RAF/MAP kinase cascade (Homo sapiens)

From WikiPathways

Revision as of 11:04, 10 June 2014 by ReactomeTeam (Talk | contribs)

(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)

Description

The MAP kinase cascade describes a sequence of phosphorylation events involving serine/threonine-specific protein kinases. Used by various signal transduction pathways, this cascade constitutes a common 'module' in the transmission of an extracellular signal into the nucleus. Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=109869

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

Bibliography

View all...

Mason CS, Springer CJ, Cooper RG, Superti-Furga G, Marshall CJ, Marais R.; ''Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.''; PubMed Europe PMC Scholia
Chadee DN, Kyriakis JM.; ''MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation.''; PubMed Europe PMC Scholia
Cohen BD, Green JM, Foy L, Fell HP.; ''HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers.''; PubMed Europe PMC Scholia
King JA, Corcoran NM, D'Abaco GM, Straffon AF, Smith CT, Poon CL, Buchert M, I S, Hall NE, Lock P, Hovens CM.; ''Eve-3: a liver enriched suppressor of Ras/MAPK signaling.''; PubMed Europe PMC Scholia
Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G.; ''Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain.''; PubMed Europe PMC Scholia
Lidke DS, Huang F, Post JN, Rieger B, Wilsbacher J, Thomas JL, Pouysségur J, Jovin TM, Lenormand P.; ''ERK nuclear translocation is dimerization-independent but controlled by the rate of phosphorylation.''; PubMed Europe PMC Scholia
Van Noesel CJ, Brouns GS, van Schijndel GM, Bende RJ, Mason DY, Borst J, van Lier RA.; ''Comparison of human B cell antigen receptor complexes: membrane-expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers.''; PubMed Europe PMC Scholia
Weber C, Fraemohs L, Dejana E.; ''The role of junctional adhesion molecules in vascular inflammation.''; PubMed Europe PMC Scholia
Jones FE, Welte T, Fu XY, Stern DF.; ''ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation.''; PubMed Europe PMC Scholia
Rushworth LK, Hindley AD, O'Neill E, Kolch W.; ''Regulation and role of Raf-1/B-Raf heterodimerization.''; PubMed Europe PMC Scholia
Wellbrock C, Karasarides M, Marais R.; ''The RAF proteins take centre stage.''; PubMed Europe PMC Scholia
Heldin CH, Ostman A, Rönnstrand L.; ''Signal transduction via platelet-derived growth factor receptors.''; PubMed Europe PMC Scholia
Whitehurst AW, Wilsbacher JL, You Y, Luby-Phelps K, Moore MS, Cobb MH.; ''ERK2 enters the nucleus by a carrier-independent mechanism.''; PubMed Europe PMC Scholia
Stewart S, Sundaram M, Zhang Y, Lee J, Han M, Guan KL.; ''Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.''; PubMed Europe PMC Scholia
Pritchard CA, Samuels ML, Bosch E, McMahon M.; ''Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells.''; PubMed Europe PMC Scholia
Peng SB, Henry JR, Kaufman MD, Lu WP, Smith BD, Vogeti S, Rutkoski TJ, Wise S, Chun L, Zhang Y, Van Horn RD, Yin T, Zhang X, Yadav V, Chen SH, Gong X, Ma X, Webster Y, Buchanan S, Mochalkin I, Huber L, Kays L, Donoho GP, Walgren J, McCann D, Patel P, Conti I, Plowman GD, Starling JJ, Flynn DL.; ''Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.''; PubMed Europe PMC Scholia
Park CY, Hoover PJ, Mullins FM, Bachhawat P, Covington ED, Raunser S, Walz T, Garcia KC, Dolmetsch RE, Lewis RS.; ''STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1.''; PubMed Europe PMC Scholia
Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, Fee F, Katsanakis KD, Rose DW, Mischak H, Sedivy JM, Kolch W.; ''Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP.''; PubMed Europe PMC Scholia
Sjölander A, Yamamoto K, Huber BE, Lapetina EG.; ''Association of p21ras with phosphatidylinositol 3-kinase.''; PubMed Europe PMC Scholia
Maki RG.; ''Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer.''; PubMed Europe PMC Scholia
Park S, Rath O, Beach S, Xiang X, Kelly SM, Luo Z, Kolch W, Yeung KC.; ''Regulation of RKIP binding to the N-region of the Raf-1 kinase.''; PubMed Europe PMC Scholia
Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, Hillan K, Crowley C, Brush J, Godowski PJ.; ''Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4.''; PubMed Europe PMC Scholia
Rauen KA.; ''The RASopathies.''; PubMed Europe PMC Scholia
Xiang X, Zang M, Waelde CA, Wen R, Luo Z, Luo Z.; ''Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1.''; PubMed Europe PMC Scholia
Pinkas-Kramarski R, Soussan L, Waterman H, Levkowitz G, Alroy I, Klapper L, Lavi S, Seger R, Ratzkin BJ, Sela M, Yarden Y.; ''Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions.''; PubMed Europe PMC Scholia
Agianian B, Gavathiotis E.; ''Current Insights of BRAF Inhibitors in Cancer.''; PubMed Europe PMC Scholia
Maertens O, Johnson B, Hollstein P, Frederick DT, Cooper ZA, Messiaen L, Bronson RT, McMahon M, Granter S, Flaherty K, Wargo JA, Marais R, Cichowski K.; ''Elucidating distinct roles for NF1 in melanomagenesis.''; PubMed Europe PMC Scholia
DeFea KA, Zalevsky J, Thoma MS, Déry O, Mullins RD, Bunnett NW.; ''beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2.''; PubMed Europe PMC Scholia
Bottorff D, Stang S, Agellon S, Stone JC.; ''RAS signalling is abnormal in a c-raf1 MEK1 double mutant.''; PubMed Europe PMC Scholia
Shao H, Andres DA.; ''A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras.''; PubMed Europe PMC Scholia
Shi H, Moriceau G, Kong X, Lee MK, Lee H, Koya RC, Ng C, Chodon T, Scolyer RA, Dahlman KB, Sosman JA, Kefford RF, Long GV, Nelson SF, Ribas A, Lo RS.; ''Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance.''; PubMed Europe PMC Scholia
Sun Y, Ikrar T, Davis MF, Gong N, Zheng X, Luo ZD, Lai C, Mei L, Holmes TC, Gandhi SP, Xu X.; ''Neuregulin-1/ErbB4 Signaling Regulates Visual Cortical Plasticity.''; PubMed Europe PMC Scholia
Baljuls A, Schmitz W, Mueller T, Zahedi RP, Sickmann A, Hekman M, Rapp UR.; ''Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites.''; PubMed Europe PMC Scholia
Giroux S, Tremblay M, Bernard D, Cardin-Girard JF, Aubry S, Larouche L, Rousseau S, Huot J, Landry J, Jeannotte L, Charron J.; ''Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta.''; PubMed Europe PMC Scholia
Cacace AM, Michaud NR, Therrien M, Mathes K, Copeland T, Rubin GM, Morrison DK.; ''Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression.''; PubMed Europe PMC Scholia
Cutler RE, Stephens RM, Saracino MR, Morrison DK.; ''Autoregulation of the Raf-1 serine/threonine kinase.''; PubMed Europe PMC Scholia
Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A.; ''A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.''; PubMed Europe PMC Scholia
Schober A, Weber C.; ''Mechanisms of monocyte recruitment in vascular repair after injury.''; PubMed Europe PMC Scholia
