Limb development (Mus musculus)

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Telomeric gene desert4, 59Hoxd genesTbx genesGCRFgf genesHoxd10ShhlacZHoxd11Hoxd12Hoxd13Fgf10Tbx4Tbx5Island 2Island 4CsBCscCNS 65CNS 3931, 24, 5GeneProductFgf8Fgf46-86-8


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Bibliography

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  1. Tarchini B, Duboule D, Kmita M; ''Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity.''; Nature, 2006 PubMed Europe PMC Scholia
  2. Duboc V, Logan MP; ''Regulation of limb bud initiation and limb-type morphology.''; Dev Dyn, 2011 PubMed Europe PMC Scholia
  3. Andrey G, Montavon T, Mascrez B, Gonzalez F, Noordermeer D, Leleu M, Trono D, Spitz F, Duboule D; ''A switch between topological domains underlies HoxD genes collinearity in mouse limbs.''; Science, 2013 PubMed Europe PMC Scholia
  4. Mao J, McGlinn E, Huang P, Tabin CJ, McMahon AP; ''Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb.''; Dev Cell, 2009 PubMed Europe PMC Scholia
  5. Kawakami Y, Uchiyama Y, Rodriguez Esteban C, Inenaga T, Koyano-Nakagawa N, Kawakami H, Marti M, Kmita M, Monaghan-Nichols P, Nishinakamura R, Izpisua Belmonte JC; ''Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities.''; Development, 2009 PubMed Europe PMC Scholia
  6. Schneider I, Shubin NH; ''The origin of the tetrapod limb: from expeditions to enhancers.''; Trends Genet, 2013 PubMed Europe PMC Scholia
  7. Ioannides AS, Henderson DJ, Spitz L, Copp AJ; ''Role of Sonic hedgehog in the development of the trachea and oesophagus.''; J Pediatr Surg, 2003 PubMed Europe PMC Scholia
  8. Sheth R, Grégoire D, Dumouchel A, Scotti M, Pham JM, Nemec S, Bastida MF, Ros MA, Kmita M; ''Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth.''; Development, 2013 PubMed Europe PMC Scholia
  9. Montavon T, Soshnikova N, Mascrez B, Joye E, Thevenet L, Splinter E, de Laat W, Spitz F, Duboule D; ''A regulatory archipelago controls Hox genes transcription in digits.''; Cell, 2011 PubMed Europe PMC Scholia
  10. King M, Arnold JS, Shanske A, Morrow BE; ''T-genes and limb bud development.''; Am J Med Genet A, 2006 PubMed Europe PMC Scholia
  11. Nohno T, Noji S, Koyama E, Ohyama K, Myokai F, Kuroiwa A, Saito T, Taniguchi S; ''Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development.''; Cell, 1991 PubMed Europe PMC Scholia
  12. Galli A, Robay D, Osterwalder M, Bao X, Bénazet JD, Tariq M, Paro R, Mackem S, Zeller R; ''Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.''; PLoS Genet, 2010 PubMed Europe PMC Scholia
  13. Bouldin CM, Gritli-Linde A, Ahn S, Harfe BD; ''Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  14. Izpisúa-Belmonte JC, Tickle C, Dollé P, Wolpert L, Duboule D; ''Expression of the homeobox Hox-4 genes and the specification of position in chick wing development.''; Nature, 1991 PubMed Europe PMC Scholia
  15. Riddle RD, Johnson RL, Laufer E, Tabin C; ''Sonic hedgehog mediates the polarizing activity of the ZPA.''; Cell, 1993 PubMed Europe PMC Scholia
  16. Agarwal P, Wylie JN, Galceran J, Arkhitko O, Li C, Deng C, Grosschedl R, Bruneau BG; ''Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo.''; Development, 2003 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117911view10:32, 23 May 2021EweitzModified title
88674view15:39, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
