Mitochondrial unfolded-protein response (Caenorhabditis elegans)

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244434344313433MitochondrionNucleusMitochondrial ChaperonesStress signalProteinConformational Stress(Unfolded Proteins)CLPP-1ParaquatATFS-1ethidium bromideeIF2-alpha(Y37E3.10)Unknownubl-5HAF-1DVE-1ATFS-1 FragmentsGSP-1HSP-6SPG-7hsp-6Unfolded ProteinsDVE-1translationProtein Fragmentshsp-60UBL-5GCN-2UBL-5HSP-60Lon Protease/C34B2.6PHB-231translationATFS-1ATFS-1HSP-60HSP-6eIF2-alpha(Y37E3.10)translation3DVE-1UBL-54


Description

hypothetical pathway based on a single review article. Input on alternatives is welcome

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Broadley SA, Hartl FU; ''Mitochondrial stress signaling: a pathway unfolds.''; Trends Cell Biol, 2008 PubMed Europe PMC Scholia
  2. Haynes CM, Ron D; ''The mitochondrial UPR - protecting organelle protein homeostasis.''; J Cell Sci, 2010 PubMed Europe PMC Scholia
  3. Pellegrino MW, Nargund AM, Haynes CM; ''Signaling the mitochondrial unfolded protein response.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
  4. Haynes CM, Petrova K, Benedetti C, Yang Y, Ron D; ''ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.''; Dev Cell, 2007 PubMed Europe PMC Scholia
  5. Yoneda T, Benedetti C, Urano F, Clark SG, Harding HP, Ron D; ''Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones.''; J Cell Sci, 2004 PubMed Europe PMC Scholia
  6. Baker BM, Nargund AM, Sun T, Haynes CM; ''Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2.''; PLoS Genet, 2012 PubMed Europe PMC Scholia
  7. Haynes CM, Yang Y, Blais SP, Neubert TA, Ron D; ''The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans.''; Mol Cell, 2010 PubMed Europe PMC Scholia
  8. Nargund AM, Pellegrino MW, Fiorese CJ, Baker BM, Haynes CM; ''Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.''; Science, 2012 PubMed Europe PMC Scholia
  9. Benedetti C, Haynes CM, Yang Y, Harding HP, Ron D; ''Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response.''; Genetics, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135406view17:36, 3 September 2024EgonwConverted to use Ensembl identifiers
117061view14:22, 16 May 2021EweitzModified title
111636view05:47, 1 September 2020EgonwModified title
107348view19:41, 26 September 2019Khansperstest
84475view19:37, 25 February 2016AlexanderPicoQuick edit to datanode annotation or property
78459view10:27, 7 January 2015MaintBotadded missing graphIds
74871view17:35, 5 May 2014CgroveChanged ATFS-1 to activating dnj-10 expression instead of inhibiting
74855view23:28, 1 May 2014CgroveCleaning up
74097view14:19, 29 March 2014EgonwReplaced an outdated HMDB identifier with the ChEBI one.
73816view01:17, 25 February 2014CgroveAdded CheBI identifier to ethidium bromide
73815view01:15, 25 February 2014CgroveConnected lines to Unfolded proteins and Protein Fragments data nodes instead of graphical cartoons
73814view01:14, 25 February 2014CgrovePeriodical save, work in progress
73487view22:59, 29 January 2014CgroveAdded "Gene Transcription" to legend
73486view22:42, 29 January 2014CgroveCleaning up legend
73485view22:39, 29 January 2014CgroveAdding legend text
73484view22:39, 29 January 2014CgrovePeriodical save, work in progress
73483view22:37, 29 January 2014CgroveEditing legend
73482view22:36, 29 January 2014CgroveAdding legend
73481view22:36, 29 January 2014CgroveCleaning up
73480view22:35, 29 January 2014CgroveCleaning up
73479view22:33, 29 January 2014CgroveCleaning up
73478view22:32, 29 January 2014CgroveCleaning up
73477view22:32, 29 January 2014CgroveCleaning up
73476view22:29, 29 January 2014CgroveCleaning up
73465view22:23, 29 January 2014CgroveCleaning up
73460view22:21, 29 January 2014CgroveCleaning up
73456view22:19, 29 January 2014CgroveTesting Save
73376view20:23, 24 January 2014CgroveCleaning up
73375view20:20, 24 January 2014CgroveCleaning up
73374view20:11, 24 January 2014CgroveCleaning up
73373view20:07, 24 January 2014CgroveCleaning up
73372view20:03, 24 January 2014CgrovePeriodical save, work in progress
73371view20:03, 24 January 2014CgroveMajor Cleaning Up
73370view19:53, 24 January 2014CgrovePeriodical save, work in progress
73369view19:43, 24 January 2014CgrovePeriodical save, work in progress
73368view19:33, 24 January 2014CgrovePeriodical save, work in progress
73147view21:18, 7 January 2014KyookOntology Term : 'PW:0000379' removed !
73146view21:18, 7 January 2014KyookOntology Term : 'stress response pathway' added !
73097view00:19, 3 January 2014KyookModified description
73096view00:19, 3 January 2014KyookModified title
73090view22:55, 2 January 2014CgroveModified description
73086view21:15, 2 January 2014Cgrovecleaning up
73040view00:55, 21 December 2013CgrovePeriodical save, work in progress
73039view00:45, 21 December 2013CgrovePeriodical save, work in progress
73038view00:33, 21 December 2013CgroveAdded references
73037view00:31, 21 December 2013CgroveCleaning up
73036view00:25, 21 December 2013CgrovePeriodical save, work in progress
73035view00:21, 21 December 2013CgroveAdded mitochondrial membrane protein transporters TIOMM-40 and TIMM-23 and reference
73034view00:15, 21 December 2013CgrovePeriodical save, work in progress
73033view00:10, 21 December 2013CgroveCleaning up

