Host Interactions of HIV factors (Homo sapiens)

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27443, 31, 45114820, 3954334, 48546, 47, 49297, 37, 4143178179, 212332, 4128818334, 13, 14, 16, 19...2525469651110, 385472023251525111711841, 4227252712, 30minus sssDNARNA templatetRNA primer Rev multimer-bound HIV-1 mRNACrm1RanGTP ANT1Vpr complex Rev multimer-bound HIV-1 mRNA RanBP1Ran-GTPCRM1Rev-bound mRNA complex Crm1Ran GTPaseGTP Adaptor protein complex 2 nucleoplasmIN bound to sticky 3' ends of viral DNA in PIC RT AP-1 mu Rev-bound HIV-1 mRNA Revimportin-betaB23Ran-GTP complex AP-2 Complex Rev multimer-bound HIV-1 mRNACRM1 complex RT Rev-bound HIV-1 mRNA viral DNA with 3' sticky ends Nup107 Complex CD4Vpubeta-TrCP_1Skp1 complex Adaptor protein complex 2 RevImportin-betaB23 early endosome membraneRev-bound HIV-1 mRNA AP-1 mu RT Nefclass I MHC complex AP-1 Complex Nuclear Pore Complex RanGTP Vprimportin-alpha complex Matrix Rev multimer-bound HIV-1 mRNA IN bound to sticky 3' ends of viral DNA in PIC IN bound to sticky 3' ends of viral DNA TatP-TEFbImportin beta-1Rev multimer complex AP-2 Complex P-TEFbNup107 Complex Adaptor protein complex 2 P-TEFbmulti-ubiquitinated APOBEC3GVifCul5SCF complex IN bound to sticky 3' ends of viral DNA Adaptor protein complex 2 Nup62 Complex Matrix endoplasmic reticulum lumenImportin-betaRan GTP complex AP-1 sigma NefCD28 Complex Nuclear Pore Complex APOBEC3G CD8Nef Complex AP-1 sigma CD4Vpubeta-TrCP_1Skp1 complex CD4NefAP-2 Complexv-ATPase Complex Matrix DOCK2ELMO1RAC1Nef Complex Internalized CD4NefClathrin-Coated Pit Adapter Proteinv-ATPase multiubiquitinated CD4Vpubeta-TrCP_1Skp1 complex Cul5-SCF complex CD4Lck Complex CD4Vpubeta-TrCP_1 RevImportin-betaNPM1 p6 protein CD4Vpu complex viral DNA with 3' sticky ends p6 protein AP-2 Complex 26S proteasome Rev multimer-bound HIV-1 mRNACRM1 complex NefCD28 Complex Ran-GTP Nefclass I MHC complexAP-1PACS-1 Complex Rev-bound HIV-1 mRNA APOBEC3GRTC with deaminated minus sssDNAtRNA primerRNA template APOBEC3G Nuclear Pore Complex APOBEC3GRTC with minus sssDNAtRNA primerRNA template NefT cell Receptor zetaLipid Raft Pak 2 Complex Rev multimer-bound HIV-1 mRNA APOBEC3G APOBEC3GVifCul5SCF complex Rev-bound HIV-1 mRNA VifCul5SCF complex Adaptor protein complex 2 Rev multimer-bound HIV-1 mRNA Importin beta-1Rev multimer complex Vpubeta-TrCP1Skp1 complex Rev multimer-bound HIV-1 mRNACrm1RanGTP Ran-GTP AP-2 Complex FynNef Complex Rev multimer-bound HIV-1 mRNACRM1 complex viral DNA with 3' sticky ends LckNef minus sssDNA containing deaminated C residuesRNA templatetRNA primer p6 protein class I MHC complex IN bound to sticky 3' ends of viral DNA in PIC Adaptor protein complex 2 Matrix Rev multimer-bound HIV-1 mRNA Nup62 Complex Ub APOBEC3G RanGTP p6 protein APOBEC3GVifCul5SCF complex Arf1Nefendosomal CD4 p6 protein Nefclass I MHC complexAp-1PACS-1 Complex VifAPOBEC3G complex APOBEC3GHIV-1PIC RevImportin-betaB23 AP-1 Complex AP-2 Complex Nup62 Complex CD4Vpu complex IN bound to sticky 3' ends of viral DNA Rev-bound HIV-1 mRNA Ran-GTP AP-1 Complex Matrix Cul5-SCF complex Rev multimer-bound HIV-1 mRNACrm1RanGTP CD4Vpu complex AP-2 Complex CD8Nef Complex IN bound to sticky 3' ends of viral DNA RTC with minus sssDNAtRNA primerRNA template CD4Vpubeta-TrCP_1 RTC with minus sssDNA containing deaminated C residuestRNA primerRNA template mitochondrial intermembrane spaceminus sssDNARNA templatetRNA primer cytosolRTC with minus sssDNAtRNA primerRNA template CD28NefClathrin-coated Pit Adapter Protein Complex Matrix Rev multimer-bound HIV-1 mRNACrm1RanGTPNPC Importin beta-1Rev multimer complex early endosome membraneAP-2 Complex VifAPOBEC3G complex Internalized CD8NefClathrin-Coated Pit Adapter Proteinv-ATPase ADP/ATP translocase monomer mitochondrial matrixRev multimer-bound HIV-1 mRNACrm1RanGTP p6 protein Rev multimer-bound HIV-1 mRNA CD28NefClathrin-coated Pit Adapter Protein Ran-GTP Cul5-SCF complex Cul5-SCF complex Crm1Ran GTPaseGTP Hck-1Nef Golgi lumenclass I MHC complex Matrix Nuclear Pore Complex Nup107 Complex Ran-GTP Nup62 Complex Nup107 Complex CD4Nef Complex CD4Nef Complex viral DNA with 3' sticky ends RevImportin-betaNPM1 CD8NefAP-2 Complexv-ATPase Complex CD4Vpu complex Ub Ran-GDP Ran-GTP CD4Vpubeta-TrCP_1 PIC anchored to the NPC Importin beta-1Rev multimer complex APOBEC3G AP-1 sigma IN bound to sticky 3' ends of viral DNA in PIC class I MHC complex class I MHC complex VifAPOBEC3G complex Adaptor protein complex 2 nucleoporin-associated RevImportin-betaB23 complex Ran GTPaseGDP Rev-bound HIV-1 mRNA RanGTP APOBEC3G p6 protein Importin beta-1Rev multimer complex AP-1 mu 26S proteasome APOBEC3G-3 BTRCNUP155 PPIA CD28NefClathrin-coated Pit Adapter ProteinAP1S3 RAN BTRC SEH1L-2 HMGA1 Nefclass I MHC complexNUPL2 myristoylated Nef Protein NUP210 AP1S3 TPR NUPL2 GTPPSME2 HLA class I histocompatibility antigen, A-2 alpha chain CD28 AP1S3 NUP35 NUP62 PiPSMD8 multiubiquitinated CD4Vpubeta-TrCP_1Skp1 complexPSMC3 PSME4 PSMA6 PSMD1 VifAPOBEC3G complexAP1S2 NUP205AP2S1 NUP62 HLA class I histocompatibility antigen, A-2 alpha chain CD28NefClathrin-coated Pit Adapter Protein ComplexPSMB11 REV NUP153 Reverse transcriptase/ribonuclease