DNA replication (Rattus norvegicus)

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1-3Mcm5Mcm24. Switching of origins to post-replicative stateMcm6Orc3Mcm10Mcm4Mcm2Mcm3DNA polymerase alpha:primase: origin complexOrc5Phosphorylation ofMcm 2-7 complexMcm10Orc1Mcm7Orc2p49Orc4DNAPolymerase APrimasep70Degraded byproteasomein cytosolOrc3UbiquitinMcm5RFC37Orc2Orc complexCdt1Orc complexPre-replicative complexOrc complexOrc3Mcm7p58Cdc6Mcm3Phosphorylated Orc1Cdc6UbiquitinCdt1Phosphorylated Cdc6RFC36Pre-replicative complexUbiquitinated Cdc6RFC403. DNA replication initiationRNA primer-DNA primerMcm 4,6,7 trimer forms andassociates with the replication forkMcm4RFC38Cdc6Cdt1OriginGemininRFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerOrc3DNA polymerase alpha:primase: origin complexOrc2Processive complexRNA PrimerDegraded by proteasome in cytosolCdt1RNA primer-DNA primer:origin duplex:PCNARNA primer-DNA primerCdt1Orc51. Assembly of the pre-replicative complexUbiquitinated Orc1Cdc6Orc4RFC Heteropentamer:RNA primer-DNA primerMcm6Orc22. Activation of the pre-replicative complexp1805. Leading/lagging strand synthesisOrc complexOrc complexRFC140Orc5Orc1lCdc6Orc5lRfc5Pold1POLARfc3Rpa2dATPPola2Cdk2Pold2Rfc4ATPADPDbf4Prim2ADPdGTPUbcOrc6lGmnnPRIM1Mcm2Mcm3RPA4Mcm10Pold3Mcm5Orc2lRfc1dUTPPoleCdt1CTPUTPATPCdc7Pold4Cdc45lOrc3lGTPATPMcm4dCTPPole2Rfc2PcnaMcm6Uba52Orc4lRpa1Rpa3ATPMcm7


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 70% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  3. Cimbora DM, Groudine M; ''The control of mammalian DNA replication: a brief history of space and timing.''; Cell, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116954view10:07, 16 May 2021EweitzModified title
71773view20:30, 17 October 2013MaintBotAutomated update of data sources
69342view18:51, 8 July 2013MaintBotUpdated to 2013 gpml schema
67163view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41654view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
35215view15:47, 11 February 2010Thomasadded literature
35214view15:46, 11 February 2010ThomasModified description
35200view15:39, 11 February 2010ThomasModified description
34052view19:03, 9 December 2009MaintBotAutomatic update of empty xrefs
32445view17:19, 15 August 2009MaintBotFixed text labels
32119view13:51, 14 August 2009MaintBotFixed group labels
31462view21:16, 13 August 2009MaintBotFixed text labels
30930view00:37, 30 July 2009MaintBotConverted from Homo sapiens
21698view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:DNA replication Reactome]] moved to [[Pathway:WP484]]: Moved to stable identifier
10211view18:29, 16 January 2008MaintBotSpecify description
10047view15:05, 11 January 2008MaintBot
7994view13:46, 7 January 2008MaintBot[[Pathway:Rat:DNA replication Reactome]] moved to [[Pathway:Rattus norvegicus:DNA replication Reactome]]: Renaming species
7211view12:33, 4 November 2007MaintBotAdded categories to GPML
19419view22:19, 22 May 2007D.Korengpml file for [[Rat:DNA_replication_Reactome]]
6530view22:19, 22 May 2007Kdahlquistgpml file for [[Rat:DNA_replication_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ATPMetabolite
CTPMetabolite
Cdc45lGeneProduct287961 (Entrez Gene)
Cdc6GeneProduct360621 (Entrez Gene)
Cdc7GeneProduct360908 (Entrez Gene)
Cdk2GeneProduct362817 (Entrez Gene)
Cdt1GeneProduct292071 (Entrez Gene)
Dbf4GeneProduct312046 (Entrez Gene)
GTPMetabolite
GmnnGeneProduct291137 (Entrez Gene)
Mcm10GeneProduct307126 (Entrez Gene)
Mcm2GeneProduct312538 (Entrez Gene)
Mcm3GeneProduct316273 (Entrez Gene)
Mcm4GeneProduct29728 (Entrez Gene)
Mcm5GeneProduct291885 (Entrez Gene)
Mcm6GeneProduct29685 (Entrez Gene)
Mcm7GeneProduct288532 (Entrez Gene)
Orc1lGeneProduct313479 (Entrez Gene)
Orc2lGeneProduct301430 (Entrez Gene)
Orc3lGeneProduct313138 (Entrez Gene)
Orc4lGeneProduct295596 (Entrez Gene)
Orc5lGeneProduct362304 (Entrez Gene)
Orc6lGeneProduct291927 (Entrez Gene)
POLAGeneProduct
PRIM1GeneProduct246327 (Entrez Gene)
PcnaGeneProduct25737 (Entrez Gene)
Pola2GeneProduct85242 (Entrez Gene)
Pold1GeneProduct59294 (Entrez Gene)
Pold2GeneProduct289758 (Entrez Gene)
Pold3GeneProduct293144 (Entrez Gene)
Pold4GeneProduct361698 (Entrez Gene)
Pole2GeneProduct299112 (Entrez Gene)
PoleGeneProduct304573 (Entrez Gene)
Prim2GeneProduct301323 (Entrez Gene)
RPA4GeneProduct
Rfc1GeneProduct89809 (Entrez Gene)
Rfc2GeneProduct116468 (Entrez Gene)
Rfc3GeneProduct288414 (Entrez Gene)
Rfc4GeneProduct288003 (Entrez Gene)
Rfc5GeneProduct304528 (Entrez Gene)
Rpa1GeneProduct287524 (Entrez Gene)
Rpa2GeneProduct59102 (Entrez Gene)
Rpa3GeneProduct296883 (Entrez Gene)
UTPMetabolite
Uba52GeneProduct64156 (Entrez Gene)
UbcGeneProduct50522 (Entrez Gene)
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite

Annotated Interactions

No annotated interactions
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