Schaeffer HJ, Catling AD, Eblen ST, Collier LS, Krauss A, Weber MJ.; ''MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade.''; PubMed Europe PMC Scholia
Lupi C, Giannini R, Ugolini C, Proietti A, Berti P, Minuto M, Materazzi G, Elisei R, Santoro M, Miccoli P, Basolo F.; ''Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma.''; PubMed Europe PMC Scholia
Saxena M, Williams S, Brockdorff J, Gilman J, Mustelin T.; ''Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP).''; PubMed Europe PMC Scholia
Gilmore-Hebert M, Ramabhadran R, Stern DF.; ''Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.''; PubMed Europe PMC Scholia
Tsang E, Giannetti AM, Shaw D, Dinh M, Tse JK, Gandhi S, Ho H, Wang S, Papp E, Bradshaw JM.; ''Molecular mechanism of the Syk activation switch.''; PubMed Europe PMC Scholia
Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB.; ''RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).''; PubMed Europe PMC Scholia
da Costa Martins P, van den Berk N, Ulfman LH, Koenderman L, Hordijk PL, Zwaginga JJ.; ''Platelet-monocyte complexes support monocyte adhesion to endothelium by enhancing secondary tethering and cluster formation.''; PubMed Europe PMC Scholia
Wei SJ, Williams JG, Dang H, Darden TA, Betz BL, Humble MM, Chang FM, Trempus CS, Johnson K, Cannon RE, Tennant RW.; ''Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation.''; PubMed Europe PMC Scholia
Becker BF, Heindl B, Kupatt C, Zahler S.; ''Endothelial function and hemostasis.''; PubMed Europe PMC Scholia
Müller J, Cacace AM, Lyons WE, McGill CB, Morrison DK.; ''Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling.''; PubMed Europe PMC Scholia
Lorentzen A, Kinkhabwala A, Rocks O, Vartak N, Bastiaens PI.; ''Regulation of Ras localization by acylation enables a mode of intracellular signal propagation.''; PubMed Europe PMC Scholia
Gauld SB, Cambier JC.; ''Src-family kinases in B-cell development and signaling.''; PubMed Europe PMC Scholia
Deng Y, Shipps GW, Cooper A, English JM, Annis DA, Carr D, Nan Y, Wang T, Zhu HY, Chuang CC, Dayananth P, Hruza AW, Xiao L, Jin W, Kirschmeier P, Windsor WT, Samatar AA.; ''Discovery of novel, dual mechanism ERK inhibitors by affinity selection screening of an inactive kinase.''; PubMed Europe PMC Scholia
Turjanski AG, Vaqué JP, Gutkind JS.; ''MAP kinases and the control of nuclear events.''; PubMed Europe PMC Scholia
Harwood NE, Batista FD.; ''Early events in B cell activation.''; PubMed Europe PMC Scholia
Sharma C, Vomastek T, Tarcsafalvi A, Catling AD, Schaeffer HJ, Eblen ST, Weber MJ.; ''MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling.''; PubMed Europe PMC Scholia
Plotnikov A, Zehorai E, Procaccia S, Seger R.; ''The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation.''; PubMed Europe PMC Scholia
Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC.; ''Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1.''; PubMed Europe PMC Scholia
Whitehurst AW, Robinson FL, Moore MS, Cobb MH.; ''The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions.''; PubMed Europe PMC Scholia
Ferro E, Trabalzini L.; ''RalGDS family members couple Ras to Ral signalling and that's not all.''; PubMed Europe PMC Scholia
Pylayeva-Gupta Y, Grabocka E, Bar-Sagi D.; ''RAS oncogenes: weaving a tumorigenic web.''; PubMed Europe PMC Scholia
Khokhlatchev AV, Canagarajah B, Wilsbacher J, Robinson M, Atkinson M, Goldsmith E, Cobb MH.; ''Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation.''; PubMed Europe PMC Scholia
Ishibe S, Joly D, Zhu X, Cantley LG.; ''Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis.''; PubMed Europe PMC Scholia
Lanier LL.; ''DAP10- and DAP12-associated receptors in innate immunity.''; PubMed Europe PMC Scholia
Komuro A, Nagai M, Navin NE, Sudol M.; ''WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus.''; PubMed Europe PMC Scholia
Del Pino I, García-Frigola C, Dehorter N, Brotons-Mas JR, Alvarez-Salvado E, Martínez de Lagrán M, Ciceri G, Gabaldón MV, Moratal D, Dierssen M, Canals S, Marín O, Rico B.; ''Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes.''; PubMed Europe PMC Scholia
McKay MM, Morrison DK.; ''Integrating signals from RTKs to ERK/MAPK.''; PubMed Europe PMC Scholia
Hazan R, Margolis B, Dombalagian M, Ullrich A, Zilberstein A, Schlessinger J.; ''Identification of autophosphorylation sites of HER2/neu.''; PubMed Europe PMC Scholia
Blalock WL, Weinstein-Oppenheimer C, Chang F, Hoyle PE, Wang XY, Algate PA, Franklin RA, Oberhaus SM, Steelman LS, McCubrey JA.; ''Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs.''; PubMed Europe PMC Scholia
Waterfall JJ, Arons E, Walker RL, Pineda M, Roth L, Killian JK, Abaan OD, Davis SR, Kreitman RJ, Meltzer PS.; ''High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias.''; PubMed Europe PMC Scholia
McClatchey AI, Cichowski K.; ''SPRED proteins provide a NF-ty link to Ras suppression.''; PubMed Europe PMC Scholia
Fischer A, Baljuls A, Reinders J, Nekhoroshkova E, Sibilski C, Metz R, Albert S, Rajalingam K, Hekman M, Rapp UR.; ''Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins.''; PubMed Europe PMC Scholia
Hollstein PE, Cichowski K.; ''Identifying the Ubiquitin Ligase complex that regulates the NF1 tumor suppressor and Ras.''; PubMed Europe PMC Scholia
Chou FL, Hill JM, Hsieh JC, Pouyssegur J, Brunet A, Glading A, Uberall F, Ramos JW, Werner MH, Ginsberg MH.; ''PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation.''; PubMed Europe PMC Scholia
Maertens O, Cichowski K.; ''An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer.''; PubMed Europe PMC Scholia
Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, Jones CM, Marshall CJ, Springer CJ, Barford D, Marais R, Cancer Genome Project.; ''Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.''; PubMed Europe PMC Scholia
King AJ, Sun H, Diaz B, Barnard D, Miao W, Bagrodia S, Marshall MS.; ''The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338.''; PubMed Europe PMC Scholia
Spaargaren M, Bischoff JR.; ''Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.''; PubMed Europe PMC Scholia
Vivanco I, Sawyers CL.; ''The phosphatidylinositol 3-Kinase AKT pathway in human cancer.''; PubMed Europe PMC Scholia
Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J.; ''Phosphatidylinositol-3-OH kinase as a direct target of Ras.''; PubMed Europe PMC Scholia
Rönnstrand L.; ''Signal transduction via the stem cell factor receptor/c-Kit.''; PubMed Europe PMC Scholia
Brown MD, Sacks DB.; ''Protein scaffolds in MAP kinase signalling.''; PubMed Europe PMC Scholia
Carpenter G.; ''Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways.''; PubMed Europe PMC Scholia
Martin GA, Viskochil D, Bollag G, McCabe PC, Crosier WJ, Haubruck H, Conroy L, Clark R, O'Connell P, Cawthon RM.; ''The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21.''; PubMed Europe PMC Scholia