H AP2S1 NUP50 NPM1CDK9 NUP205TCEB1 VPR BTRC UBCPSMD13 PSMD6RANBP1MA UBCNUP155 PSME1 PSMB5 GTP PSMD1 PSMD11 RAN UBBNUP85 class I MHC complexAP2A1 UBCAP-2 ComplexGDPNUPL2 REV PAK2CCNT1 NUP88 PSIP1 CD4Vpu complexNup45 APOBEC3GVifCul5SCF complexPSMA5 VPU PSMD4AP1G1 VPR NUP214 APOBEC3GVPU NUPL1-2 p51 AP2S1 PSMD10 TCEB2 HCKIN NefT cell Receptor zetaLipid Raft Pak 2 ComplexPSMD12 PSMD14 PSMD13 NUP214 myristoylated Nef Protein DOCK2 KPNB1 PSMB9 AP-2 ComplexTPR PSMD5 SKP1 AP1M2NUP210 KPNB1 PSMD6NUP205NUP107 myristoylated Nef Protein BTRC myristoylated Nef Protein RBX1 UBBCD247-1 VPR HIV-1 unspliced RNARAE1 VPU GDP AP1S1 BANF1 NUP188NPM1PSMF1PSMA1 RPS27AXPO1 myristoylated Nef Protein AP-2 ComplexPSMB3 FynNef ComplexUBCRan GTPaseGDPPSMD3 p6 AP2A1 AP2A1 CD8B SEH1L-2 BANF1 Internalized CD4NefClathrin-Coated Pit Adapter Proteinv-ATPaseRev-multimerPSMB4 Rev-bound HIV-1 mRNAmulti-ubiquitinated APOBEC3GVifCul5SCF complexREV HMGA1 NUP205p6 NUPL1-2 CD4XPO1 PSMA7PSMD7AP2A2CD4NUP37 NUP37 Rev multimer-bound HIV-1 mRNACrm1RanGTPNUPL1-2 FYNTPR NUP37 ANT1Vpr complexGDP IN ATP6V1HVIF VPU CD4Vpubeta-TrCP_1MA myristoylated Nef Protein REV CD4 AP-1 ComplexNUP133 IN AP2A2VIF KPNB1 UBBNUP153 PSMC1MA AP2M1 FYNGTP REV SEH1L-2 VPR VPR myristoylated Nef Protein PSMB8 PPIA IN Internalized CD8NefClathrin-Coated Pit Adapter Proteinv-ATPaseAP1S2 REV UBBAP2B1 MA myristoylated Nef Protein AP2A1 PSMB10 Rev multimer-bound HIV-1 mRNAAP1S1 PACS1SKP1MA HIV-1 RNA template VPU Rev multimer-bound HIV-1 mRNACrm1RanGTPNPCNUP160 NPM1 NUP153 myristoylated Nef Protein IN bound to sticky 3' ends of viral DNA in PICPSME1 RAC1-1VIF SLC25A4 NUP153 DOCK2HIV-1 mRNA NUP50 LCKIN NUP62 TatP-TEFbRANBP2 PSMD12 PSME2 ATP6V1H RAN RAN LCKHck-1NefPSMA8 ELMO1 AP1B1 PSME3 NUP107 UBBPPIA CUL5 ATP6V1HAP2B1 NUP107 SKP1 REV KPNB1 Ran-GTPXPO1LCK TCEB1 PSMB8 myristoylated Nef Protein PIC anchored to the NPCAP1S2 ARF1myristoylated Nef Protein NUP98-5 PSMB11 APOBEC3GRTC with minus sssDNAtRNA primerRNA templateGTP HIV-1 RNA template Ran-GDPPSMB7 CCNT1 PSIP1 AP1B1 UBCCD4 AP1S1 SKP1 AP1B1 NUP54 UBCAP2M1 MA POM121 NUP210 REV Nefclass I MHC complexAP-1PACS-1 ComplexPSMA8 REV DOCK2ELMO1RAC1Nef ComplexNUP155 myristoylated Nef Protein KPNB1 RPS27ABANF1 ELMO1AP2M1 AP2S1 myristoylated Nef Protein UBCPSMB6 VIF POM121 KPNB1 TCEB2 GTP NUP98-5 B2MAP2A1 AP2M1 PSMA4 MA ARF1Nefclass I MHC complexAp-1PACS-1 Complexmyristoylated Nef Protein NUP85 LckNefNUP93 B2Mp6 CDK9 APOBEC3G-3 TCEB1 VIF CD28 KPNA1 RBX1 PSMC4 NUP98-5 NUP50 CD4 HMGA1 Nup45 PSMC1AP1M1 PSMD14 NUP188NUP43 Vpubeta-TrCP1Skp1 complexp6 UBA52IN NUP62 RanBP1Ran-GTPCRM1Rev-bound mRNA complexNUP54 CD8B NUP188MA VPR CD4 AP2S1 ADP/ATP translocase monomer REV RANBP2 RAN AP2B1 IN PSMC3 AAAS Revimportin-betaB23Ran-GTP complexNUP88 AP2A1 GTP VIF myristoylated Nef Protein PSMA2 SLC25A6 REV PSMD9 PSMA4 PACS1RANBP1PSMD10 VIF Reverse transcriptase/ribonuclease H NUP210 SLC25A5 CD8B 26S proteasomeP-TEFbPSMC2 RAN AAAS NUP93 PSMB3 GTP CD28PSMB1 VIF REV p6 p6 RanGTPRANBP2 NUP98-5 UBCPSME4 p6 NUP88 UbVPR POM121 RBX1 NUP85 myristoylated Nef Protein XPO1 GTP p6 VIF PSMD5 CD4Vpubeta-TrCP_1Skp1 complexAP2A2Tat AP2M1 UBCCul5-SCF complexVPU AP2S1 PSMA2 NUP160 AP1M1 KPNA1NUP35 NUP214 Rev-multimerAP2M1 PSMA7RAN VPU CD28 VIF AP2B1 PSMD11 XPO1Vprimportin-alpha complexTCEB2 KPNB1PSMF1BTRC PSMB7 MA myristoylated Nef Protein PSMA1 PSMA5 PSMB2 VIF NUP133 VIF UBCAP2A2CD4Nef Complexp6 AP1G1 APOBEC3G-3 NH3RANGAP1Importin beta-1Rev multimer complexCD247-1ATP6V1HRan-GTPTPR p6 PSMD2 NUPL1-2 XPO1 Nuclear Pore Complex CD4 VifCul5SCF complexp51 CUL5 PSMB5 Rev multimer-bound HIV-1 mRNACRM1 complexAP2A2NUP214 AP2A1 Nup45 PSMB2 NefCD28 ComplexXPO1 REV PSMC6PSMC4 AP2S1 APOBEC3GRTC with deaminated minus sssDNAtRNA primerRNA templateAPOBEC3G-3 MA p51 NPM1 PACS1NUP160 PSMB9 HIV-1 mRNA NUP188UBCCD4Lck ComplexRANBP2 NUP54 NUP85 myristoylated Nef Protein NUP133 HLA class I histocompatibility antigen, A-2 alpha chain VPR NUP107 nucleoporin-associated RevImportin-betaB23 complexHIV-1 mRNA PSIP1 NPM1 CD8Nef ComplexNPM1 POM121 PSMB1 PSMB6 NUP43 NUP43 CUL5 PSMD9 NUP50 NUP43 VPR HMGA1 p6 RAN HIV-1 RNA template UBCmyristoylated Nef Protein RBX1 UBCUBBNUP155 CD4 APOBEC3G-3 p6 PSMA3 NUP37 PSMB4 AP1M2Importin-betaRan GTP complexAP1M2PSMC2 PSMC6PSIP1 Reverse transcriptase/ribonuclease H AP2M1 UBCCUL5 RTC with minus sssDNAtRNA primerRNA templatep6 HCKTCEB2 PSMC5 PSMA3 RAN HIV-1 mRNA REV UBCRAN NUP160 PSME3 GTP BANF1 VPU RAN RevImportin-betaB23myristoylated Nef Protein AP2B1 CD8NefAP-2 Complexv-ATPase ComplexNUP88 AP2M1NUP54 MA RAE1 PSMA6 AP2B1 Rev multimer-bound HIV-1 mRNACrm1RanGTPRevImportin-betaNPM1REV GTP UBCVPR AAAS UBA52UBCp6 PSMB10 VPU VPU RAE1 NUP133 RAE1 HLA class I histocompatibility antigen, A-2 alpha chain PSMD7AP1M1 myristoylated Nef Protein TCEB1 Arf1Nefendosomal CD4LCK PAK2HIV-1 mRNACD4 AP1G1 APOBEC3G-3 UBCTat myristoylated Nef Protein NUP35 CD4 ATP6V1H MA VPU AP2A2SEH1L-2 MA ATP6V1HAP2M1 CD4 RAC1-1 VPU B2MATP6V1H NUP93 Lipid RaftAP2B1 HIV-1 mRNA NUPL2 PSMD3 CD4NefAP-2 Complexv-ATPase Complex26S proteasomeNup45 HIV-1 mRNA NUP35 MA NUP93 RCC1PSMD2 AAAS APOBEC3GHIV-1PICH2OAP2M1 ATP6V1H HIV-1 mRNA REV AP2A2VPU PSMD8 B2MPSMD4PSMC5 2226, 352626221, 2, 36


