DON mycotoxin biosynthesis (Gibberella zeae)

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Regulators and associated factorsTri7 BTri1Tri3TrichodieneCatalystTri11CatalystCatalystFarnesyl pyrophosphate2-HydroxytrichodieneCatalystCatalystTri4Tri101Tri5CatalystProductCatalystTri8Tri13 B4,15-diANIVCatalystCatalyst12,13-Epoxy-9,10-trichoene-2-ol2, 4, 5IsotrichotriolIsotrichodiolGeneProductGeneProductTrichotriolIsotrichodermolIsotrichodermin15-decalonectrinCalonectrinTriacetoxyscirpenol7,8-Hydroxy-triacetoxyscirpenol3,15-Diacetylnivalenol8-Hydroxycalonectrin7,8-Dihydroxycalonectrin3,15-Diacetyldeoxynivalenol15-ADONDeoxynivlenolDONNivalenolTri8Tri7 ATri13 ATri6Tri10Tri12Tri12


Description

Gibberella zeae (Fusarium graminearum) is a fungal pathogen of major staple food crops including wheat, maize and rice. The fungus produces a range of mycotoxins including the dexoynivalenol (DON) trichothecene mycotoxin. DON contamination of food crops is a major thread to human and animal health. In wheat, but not in maize, DON was proven to be a virulence factor. Also see Wikipedia article on Vomitoxin.

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Ontology Terms

 