Castellano E, Downward J.; ''RAS Interaction with PI3K: More Than Just Another Effector Pathway.''; PubMed Europe PMC Scholia
Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D.; ''A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.''; PubMed Europe PMC Scholia
Kubicek M, Pacher M, Abraham D, Podar K, Eulitz M, Baccarini M.; ''Dephosphorylation of Ser-259 regulates Raf-1 membrane association.''; PubMed Europe PMC Scholia
Zehir A, Benayed R, Shah RH, Syed A, Middha S, Kim HR, Srinivasan P, Gao J, Chakravarty D, Devlin SM, Hellmann MD, Barron DA, Schram AM, Hameed M, Dogan S, Ross DS, Hechtman JF, DeLair DF, Yao J, Mandelker DL, Cheng DT, Chandramohan R, Mohanty AS, Ptashkin RN, Jayakumaran G, Prasad M, Syed MH, Rema AB, Liu ZY, Nafa K, Borsu L, Sadowska J, Casanova J, Bacares R, Kiecka IJ, Razumova A, Son JB, Stewart L, Baldi T, Mullaney KA, Al-Ahmadie H, Vakiani E, Abeshouse AA, Penson AV, Jonsson P, Camacho N, Chang MT, Won HH, Gross BE, Kundra R, Heins ZJ, Chen HW, Phillips S, Zhang H, Wang J, Ochoa A, Wills J, Eubank M, Thomas SB, Gardos SM, Reales DN, Galle J, Durany R, Cambria R, Abida W, Cercek A, Feldman DR, Gounder MM, Hakimi AA, Harding JJ, Iyer G, Janjigian YY, Jordan EJ, Kelly CM, Lowery MA, Morris LGT, Omuro AM, Raj N, Razavi P, Shoushtari AN, Shukla N, Soumerai TE, Varghese AM, Yaeger R, Coleman J, Bochner B, Riely GJ, Saltz LB, Scher HI, Sabbatini PJ, Robson ME, Klimstra DS, Taylor BS, Baselga J, Schultz N, Hyman DM, Arcila ME, Solit DB, Ladanyi M, Berger MF.; ''Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.''; PubMed Europe PMC Scholia
Edin ML, Juliano RL.; ''Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor.''; PubMed Europe PMC Scholia
Bollag G, Clapp DW, Shih S, Adler F, Zhang YY, Thompson P, Lange BJ, Freedman MH, McCormick F, Jacks T, Shannon K.; ''Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells.''; PubMed Europe PMC Scholia
Holzenberger M.; ''Igf-I signaling and effects on longevity.''; PubMed Europe PMC Scholia
Papin C, Eychène A, Brunet A, Pagès G, Pouysségur J, Calothy G, Barnier JV.; ''B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.''; PubMed Europe PMC Scholia
Sun Y, Alberta JA, Pilarz C, Calligaris D, Chadwick EJ, Ramkissoon SH, Ramkissoon LA, Garcia VM, Mazzola E, Goumnerova L, Kane M, Yao Z, Kieran MW, Ligon KL, Hahn WC, Garraway LA, Rosen N, Gray NS, Agar NY, Buhrlage SJ, Segal RA, Stiles CD.; ''A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas.''; PubMed Europe PMC Scholia
Kunkel HG.; ''Surface markers of human lymphocytes.''; PubMed Europe PMC Scholia
Mitchell RM, Janssen MJ, Karavanova I, Vullhorst D, Furth K, Makusky A, Markey SP, Buonanno A.; ''ErbB4 reduces synaptic GABAA currents independent of its receptor tyrosine kinase activity.''; PubMed Europe PMC Scholia
Sundaram M, Han M.; ''The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction.''; PubMed Europe PMC Scholia
Higgins EM, Bos JM, Mason-Suares H, Tester DJ, Ackerman JP, MacRae CA, Sol-Church K, Gripp KW, Urrutia R, Ackerman MJ.; ''Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy.''; PubMed Europe PMC Scholia
Kornfeld K, Hom DB, Horvitz HR.; ''The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans.''; PubMed Europe PMC Scholia
Okaniwa M, Hirose M, Arita T, Yabuki M, Nakamura A, Takagi T, Kawamoto T, Uchiyama N, Sumita A, Tsutsumi S, Tottori T, Inui Y, Sang BC, Yano J, Aertgeerts K, Yoshida S, Ishikawa T.; ''Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives.''; PubMed Europe PMC Scholia
Jaumot M, Hancock JF.; ''Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions.''; PubMed Europe PMC Scholia
von Kriegsheim A, Pitt A, Grindlay GJ, Kolch W, Dhillon AS.; ''Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5.''; PubMed Europe PMC Scholia
Alessi DR, Saito Y, Campbell DG, Cohen P, Sithanandam G, Rapp U, Ashworth A, Marshall CJ, Cowley S.; ''Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.''; PubMed Europe PMC Scholia
Rodriguez-Viciana P, Rauen KA.; ''Biochemical characterization of novel germline BRAF and MEK mutations in cardio-facio-cutaneous syndrome.''; PubMed Europe PMC Scholia
Bezniakow N, Gos M, Obersztyn E.; ''The RASopathies as an example of RAS/MAPK pathway disturbances - clinical presentation and molecular pathogenesis of selected syndromes.''; PubMed Europe PMC Scholia
Cargnello M, Roux PP.; ''Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.''; PubMed Europe PMC Scholia
Tang J, Qi X, Mercola D, Han J, Chen G.; ''Essential role of p38gamma in K-Ras transformation independent of phosphorylation.''; PubMed Europe PMC Scholia
Vakana E, Pratt S, Blosser W, Dowless M, Simpson N, Yuan XJ, Jaken S, Manro J, Stephens J, Zhang Y, Huber L, Peng SB, Stancato LF.; ''LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer.''; PubMed Europe PMC Scholia
Vomastek T, Schaeffer HJ, Tarcsafalvi A, Smolkin ME, Bissonette EA, Weber MJ.; ''Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists.''; PubMed Europe PMC Scholia
Rajalingam K, Wunder C, Brinkmann V, Churin Y, Hekman M, Sievers C, Rapp UR, Rudel T.; ''Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration.''; PubMed Europe PMC Scholia
Simanshu DK, Nissley DV, McCormick F.; ''RAS Proteins and Their Regulators in Human Disease.''; PubMed Europe PMC Scholia
Ray LB, Sturgill TW.; ''Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo.''; PubMed Europe PMC Scholia
Arasada RR, Carpenter G.; ''Secretase-dependent tyrosine phosphorylation of Mdm2 by the ErbB-4 intracellular domain fragment.''; PubMed Europe PMC Scholia
Lito P, Rosen N, Solit DB.; ''Tumor adaptation and resistance to RAF inhibitors.''; PubMed Europe PMC Scholia
Rowley RB, Burkhardt AL, Chao HG, Matsueda GR, Bolen JB.; ''Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation.''; PubMed Europe PMC Scholia
Marshall CB, Meiri D, Smith MJ, Mazhab-Jafari MT, Gasmi-Seabrook GM, Rottapel R, Stambolic V, Ikura M.; ''Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts.''; PubMed Europe PMC Scholia
Zhang H, Koo CY, Stebbing J, Giamas G.; ''The dual function of KSR1: a pseudokinase and beyond.''; PubMed Europe PMC Scholia
Garnett MJ, Rana S, Paterson H, Barford D, Marais R.; ''Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.''; PubMed Europe PMC Scholia
Muraoka-Cook RS, Sandahl M, Hunter D, Miraglia L, Earp HS.; ''Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation.''; PubMed Europe PMC Scholia
Rodriguez-Viciana P, Oses-Prieto J, Burlingame A, Fried M, McCormick F.; ''A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.''; PubMed Europe PMC Scholia
Cichowski K, Santiago S, Jardim M, Johnson BW, Jacks T.; ''Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor.''; PubMed Europe PMC Scholia
Friedman WJ, Greene LA.; ''Neurotrophin signaling via Trks and p75.''; PubMed Europe PMC Scholia