Description

Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewise requires evasion of APOBEC3G-mediated mutagenesis of reverse transcripts, a process mediated by the viral Vif protein. Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=162909

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Bibliography

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History

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CompareRevisionActionTimeUserComment
114683view16:15, 25 January 2021ReactomeTeamReactome version 75
113130view11:19, 2 November 2020ReactomeTeamReactome version 74
112362view15:29, 9 October 2020ReactomeTeamReactome version 73
101263view11:15, 1 November 2018ReactomeTeamreactome version 66
100801view20:43, 31 October 2018ReactomeTeamreactome version 65
100343view19:21, 31 October 2018ReactomeTeamreactome version 64
99888view16:03, 31 October 2018ReactomeTeamreactome version 63
99445view14:37, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
96358view20:11, 9 March 2018AndrewlmasonHIV down regulated
93974view13:49, 16 August 2017ReactomeTeamreactome version 61
93575view11:27, 9 August 2017ReactomeTeamreactome version 61
87139view18:51, 18 July 2016MkutmonOntology Term : 'infectious disease pathway' added !
86678view09:24, 11 July 2016ReactomeTeamreactome version 56
83092view09:57, 18 November 2015ReactomeTeamVersion54
81413view12:56, 21 August 2015ReactomeTeamVersion53
76883view08:15, 17 July 2014ReactomeTeamFixed remaining interactions
76588view11:56, 16 July 2014ReactomeTeamFixed remaining interactions
75920view09:57, 11 June 2014ReactomeTeamRe-fixing comment source
75621view10:48, 10 June 2014ReactomeTeamReactome 48 Update
74976view13:49, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74620view08:40, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
26S proteasomeComplexREACT_2353 (Reactome)
AAAS ProteinQ9NRG9 (Uniprot-TrEMBL)
ADP/ATP translocase monomer ProteinREACT_8605 (Reactome)
ANT1 Vpr complexComplexREACT_8897 (Reactome)
AP-1 ComplexComplexREACT_11249 (Reactome)
AP-2 ComplexComplexREACT_11732 (Reactome)
AP1B1 ProteinQ10567 (Uniprot-TrEMBL)
AP1G1 ProteinO43747 (Uniprot-TrEMBL)
AP1M1 ProteinQ9BXS5 (Uniprot-TrEMBL)
AP1M2ProteinQ9Y6Q5 (Uniprot-TrEMBL)
AP1S1 ProteinP61966 (Uniprot-TrEMBL)
AP1S2 ProteinP56377 (Uniprot-TrEMBL)
AP1S3 ProteinQ96PC3 (Uniprot-TrEMBL)
AP2A1 ProteinO95782 (Uniprot-TrEMBL)
AP2A2ProteinO94973 (Uniprot-TrEMBL)
AP2B1 ProteinP63010 (Uniprot-TrEMBL)
AP2M1 ProteinQ96CW1 (Uniprot-TrEMBL)
AP2M1ProteinQ96CW1 (Uniprot-TrEMBL)
AP2S1 ProteinP53680 (Uniprot-TrEMBL)
APOBEC3G HIV-1PICComplexREACT_9691 (Reactome)
APOBEC3G

RTC with deaminated minus sssDNA tRNA primer

RNA template		ComplexREACT_9785 (Reactome)
APOBEC3G

RTC with minus sssDNA tRNA primer

RNA template		ComplexREACT_9745 (Reactome)
APOBEC3G

Vif Cul5

SCF complex		ComplexREACT_9643 (Reactome)
APOBEC3G-3 ProteinQ9HC16-3 (Uniprot-TrEMBL)
APOBEC3GProteinREACT_9891 (Reactome)
ARF1ProteinP84077 (Uniprot-TrEMBL)
ATP6V1H ProteinQ9UI12 (Uniprot-TrEMBL)
ATP6V1HProteinQ9UI12 (Uniprot-TrEMBL)
Arf1

Nef

endosomal CD4		ComplexREACT_11580 (Reactome)
B2MProteinP61769 (Uniprot-TrEMBL)
BANF1 ProteinO75531 (Uniprot-TrEMBL)
BTRC ProteinQ9Y297 (Uniprot-TrEMBL)
BTRCProteinQ9Y297 (Uniprot-TrEMBL)
CCNT1 ProteinO60563 (Uniprot-TrEMBL)
CD247-1 ProteinP20963-1 (Uniprot-TrEMBL)
CD247-1ProteinP20963-1 (Uniprot-TrEMBL)
CD28

