Eukaryotic translation termination (Homo sapiens)

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2, 3114, 5eRF3-GTPeRF180S RibosomemRNApeptidyl-tRNA Complex 80S RibosomemRNApeptidyl-tRNA with elongating peptide 40S ribosomal complex 60S ribosomal complex 60S ribosomal complex 80S RibosomemRNApeptidyl-tRNA with elongating peptide 60S ribosomal complex GTP bound eRF3 40S ribosomal complex cytosolGTP bound eRF3 eRF3-GDPeRF180S RibosomemRNAtRNA Complex 80S ribosome 40S ribosomal complex 80S RibosomemRNApeptidyl-tRNA with elongating peptide eRF3-GDPeRF180S RibosomemRNApeptidyl-tRNA Complex 80S ribosome GDP bound eRF3 40S ribosomal complex GDP bound eRF3 60S ribosomal complex 80S ribosome 80S ribosome RPS4X 5S rRNA RPL18 RPS25.8S rRNA RPL26 RPL26L1RPS10 RPL34 RPL26L1RPL36 RPS23 RPL27RPS3 5.8S rRNA RPSA RPL35 RPS25 RPL10 RPS3A RPS11 RPS12 RPL4 RPL12 18S rRNA RPL18A RPL39 RPS15 RPS27ARPS26 RPL23A RPL10A eRF3-GDPeRF180S RibosomemRNAtRNA ComplexRPL11 RPL23A RPS17 RPS21 RPS18 RPS15A RPS12 GDP RPL18 RPL8 RPS25 RPS19 RPL7 RPL35 RPL4 RPL3LRPS17 RPL12 RPL37A RPL32 RPS11 ETF1RPS9 RPL9 RPL29 RPL36A RPL26L1RPL7A RPS15 RPL6 RPL18 RPL30RPL41 80S RibosomemRNApeptidyl-tRNA with elongating peptideRPL23A RPS27ARPL12 RPS4Y1RPS16 18S rRNA RPL7A GSPT2 FAU RPS25 RPL7A RPS5RPS27 RPS27 GSPT2 GTP bound eRF3RPS12 RPL19 RPL36 RPS2RPS14 RPS24 5S rRNA RPS6 RPL27A RPS13RPS13GTP RPL7 RPL10A tRNA RPS28 RPS18 RPS4X RPL10 eRF3-GDPeRF180S RibosomemRNApeptidyl-tRNA ComplexRPL24 RPL3 RPL28 RPS20 RPL30RPL14 RPL8 5S rRNA RPS19 RPS19 RPL29 RPL18 RPL31 RPL7 5.8S rRNA RPL37 RPLP1RPL26L1RPS17 28S rRNA RPL37A 18S rRNA UBA52RPL38 RPS4X RPL7 RPL13RPS23 RPL39 ETF1 RPL14 RPL3LRPL29 RPL14 RPS23 RPL3 RPL34 RPS25 RPLP2 RPS13RPL5 RPLP2 RPS24 RPL11 RPLP1RPL13A RPS2RPL28 RPL19 RPS13RPL10 RPL22 RPL26 RPLP2 GDP RPL35 RPL41 RPS23 RPL23 RPS7 RPS14 RPS6 RPL13A RPSA RPL6 RPL4 RPL15RPL10A RPL22 RPL9 RPL21 RPL41 28S rRNA RPL23 RPL21 RPL36A RPS26 RPS2RPL37 RPLP0 RPL24 RPS7 GTP RPS28 RPL35 RPS24 RPS85.8S rRNA RPL27A RPS8RPL38 RPL11 RPS27ARPS3A RPL3LRPS26 RPL23 RPL39 RPL22 RPL23 RPS21 RPL36 RPL3LFAU RPL31 RPL36 UBA5228S rRNA RPL37A RPS15 RPL18A RPL26 RPS12 RPL19 eRF3-GTPeRF180S RibosomemRNApeptidyl-tRNA ComplexRPS15A RPL3 RPL17 RPL27RPL5 RPS4Y1RPL24 RPS15A RPL13RPL37 RPL5 RPL11 RPS20 RPL38 RPL13RPS6 RPS4Y1RPS9 RPLP0 RPL13RPS21 RPS10 RPS29 RPL35A RPL36A RPS5RPL18A RPS16 RPL17 RPS15A RPL17 RPL13A RPS29 FAU RPL34 RPL19 RPS7 RPS21 RPL35A RPL31 RPL22 RPL13A RPL38 RPL17 RPLP2 RPL5 RPL6 RPL6 RPL15RPS14 18S rRNA RPL23A RPL10A RPS3A RPL32 RPS9 RPL27A RPSA RPL9 RPL30RPL30RPS6 RPS26 RPLP1RPL3 RPS29 RPS4X UBA52RPL12 RPS9 RPS3 RPS29 RPL32 ETF1 RPL15RPS20 RPS3A RPL28 RPL31 GSPT2 RPS17 RPL8 UBA52RPS3 RPS20 RPL28 28S rRNA RPL41 RPS5RPS4Y1RPL24 RPL7A RPLP0 RPS27 RPL14 RPS18 RPL21 RPS8RPL8 ETF1 RPL29 RPL4 RPS28 RPL21 RPL39 RPS27 RPS27ARPS16 RPL35A GSPT2 RPL37A RPS18 RPS24 RPS15 RPS28 RPL27RPS3 RPLP1PiRPL36A RPS8RPL35A RPS14 RPS7 RPL18A RPL15RPL27A FAU RPS10 RPL34 RPS19 RPL32 RPS10 RPLP0 RPSA RPS11 RPL10 polypeptideRPL26 RPL37 RPS5RPL27RPS11 RPL9 5S rRNA RPS16