Luk PP, Yu B, Ng CC, Mercorella B, Selinger C, Lum T, Kao S, O'Toole SA, Cooper WA.; ''BRAF mutations in non-small cell lung cancer.''; PubMed Europe PMC Scholia
Zheng CF, Guan KL.; ''Cytoplasmic localization of the mitogen-activated protein kinase activator MEK.''; PubMed Europe PMC Scholia
Muik M, Frischauf I, Derler I, Fahrner M, Bergsmann J, Eder P, Schindl R, Hesch C, Polzinger B, Fritsch R, Kahr H, Madl J, Gruber H, Groschner K, Romanin C.; ''Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.''; PubMed Europe PMC Scholia
Udell CM, Rajakulendran T, Sicheri F, Therrien M.; ''Mechanistic principles of RAF kinase signaling.''; PubMed Europe PMC Scholia
Müller J, Ory S, Copeland T, Piwnica-Worms H, Morrison DK.; ''C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1.''; PubMed Europe PMC Scholia
Anastasaki C, Estep AL, Marais R, Rauen KA, Patton EE.; ''Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors.''; PubMed Europe PMC Scholia
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW.; ''A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.''; PubMed Europe PMC Scholia
Lanier LL, Corliss BC, Wu J, Leong C, Phillips JH.; ''Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells.''; PubMed Europe PMC Scholia
Wienands J, Freuler F, Baumann G.; ''Tyrosine-phosphorylated forms of Ig beta, CD22, TCR zeta and HOSS are major ligands for tandem SH2 domains of Syk.''; PubMed Europe PMC Scholia
Nussinov R, Muratcioglu S, Tsai CJ, Jang H, Gursoy A, Keskin O.; ''The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas.''; PubMed Europe PMC Scholia
Casar B, Pinto A, Crespo P.; ''Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes.''; PubMed Europe PMC Scholia
Cordeddu V, Di Schiavi E, Pennacchio LA, Ma'ayan A, Sarkozy A, Fodale V, Cecchetti S, Cardinale A, Martin J, Schackwitz W, Lipzen A, Zampino G, Mazzanti L, Digilio MC, Martinelli S, Flex E, Lepri F, Bartholdi D, Kutsche K, Ferrero GB, Anichini C, Selicorni A, Rossi C, Tenconi R, Zenker M, Merlo D, Dallapiccola B, Iyengar R, Bazzicalupo P, Gelb BD, Tartaglia M.; ''Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair.''; PubMed Europe PMC Scholia
Ahmadian MR, Kiel C, Stege P, Scheffzek K.; ''Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP.''; PubMed Europe PMC Scholia
Haskins JW, Zhang S, Means RE, Kelleher JK, Cline GW, Canfrán-Duque A, Suárez Y, Stern DF.; ''Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake.''; PubMed Europe PMC Scholia
Oh-hora M, Ogata M, Mori Y, Adachi M, Imai K, Kosugi A, Hamaoka T.; ''Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase.''; PubMed Europe PMC Scholia
Wang X, Lupardus P, Laporte SL, Garcia KC.; ''Structural biology of shared cytokine receptors.''; PubMed Europe PMC Scholia
Rajalingam K, Rudel T.; ''Ras-Raf signaling needs prohibitin.''; PubMed Europe PMC Scholia
Bermudez O, Pagès G, Gimond C.; ''The dual-specificity MAP kinase phosphatases: critical roles in development and cancer.''; PubMed Europe PMC Scholia
Ahmadian MR, Stege P, Scheffzek K, Wittinghofer A.; ''Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras.''; PubMed Europe PMC Scholia
Saouaf SJ, Mahajan S, Rowley RB, Kut SA, Fargnoli J, Burkhardt AL, Tsukada S, Witte ON, Bolen JB.; ''Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement.''; PubMed Europe PMC Scholia
Jaiswal RK, Moodie SA, Wolfman A, Landreth GE.; ''The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras.''; PubMed Europe PMC Scholia
Clapéron A, Therrien M.; ''KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.''; PubMed Europe PMC Scholia
McKay MM, Ritt DA, Morrison DK.; ''Signaling dynamics of the KSR1 scaffold complex.''; PubMed Europe PMC Scholia
Brummer T, Naegele H, Reth M, Misawa Y.; ''Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf.''; PubMed Europe PMC Scholia
Formstecher E, Ramos JW, Fauquet M, Calderwood DA, Hsieh JC, Canton B, Nguyen XT, Barnier JV, Camonis J, Ginsberg MH, Chneiweiss H.; ''PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase.''; PubMed Europe PMC Scholia
Stone JC.; ''Regulation of Ras in lymphocytes: get a GRP.''; PubMed Europe PMC Scholia
Wali VB, Haskins JW, Gilmore-Hebert M, Platt JT, Liu Z, Stern DF.; ''Convergent and divergent cellular responses by ErbB4 isoforms in mammary epithelial cells.''; PubMed Europe PMC Scholia
Bélanger LF, Roy S, Tremblay M, Brott B, Steff AM, Mourad W, Hugo P, Erikson R, Charron J.; ''Mek2 is dispensable for mouse growth and development.''; PubMed Europe PMC Scholia
Hou SW, Zhi HY, Pohl N, Loesch M, Qi XM, Li RS, Basir Z, Chen G.; ''PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction.''; PubMed Europe PMC Scholia
Eswarakumar VP, Lax I, Schlessinger J.; ''Cellular signaling by fibroblast growth factor receptors.''; PubMed Europe PMC Scholia
Beenken A, Mohammadi M.; ''The FGF family: biology, pathophysiology and therapy.''; PubMed Europe PMC Scholia
Ritt DA, Monson DM, Specht SI, Morrison DK.; ''Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling.''; PubMed Europe PMC Scholia
Roskoski R.; ''Targeting ERK1/2 protein-serine/threonine kinases in human cancers.''; PubMed Europe PMC Scholia
Irish JM, Czerwinski DK, Nolan GP, Levy R.; ''Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry.''; PubMed Europe PMC Scholia
Omerovic J, Santangelo L, Puggioni EM, Marrocco J, Dall'Armi C, Palumbo C, Belleudi F, Di Marcotullio L, Frati L, Torrisi MR, Cesareni G, Gulino A, Alimandi M.; ''The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation.''; PubMed Europe PMC Scholia
Amin DN, Perkins AS, Stern DF.; ''Gene expression profiling of ErbB receptor and ligand-dependent transcription.''; PubMed Europe PMC Scholia
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA.; ''Mutations of the BRAF gene in human cancer.''; PubMed Europe PMC Scholia
Leicht DT, Balan V, Zhu J, Kaplun A, Bronisz A, Rana A, Tzivion G.; ''MEK-1 activates C-Raf through a Ras-independent mechanism.''; PubMed Europe PMC Scholia
Reber L, Da Silva CA, Frossard N.; ''Stem cell factor and its receptor c-Kit as targets for inflammatory diseases.''; PubMed Europe PMC Scholia
Xia K, Mukhopadhyay NK, Inhorn RC, Barber DL, Rose PE, Lee RS, Narsimhan RP, D'Andrea AD, Griffin JD, Roberts TM.; ''The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner.''; PubMed Europe PMC Scholia
Ditlevsen DK, Povlsen GK, Berezin V, Bock E.; ''NCAM-induced intracellular signaling revisited.''; PubMed Europe PMC Scholia
Orru G, Coghe F, Faa G, Pillai S, Manieli C, Montaldo C, Pilia F, Pichiri G, Piras V, Coni P.; ''Rapid multiplex real-time PCR by molecular beacons for different BRAF allele detection in papillary thyroid carcinoma.''; PubMed Europe PMC Scholia
Hata D, Nakamura T, Kawakami T, Kawakami Y, Herren B, Mayumi M.; ''Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking.''; PubMed Europe PMC Scholia