Nef

Clathrin-coated Pit Adapter Protein Complex		ComplexREACT_11677 (Reactome)
CD28

Nef

Clathrin-coated Pit Adapter Protein		ComplexREACT_11442 (Reactome)
CD28 ProteinP10747 (Uniprot-TrEMBL)
CD28ProteinP10747 (Uniprot-TrEMBL)
CD4 Lck ComplexComplexREACT_11737 (Reactome)
CD4

Nef AP-2 Complex

v-ATPase Complex		ComplexREACT_11339 (Reactome)
CD4 Nef ComplexComplexREACT_11987 (Reactome)
CD4

Vpu beta-TrCP_1

Skp1 complex		ComplexREACT_9120 (Reactome)
CD4

Vpu

beta-TrCP_1		ComplexREACT_9238 (Reactome)
CD4 Vpu complexComplexREACT_9255 (Reactome)
CD4 ProteinP01730 (Uniprot-TrEMBL)
CD4ProteinP01730 (Uniprot-TrEMBL)
CD8

Nef AP-2 Complex

v-ATPase Complex		ComplexREACT_11369 (Reactome)
CD8 Nef ComplexComplexREACT_11411 (Reactome)
CD8B ProteinP10966 (Uniprot-TrEMBL)
CDK9 ProteinP50750 (Uniprot-TrEMBL)
CUL5 ProteinQ93034 (Uniprot-TrEMBL)
Cul5-SCF complexComplexREACT_9690 (Reactome)
DOCK2

ELMO1 RAC1

Nef Complex		ComplexREACT_11827 (Reactome)
DOCK2 ProteinQ92608 (Uniprot-TrEMBL)
DOCK2ProteinQ92608 (Uniprot-TrEMBL)
ELMO1 ProteinQ92556 (Uniprot-TrEMBL)
ELMO1ProteinQ92556 (Uniprot-TrEMBL)
FYNProteinP06241 (Uniprot-TrEMBL)
Fyn Nef ComplexComplexREACT_11637 (Reactome)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HCKProteinP08631 (Uniprot-TrEMBL)
HIV-1 RNA template ProteinAF033819 (EMBL)
HIV-1 mRNA ProteinAF033819 (EMBL)
HIV-1 mRNARnaAF033819 (EMBL)
HIV-1 unspliced RNARnaAF033819 (EMBL)
HLA class I histocompatibility antigen, A-2 alpha chain ProteinP01892 (Uniprot-TrEMBL)
HMGA1 ProteinP17096 (Uniprot-TrEMBL)
Hck-1 NefComplexREACT_11973 (Reactome)
IN ProteinP04585 (Uniprot-TrEMBL)
IN bound to sticky 3' ends of viral DNA in PICComplexREACT_8354 (Reactome)
Importin beta-1 Rev multimer complexComplexREACT_9841 (Reactome)
Importin-beta Ran GTP complexComplexREACT_9883 (Reactome)
Internalized CD4

Nef Clathrin-Coated Pit Adapter Protein

v-ATPase		ComplexREACT_11967 (Reactome)
Internalized CD8

Nef Clathrin-Coated Pit Adapter Protein

v-ATPase		ComplexREACT_11305 (Reactome)
KPNA1 ProteinP52294 (Uniprot-TrEMBL)
KPNA1ProteinP52294 (Uniprot-TrEMBL)
KPNB1 ProteinQ14974 (Uniprot-TrEMBL)
KPNB1ProteinQ14974 (Uniprot-TrEMBL)
LCK ProteinP06239 (Uniprot-TrEMBL)
LCKProteinP06239 (Uniprot-TrEMBL)
Lck NefComplexREACT_11930 (Reactome)
Lipid RaftREACT_11624 (Reactome)
MA ProteinP04585 (Uniprot-TrEMBL)
MA ProteinP04591 (Uniprot-TrEMBL)
NH3MetaboliteCHEBI:16134 (ChEBI)
NPM1 ProteinP06748 (Uniprot-TrEMBL)
NPM1ProteinP06748 (Uniprot-TrEMBL)
NUP107 ProteinP57740 (Uniprot-TrEMBL)
NUP133 ProteinQ8WUM0 (Uniprot-TrEMBL)
NUP153 ProteinP49790 (Uniprot-TrEMBL)
NUP155 ProteinO75694 (Uniprot-TrEMBL)
NUP160 ProteinQ12769 (Uniprot-TrEMBL)
NUP188ProteinQ5SRE5 (Uniprot-TrEMBL)
NUP205ProteinQ92621 (Uniprot-TrEMBL)
NUP210 ProteinQ8TEM1 (Uniprot-TrEMBL)
NUP214 ProteinP35658 (Uniprot-TrEMBL)
NUP35 ProteinQ8NFH5 (Uniprot-TrEMBL)
NUP37 ProteinQ8NFH4 (Uniprot-TrEMBL)
NUP43 ProteinQ8NFH3 (Uniprot-TrEMBL)
NUP50 ProteinQ9UKX7 (Uniprot-TrEMBL)
NUP54 ProteinQ7Z3B4 (Uniprot-TrEMBL)
NUP62 ProteinP37198 (Uniprot-TrEMBL)
NUP85 ProteinQ9BW27 (Uniprot-TrEMBL)
NUP88 ProteinQ99567 (Uniprot-TrEMBL)
NUP93 ProteinQ8N1F7 (Uniprot-TrEMBL)
NUP98-5 ProteinP52948-5 (Uniprot-TrEMBL)
NUPL1-2 ProteinQ9BVL2-1 (Uniprot-TrEMBL)
NUPL2 ProteinO15504 (Uniprot-TrEMBL)
Nef CD28 ComplexComplexREACT_11853 (Reactome)
Nef

