Actin cytoskeleton regulation (Bos taurus)

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Growth Factor (GF)Focal complexassemblyGFActin polymerizationstress fiberActin polymerizationGene ExpressionStabilizationof actinGPCRChemotatic factorChemotactic factor?LamellipodiaActomyosinassembly contractionFilipodiaRASGPCR-pPI3KPI3KRTKFocal adhesionassemblystress fiber+pRASActin polymerizationRTKFGF5PAK1PIP2DOCK1INS2SSH1PDGFRBCHRM1CHRM3FGFR3PIP5K1CMAP2K2ITGA1RRAS2LPSPAK7EGFFGF8SSH3FGF7PIK3C2ASOS2FGF22AcetylcholineCSKCFL2VAV1LOC442775PIK3R2MAPK6PIK3R4FGF17PDGFBAdherens junctionpathwayFGF13PIK3CBWASF2BRAFFocal AdhesionpathwayPIK3C3FGF20GSNFGFR1LOC100336547RAF1PIK3CAGIT1RASSF7FGF16MYL1APCACTBFGFR4PDGFABradykininARHGEF6Focal AdhesionpathwayPXNACTBRRASFGF3GNA13FGF2PIK3R3BDKRB2PAK6FN1GNA12PDGFRAMAPK4VCLINS1FGF10PIP5KL1PAK4RHOAACTN1ARPC5MYH10PIK3R1FGFR2PFN1MSNMAPK SignalingpathwayARPC5FGF14FGF23FGD1CYFIP2FGF6MRASACTG1PIK3R5ACTBPIK3C2BF2RCHRM5KRASFGF4F2ARHGEF4FGF12MAP2K1ABI2PIP4K2ARAC3PPP1R12AIQGAP1PAK3CHRM4FGF11Apc2ENAHLIMK1GNG12TMSB4XACTG1CRKEGFRMYL3MAPK1ARHGEF1DIAP3CFL1BDKRB1PIK3CGNRASACTG1PIP4K2BPIP3BRK1PIP4K2APFN1RAC2RAC1CDC42ARHGAP35MYLKPIP5K1BFGF9NCKAP1EZRCD14PIK3C2GPAK2ARHGEF6ROCK1SLC9A1PTK2RDXMOSFGF1ARHGEF7PIP5K1AMAPK3VIL1BAIAP2DIAP1FGF18SOS1FGF15WASF1PIP4K2CSSH2VCLPIK3CDCHRM2FGF21RAC1P4BCAR1BAIAP2PIP2ROCK2


Description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP51(r45278) with a 90% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
120933view09:05, 1 February 2022EgonwMade four pathways clickable
117595view11:36, 21 May 2021EweitzModified title
80894view15:30, 30 June 2015Mkutmonhomology conversion
72126view07:48, 25 October 2013Mkutmonadded datasource for pathway datanodes
71429view19:03, 17 October 2013MaintBotAutomated update of data sources
63458view17:18, 10 May 2013MaintBotUpdated to 2013 gpml schema
48126view05:45, 9 May 2012MaintBotUpdating from human to fix xref duplication
40593view19:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
33830view00:28, 9 December 2009MaintBotAutomatic update of empty xrefs
32520view12:56, 17 August 2009MaintBotFixed text labels
32207view12:41, 15 August 2009MaintBotFixed text labels
31695view11:48, 14 August 2009MaintBotFixed group labels
31218view19:40, 13 August 2009MaintBotFixed text labels
30631view22:26, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABI2GeneProduct537711 (Entrez Gene)
ACTBGeneProduct280979 (Entrez Gene)
ACTG1GeneProduct404122 (Entrez Gene)
ACTN1GeneProduct524770 (Entrez Gene)
APCGeneProduct533233 (Entrez Gene)
ARHGAP35GeneProduct540310 (Entrez Gene)
ARHGEF1GeneProduct513377 (Entrez Gene)
ARHGEF4GeneProduct505852 (Entrez Gene)
ARHGEF6GeneProduct533823 (Entrez Gene)