Germann UA, Furey BF, Markland W, Hoover RR, Aronov AM, Roix JJ, Hale M, Boucher DM, Sorrell DA, Martinez-Botella G, Fitzgibbon M, Shapiro P, Wick MJ, Samadani R, Meshaw K, Groover A, DeCrescenzo G, Namchuk M, Emery CM, Saha S, Welsch DJ.; ''Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib).''; PubMed Europe PMC Scholia
Pettiford SM, Herbst R.; ''The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP.''; PubMed Europe PMC Scholia
King AJ, Patrick DR, Batorsky RS, Ho ML, Do HT, Zhang SY, Kumar R, Rusnak DW, Takle AK, Wilson DM, Hugger E, Wang L, Karreth F, Lougheed JC, Lee J, Chau D, Stout TJ, May EW, Rominger CM, Schaber MD, Luo L, Lakdawala AS, Adams JL, Contractor RG, Smalley KS, Herlyn M, Morrissey MM, Tuveson DA, Huang PS.; ''Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.''; PubMed Europe PMC Scholia
Williams CC, Allison JG, Vidal GA, Burow ME, Beckman BS, Marrero L, Jones FE.; ''The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone.''; PubMed Europe PMC Scholia
Gibbs JB, Sigal IS, Poe M, Scolnick EM.; ''Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.''; PubMed Europe PMC Scholia
Tran NH, Frost JA.; ''Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition.''; PubMed Europe PMC Scholia
Dailey L, Ambrosetti D, Mansukhani A, Basilico C.; ''Mechanisms underlying differential responses to FGF signaling.''; PubMed Europe PMC Scholia
Roskoski R.; ''ERK1/2 MAP kinases: structure, function, and regulation.''; PubMed Europe PMC Scholia
Hayes NV, Blackburn E, Smart LV, Boyle MM, Russell GA, Frost TM, Morgan BJ, Baines AJ, Gullick WJ.; ''Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer.''; PubMed Europe PMC Scholia
Moschos SJ, Sullivan RJ, Hwu WJ, Ramanathan RK, Adjei AA, Fong PC, Shapira-Frommer R, Tawbi HA, Rubino J, Rush TS, Zhang D, Miselis NR, Samatar AA, Chun P, Rubin EH, Schiller J, Long BJ, Dayananth P, Carr D, Kirschmeier P, Bishop WR, Deng Y, Cooper A, Shipps GW, Moreno BH, Robert L, Ribas A, Flaherty KT.; ''Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors.''; PubMed Europe PMC Scholia
Hatzivassiliou G, Haling JR, Chen H, Song K, Price S, Heald R, Hewitt JF, Zak M, Peck A, Orr C, Merchant M, Hoeflich KP, Chan J, Luoh SM, Anderson DJ, Ludlam MJ, Wiesmann C, Ultsch M, Friedman LS, Malek S, Belvin M.; ''Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.''; PubMed Europe PMC Scholia
Ahrens S, Jaramillo S, Yu K, Ghosh S, Hwang GR, Paik R, Lai C, He M, Huang ZJ, Li B.; ''ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection.''; PubMed Europe PMC Scholia
Lenormand P, Sardet C, Pagès G, L'Allemain G, Brunet A, Pouysségur J.; ''Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts.''; PubMed Europe PMC Scholia
Jackson SP, Mistry N, Yuan Y.; ''Platelets and the injured vessel wall-- "rolling into action": focus on glycoprotein Ib/V/IX and the platelet cytoskeleton.''; PubMed Europe PMC Scholia
Carter RH, Park DJ, Rhee SG, Fearon DT.; ''Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes.''; PubMed Europe PMC Scholia
Schmid RS, Maness PF.; ''L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth.''; PubMed Europe PMC Scholia
Shinohara H, Kurosaki T.; ''Comprehending the complex connection between PKCbeta, TAK1, and IKK in BCR signaling.''; PubMed Europe PMC Scholia
Wells A.; ''EGF receptor.''; PubMed Europe PMC Scholia
Fu SM, Winchester RJ, Kunkel HG.; ''Similar idiotypic specificity for the membrane IgD and IgM of human B lymphocytes.''; PubMed Europe PMC Scholia
Yamamori B, Kuroda S, Shimizu K, Fukui K, Ohtsuka T, Takai Y.; ''Purification of a Ras-dependent mitogen-activated protein kinase kinase kinase from bovine brain cytosol and its identification as a complex of B-Raf and 14-3-3 proteins.''; PubMed Europe PMC Scholia
Marais R, Light Y, Paterson HF, Mason CS, Marshall CJ.; ''Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases.''; PubMed Europe PMC Scholia
Feng L, Xie X, Ding Q, Luo X, He J, Fan F, Liu W, Wang Z, Chen Y.; ''Spatial regulation of Raf kinase signaling by RKTG.''; PubMed Europe PMC Scholia
Annunziata M, Granata R, Ghigo E.; ''The IGF system.''; PubMed Europe PMC Scholia
Lu Y, Sun XD, Hou FQ, Bi LL, Yin DM, Liu F, Chen YJ, Bean JC, Jiao HF, Liu X, Li BM, Xiong WC, Gao TM, Mei L.; ''Maintenance of GABAergic activity by neuregulin 1-ErbB4 in amygdala for fear memory.''; PubMed Europe PMC Scholia
Law CL, Sidorenko SP, Chandran KA, Draves KE, Chan AC, Weiss A, Edelhoff S, Disteche CM, Clark EA.; ''Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.''; PubMed Europe PMC Scholia
Tsai J, Lee JT, Wang W, Zhang J, Cho H, Mamo S, Bremer R, Gillette S, Kong J, Haass NK, Sproesser K, Li L, Smalley KS, Fong D, Zhu YL, Marimuthu A, Nguyen H, Lam B, Liu J, Cheung I, Rice J, Suzuki Y, Luu C, Settachatgul C, Shellooe R, Cantwell J, Kim SH, Schlessinger J, Zhang KY, West BL, Powell B, Habets G, Zhang C, Ibrahim PN, Hirth P, Artis DR, Herlyn M, Bollag G.; ''Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.''; PubMed Europe PMC Scholia
Rochman Y, Spolski R, Leonard WJ.; ''New insights into the regulation of T cells by gamma(c) family cytokines.''; PubMed Europe PMC Scholia
Sun H, King AJ, Diaz HB, Marshall MS.; ''Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak.''; PubMed Europe PMC Scholia
Zhu J, Balan V, Bronisz A, Balan K, Sun H, Leicht DT, Luo Z, Qin J, Avruch J, Tzivion G.; ''Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding.''; PubMed Europe PMC Scholia
Zhu Y, Sullivan LL, Nair SS, Williams CC, Pandey AK, Marrero L, Vadlamudi RK, Jones FE.; ''Coregulation of estrogen receptor by ERBB4/HER4 establishes a growth-promoting autocrine signal in breast tumor cells.''; PubMed Europe PMC Scholia
Denley A, Kang S, Karst U, Vogt PK.; ''Oncogenic signaling of class I PI3K isoforms.''; PubMed Europe PMC Scholia
Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA.; ''Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP.''; PubMed Europe PMC Scholia
Walmod PS, Kolkova K, Berezin V, Bock E.; ''Zippers make signals: NCAM-mediated molecular interactions and signal transduction.''; PubMed Europe PMC Scholia
Povlsen GK, Ditlevsen DK, Berezin V, Bock E.; ''Intracellular signaling by the neural cell adhesion molecule.''; PubMed Europe PMC Scholia
Marconcini R, Galli L, Antonuzzo A, Bursi S, Roncella C, Fontanini G, Sensi E, Falcone A.; ''Metastatic BRAF K601E-mutated melanoma reaches complete response to MEK inhibitor trametinib administered for over 36 months.''; PubMed Europe PMC Scholia
Lloyd AC.; ''Distinct functions for ERKs?''; PubMed Europe PMC Scholia
Chadee DN, Xu D, Hung G, Andalibi A, Lim DJ, Luo Z, Gutmann DH, Kyriakis JM.; ''Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.''; PubMed Europe PMC Scholia
Penington DJ, Bryant I, Riese DJ.; ''Constitutively active ErbB4 and ErbB2 mutants exhibit distinct biological activities.''; PubMed Europe PMC Scholia
Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouysségur J.; ''Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry.''; PubMed Europe PMC Scholia
Wagle N, Emery C, Berger MF, Davis MJ, Sawyer A, Pochanard P, Kehoe SM, Johannessen CM, Macconaill LE, Hahn WC, Meyerson M, Garraway LA.; ''Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling.''; PubMed Europe PMC Scholia
Chen KE, Lin SY, Wu MJ, Ho MR, Santhanam A, Chou CC, Meng TC, Wang AH.; ''Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formation.''; PubMed Europe PMC Scholia
Casar B, Pinto A, Crespo P.; ''ERK dimers and scaffold proteins: unexpected partners for a forgotten (cytoplasmic) task.''; PubMed Europe PMC Scholia
Sofroniew MV, Howe CL, Mobley WC.; ''Nerve growth factor signaling, neuroprotection, and neural repair.''; PubMed Europe PMC Scholia
Wolthuis RM, Bauer B, van 't Veer LJ, de Vries-Smits AM, Cool RH, Spaargaren M, Wittinghofer A, Burgering BM, Bos JL.; ''RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.''; PubMed Europe PMC Scholia
Omerovic J, Puggioni EM, Napoletano S, Visco V, Fraioli R, Frati L, Gulino A, Alimandi M.; ''Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level.''; PubMed Europe PMC Scholia
White MF, Kahn CR.; ''The insulin signaling system.''; PubMed Europe PMC Scholia
Blake JF, Burkard M, Chan J, Chen H, Chou KJ, Diaz D, Dudley DA, Gaudino JJ, Gould SE, Grina J, Hunsaker T, Liu L, Martinson M, Moreno D, Mueller L, Orr C, Pacheco P, Qin A, Rasor K, Ren L, Robarge K, Shahidi-Latham S, Stults J, Sullivan F, Wang W, Yin J, Zhou A, Belvin M, Merchant M, Moffat J, Schwarz JB.; ''Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.''; PubMed Europe PMC Scholia
Yamanashi Y, Kakiuchi T, Mizuguchi J, Yamamoto T, Toyoshima K.; ''Association of B cell antigen receptor with protein tyrosine kinase Lyn.''; PubMed Europe PMC Scholia
Fredriksson L, Li H, Eriksson U.; ''The PDGF family: four gene products form five dimeric isoforms.''; PubMed Europe PMC Scholia
Therrien M, Michaud NR, Rubin GM, Morrison DK.; ''KSR modulates signal propagation within the MAPK cascade.''; PubMed Europe PMC Scholia
Pavelić J, Matijević T, Knezević J.; ''Biological & physiological aspects of action of insulin-like growth factor peptide family.''; PubMed Europe PMC Scholia
Martini M, De Santis MC, Braccini L, Gulluni F, Hirsch E.; ''PI3K/AKT signaling pathway and cancer: an updated review.''; PubMed Europe PMC Scholia
Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, Chodon T, Nelson SF, McArthur G, Sosman JA, Ribas A, Lo RS.; ''Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.''; PubMed Europe PMC Scholia
Karoulia Z, Gavathiotis E, Poulikakos PI.; ''New perspectives for targeting RAF kinase in human cancer.''; PubMed Europe PMC Scholia
Carraway KL, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M, Lai C.; ''Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases.''; PubMed Europe PMC Scholia
Marais R, Light Y, Paterson HF, Marshall CJ.; ''Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.''; PubMed Europe PMC Scholia
Seger R, Seger D, Reszka AA, Munar ES, Eldar-Finkelman H, Dobrowolska G, Jensen AM, Campbell JS, Fischer EH, Krebs EG.; ''Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.''; PubMed Europe PMC Scholia
Muñoz JJ, Tárrega C, Blanco-Aparicio C, Pulido R.; ''Differential interaction of the tyrosine phosphatases PTP-SL, STEP and HePTP with the mitogen-activated protein kinases ERK1/2 and p38alpha is determined by a kinase specificity sequence and influenced by reducing agents.''; PubMed Europe PMC Scholia
Schlessinger J.; ''Common and distinct elements in cellular signaling via EGF and FGF receptors.''; PubMed Europe PMC Scholia
Woo RS, Lee JH, Kim HS, Baek CH, Song DY, Suh YH, Baik TK.; ''Neuregulin-1 protects against neurotoxicities induced by Swedish amyloid precursor protein via the ErbB4 receptor.''; PubMed Europe PMC Scholia
Mori Y, Wakamori M, Miyakawa T, Hermosura M, Hara Y, Nishida M, Hirose K, Mizushima A, Kurosaki M, Mori E, Gotoh K, Okada T, Fleig A, Penner R, Iino M, Kurosaki T.; ''Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes.''; PubMed Europe PMC Scholia
Roberts PJ, Der CJ.; ''Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.''; PubMed Europe PMC Scholia
Ornitz DM, Marie PJ.; ''FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease.''; PubMed Europe PMC Scholia
Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, Dummer R, Garbe C, Testori A, Maio M, Hogg D, Lorigan P, Lebbe C, Jouary T, Schadendorf D, Ribas A, O'Day SJ, Sosman JA, Kirkwood JM, Eggermont AM, Dreno B, Nolop K, Li J, Nelson B, Hou J, Lee RJ, Flaherty KT, McArthur GA, BRIM-3 Study Group.; ''Improved survival with vemurafenib in melanoma with BRAF V600E mutation.''; PubMed Europe PMC Scholia
Rath O, Park S, Tang HH, Banfield MJ, Brady RL, Lee YC, Dignam JD, Sedivy JM, Kolch W, Yeung KC.; ''The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK.''; PubMed Europe PMC Scholia
Rommel C, Radziwill G, Lovrić J, Noeldeke J, Heinicke T, Jones D, Aitken A, Moelling K.; ''Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1.''; PubMed Europe PMC Scholia
Kato R, Nonami A, Taketomi T, Wakioka T, Kuroiwa A, Matsuda Y, Yoshimura A.; ''Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation.''; PubMed Europe PMC Scholia
Guan YF, Wu CY, Fang YY, Zeng YN, Luo ZY, Li SJ, Li XW, Zhu XH, Mei L, Gao TM.; ''Neuregulin 1 protects against ischemic brain injury via ErbB4 receptors by increasing GABAergic transmission.''; PubMed Europe PMC Scholia
Philips MR.; ''Sef: a MEK/ERK catcher on the Golgi.''; PubMed Europe PMC Scholia
Ren JG, Li Z, Sacks DB.; ''IQGAP1 modulates activation of B-Raf.''; PubMed Europe PMC Scholia
Kaplan DR, Miller FD.; ''Neurotrophin signal transduction in the nervous system.''; PubMed Europe PMC Scholia
Chowdhury I, Thompson WE, Thomas K.; ''Prohibitins role in cellular survival through Ras-Raf-MEK-ERK pathway.''; PubMed Europe PMC Scholia
Bollag G, McCormick F.; ''Ras regulation. NF is enough of GAP.''; PubMed Europe PMC Scholia
Masson K, Rönnstrand L.; ''Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3.''; PubMed Europe PMC Scholia
Yang X, Lee WH, Sobott F, Papagrigoriou E, Robinson CV, Grossmann JG, Sundström M, Doyle DA, Elkins JM.; ''Structural basis for protein-protein interactions in the 14-3-3 protein family.''; PubMed Europe PMC Scholia
Rauen KA, Tidyman WE, Estep AL, Sampath S, Peltier HM, Bale SJ, Lacassie Y.; ''Molecular and functional analysis of a novel MEK2 mutation in cardio-facio-cutaneous syndrome: transmission through four generations.''; PubMed Europe PMC Scholia
Pacold ME, Suire S, Perisic O, Lara-Gonzalez S, Davis CT, Walker EH, Hawkins PT, Stephens L, Eccleston JF, Williams RL.; ''Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma.''; PubMed Europe PMC Scholia
