Platelet homeostasis (Homo sapiens)

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16-82530228222916, 1720, 214, 59, 102326, 2711, 12182413-15193132529cytosolplatelet dense tubular network lumenendoplasmic reticulum lumenGDPFGRMAP kinase p38 alphaGTPpyrophosphateATPPlasma membrane Ca2+ ATPasesCyclic GMP-dependent protein kinases (PKGs)ATPPP2ACalciumLDL:p-ApoER2:FGRGTPApoER2CRAC channelH+3',5'-Cyclic GMPPECAM-1:SHP-2 complexSHP1IRAG:IP3 receptor type 1sodium ionSHP2Cationsphosphorylated PECAM-1ADPATPG-protein alpha (s):GTPG-protein beta-gamma complexsodium ionNitric oxide synthaseNitric oxideSarco/endoplasmic reticulum Ca2+ ATPases (SERCAs)Guanylate cyclase:NOLDLL-CitrullineProstacyclin:prostacyclin receptor:G-protein Gs (active)GMPATPProstacyclinNADPHNa+/Ca2+ exchanger proteinsOrai1 dimerDAG-activated TRPC3/6/7Heterotrimeric G-protein Gs (inactive)PECAM-1:SHP-1 complexPhosphorylated IRAG:IP3 receptor type 1LDL:ApoER2P2X purinoceptor 1BK channel, phophorylatedCationsIP receptor:ProstacyclinPhospho-MAP kinase p38 alphacPLA2NADP+IP3 receptor bound to IP3 and Ca++phospho-cPLA2IP receptorStromal interaction molecule 1Activated cGMP-dependent protein kinase (PKGs)P2X1 purinoreceptor bound to ATPcGMP phosphodiesterasesL-ArginineOxygenProstacyclin:prostacyclin receptor:Gs (inactive)CalciumBK channelH+p-PECAM:PP2AGuanylate cyclase, solubleCalcium


Description

Cyclooxygenase-2 (COX-2) and endothelial nitric oxide synthase (eNOS) are primarily expressed in endothelial cells and are considered as important regulators of vascular function. Under normal conditions, laminar flow induces vascular endothelial COX-2 expression and synthesis of Prostacyclin (PGI2) which in turn stimulates endothelial Nitric Oxide Synthase (eNOS) activity. PGI2 and NO both oppose platelet activation and aggregation, as does the CD39 ecto-ADPase (not annotated here) which decreases platelet activation and recruitment by metabolizing platelet-released ADP.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
114759view16:24, 25 January 2021ReactomeTeamReactome version 75
113203view11:27, 2 November 2020ReactomeTeamReactome version 74
112428view15:37, 9 October 2020ReactomeTeamReactome version 73
101332view11:22, 1 November 2018ReactomeTeamreactome version 66
100870view20:55, 31 October 2018ReactomeTeamreactome version 65
100411view19:28, 31 October 2018ReactomeTeamreactome version 64
99960view16:13, 31 October 2018ReactomeTeamreactome version 63
99515view14:46, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99157view12:41, 31 October 2018ReactomeTeamreactome version 62
93869view13:42, 16 August 2017ReactomeTeamreactome version 61
93435view11:23, 9 August 2017ReactomeTeamreactome version 61
88100view09:31, 26 July 2016RyanmillerOntology Term : 'homeostasis pathway' added !
88099view09:30, 26 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
86527view09:20, 11 July 2016ReactomeTeamreactome version 56
83192view10:19, 18 November 2015ReactomeTeamVersion54
81566view13:06, 21 August 2015ReactomeTeamVersion53
77031view08:33, 17 July 2014ReactomeTeamFixed remaining interactions
76736view12:09, 16 July 2014ReactomeTeamFixed remaining interactions
76061view10:12, 11 June 2014ReactomeTeamRe-fixing comment source
75771view11:28, 10 June 2014ReactomeTeamReactome 48 Update
75121view14:07, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74768view08:51, 30 April 2014ReactomeTeamReactome46
72011view12:23, 24 October 2013EgonwMore Uniprot-TrEMBL data source fixes.
72010view12:21, 24 October 2013EgonwFixed the Uniprot-TrEMBL data source.
42101view21:57, 4 March 2011MaintBotAutomatic update
39911view05:56, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3',5'-Cyclic GMP Metabolite16356 (ChEBI)
ADP Metabolite16761 (ChEBI)
ATP Metabolite15422 (ChEBI)
Activated cGMP-

dependent protein kinase (PKGs)

ComplexREACT_24034 (Reactome)
ApoER2 ProteinQ14114 (UniProt)
BK channel ComplexREACT_24118 (Reactome) BK channels (also called Maxi-K or slo1) are potassium ion channels. They are activated by changes in membrane electrical potential and increases in intracellular [Ca2+]. Opening of BK channels results in cell membrane hyperpolarization. BK channels are tetramers of dimer subunits formed by the association of a pore-forming alpha subunit, always derived from the same gene KCNMA1, and a modulatory beta subunit, dervied from one of 4 human genes KCNMB11-4. Intracellular calcium regulates the physical association between the alpha and beta subunits.
BK channel,

phophorylated

ComplexREACT_24816 (Reactome) BK channels (also called Maxi-K or slo1) are potassium ion channels. They are activated by changes in membrane electrical potential and increases in intracellular [Ca2+]. Opening of BK channels results in cell membrane hyperpolarization. BK channels are tetramers of dimer subunits formed by the association of a pore-forming alpha subunit, always derived from the same gene KCNMA1, and a modulatory beta subunit, dervied from one of 4 human genes KCNMB11-4. Intracellular calcium regulates the physical association between the alpha and beta subunits.
CRAC channel ComplexREACT_24443 (Reactome)
Calcium Metabolite29108 (ChEBI)
Cations MetaboliteREACT_24030 (Reactome)
Cations MetaboliteREACT_24868 (Reactome)
Cyclic GMP-dependent

protein kinases (PKGs)