72924view22:13, 15 December 2013KmastickPeriodical save, work in progress
72923view22:03, 15 December 2013KmastickPeriodical save, work in progress
72922view21:53, 15 December 2013KmastickPeriodical save, work in progress
72890view23:10, 13 December 2013KmastickPtch1, Grem1
72889view23:01, 13 December 2013KmastickPeriodical save, work in progress
72888view22:51, 13 December 2013KmastickPeriodical save, work in progress
72887view22:48, 13 December 2013KmastickSpecify description
72886view22:41, 13 December 2013KmastickPeriodical save, work in progress
72805view17:54, 9 December 2013Luke.fuhrmanfgf
72709view19:44, 2 December 2013Luke.fuhrmanfixes and enhancer shape
72708view19:38, 2 December 2013Luke.fuhrmanfixes
72707view19:35, 2 December 2013Luke.fuhrmanfixes
72699view18:22, 2 December 2013Luke.fuhrmanSpecify description
72695view14:00, 2 December 2013Josh.hanscomAdded part of Mao et al. 2009
72665view22:31, 30 November 2013Luke.fuhrmaneditting
72664view22:26, 30 November 2013Luke.fuhrmanPeriodical save, work in progress
72663view21:23, 30 November 2013Luke.fuhrmanAdding genes
72613view18:34, 26 November 2013Luke.fuhrmanAdding Gli3
72529view03:33, 19 November 2013Luke.fuhrmanPeriodical save, work in progress
72528view03:11, 19 November 2013Luke.fuhrmanPeriodical save, work in progress
72526view03:01, 19 November 2013Luke.fuhrmanPeriodical save, work in progress
72525view02:51, 19 November 2013Luke.fuhrmanPeriodical save, work in progress
72524view02:41, 19 November 2013Luke.fuhrmanPeriodical save, work in progress
72523view02:30, 19 November 2013Luke.fuhrmanPeriodical save, work in progress
72522view19:35, 18 November 2013Luke.fuhrmanAdd references
72521view19:35, 18 November 2013Luke.fuhrmanPeriodical save, work in progress
72520view18:58, 18 November 2013Luke.fuhrmanCommenting
72519view18:50, 18 November 2013Luke.fuhrmangrouping
72518view18:50, 18 November 2013Luke.fuhrmanPeriodical save, work in progress
72517view18:41, 18 November 2013Luke.fuhrmangrouping
72516view18:39, 18 November 2013Luke.fuhrmangrouping
72515view18:29, 18 November 2013Luke.fuhrmanPeriodical save, work in progress
72514view18:19, 18 November 2013Luke.fuhrmanPeriodical save, work in progress
72512view18:10, 18 November 2013Luke.fuhrmanlinked genes to MBI
72511view18:09, 18 November 2013Luke.fuhrmanPeriodical save, work in progress
72417view19:44, 13 November 2013Luke.fuhrmanadded genes
72416view19:38, 13 November 2013Luke.fuhrman
72415view19:30, 13 November 2013Luke.fuhrman
72414view19:22, 13 November 2013Luke.fuhrman
72405view18:36, 13 November 2013KmastickNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CNS 39GeneProductConserved Noncoding Sequence
CNS 65GeneProductConserved Noncoding Sequence
CsBGeneProduct
CscGeneProduct
Fgf genesGeneProduct
Fgf10GeneProductMGI:1099809 (MGI)
Fgf4GeneProductMGI:95518 (MGI)
Fgf8GeneProductMGI:99604 (MGI)
GCRGeneProduct
  • Late phase enhancers
  • Centromeric to Hoxd
GeneProductGeneProduct
Hoxd10GeneProductMGI:96202 (MGI)
Hoxd11GeneProductMGI:96203 (MGI)
Hoxd12GeneProductMGI:96204 (MGI)
Hoxd13GeneProductMGI:96205 (MGI)
Island 2GeneProduct
Island 4GeneProduct
ShhGeneProductMGI:98297 (MGI)
Tbx genesGeneProduct
Tbx4GeneProductMGI:102556 (MGI)
Tbx5GeneProductMGI:102541 (MGI)
Telomeric gene desertGeneProduct
  • Telomeric to Hoxd
  • Early phase enhancers
lacZGeneProduct

Annotated Interactions

No annotated interactions

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