and kinesin superfamily proteins, KIFs: structure, function, and dynamics.''; PubMed Europe PMC Scholia
  17. Verhey KJ, Hammond JW.; ''Traffic control: regulation of kinesin motors.''; PubMed Europe PMC Scholia
  18. Yang JT, Saxton WM, Stewart RJ, Raff EC, Goldstein LS.; ''Evidence that the head of kinesin is sufficient for force generation and motility in vitro.''; PubMed Europe PMC Scholia
  19. Wordeman L, Mitchison TJ.; ''Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis.''; PubMed Europe PMC Scholia
  20. Kuznetsov SA, Vaisberg EA, Shanina NA, Magretova NN, Chernyak VY, Gelfand VI.; ''The quaternary structure of bovine brain kinesin.''; PubMed Europe PMC Scholia
  21. Yang JT, Laymon RA, Goldstein LS.; ''A three-domain structure of kinesin heavy chain revealed by DNA sequence and microtubule binding analyses.''; PubMed Europe PMC Scholia
  22. Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L.; ''A standardized kinesin nomenclature.''; PubMed Europe PMC Scholia
  23. Blangy A, Lane HA, d'Hérin P, Harper M, Kress M, Nigg EA.; ''Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo.''; PubMed Europe PMC Scholia
  24. Kuznetsov SA, Vaisberg YA, Rothwell SW, Murphy DB, Gelfand VI.; ''Isolation of a 45-kDa fragment from the kinesin heavy chain with enhanced ATPase and microtubule-binding activities.''; PubMed Europe PMC Scholia
  25. Hammond JW, Cai D, Blasius TL, Li Z, Jiang Y, Jih GT, Meyhofer E, Verhey KJ.; ''Mammalian Kinesin-3 motors are dimeric in vivo and move by processive motility upon release of autoinhibition.''; PubMed Europe PMC Scholia
  26. Bloom GS, Wagner MC, Pfister KK, Brady ST.; ''Native structure and physical properties of bovine brain kinesin and identification of the ATP-binding subunit polypeptide.''; PubMed Europe PMC Scholia
  27. Mishima M, Kaitna S, Glotzer M.; ''Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114738view16:22, 25 January 2021ReactomeTeamReactome version 75
113182view11:24, 2 November 2020ReactomeTeamReactome version 74
112409view15:34, 9 October 2020ReactomeTeamReactome version 73
101313view11:20, 1 November 2018ReactomeTeamreactome version 66
100850view20:51, 31 October 2018ReactomeTeamreactome version 65
100391view19:26, 31 October 2018ReactomeTeamreactome version 64
99939view16:10, 31 October 2018ReactomeTeamreactome version 63
99495view14:43, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99144view12:40, 31 October 2018ReactomeTeamreactome version 62
93827view13:39, 16 August 2017ReactomeTeamreactome version 61
93377view11:21, 9 August 2017ReactomeTeamreactome version 61
86463view09:18, 11 July 2016ReactomeTeamreactome version 56
83275view10:37, 18 November 2015ReactomeTeamVersion54
81393view12:55, 21 August 2015ReactomeTeamVersion53
76861view08:13, 17 July 2014ReactomeTeamFixed remaining interactions
76566view11:55, 16 July 2014ReactomeTeamFixed remaining interactions
75899view09:55, 11 June 2014ReactomeTeamRe-fixing comment source
75599view10:44, 10 June 2014ReactomeTeamReactome 48 Update
74954view13:47, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74598view08:38, 30 April 2014ReactomeTeamReactome46
71654view19:36, 17 October 2013MaintBotUpdated data sources
71187view15:46, 11 October 2013EgonwReplaced DataSource Uniprot with Uniprot/TrEMBL.
44882view10:09, 6 October 2011MartijnVanIerselOntology Term : 'transport pathway' added !
42003view21:30, 4 March 2011MaintBotAutomatic update
39868view05:53, 21 January 2011MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADP Metabolite16761 (ChEBI)
ATP Metabolite15422 (ChEBI)
CENP-E ProteinQ02224 (Uniprot-TrEMBL)
CENP-E dimer ComplexREACT_26478 (Reactome)
Centralspindlin ComplexREACT_25726 (Reactome)
Chromokinesin

dimers

ComplexREACT_26861 (Reactome)
Chromokinesin

monomers

ProteinREACT_25504 (Reactome)
KIF15 dimer ComplexREACT_26477 (Reactome)
KIF18A ProteinQ8NI77 (Uniprot-TrEMBL)
KIF18A dimer ComplexREACT_26936 (Reactome)
KIF3A partners ProteinREACT_25838 (Reactome)
KIF9 dimer ComplexREACT_26592 (Reactome)
Kinesin-1 ComplexREACT_26141 (Reactome)
Kinesin-1 heavy

chain

ProteinREACT_26554 (Reactome)
Kinesin-1 light

chains

ProteinREACT_26537 (Reactome)
Kinesin-13

monomers

ProteinREACT_26496 (Reactome)
Kinesin-13 dimers ComplexREACT_25940 (Reactome)
Kinesin-14 ComplexREACT_26798 (Reactome)
Kinesin-2 ComplexREACT_26940 (Reactome)
Kinesin-3

monomers

ProteinREACT_26661 (Reactome)
Kinesin-3 dimers ComplexREACT_26306 (Reactome)
Kinesin-5 ProteinP52732 (Uniprot-TrEMBL)
Kinesin-5

homotetramer

ComplexREACT_26711 (Reactome)
Kinesin-6 ProteinREACT_26851 (Reactome)
Kinesin-associated

protein 3

ProteinQ92845 (Uniprot-TrEMBL)
Kinesin-like

protein KIF15

ProteinQ9NS87 (Uniprot-TrEMBL)
Kinesin-like

protein KIF3A

ProteinQ9Y496 (Uniprot-TrEMBL)
Kinesin-like

protein KIF9

ProteinQ9HAQ2 (Uniprot-TrEMBL)
Kinesin-like

protein KIFC1

ProteinQ9BW19 (Uniprot-TrEMBL)
Kinesins ComplexREACT_26925 (Reactome)
Kinesins:

microtubule

ComplexREACT_26291 (Reactome)
RACGAP1 ProteinQ9H0H5 (Uniprot-TrEMBL)
microtubule UnknownREACT_10446 (Reactome)

Annotated Interactions

No annotated interactions

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