Description

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Comments

Wikipathways-description 
The arrival of any of the three stop codons (UAA, UAG and UGA) into the ribosomal A-site triggers the binding of a release factor (RF) to the ribosome and subsequent polypeptide chain release. In eukaryotes, the RF is composed of two proteins, eRF1 and eRF3. eRF1 is responsible for the hydrolysis of the peptidyl-tRNA, while eRF3 provides a GTP-dependent function. The ribosome releases the mRNA and dissociates into its two complex subunits, which can reassemble on another molecule to begin a new round of protein synthesis. It should be noted that at present, there is no factor identified in eukaryotes that would be the functional equivalent of the bacterial ribosome release (or recycling) factor, RRF, that catalyzes dissociation of the ribosome from the mRNA following release of the polypeptide

Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=72764

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Bibliography

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  1. Hoshino S, Imai M, Kobayashi T, Uchida N, Katada T.; ''The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein.''; PubMed Europe PMC Scholia
  2. Frolova L, Le Goff X, Rasmussen HH, Cheperegin S, Drugeon G, Kress M, Arman I, Haenni AL, Celis JE, Philippe M.; ''A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor.''; PubMed Europe PMC Scholia
  3. Salas-Marco J, Bedwell DM.; ''GTP hydrolysis by eRF3 facilitates stop codon decoding during eukaryotic translation termination.''; PubMed Europe PMC Scholia
  4. Jones WM, Scaloni A, Bossa F, Popowicz AM, Schneewind O, Manning JM.; ''Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities.''; PubMed Europe PMC Scholia
  5. Erlandsson R, Boldog F, Persson B, Zabarovsky ER, Allikmets RL, Sümegi J, Klein G, Jörnvall H.; ''The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase.''; PubMed Europe PMC Scholia
  6. Figaro S, Scrima N, Buckingham RH, Heurgué-Hamard V.; ''HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1.''; PubMed Europe PMC Scholia
  7. Hoshino S, Imai M, Mizutani M, Kikuchi Y, Hanaoka F, Ui M, Katada T.; ''Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1.''; PubMed Europe PMC Scholia
  8. Ichikawa S, Kaji A.; ''Molecular cloning and expression of ribosome releasing factor.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117721view12:33, 22 May 2021EweitzModified title
115033view16:57, 25 January 2021ReactomeTeamReactome version 75
113477view11:55, 2 November 2020ReactomeTeamReactome version 74
112677view16:07, 9 October 2020ReactomeTeamReactome version 73
101594view11:46, 1 November 2018ReactomeTeamreactome version 66
101130view21:31, 31 October 2018ReactomeTeamreactome version 65
100658view20:05, 31 October 2018ReactomeTeamreactome version 64
100208view16:50, 31 October 2018ReactomeTeamreactome version 63
99759view15:16, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93873view13:42, 16 August 2017ReactomeTeamreactome version 61
93440view11:23, 9 August 2017ReactomeTeamreactome version 61
86531view09:20, 11 July 2016ReactomeTeamreactome version 56
83397view11:07, 18 November 2015ReactomeTeamVersion54
81591view13:08, 21 August 2015ReactomeTeamVersion53
77051view08:35, 17 July 2014ReactomeTeamFixed remaining interactions
76756view12:11, 16 July 2014ReactomeTeamFixed remaining interactions
76081view10:14, 11 June 2014ReactomeTeamRe-fixing comment source
75791view11:32, 10 June 2014ReactomeTeamReactome 48 Update
75141view14:08, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74832view10:05, 30 April 2014ReactomeTeamReactome46
74788view08:52, 30 April 2014ReactomeTeamReactome46
68957view17:38, 8 July 2013MaintBotUpdated to 2013 gpml schema
45251view18:37, 7 October 2011AlexanderPicoOntology Term : 'translation termination pathway' added !
42036view21:52, 4 March 2011MaintBotAutomatic update
39839view05:52, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
18S rRNA ProteinX03205 (EMBL)
28S rRNA ProteinM11167 (EMBL)
5.8S rRNA ProteinJ01866 (EMBL)
5S rRNA ProteinV00589 (EMBL)
80S Ribosome