ARHGEF7GeneProduct524352 (Entrez Gene)
ARPC5GeneProduct614345 (Entrez Gene)
AcetylcholineMetabolite51-84-3 (CAS)
Adherens junction pathwayPathway
Apc2GeneProduct
BAIAP2GeneProduct507837 (Entrez Gene)
BCAR1GeneProduct527550 (Entrez Gene)
BDKRB1GeneProduct532119 (Entrez Gene)
BDKRB2GeneProduct538896 (Entrez Gene)
BRAFGeneProduct536051 (Entrez Gene)
BRK1GeneProduct540092 (Entrez Gene)
BradykininMetabolite58-82-2 (CAS)
CD14GeneProduct281048 (Entrez Gene)
CDC42GeneProduct532712 (Entrez Gene)
CFL1GeneProduct534553 (Entrez Gene)
CFL2GeneProduct539332 (Entrez Gene)
CHRM1GeneProduct281684 (Entrez Gene)
CHRM2GeneProduct522170 (Entrez Gene)
CHRM3GeneProduct281685 (Entrez Gene)
CHRM4GeneProduct512928 (Entrez Gene)
CHRM5GeneProduct281686 (Entrez Gene)
CRKGeneProduct512841 (Entrez Gene)
CSKGeneProduct509246 (Entrez Gene)
CYFIP2GeneProduct518833 (Entrez Gene)
DIAP1GeneProduct
DIAP3GeneProduct
DOCK1GeneProduct537203 (Entrez Gene)
EGFGeneProduct530315 (Entrez Gene)
EGFRGeneProduct407217 (Entrez Gene)
ENAHGeneProduct513095 (Entrez Gene)
EZRGeneProduct281574 (Entrez Gene)
F2GeneProduct280685 (Entrez Gene)
F2RGeneProduct526585 (Entrez Gene)
FGD1GeneProduct100124501 (Entrez Gene)
FGF10GeneProduct326285 (Entrez Gene)
FGF11GeneProduct613386 (Entrez Gene)
FGF12GeneProduct
FGF1GeneProduct281160 (Entrez Gene)
FGF13GeneProduct506924 (Entrez Gene)
FGF14GeneProduct
FGF15GeneProduct
FGF16GeneProduct540758 (Entrez Gene)
FGF17GeneProduct
FGF18GeneProduct533929 (Entrez Gene)
FGF20GeneProduct539083 (Entrez Gene)
FGF21GeneProduct785576 (Entrez Gene)
FGF22GeneProduct519657 (Entrez Gene)
FGF2GeneProduct281161 (Entrez Gene)
FGF23GeneProduct530239 (Entrez Gene)
FGF3GeneProduct618481 (Entrez Gene)
FGF4GeneProduct618474 (Entrez Gene)
FGF5GeneProduct536771 (Entrez Gene)
FGF6GeneProduct540317 (Entrez Gene)
FGF7GeneProduct616885 (Entrez Gene)
FGF8GeneProduct326284 (Entrez Gene)
FGF9GeneProduct613731 (Entrez Gene)
FGFR1GeneProduct281768 (Entrez Gene)
FGFR2GeneProduct404193 (Entrez Gene)
FGFR3GeneProduct281769 (Entrez Gene)
FGFR4GeneProduct317696 (Entrez Gene)
FN1GeneProduct
Focal Adhesion pathwayPathwayWP306 (WikiPathways)
GIT1GeneProduct515088 (Entrez Gene)
GNA12GeneProduct515159 (Entrez Gene)
GNA13GeneProduct505611 (Entrez Gene)
GNG12GeneProduct286850 (Entrez Gene)
GSNGeneProduct535077 (Entrez Gene)
INS1GeneProduct
INS2GeneProduct
IQGAP1GeneProduct532715 (Entrez Gene)
ITGA1GeneProduct535951 (Entrez Gene)
KRASGeneProduct541140 (Entrez Gene)
LIMK1GeneProduct535225 (Entrez Gene)
LOC100336547GeneProduct100336547 (Entrez Gene)
LOC442775GeneProduct
LPSMetaboliteC00338 (KEGG Compound)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAPK Signaling pathwayPathwayWP382 (WikiPathways)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MAPK4GeneProduct