ProteinREACT_24186 (Reactome)
DAG-activated

TRPC3/6/7

ComplexREACT_24061 (Reactome)
FGR ProteinP09769 (UniProt)
G-protein alpha

(s):GTP

ComplexREACT_5470 (Reactome)
G-protein beta-

gamma complex

ComplexREACT_15674 (Reactome)
GDP Metabolite17552 (ChEBI)
GMP Metabolite17345 (ChEBI)
GTP Metabolite15996 (ChEBI)
Guanylate cyclase,

soluble

ComplexREACT_24123 (Reactome)
Guanylate cyclase:NO ComplexREACT_24768 (Reactome)
H+ Metabolite15378 (ChEBI)
Heterotrimeric G-

protein Gs (inactive)

ComplexREACT_18222 (Reactome)
IP receptor ProteinP43119 (Uniprot-TrEMBL)
IP receptor:

Prostacyclin

ComplexREACT_17421 (Reactome)
IP3 receptor bound

to IP3 and Ca++

ComplexREACT_4346 (Reactome)
IRAG:IP3 receptor

type 1

ComplexREACT_24389 (Reactome)
L-Arginine Metabolite16467 (ChEBI)
L-Citrulline Metabolite16349 (ChEBI)
LDL ComplexREACT_7774 (Reactome) LDL (low density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipids. LDL complexes contain single molecules of apoB-100, but their content of lipids is variable (Chapman et al. 1988; Mateu et al. 1972; Tardieu et al. 1976). High levels of LDL in the blood are strongly correlated with increased risk of atherosclerosis, and recent studies have raised the possibility that this risk is further increased in individuals whose blood LDL population is enriched in high-density (low lipid content) LDL complexes (Rizzo and Berneis 2006). The LDL complex annotated here contains an average lipid composition.
LDL:ApoER2 ComplexREACT_24595 (Reactome)
LDL:p-ApoER2:FGR ComplexREACT_24077 (Reactome)
MAP kinase p38 alpha ProteinQ16539 (UniProt)
NADP+ Metabolite18009 (ChEBI)
NADPH Metabolite16474 (ChEBI)
Na+/Ca2+

exchanger proteins

ProteinREACT_20277 (Reactome)
Nitric oxide Metabolite16480 (ChEBI)
Nitric oxide synthase ProteinREACT_24417 (Reactome)
Orai1

dimer

ComplexREACT_24301 (Reactome)
Oxygen Metabolite15379 (ChEBI)
P2X purinoceptor

1

ProteinP51575 (UniProt)
P2X1

purinoreceptor bound to ATP

ComplexREACT_3044 (Reactome) P2X1 protein readily forms stable trimers and hexamers, suggesting that the intact receptor is a multimer of three or six subunits in heterologous expression systems. However,assembly in native cells may be influenced significantly by associated proteins that are not present in heterologous expression systems.
PECAM-1:SHP-1

complex

ComplexREACT_13228 (Reactome)
PECAM-1:SHP-2

complex

ComplexREACT_13041 (Reactome)
PP2A ComplexREACT_10628 (Reactome)
Phospho-MAP kinase

p38 alpha

ProteinQ16539 (UniProt)
Phosphorylated

IRAG:IP3 receptor type 1

ComplexREACT_24181 (Reactome)
Plasma membrane

Ca2+ ATPases

ProteinREACT_24662 (Reactome)
Prostacyclin Metabolite15552 (ChEBI)
Prostacyclin:

prostacyclin receptor:G-protein Gs (active)

ComplexREACT_24753 (Reactome)
Prostacyclin:

prostacyclin receptor:Gs (inactive)

ComplexREACT_24060 (Reactome)
SHP1 ProteinP29350 (UniProt)
SHP2 ProteinQ06124 (UniProt)
Sarco/endoplasmic

reticulum Ca2+ ATPases (SERCAs)

ProteinREACT_24286 (Reactome)
Stromal interaction

molecule 1

ProteinQ13586 (Uniprot-TrEMBL)
cGMP

phosphodiesterases

ProteinREACT_24101 (Reactome)
cPLA2 ProteinP47712 (UniProt)
p-PECAM:PP2A ComplexREACT_24470 (Reactome)
phospho-cPLA2 ProteinP47712 (UniProt)
phosphorylated

PECAM-1

ProteinP16284 (UniProt)
pyrophosphate Metabolite29888 (ChEBI)
sodium ion Metabolite29101 (ChEBI)

Annotated Interactions

No annotated interactions

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