mRNA

peptidyl-tRNA with elongating peptide		ComplexREACT_4835 (Reactome)
ETF1 ProteinP62495 (Uniprot-TrEMBL)
ETF1ProteinP62495 (Uniprot-TrEMBL)
FAU ProteinP62861 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GSPT2 ProteinQ8IYD1 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTP bound eRF3ComplexREACT_5462 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
RPL10 ProteinP27635 (Uniprot-TrEMBL)
RPL10A ProteinP62906 (Uniprot-TrEMBL)
RPL11 ProteinP62913 (Uniprot-TrEMBL)
RPL12 ProteinP30050 (Uniprot-TrEMBL)
RPL13A ProteinP40429 (Uniprot-TrEMBL)
RPL13ProteinP26373 (Uniprot-TrEMBL)
RPL14 ProteinP50914 (Uniprot-TrEMBL)
RPL15ProteinP61313 (Uniprot-TrEMBL)
RPL17 ProteinP18621 (Uniprot-TrEMBL)
RPL18 ProteinQ07020 (Uniprot-TrEMBL)
RPL18A ProteinQ02543 (Uniprot-TrEMBL)
RPL19 ProteinP84098 (Uniprot-TrEMBL)
RPL21 ProteinP46778 (Uniprot-TrEMBL)
RPL22 ProteinP35268 (Uniprot-TrEMBL)
RPL23 ProteinP62829 (Uniprot-TrEMBL)
RPL23A ProteinP62750 (Uniprot-TrEMBL)
RPL24 ProteinP83731 (Uniprot-TrEMBL)
RPL26 ProteinP61254 (Uniprot-TrEMBL)
RPL26L1ProteinQ9UNX3 (Uniprot-TrEMBL)
RPL27A ProteinP46776 (Uniprot-TrEMBL)
RPL27ProteinP61353 (Uniprot-TrEMBL)
RPL28 ProteinP46779 (Uniprot-TrEMBL)
RPL29 ProteinP47914 (Uniprot-TrEMBL)
RPL3 ProteinP39023 (Uniprot-TrEMBL)
RPL30ProteinP62888 (Uniprot-TrEMBL)
RPL31 ProteinP62899 (Uniprot-TrEMBL)
RPL32 ProteinP62910 (Uniprot-TrEMBL)
RPL34 ProteinP49207 (Uniprot-TrEMBL)
RPL35 ProteinP42766 (Uniprot-TrEMBL)
RPL35A ProteinP18077 (Uniprot-TrEMBL)
RPL36 ProteinQ9Y3U8 (Uniprot-TrEMBL)
RPL36A ProteinP83881 (Uniprot-TrEMBL)
RPL37 ProteinP61927 (Uniprot-TrEMBL)
RPL37A ProteinP61513 (Uniprot-TrEMBL)
RPL38 ProteinP63173 (Uniprot-TrEMBL)
RPL39 ProteinP62891 (Uniprot-TrEMBL)
RPL3LProteinQ92901 (Uniprot-TrEMBL)
RPL4 ProteinP36578 (Uniprot-TrEMBL)
RPL41 ProteinP62945 (Uniprot-TrEMBL)
RPL5 ProteinP46777 (Uniprot-TrEMBL)
RPL6 ProteinQ02878 (Uniprot-TrEMBL)
RPL7 ProteinP18124 (Uniprot-TrEMBL)
RPL7A ProteinP62424 (Uniprot-TrEMBL)
RPL8 ProteinP62917 (Uniprot-TrEMBL)
RPL9 ProteinP32969 (Uniprot-TrEMBL)
RPLP0 ProteinP05388 (Uniprot-TrEMBL)
RPLP1ProteinP05386 (Uniprot-TrEMBL)
RPLP2 ProteinP05387 (Uniprot-TrEMBL)
RPS10 ProteinP46783 (Uniprot-TrEMBL)
RPS11 ProteinP62280 (Uniprot-TrEMBL)
RPS12 ProteinP25398 (Uniprot-TrEMBL)
RPS13ProteinP62277 (Uniprot-TrEMBL)
RPS14 ProteinP62263 (Uniprot-TrEMBL)
RPS15 ProteinP62841 (Uniprot-TrEMBL)
RPS15A ProteinP62244 (Uniprot-TrEMBL)
RPS16 ProteinP62249 (Uniprot-TrEMBL)
RPS17 ProteinP08708 (Uniprot-TrEMBL)
RPS18 ProteinP62269 (Uniprot-TrEMBL)
RPS19 ProteinP39019 (Uniprot-TrEMBL)
RPS20 ProteinP60866 (Uniprot-TrEMBL)
RPS21 ProteinP63220 (Uniprot-TrEMBL)
RPS23 ProteinP62266 (Uniprot-TrEMBL)
RPS24 ProteinP62847 (Uniprot-TrEMBL)
RPS25 ProteinP62851 (Uniprot-TrEMBL)
RPS26 ProteinP62854 (Uniprot-TrEMBL)
RPS27 ProteinP42677 (Uniprot-TrEMBL)
RPS27AProteinP62979 (Uniprot-TrEMBL)
RPS28 ProteinP62857 (Uniprot-TrEMBL)
RPS29 ProteinP62273 (Uniprot-TrEMBL)
RPS2ProteinP15880 (Uniprot-TrEMBL)
RPS3 ProteinP23396 (Uniprot-TrEMBL)
RPS3A ProteinP61247 (Uniprot-TrEMBL)
RPS4X ProteinP62701 (Uniprot-TrEMBL)
RPS4Y1ProteinP22090 (Uniprot-TrEMBL)
RPS5ProteinP46782 (Uniprot-TrEMBL)
RPS6 ProteinP62753 (Uniprot-TrEMBL)
RPS7 ProteinP62081 (Uniprot-TrEMBL)
RPS8ProteinP62241 (Uniprot-TrEMBL)
RPS9 ProteinP46781 (Uniprot-TrEMBL)
RPSA ProteinP08865 (Uniprot-TrEMBL)
UBA52ProteinP62987 (Uniprot-TrEMBL)
eRF3-GDP