T cell Receptor zeta Lipid Raft

Pak 2 Complex		ComplexREACT_11396 (Reactome)
Nef

class I MHC complex AP-1

PACS-1 Complex		ComplexREACT_11657 (Reactome)
Nef

class I MHC complex Ap-1

PACS-1 Complex		ComplexREACT_11308 (Reactome)
Nef class I MHC complexComplexREACT_11813 (Reactome)
Nuclear Pore Complex ComplexREACT_5542 (Reactome)
Nup45 ProteinQ9BVL2-2 (Uniprot-TrEMBL)
P-TEFbComplexREACT_6577 (Reactome)
PACS1ProteinQ6VY07 (Uniprot-TrEMBL)
PAK2ProteinQ13177 (Uniprot-TrEMBL)
PIC anchored to the NPCComplexREACT_8912 (Reactome)
POM121 ProteinQ96HA1 (Uniprot-TrEMBL)
PPIA ProteinP62937 (Uniprot-TrEMBL)
PSIP1 ProteinO75475 (Uniprot-TrEMBL)
PSMA1 ProteinP25786 (Uniprot-TrEMBL)
PSMA2 ProteinP25787 (Uniprot-TrEMBL)
PSMA3 ProteinP25788 (Uniprot-TrEMBL)
PSMA4 ProteinP25789 (Uniprot-TrEMBL)
PSMA5 ProteinP28066 (Uniprot-TrEMBL)
PSMA6 ProteinP60900 (Uniprot-TrEMBL)
PSMA7ProteinO14818 (Uniprot-TrEMBL)
PSMA8 ProteinQ8TAA3 (Uniprot-TrEMBL)
PSMB1 ProteinP20618 (Uniprot-TrEMBL)
PSMB10 ProteinP40306 (Uniprot-TrEMBL)
PSMB11 ProteinA5LHX3 (Uniprot-TrEMBL)
PSMB2 ProteinP49721 (Uniprot-TrEMBL)
PSMB3 ProteinP49720 (Uniprot-TrEMBL)
PSMB4 ProteinP28070 (Uniprot-TrEMBL)
PSMB5 ProteinP28074 (Uniprot-TrEMBL)
PSMB6 ProteinP28072 (Uniprot-TrEMBL)
PSMB7 ProteinQ99436 (Uniprot-TrEMBL)
PSMB8 ProteinP28062 (Uniprot-TrEMBL)
PSMB9 ProteinP28065 (Uniprot-TrEMBL)
PSMC1ProteinP62191 (Uniprot-TrEMBL)
PSMC2 ProteinP35998 (Uniprot-TrEMBL)
PSMC3 ProteinP17980 (Uniprot-TrEMBL)
PSMC4 ProteinP43686 (Uniprot-TrEMBL)
PSMC5 ProteinP62195 (Uniprot-TrEMBL)
PSMC6ProteinP62333 (Uniprot-TrEMBL)
PSMD1 ProteinQ99460 (Uniprot-TrEMBL)
PSMD10 ProteinO75832 (Uniprot-TrEMBL)
PSMD11 ProteinO00231 (Uniprot-TrEMBL)
PSMD12 ProteinO00232 (Uniprot-TrEMBL)
PSMD13 ProteinQ9UNM6 (Uniprot-TrEMBL)
PSMD14 ProteinO00487 (Uniprot-TrEMBL)
PSMD2 ProteinQ13200 (Uniprot-TrEMBL)
PSMD3 ProteinO43242 (Uniprot-TrEMBL)
PSMD4ProteinP55036 (Uniprot-TrEMBL)
PSMD5 ProteinQ16401 (Uniprot-TrEMBL)
PSMD6ProteinQ15008 (Uniprot-TrEMBL)
PSMD7ProteinP51665 (Uniprot-TrEMBL)
PSMD8 ProteinP48556 (Uniprot-TrEMBL)
PSMD9 ProteinO00233 (Uniprot-TrEMBL)
PSME1 ProteinQ06323 (Uniprot-TrEMBL)
PSME2 ProteinQ9UL46 (Uniprot-TrEMBL)
PSME3 ProteinP61289 (Uniprot-TrEMBL)
PSME4 ProteinQ14997 (Uniprot-TrEMBL)
PSMF1ProteinQ92530 (Uniprot-TrEMBL)
PiMetaboliteCHEBI:18367 (ChEBI)
RAC1-1 ProteinP63000-1 (Uniprot-TrEMBL)
RAC1-1ProteinP63000-1 (Uniprot-TrEMBL)
RAE1 ProteinP78406 (Uniprot-TrEMBL)
RAN ProteinP62826 (Uniprot-TrEMBL)
RANBP1ProteinP43487 (Uniprot-TrEMBL)
RANBP2 ProteinP49792 (Uniprot-TrEMBL)
RANGAP1ProteinP46060 (Uniprot-TrEMBL)
RBX1 ProteinP62877 (Uniprot-TrEMBL)
RCC1ProteinP18754 (Uniprot-TrEMBL)
REV ProteinP04618 (Uniprot-TrEMBL)
RPS27AProteinP62979 (Uniprot-TrEMBL)
RTC with minus sssDNA

tRNA primer

RNA template		ComplexREACT_9297 (Reactome)
Ran GTPComplexREACT_8632 (Reactome)
Ran GTPase GDPComplexREACT_6416 (Reactome)
Ran-GDPComplexREACT_9732 (Reactome)
Ran-GTPComplexREACT_8980 (Reactome)
RanBP1

Ran-GTP CRM1

Rev-bound mRNA complex		ComplexREACT_8366 (Reactome)
Rev

Importin-beta

B23		ComplexREACT_9742 (Reactome)
Rev

Importin-beta

NPM1		ComplexREACT_9868 (Reactome)
Rev

importin-beta B23

Ran-GTP complex		ComplexREACT_9842 (Reactome)
Rev multimer-bound HIV-1 mRNA CRM1 complexComplexREACT_8117 (Reactome)
Rev multimer-bound HIV-1 mRNA

Crm1 Ran GTP

NPC		ComplexREACT_6537 (Reactome)
Rev multimer-bound HIV-1 mRNA

Crm1 Ran

GTP		ComplexREACT_6428 (Reactome)
Rev multimer-bound HIV-1 mRNA

Crm1 Ran

GTP		ComplexREACT_6601 (Reactome)
Rev multimer-bound HIV-1 mRNAComplexREACT_6517 (Reactome)
Rev-bound HIV-1 mRNAComplexREACT_6419 (Reactome)
Rev-multimerREACT_6379 (Reactome)
Rev-multimerREACT_6511 (Reactome)
Reverse transcriptase/ribonuclease H ProteinP04585 (Uniprot-TrEMBL)
SEH1L-2 ProteinQ96EE3-2 (Uniprot-TrEMBL)
SKP1 ProteinP63208 (Uniprot-TrEMBL)
SKP1ProteinP63208 (Uniprot-TrEMBL)
SLC25A4 ProteinP12235 (Uniprot-TrEMBL)
SLC25A5 ProteinP05141 (Uniprot-TrEMBL)
SLC25A6 ProteinP12236 (Uniprot-TrEMBL)
TCEB1 ProteinQ15369 (Uniprot-TrEMBL)
TCEB2 ProteinQ15370 (Uniprot-TrEMBL)
TPR ProteinP12270 (Uniprot-TrEMBL)
Tat P-TEFbComplexREACT_6496 (Reactome)
Tat ProteinP04608 (Uniprot-TrEMBL)
UBA52ProteinP62987 (Uniprot-TrEMBL)
UBBProteinP0CG47 (Uniprot-TrEMBL)
UBCProteinP0CG48 (Uniprot-TrEMBL)
UbProteinREACT_3316 (Reactome)
VIF ProteinP69723 (Uniprot-TrEMBL)
VPR ProteinP69726 (Uniprot-TrEMBL)
VPU ProteinP05919 (Uniprot-TrEMBL)
Vif APOBEC3G complexComplexREACT_9662 (Reactome)
Vif

Cul5

SCF complex		ComplexREACT_9902 (Reactome)
Vpr importin-alpha complexComplexREACT_8944 (Reactome)
Vpu

beta-TrCP1

Skp1 complex		ComplexREACT_9101 (Reactome)
XPO1 ProteinO14980 (Uniprot-TrEMBL)
XPO1ProteinO14980 (Uniprot-TrEMBL)
class I MHC complexComplexREACT_11465 (Reactome)
multi-ubiquitinated APOBEC3G

Vif Cul5

SCF complex		ComplexREACT_9570 (Reactome)
multiubiquitinated CD4

Vpu beta-TrCP_1

Skp1 complex		ComplexREACT_9344 (Reactome)
myristoylated Nef Protein ProteinP04601 (Uniprot-TrEMBL)
nucleoporin-associated Rev