External references

DataNodes

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NameTypeDatabase referenceComment
ATFS-1 FragmentsMetaboliteCHEBI:16670 (ChEBI)
ATFS-1ProteinZC376.7 (WormBase)
CLPP-1ProteinZK970.2 (WormBase)
DVE-1GeneProductZK1193.5 (WormBase)
GCN-2ProteinY81G3A.3 (WormBase)
GSP-1GeneProductF29F11.6 (WormBase) GSP-1 is an eIF2-alpha phosphatase
HAF-1ProteinC30H6.6 (WormBase)
HSP-60ProteinY22D7AL.5 (WormBase)
HSP-6ProteinC37H5.8 (WormBase)
Lon Protease/ C34B2.6GeneProductC34B2.6 (WormBase)
PHB-2ProteinT24H7.1 (WormBase) PHB-2, along with PHB-1, forms the mitochondrial inner membrane Prohibitin complex which is implicated in assembly of components of the respiratory chain.
ParaquatMetaboliteHMDB33120 (HMDB)
Protein FragmentsMetaboliteCHEBI:16670 (ChEBI)
SPG-7ProteinY47G6A.10 (WormBase)
UBL-5ProteinF46F11.4 (WormBase)
Unfolded ProteinsProtein
Unknown
eIF2-alpha (Y37E3.10)ProteinY37E3.10 (WormBase)
ethidium bromideMetabolite
hsp-60GeneProductY22D7AL.5 (WormBase)
hsp-6GeneProductC37H5.8 (WormBase)
translationPathwayGO:0006412 (GeneOntology)
ubl-5GeneProductF46F11.4 (WormBase)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
UBL-5UBL-5ArrowWBInteraction000502398 (WormBase) Mitochondrial stress promotes accumulation of GFP-tagged UBL-5 in nuclei of transgenic worms.
hsp-60mim-stimulationWBInteraction000502398 (WormBase) RNAi knockdown of dve-1 prevents expression of a Phsp-60::GFP reporter transgene in response to the zc32 allele at 25 degrees Celsius, spg-7 RNAi, or exposure to Ethidium Bromide (all known to induce UPRmt and, hence, hsp-60 expression). dve-1 RNAi also disrupts induction of endogenous hsp-60 expression induced by spg-7 RNAi, as determined by QRT-PCR. ubl-5 RNAi results in diminished expression of an hsp-60::GFP reporter and endogenous hsp-60.
hsp-6mim-stimulationWBInteraction000520482 (WormBase) ubl-5 RNAi results in diminished expression of an hsp-6::GFP reporter and endogenous hsp-6. Also, mitochondrial stress promotes accumulation of GFP-tagged UBL-5 in nuclei of transgenic worms.
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