eRF1 80S Ribosome mRNA

peptidyl-tRNA Complex		ComplexREACT_5057 (Reactome)
eRF3-GDP

eRF1 80S Ribosome mRNA

tRNA Complex		ComplexREACT_4303 (Reactome)
eRF3-GTP

eRF1 80S Ribosome mRNA

peptidyl-tRNA Complex		ComplexREACT_4059 (Reactome)
polypeptideREACT_3573 (Reactome)
tRNA MetaboliteCHEBI:17843 (ChEBI)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
80S Ribosome

mRNA

peptidyl-tRNA with elongating peptide		REACT_227 (Reactome)
ETF1REACT_227 (Reactome)
GTP bound eRF3REACT_227 (Reactome)
PiArrowREACT_1654 (Reactome)
REACT_1654 (Reactome) Please note that this reaction was inferred from experiments performed using Saccharomyces cerevisiae.
REACT_227 (Reactome) Please note that this reaction was inferred from experiments performed using Saccharomyces cerevisiae.
REACT_389 (Reactome) Please note that this reaction was inferred from experiments performed using Saccharomyces cerevisiae.
eRF3-GDP

eRF1 80S Ribosome mRNA

peptidyl-tRNA Complex		ArrowREACT_1654 (Reactome)
eRF3-GDP

eRF1 80S Ribosome mRNA

tRNA Complex		ArrowREACT_389 (Reactome)
polypeptideArrowREACT_389 (Reactome)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1813"
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