Importin-beta

B23 complex		ComplexREACT_9793 (Reactome)
p51 ProteinP04585 (Uniprot-TrEMBL)
p6 ProteinP04585 (Uniprot-TrEMBL)
p6 ProteinP04591 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
26S proteasomemim-catalysisREACT_9018 (Reactome)
26S proteasomemim-catalysisREACT_9466 (Reactome)
ADP/ATP translocase monomer REACT_7958 (Reactome)
AP-1 ComplexArrowREACT_11147 (Reactome)
AP-1 ComplexREACT_11186 (Reactome)
AP-2 ComplexArrowREACT_11144 (Reactome)
AP-2 ComplexArrowREACT_11177 (Reactome)
AP-2 ComplexREACT_11091 (Reactome)
AP-2 ComplexREACT_11125 (Reactome)
AP2M1REACT_11122 (Reactome)
APOBEC3G

RTC with deaminated minus sssDNA tRNA primer

RNA template		ArrowREACT_9435 (Reactome)
APOBEC3G

RTC with minus sssDNA tRNA primer

RNA template		REACT_9435 (Reactome)
APOBEC3G

Vif Cul5

SCF complex		REACT_9471 (Reactome)
APOBEC3G

Vif Cul5

SCF complex		mim-catalysisREACT_9471 (Reactome)
APOBEC3GREACT_9444 (Reactome)
APOBEC3GREACT_9445 (Reactome)
APOBEC3GREACT_9450 (Reactome)
APOBEC3Gmim-catalysisREACT_9435 (Reactome)
ARF1REACT_11227 (Reactome)
ATP6V1HArrowREACT_11144 (Reactome)
ATP6V1HArrowREACT_11177 (Reactome)
ATP6V1HREACT_11091 (Reactome)
ATP6V1HREACT_11125 (Reactome)
BTRCREACT_9009 (Reactome)
CD247-1REACT_11221 (Reactome)
CD28REACT_11194 (Reactome)
CD4 Lck ComplexREACT_11148 (Reactome)
CD4 Nef ComplexArrowREACT_11148 (Reactome)
CD4 Nef ComplexREACT_11091 (Reactome)
CD4