Hofer F, Fields S, Schneider C, Martin GS.; ''Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.''; PubMed Europe PMC Scholia
King JA, Straffon AF, D'Abaco GM, Poon CL, I ST, Smith CM, Buchert M, Corcoran NM, Hall NE, Callus BA, Sarcevic B, Martin D, Lock P, Hovens CM.; ''Distinct requirements for the Sprouty domain for functional activity of Spred proteins.''; PubMed Europe PMC Scholia
Chen PC, Yin J, Yu HW, Yuan T, Fernandez M, Yung CK, Trinh QM, Peltekova VD, Reid JG, Tworog-Dube E, Morgan MB, Muzny DM, Stein L, McPherson JD, Roberts AE, Gibbs RA, Neel BG, Kucherlapati R.; ''Next-generation sequencing identifies rare variants associated with Noonan syndrome.''; PubMed Europe PMC Scholia
Riese DJ, Komurasaki T, Plowman GD, Stern DF.; ''Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2.''; PubMed Europe PMC Scholia
Sanchez M, Misulovin Z, Burkhardt AL, Mahajan S, Costa T, Franke R, Bolen JB, Nussenzweig M.; ''Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta.''; PubMed Europe PMC Scholia
Flaswinkel H, Reth M.; ''Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor.''; PubMed Europe PMC Scholia
Fan F, Feng L, He J, Wang X, Jiang X, Zhang Y, Wang Z, Chen Y.; ''RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells.''; PubMed Europe PMC Scholia
Furie B, Furie BC.; ''The molecular basis of platelet and endothelial cell interaction with neutrophils and monocytes: role of P-selectin and the P-selectin ligand, PSGL-1.''; PubMed Europe PMC Scholia
Matheny SA, White MA.; ''Signaling threshold regulation by the Ras effector IMP.''; PubMed Europe PMC Scholia
Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM.; ''KSR, a novel protein kinase required for RAS signal transduction.''; PubMed Europe PMC Scholia
Young LC, Hartig N, Muñoz-Alegre M, Oses-Prieto JA, Durdu S, Bender S, Vijayakumar V, Vietri Rudan M, Gewinner C, Henderson S, Jathoul AP, Ghatrora R, Lythgoe MF, Burlingame AL, Rodriguez-Viciana P.; ''An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growth.''; PubMed Europe PMC Scholia
Guthridge MA, Stomski FC, Thomas D, Woodcock JM, Bagley CJ, Berndt MC, Lopez AF.; ''Mechanism of activation of the GM-CSF, IL-3, and IL-5 family of receptors.''; PubMed Europe PMC Scholia
Ory S, Zhou M, Conrads TP, Veenstra TD, Morrison DK.; ''Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites.''; PubMed Europe PMC Scholia
Xu Be, Wilsbacher JL, Collisson T, Cobb MH.; ''The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo.''; PubMed Europe PMC Scholia
Scheffzek K, Ahmadian MR, Kabsch W, Wiesmüller L, Lautwein A, Schmitz F, Wittinghofer A.; ''The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.''; PubMed Europe PMC Scholia
Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, O'Dwyer PJ, Lee RJ, Grippo JF, Nolop K, Chapman PB.; ''Inhibition of mutated, activated BRAF in metastatic melanoma.''; PubMed Europe PMC Scholia
Siddle K.; ''Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances.''; PubMed Europe PMC Scholia
Mace PD, Wallez Y, Egger MF, Dobaczewska MK, Robinson H, Pasquale EB, Riedl SJ.; ''Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.''; PubMed Europe PMC Scholia
Tomasello E, Vivier E.; ''KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions.''; PubMed Europe PMC Scholia
Eisenhardt AE, Olbrich H, Röring M, Janzarik W, Anh TN, Cin H, Remke M, Witt H, Korshunov A, Pfister SM, Omran H, Brummer T.; ''Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma.''; PubMed Europe PMC Scholia
Tran NH, Wu X, Frost JA.; ''B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms.''; PubMed Europe PMC Scholia
Weber CK, Slupsky JR, Kalmes HA, Rapp UR.; ''Active Ras induces heterodimerization of cRaf and BRaf.''; PubMed Europe PMC Scholia
Zhang M, Jang H, Nussinov R.; ''The structural basis for Ras activation of PI3Kα lipid kinase.''; PubMed Europe PMC Scholia
Kikuchi A, Demo SD, Ye ZH, Chen YW, Williams LT.; ''ralGDS family members interact with the effector loop of ras p21.''; PubMed Europe PMC Scholia
Van Allen EM, Wagle N, Sucker A, Treacy DJ, Johannessen CM, Goetz EM, Place CS, Taylor-Weiner A, Whittaker S, Kryukov GV, Hodis E, Rosenberg M, McKenna A, Cibulskis K, Farlow D, Zimmer L, Hillen U, Gutzmer R, Goldinger SM, Ugurel S, Gogas HJ, Egberts F, Berking C, Trefzer U, Loquai C, Weide B, Hassel JC, Gabriel SB, Carter SL, Getz G, Garraway LA, Schadendorf D, Dermatologic Cooperative Oncology Group of Germany (DeCOG).; ''The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma.''; PubMed Europe PMC Scholia
Wakioka T, Sasaki A, Kato R, Shouda T, Matsumoto A, Miyoshi K, Tsuneoka M, Komiya S, Baron R, Yoshimura A.; ''Spred is a Sprouty-related suppressor of Ras signalling.''; PubMed Europe PMC Scholia
Wu LC.; ''Immunoglobulin E receptor signaling and asthma.''; PubMed Europe PMC Scholia
Hou XJ, Ni KM, Yang JM, Li XM.; ''Neuregulin 1/ErbB4 enhances synchronized oscillations of prefrontal cortex neurons via inhibitory synapses.''; PubMed Europe PMC Scholia
Voges D, Zwickl P, Baumeister W.; ''The 26S proteasome: a molecular machine designed for controlled proteolysis.''; PubMed Europe PMC Scholia
Torii S, Kusakabe M, Yamamoto T, Maekawa M, Nishida E.; ''Sef is a spatial regulator for Ras/MAP kinase signaling.''; PubMed Europe PMC Scholia
Hayes SD, Liu H, MacDonald E, Sanderson CM, Coulson JM, Clague MJ, Urbé S.; ''Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15.''; PubMed Europe PMC Scholia
Lefloch R, Pouysségur J, Lenormand P.; ''Total ERK1/2 activity regulates cell proliferation.''; PubMed Europe PMC Scholia
Gysin S, Salt M, Young A, McCormick F.; ''Therapeutic strategies for targeting ras proteins.''; PubMed Europe PMC Scholia
Teis D, Taub N, Kurzbauer R, Hilber D, de Araujo ME, Erlacher M, Offterdinger M, Villunger A, Geley S, Bohn G, Klein C, Hess MW, Huber LA.; ''p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis.''; PubMed Europe PMC Scholia
Lennartsson J, Rönnstrand L.; ''The stem cell factor receptor/c-Kit as a drug target in cancer.''; PubMed Europe PMC Scholia
Diaz B, Barnard D, Filson A, MacDonald S, King A, Marshall M.; ''Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling.''; PubMed Europe PMC Scholia
Elenius K, Paul S, Allison G, Sun J, Klagsbrun M.; ''Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation.''; PubMed Europe PMC Scholia
Li Z, Mei Y, Liu X, Zhou M.; ''Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners.''; PubMed Europe PMC Scholia
Luik RM, Wang B, Prakriya M, Wu MM, Lewis RS.; ''Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation.''; PubMed Europe PMC Scholia
Kiryushko D, Berezin V, Bock E.; ''Regulators of neurite outgrowth: role of cell adhesion molecules.''; PubMed Europe PMC Scholia
Ni CY, Murphy MP, Golde TE, Carpenter G.; ''gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase.''; PubMed Europe PMC Scholia