Bibliography

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  1. Desjardins AE, Bai G, Plattner RD, Proctor RH; ''Analysis of aberrant virulence of Gibberella zeae following transformation-mediated complementation of a trichothecene-deficient (Tri5) mutant.''; Microbiology, 2000 PubMed Europe PMC Scholia
  2. Proctor RH, Hohn TM, McCormick SP; ''Restoration of wild-type virulence to Tri5 disruption mutants of Gibberella zeae via gene reversion and mutant complementation.''; Microbiology, 1997 PubMed Europe PMC Scholia
  3. Proctor RH, Hohn TM, McCormick SP; ''Restoration of wild-type virulence to Tri5 disruption mutants of Gibberella zeae via gene reversion and mutant complementation.''; Microbiology, 1997 PubMed Europe PMC Scholia
  4. Proctor RH, Hohn TM, McCormick SP; ''Reduced virulence of Gibberella zeae caused by disruption of a trichothecene toxin biosynthetic gene.''; Mol Plant Microbe Interact, 1995 PubMed Europe PMC Scholia
  5. ''''; , PubMed Europe PMC Scholia
  6. Desjardins AE, Bai G, Plattner RD, Proctor RH; ''Analysis of aberrant virulence of Gibberella zeae following transformation-mediated complementation of a trichothecene-deficient (Tri5) mutant.''; Microbiology, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
106133view12:03, 16 August 2019MaintBotHMDB identifier normalization
84222view13:15, 31 January 2016Martin UrbanModified title
79762view07:05, 10 April 2015EgonwFixed a typo in the case-sensitive "Chemspider" data source name.
74449view05:34, 21 April 2014EgonwFixed PubMed IDs.
72150view10:23, 25 October 2013Mkutmonadded datasource for Tri13 B
71932view20:57, 23 October 2013EgonwAdded missing metabolite identifiers.
70241view21:29, 15 July 2013MaintBotupdated to 2013 schema
67168view10:15, 26 June 2013Christine ChichesterOntology Term : 'deoxynivalenol biosynthetic pathway' added !
52866view19:42, 23 October 2012MaintBotModified categories
52865view19:38, 23 October 2012MaintBotModified description
50698view14:33, 19 August 2012Martin UrbanPeriodical save, work in progress
50697view14:13, 19 August 2012Martin UrbanPeriodical save, work in progress
50696view14:03, 19 August 2012Martin UrbanPeriodical save, work in progress
50581view14:19, 17 August 2012Martin UrbanModified title
50492view17:42, 16 August 2012Martin Urbanupdate02
50491view17:41, 16 August 2012Martin UrbanPeriodical save, work in progress
50490view17:31, 16 August 2012Martin UrbanPeriodical save, work in progress
50489view17:20, 16 August 2012Martin UrbanPeriodical save, work in progress
50488view16:32, 16 August 2012Martin Urbanupdate01
50487view16:28, 16 August 2012Martin UrbanPeriodical save, work in progress
50486view16:18, 16 August 2012Martin UrbanPeriodical save, work in progress
50485view16:08, 16 August 2012Martin UrbanPeriodical save, work in progress
50484view15:57, 16 August 2012Martin UrbanPeriodical save, work in progress
50483view15:47, 16 August 2012Martin UrbanPeriodical save, work in progress
50482view15:36, 16 August 2012Martin UrbanPeriodical save, work in progress
50481view15:26, 16 August 2012Martin UrbanPeriodical save, work in progress
50480view15:16, 16 August 2012Martin UrbanPeriodical save, work in progress
50479view15:05, 16 August 2012Martin UrbanPeriodical save, work in progress
50478view14:54, 16 August 2012Martin UrbanPeriodical save, work in progress
50477view14:44, 16 August 2012Martin UrbanPeriodical save, work in progress
50476view14:34, 16 August 2012Martin UrbanPeriodical save, work in progress
50475view14:06, 16 August 2012Martin UrbanModified description
50474view13:58, 16 August 2012Martin UrbanOntology Term : 'disease pathway' added !
49855view22:14, 28 July 2012MaintBotadded reaction
49852view12:46, 28 July 2012Martin UrbanNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
12,13-Epoxy-9,10-trichoene-2-olMetabolite
15-ADONMetabolite
15-decalonectrinMetabolite
2-HydroxytrichodieneMetabolite
3,15-DiacetyldeoxynivalenolMetabolite113028 (Chemspider)
3,15-DiacetylnivalenolMetabolite
4,15-diANIVMetabolite
7,8-DihydroxycalonectrinMetabolite484624 (Chemspider)
7,8-Hydroxy-triacetoxyscirpenolMetabolite
8-HydroxycalonectrinMetabolite469583 (Chemspider)
CalonectrinMetabolite9648393 (Chemspider)
CatalystGeneProduct
Deoxynivlenol DONMetabolite
Farnesyl pyrophosphateMetaboliteHMDB00961 (HMDB)
GeneProductGeneProduct
IsotrichoderminMetabolite110985 (ChemSpider)
IsotrichodermolMetabolite165671 (Chemspider)
IsotrichodiolMetabolite
IsotrichotriolMetabolite
NivalenolMetabolite29515 (Chemspider)
ProductMetabolite
Tri101GeneProductFGSG_07896 (Ensembl) TRI101 encodes trichothecene 3-O-acetyltransferase (a self-protection factor)
Tri10GeneProductFGSG_03538 (Ensembl) regulatory prtoein with unknown function
Tri11GeneProductFGSG_03540 (Ensembl)
Tri12GeneProductFGSG_11025 (Ensembl) Zinc finger transcription factor
Tri12GeneProductFGSG_12013 (Ensembl) Membrane-bound efflux pump
Tri13 AGeneProductFGSG_03860 (Ensembl)
Tri13 BGeneProductFGSG_10629 (Ensembl)
Tri1GeneProductFGSG_00071 (Ensembl)
Tri3GeneProductFGSG_03534 (Ensembl) trichothecene 15-O-acetyltransferase
Tri4GeneProductFGSG_03535 (Ensembl) cytochrome P450
Tri5GeneProductFGSG_03537 (Ensembl)
Tri6GeneProductFGSG_16251 (Ensembl) trichothecene biosynthesis positive Zinc finger transcription factor
Tri7 AGeneProductFGSG_02115 (Ensembl)
Tri7 BGeneProductFGSG_03533 (Ensembl)
Tri8GeneProductFGSG_03532 (Ensembl)
TriacetoxyscirpenolMetabolite65844 (Chemspider)
TrichodieneMetaboliteCHEBI:15861 (ChEBI)
TrichotriolMetabolite10204911 (Chemspider)

Annotated Interactions

No annotated interactions

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