Vpu beta-TrCP_1

Skp1 complex		REACT_9063 (Reactome)
CD4

Vpu beta-TrCP_1

Skp1 complex		mim-catalysisREACT_9063 (Reactome)
CD4

Vpu

beta-TrCP_1		REACT_9071 (Reactome)
CD4 Vpu complexREACT_9009 (Reactome)
CD4REACT_11227 (Reactome)
CD4REACT_9024 (Reactome)
CD8 Nef ComplexREACT_11125 (Reactome)
Cul5-SCF complexREACT_9469 (Reactome)
DOCK2REACT_11090 (Reactome)
ELMO1REACT_11090 (Reactome)
FYNREACT_11075 (Reactome)
GDPArrowREACT_9507 (Reactome)
GTPREACT_9507 (Reactome)
H2OREACT_9435 (Reactome)
HCKREACT_11224 (Reactome)
HIV-1 mRNAREACT_6161 (Reactome)
HIV-1 unspliced RNAArrowREACT_6318 (Reactome)
IN bound to sticky 3' ends of viral DNA in PICREACT_7952 (Reactome)
IN bound to sticky 3' ends of viral DNA in PICREACT_8011 (Reactome)
IN bound to sticky 3' ends of viral DNA in PICREACT_9450 (Reactome)
Importin beta-1 Rev multimer complexREACT_9511 (Reactome)
Importin-beta Ran GTP complexArrowREACT_9456 (Reactome)
KPNA1REACT_8011 (Reactome)
KPNB1REACT_9394 (Reactome)
LCKArrowREACT_11148 (Reactome)
LCKREACT_11220 (Reactome)
Lipid RaftREACT_11221 (Reactome)
NH3ArrowREACT_9435 (Reactome)
NPM1ArrowREACT_9456 (Reactome)
NPM1REACT_9511 (Reactome)
Nef CD28 ComplexREACT_11122 (Reactome)
Nef class I MHC complexREACT_11186 (Reactome)
Nuclear Pore Complex ArrowREACT_6340 (Reactome)
Nuclear Pore Complex ArrowREACT_9521 (Reactome)
Nuclear Pore Complex REACT_6337 (Reactome)
Nuclear Pore Complex REACT_7952 (Reactome)
Nuclear Pore Complex REACT_9516 (Reactome)
P-TEFbREACT_6356 (Reactome)
PACS1ArrowREACT_11147 (Reactome)
PACS1REACT_11186 (Reactome)
PAK2REACT_11221 (Reactome)
PiArrowREACT_6171 (Reactome)
RAC1-1REACT_11090 (Reactome)
RANBP1ArrowREACT_6171 (Reactome)
RANBP1ArrowREACT_6318 (Reactome)
RANBP1REACT_9478 (Reactome)
RANGAP1ArrowREACT_6171 (Reactome)
RCC1mim-catalysisREACT_9507 (Reactome)
REACT_11069 (Reactome) The CD8alphabeta receptor is internalized via endocytosis.
REACT_11071 (Reactome) Nef disrupts the transport of major histocompatibility complex class I molecules by first binding to the the cytoplasmic side of the transmembrane complex.
REACT_11075 (Reactome) Nef has been shown to bind specifically to a subset of the Src family of kinases. Nef/Fyn interaction centers on a proline-rich motif (Pro-x-x-Pro), which is implicated in SH3 binding. This domain is partially disordered in the absence of the binding partner; when bound this motif fully adopts a left-handed polyproline type II helix conformation upon complex formation with the Fyn SH3 domain. Within this structure the arginine residue (Arg77) of Nef interacts with Asp 100 of the RT loop within the Fyn SH3 domain, and triggers a hydrogen-bond rearrangement which allows the loop to adapt to complement the Nef surface. The Arg96 residue of the Fyn SH3 domain is specifically accommodated in the same hydrophobic pocket of Nef. The Nef-Fyn complex forms in vivo and may have a crucial role in the T cell perturbating action of Nef by altering T cell receptor signaling.
REACT_11090 (Reactome) The infectious cycle of primate lentiviruses is intimately linked to interactions between cells of the immune system. Nef, a potent virulence factor, alters cellular environments to increase lentiviral replication in the host, functioning as an adaptor protein. Nef activates Rac in T cell lines and in primary T cells following infection with HIV-1 in the absence of antigenic stimuli. Nef activates Rac by binding the DOCK2-ELMO1 complex, and this interaction is linked to the abilities of Nef to inhibit chemotaxis and promote T cell activation. Nef targets a critical switch that regulates Rac GTPases downstream of chemokine- and antigen-initiated signaling pathways. This interaction enables Nef to influence multiple aspects of T cell function and thus provides an important mechanism by which Nef impacts pathogenesis by primate lentiviruses.
REACT_11091 (Reactome) AP-2 is recruited to the newly formed Nef:CD4 complex
REACT_11122 (Reactome) Nef induces accelerated endocytosis of CD28 via clathrin-coated pits.
REACT_11125 (Reactome) The presence of Nef accelerates endocytosis and lysosomal degradation of the transmembrane glycoprotein CD8. Nef facilitates a cascade of protein interactions that ultimately result in the degradation of internalized CD8 protein. The final set of protein interactions that direct Nef to the beta-subunit of the COPI coatomers are at this time unclear.
A number of sites within Nef are proposed to be required for CD8 down-regulation, the myristoylation signal and N-terminal anchor regions, the C-terminal flexible loop, and amino acid positions 57 to 58. Consistent with all reported Nef functions, the myristoylation signal was found to be essential for CD8 down-modulation. The flexible loop contains a dileucine-based internalization motif, which is flanked by acidic clusters and is involved in enhanced internalization of the Nef-CD4 complex.
REACT_11144 (Reactome) Once the CD8alphabeta receptor has been internalized via endocytosis, the vesicles are targeted for lysosomal degradation.
REACT_11147 (Reactome) Once the complex of Nef, major histocompatibility complex class I molecules, PACS-1 and AP-1 arrives at the endosome, the MHC I complex is targeted for degradation.
REACT_11148 (Reactome) Nef disrupts the CD4 Lck complex
REACT_11160 (Reactome) The Nef:CD4:AP-2 complex is internalized
REACT_11164 (Reactome) Once Nef has induced endocytosis of CD28, CD28 containing vesicles are targeted for lysosomal degradation.
REACT_11177 (Reactome) CD4 is degraded
REACT_11186 (Reactome) The complex formed by Nef and the major histocompatibility complex class I molecules creates binding sites for PACS-1 and the AP-1 complex.
REACT_11194 (Reactome) Down-regulation of CD28 receptors involves a dileucine-based motif in the second disordered loop of Nef, which connects Nef to adaptor protein (AP) complex, which is a part of cellular endocytosis machinery.
REACT_11220 (Reactome) The Nef protein of the primate lentiviruses, including human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV), is a myristylated protein associated with increased viral replication and enhanced pathogenicity. Both the potentiation of T-lymphocyte activation and the enhanced serine-phosphorylation of HIV-1 capsid by Nef correlate with increased viral replication. The Nef proteins from HIV-1 and SIV bind to Lck. The SH3 and SH2 domains of Lck are sufficient for coprecipitation with non-tyrosine-phosphorylated Nef proteins. The conserved core region of HIV-1 Nef is essential for the interaction with Lck and is also important for enhanced HIV-1 replication in T-lymphocytes. The SIV and HIV-1 Nef proteins are differentially tyrosine-phosphorylated. The kinase-active Lck tyrosine-phosphorylates SIVmac239 Nef but does not phosphorylate HIV-1 Nef.
REACT_11221 (Reactome) Nef drives the formation of lipid raft complexes.
REACT_11224 (Reactome) The protein Hck is a member of the Src family of non-receptor tyrosine kinases which is preferentially expressed in haematopoietic cells of the myeloid and B-lymphoid lineages. Src kinases are inhibited by tyrosine-phosphorylation at a carboxy-terminal site. The SH2 domains of these enzymes play an essential role in this regulation by binding to the tyrosine-phosphorylated tail. The SH2 domain of Hck regulates enzymatic activity indirectly; intramolecular interactions between the SH3 and catalytic domains appear to stabilize an inactive form of the kinase. The HIV-1 Nef protein, which is a high-affinity ligand for the Hck SH3 domain, binds to either the downregulated or activated form of Hck causing a large increase in Hck catalytic activity. The intact SH3-binding motif in Nef is crucial for Hck activation.
REACT_11227 (Reactome) The HIV Nef protein downregulates CD4 through sequential connection with clathrin-coated pits and the COP1 coatomer, resulting in accelerated endocytosis and lysosomal targeting. The small GTPase ARF1 controls the Nef-induced, COP-mediated late-endosomal targeting of CD4. Nef binds ARF1 directly and can recruit the GTPase onto endosomal membranes, leading to the eventual degradation of CD4 (Faure et al. 2004).
REACT_11229 (Reactome) The complex of Nef, major histocompatibility complex class I molecules, PACS-1 and AP-1 is transported from the trans-Golgi network to an endosome, where the MHC I complex will be degraded.
REACT_6140 (Reactome) RanGTP binds to a preformed Rev-CRM1 complex.
REACT_6161 (Reactome) Nuclear export of the unspliced and partially spliced HIV-1 transcripts requires the association of the HIV-1 Rev protein with a cis-acting RNA sequence known as the Rev Response Element (RRE) located within the env gene. The RRE forms a stem loop structure that associates with an arginine-rich RNA binding motif (ARM) within Rev.
REACT_6171 (Reactome) Ran-GAP, a Ran-specific GTPase-activating protein converts Ran-GTP to Ran-GDP, producing a Ran-GTP gradient across the nuclear membrane.
REACT_6228 (Reactome) In order for Rev to function, multiple molecules must bind sequentiallly to the RRE (Malim and Cullen 1991).
REACT_6318 (Reactome) The association of RanBp1 with RanGTP:CRM1:Rev promotes disassembly of the complex and release of the Rev:RNA cargo.
REACT_6337 (Reactome) The Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP complex associates with the NPC.
REACT_6340 (Reactome) Crm1 is a nucleocytoplasmic transport factor that is believed to interact with nucleoporins facilitating docking of the RRE-Rev-CRM1-RanGTP complex to the nuclear pore and the translocation of the complex across the nuclear pore complex (see Cullen 1998) Crm1 has been found in complex with two such nucleoporins, CAN/Nup214 and Nup88 which have been shown to be components of the human nuclear pore complex (Fornerod et al., 1997).
REACT_6356 (Reactome) Tat associates with the Cyclin T1 subunit of P-TEFb (Cyclin T1:Cdk9) through a region of cysteine-rich and core sequences referred to as the ARM domain within Tat (Wei et al., 1998; see also Herrmann 1995). This interaction is believed to involve metal ions stabilized by cysteine residues in both proteins (Bieniasz et al., 1998; Garber et al., 1998).
REACT_7952 (Reactome)
REACT_7958 (Reactome) Vpr interacts with the PTPC component ANT1. This interaction induces mitochondrial membrane permeabilization and release of cytochrome c and apoptotic factors.
REACT_7969 (Reactome) Vpr translocates to the mitochondria.
REACT_8011 (Reactome) Vpr interacts with importin-alpha through alphaH1 and alphaH2. The interaction via alphaH1 is indispensable for the nuclear entry of Vpr (Kamata et al., 2005) .
REACT_9009 (Reactome) Vpu links beta-TrCP to CD4 at the ER membrane through interactions with beta-TrCP and the cytoplasmic tail of CD4.
REACT_9018 (Reactome) Ubiquitinated CD4 is then subject to proteasome-mediated degradation.
REACT_9024 (Reactome) Vpu is expressed in the ER and associates with a membrane-proximal region in the cytoplasmic tail of CD4.
REACT_9063 (Reactome) CD4 is ubiquitinated in the CD4:Vpu–h-βTrCP:Skp1 complex.
REACT_9071 (Reactome) The SKP1 component of the SCF complex is recruited to the Vpu:beta-TrCP:CD4 complex.
REACT_9394 (Reactome) The association of Rev with importin-beta is mediated by the Rev nuclear localisation signal.
REACT_9399 (Reactome) Inside the nucleus, Ran-GTP associates with importin-beta.
REACT_9435 (Reactome) During reverse transcription, APOBEC3G-mediated minus-strand deamination occurs within a CC dinucleotide context over the entire length of the HIV-1 genome (Yu et al., 2004).
The polypurine tract is essential for plus strand synthesis and is located at the 3’ end of the retroviral genome. HIV-1 encodes an additional central polypurine tract located in the middle of the genome which also serves as primer for plus strand synthesis.
Deamination of the minus strand continues throughout its synthesis with the frequency of deamination events increasing from the 5’ to 3’ regions. A 400bp region downstream of the central polypurine tract seems to be protected from deamination (Wurtzer et al., 2006)
REACT_9444 (Reactome) In the target cell, HIV-1-associated APOBEC3G binds to the HIV-1 reverse transcript minus strand and catalyzes the deamination of cytidines in a specific dinucleotide context (e.g., dCC). In contrast, APOBEC3F and APOBEC3B display a preference for dTC.
REACT_9445 (Reactome) The HIV-1 Vif protein associates with the DNA editing enzyme APOBEC3G Marin et al) . The binding site has not yet been mapped but emerging evidence suggest that the N-terminal lregion of Vif is essential for APOBEC3G recognition (Tian et al) .
Substitution of a single amino acid in the human APOBEC3G (Asp128Lys) abolishes binding and renders it resistant to HIV-1 Vif (Schrofelbauer et al; Bogerd et al.).