MAPK6GeneProduct538094 (Entrez Gene)
MOSGeneProduct444869 (Entrez Gene)
MRASGeneProduct540803 (Entrez Gene)
MSNGeneProduct540426 (Entrez Gene)
MYH10GeneProduct317655 (Entrez Gene)
MYL1GeneProduct317657 (Entrez Gene)
MYL3GeneProduct618352 (Entrez Gene)
MYLKGeneProduct
NCKAP1GeneProduct100300817 (Entrez Gene)
NRASGeneProduct506322 (Entrez Gene)
PAK1GeneProduct533729 (Entrez Gene)
PAK2GeneProduct513673 (Entrez Gene)
PAK3GeneProduct534526 (Entrez Gene)
PAK4GeneProduct539742 (Entrez Gene)
PAK6GeneProduct539224 (Entrez Gene)
PAK7GeneProduct513432 (Entrez Gene)
PDGFAGeneProduct505908 (Entrez Gene)
PDGFBGeneProduct540106 (Entrez Gene)
PDGFRAGeneProduct282301 (Entrez Gene)
PDGFRBGeneProduct527165 (Entrez Gene)
PFN1GeneProduct513895 (Entrez Gene)
PIK3C2AGeneProduct537790 (Entrez Gene)
PIK3C2BGeneProduct537396 (Entrez Gene)
PIK3C2GGeneProduct513301 (Entrez Gene)
PIK3C3GeneProduct534815 (Entrez Gene)
PIK3CAGeneProduct282306 (Entrez Gene)
PIK3CBGeneProduct517948 (Entrez Gene)
PIK3CDGeneProduct504531 (Entrez Gene)
PIK3CGGeneProduct530001 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PIK3R2GeneProduct282308 (Entrez Gene)
PIK3R3GeneProduct286865 (Entrez Gene)
PIK3R4GeneProduct507414 (Entrez Gene)
PIK3R5GeneProduct614838 (Entrez Gene)
PIP2MetaboliteC04637 (KEGG Compound)
PIP3MetaboliteC05981 (KEGG Compound)
PIP4K2AGeneProduct533289 (Entrez Gene)
PIP4K2BGeneProduct539211 (Entrez Gene)
PIP4K2CGeneProduct540005 (Entrez Gene)
PIP5K1AGeneProduct100125224 (Entrez Gene)
PIP5K1BGeneProduct537654 (Entrez Gene)
PIP5K1CGeneProduct508819 (Entrez Gene)
PIP5KL1GeneProduct523736 (Entrez Gene)
PPP1R12AGeneProduct
PTK2GeneProduct506270 (Entrez Gene)
PXNGeneProduct517456 (Entrez Gene)
RAC1GeneProduct281440 (Entrez Gene)
RAC1P4GeneProduct
RAC2GeneProduct327671 (Entrez Gene)
RAC3GeneProduct619066 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RASSF7GeneProduct538490 (Entrez Gene)
RDXGeneProduct517111 (Entrez Gene)
RHOAGeneProduct338049 (Entrez Gene)
ROCK1GeneProduct785911 (Entrez Gene)
ROCK2GeneProduct282041 (Entrez Gene)
RRAS2GeneProduct519269 (Entrez Gene)
RRASGeneProduct616503 (Entrez Gene)
SLC9A1GeneProduct317654 (Entrez Gene)
SOS1GeneProduct537682 (Entrez Gene)
SOS2GeneProduct100138040 (Entrez Gene)
SSH1GeneProduct538233 (Entrez Gene)
SSH2GeneProduct512652 (Entrez Gene)
SSH3GeneProduct514643 (Entrez Gene)
TMSB4XGeneProduct
VAV1GeneProduct617345 (Entrez Gene)
VCLGeneProduct783645 (Entrez Gene)
VIL1GeneProduct281573 (Entrez Gene)
WASF1GeneProduct531488 (Entrez Gene)
WASF2GeneProduct504482 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1062"
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