REACT_9450 (Reactome) APOBEC3G is incorporated into virus particles through its association with components of the viral RNA packaging machinery. It binds to the nucleocapsid portion of Gag (NC), a region of the polyprotein that associates with genomic RNA and functions in RNA encapsidation.
REACT_9456 (Reactome) The association of importin-beta with Ran-GTP causes the disassembly of the Rev-importin β-B23 complex releasing the Rev in the nucleus.
REACT_9466 (Reactome) Following multi-ubiquitination by the Vif-Cul5-SCF complex, APOBEC3G is degraded by the 26S proteasome.
REACT_9469 (Reactome) The interaction between Vif and the E3 ubiquitin ligase complex (Cullin5, Elongin B and Elongin C, and Rbx1) takes place through direct binding of the SOCS box motif in the viral protein Vif to the host protein Elongin C. Moreover, a conserved HCCH motif in Vif allows binding to Cullin 5.
REACT_9471 (Reactome) APOBEC3G is multi-ubiquitinated by the Vif-Cul5-SCF complex.
REACT_9478 (Reactome) Upon translocation to the cytoplasm, RanBP1 associates with Ran-GTP in the Rev-CRM1-Ran-GTP complex.
REACT_9507 (Reactome) Free, nuclear RanGTP is required for export processes out of the nucleus. RCC1 catalyses the conversion of Ran-GDP to Ran-GTP in the nucleus.
REACT_9511 (Reactome) B23 may function as a shuttle for the import of HIV Rev from the cytoplasm into the nucleus or nucleolus permitting additional rounds of export of viral RNAs.
REACT_9516 (Reactome) The Rev-importin β-B23 complex is recruited to the nuclear pore by an interaction between importin β and nucleoporin.
REACT_9521 (Reactome) Following the association of Rev with importin-beta, the Rev:B23:importin-beta complex is imported into the nucleus.
REACT_9530 (Reactome) CRM1 associates directly with Rev through the Rev nuclear export signal (NES) domain and acts as the nuclear export receptor for the Rev-RRE ribonucleoprotein complex.
REV ArrowREACT_6318 (Reactome)
REV REACT_6161 (Reactome)
RTC with minus sssDNA

tRNA primer

RNA template		REACT_9444 (Reactome)
Ran GTPArrowREACT_6318 (Reactome)
Ran GTPase GDPArrowREACT_6171 (Reactome)
Ran-GDPREACT_9507 (Reactome)
Ran-GTPArrowREACT_9507 (Reactome)
Ran-GTPREACT_6140 (Reactome)
Ran-GTPREACT_9399 (Reactome)
Rev

Importin-beta

B23		ArrowREACT_9521 (Reactome)
Rev

Importin-beta

B23		REACT_9399 (Reactome)
Rev

Importin-beta

NPM1		REACT_9516 (Reactome)
Rev multimer-bound HIV-1 mRNA CRM1 complexREACT_6140 (Reactome)
Rev multimer-bound HIV-1 mRNA

Crm1 Ran

GTP		ArrowREACT_6340 (Reactome)
Rev multimer-bound HIV-1 mRNA

Crm1 Ran

GTP		REACT_6337 (Reactome)
Rev multimer-bound HIV-1 mRNA

Crm1 Ran

GTP		REACT_9478 (Reactome)
Rev multimer-bound HIV-1 mRNA

Crm1 Ran

GTP		mim-catalysisREACT_6171 (Reactome)
Rev multimer-bound HIV-1 mRNAREACT_9530 (Reactome)
Rev-bound HIV-1 mRNAREACT_6228 (Reactome)
Rev-multimerArrowREACT_6318 (Reactome)
Rev-multimerArrowREACT_9456 (Reactome)
Rev-multimerREACT_6228 (Reactome)
Rev-multimerREACT_9394 (Reactome)
SKP1REACT_9071 (Reactome)
Tat REACT_6356 (Reactome)
UbArrowREACT_9018 (Reactome)
UbArrowREACT_9466 (Reactome)
UbREACT_9063 (Reactome)
UbREACT_9471 (Reactome)
VIF REACT_9445 (Reactome)
VPR REACT_7958 (Reactome)
VPU REACT_9024 (Reactome)
Vif APOBEC3G complexREACT_9469 (Reactome)
Vif

Cul5

SCF complex		ArrowREACT_9466 (Reactome)
Vpu

beta-TrCP1

Skp1 complex		ArrowREACT_9018 (Reactome)
XPO1ArrowREACT_6318 (Reactome)
XPO1REACT_9530 (Reactome)
class I MHC complexREACT_11071 (Reactome)
myristoylated Nef Protein ArrowREACT_11144 (Reactome)
myristoylated Nef Protein ArrowREACT_11147 (Reactome)
myristoylated Nef Protein ArrowREACT_11177 (Reactome)
myristoylated Nef Protein REACT_11071 (Reactome)
myristoylated Nef Protein REACT_11075 (Reactome)
myristoylated Nef Protein REACT_11090 (Reactome)
myristoylated Nef Protein REACT_11148 (Reactome)
myristoylated Nef Protein REACT_11194 (Reactome)
myristoylated Nef Protein REACT_11220 (Reactome)
myristoylated Nef Protein REACT_11221 (Reactome)
myristoylated Nef Protein REACT_11224 (Reactome)
myristoylated Nef Protein REACT_11227 (Reactome)
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