Nikolaev SI, Rimoldi D, Iseli C, Valsesia A, Robyr D, Gehrig C, Harshman K, Guipponi M, Bukach O, Zoete V, Michielin O, Muehlethaler K, Speiser D, Beckmann JS, Xenarios I, Halazonetis TD, Jongeneel CV, Stevenson BJ, Antonarakis SE.; ''Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.''; PubMed Europe PMC Scholia
Krauthammer M, Kong Y, Bacchiocchi A, Evans P, Pornputtapong N, Wu C, McCusker JP, Ma S, Cheng E, Straub R, Serin M, Bosenberg M, Ariyan S, Narayan D, Sznol M, Kluger HM, Mane S, Schlessinger J, Lifton RP, Halaban R.; ''Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.''; PubMed Europe PMC Scholia
Fu SM, Winchester RJ, Kunkel HG.; ''Occurrence of surface IgM, IgD, and free light chains of human lymphocytes.''; PubMed Europe PMC Scholia
Roskoski R.; ''RAF protein-serine/threonine kinases: structure and regulation.''; PubMed Europe PMC Scholia
Williams EJ, Furness J, Walsh FS, Doherty P.; ''Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin.''; PubMed Europe PMC Scholia
Saouaf SJ, Kut SA, Fargnoli J, Rowley RB, Bolen JB, Mahajan S.; ''Reconstitution of the B cell antigen receptor signaling components in COS cells.''; PubMed Europe PMC Scholia
Turnbull IR, Colonna M.; ''Activating and inhibitory functions of DAP12.''; PubMed Europe PMC Scholia
Panicker AK, Buhusi M, Thelen K, Maness PF.; ''Cellular signalling mechanisms of neural cell adhesion molecules.''; PubMed Europe PMC Scholia
Naresh A, Long W, Vidal GA, Wimley WC, Marrero L, Sartor CI, Tovey S, Cooke TG, Bartlett JM, Jones FE.; ''The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells.''; PubMed Europe PMC Scholia
Tzahar E, Levkowitz G, Karunagaran D, Yi L, Peles E, Lavi S, Chang D, Liu N, Yayon A, Wen D.; ''ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms.''; PubMed Europe PMC Scholia
Nel AE, Landreth GE, Goldschmidt-Clermont PJ, Tung HE, Galbraith RM.; ''Enhanced tyrosine phosphorylation in B lymphocytes upon complexing of membrane immunoglobulin.''; PubMed Europe PMC Scholia
Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM, Kolch W.; ''Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein.''; PubMed Europe PMC Scholia
Zhang BH, Guan KL.; ''Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.''; PubMed Europe PMC Scholia
Pei D, Chen K, Liao H.; ''Targeting Ras with Macromolecules.''; PubMed Europe PMC Scholia
Adachi M, Fukuda M, Nishida E.; ''Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer.''; PubMed Europe PMC Scholia
Rio C, Buxbaum JD, Peschon JJ, Corfas G.; ''Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4.''; PubMed Europe PMC Scholia
Kim YJ, Sekiya F, Poulin B, Bae YS, Rhee SG.; ''Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.''; PubMed Europe PMC Scholia
Sim GC, Radvanyi L.; ''The IL-2 cytokine family in cancer immunotherapy.''; PubMed Europe PMC Scholia
Henry JR, Kaufman MD, Peng SB, Ahn YM, Caldwell TM, Vogeti L, Telikepalli H, Lu WP, Hood MM, Rutkoski TJ, Smith BD, Vogeti S, Miller D, Wise SC, Chun L, Zhang X, Zhang Y, Kays L, Hipskind PA, Wrobleski AD, Lobb KL, Clay JM, Cohen JD, Walgren JL, McCann D, Patel P, Clawson DK, Guo S, Manglicmot D, Groshong C, Logan C, Starling JJ, Flynn DL.; ''Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.''; PubMed Europe PMC Scholia
Genau HM, Huber J, Baschieri F, Akutsu M, Dötsch V, Farhan H, Rogov V, Behrends C.; ''CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.''; PubMed Europe PMC Scholia
Hou S, Suresh PS, Qi X, Lepp A, Mirza SP, Chen G.; ''p38γ Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.''; PubMed Europe PMC Scholia
Lorenz K, Schmid E, Deiss K.; ''RKIP: a governor of intracellular signaling.''; PubMed Europe PMC Scholia
Roy M, Li Z, Sacks DB.; ''IQGAP1 binds ERK2 and modulates its activity.''; PubMed Europe PMC Scholia
Sosman JA, Kim KB, Schuchter L, Gonzalez R, Pavlick AC, Weber JS, McArthur GA, Hutson TE, Moschos SJ, Flaherty KT, Hersey P, Kefford R, Lawrence D, Puzanov I, Lewis KD, Amaravadi RK, Chmielowski B, Lawrence HJ, Shyr Y, Ye F, Li J, Nolop KB, Lee RJ, Joe AK, Ribas A.; ''Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib.''; PubMed Europe PMC Scholia
Kaushansky A, Gordus A, Budnik BA, Lane WS, Rush J, MacBeath G.; ''System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties.''; PubMed Europe PMC Scholia
Kyriakis JM, Avruch J.; ''Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.''; PubMed Europe PMC Scholia
Ishii N, Harada N, Joseph EW, Ohara K, Miura T, Sakamoto H, Matsuda Y, Tomii Y, Tachibana-Kondo Y, Iikura H, Aoki T, Shimma N, Arisawa M, Sowa Y, Poulikakos PI, Rosen N, Aoki Y, Sakai T.; ''Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity.''; PubMed Europe PMC Scholia
Ahearn I, Zhou M, Philips MR.; ''Posttranslational Modifications of RAS Proteins.''; PubMed Europe PMC Scholia
Edling CE, Hallberg B.; ''c-Kit--a hematopoietic cell essential receptor tyrosine kinase.''; PubMed Europe PMC Scholia
Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM.; ''Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.''; PubMed Europe PMC Scholia
Goetz CA, O'Neil JJ, Farrar MA.; ''Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation.''; PubMed Europe PMC Scholia
Burack WR, Shaw AS.; ''Live Cell Imaging of ERK and MEK: simple binding equilibrium explains the regulated nucleocytoplasmic distribution of ERK.''; PubMed Europe PMC Scholia
Aqeilan RI, Donati V, Palamarchuk A, Trapasso F, Kaou M, Pekarsky Y, Sudol M, Croce CM.; ''WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function.''; PubMed Europe PMC Scholia
Brezski RJ, Monroe JG.; ''B-cell receptor.''; PubMed Europe PMC Scholia
Hennig A, Markwart R, Esparza-Franco MA, Ladds G, Rubio I.; ''Ras activation revisited: role of GEF and GAP systems.''; PubMed Europe PMC Scholia
Huang EJ, Reichardt LF.; ''Trk receptors: roles in neuronal signal transduction.''; PubMed Europe PMC Scholia
Parrella E, Longo VD.; ''Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain.''; PubMed Europe PMC Scholia
Akdis M, Burgler S, Crameri R, Eiwegger T, Fujita H, Gomez E, Klunker S, Meyer N, O'Mahony L, Palomares O, Rhyner C, Ouaked N, Schaffartzik A, Van De Veen W, Zeller S, Zimmermann M, Akdis CA.; ''Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases.''; PubMed Europe PMC Scholia
Tessarz AS, Cerwenka A.; ''The TREM-1/DAP12 pathway.''; PubMed Europe PMC Scholia
Tsang M, Friesel R, Kudoh T, Dawid IB.; ''Identification of Sef, a novel modulator of FGF signalling.''; PubMed Europe PMC Scholia
Estep AL, Palmer C, McCormick F, Rauen KA.; ''Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy.''; PubMed Europe PMC Scholia
Fürthauer M, Lin W, Ang SL, Thisse B, Thisse C.; ''Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.''; PubMed Europe PMC Scholia
Dougherty MK, Müller J, Ritt DA, Zhou M, Zhou XZ, Copeland TD, Conrads TP, Veenstra TD, Lu KP, Morrison DK.; ''Regulation of Raf-1 by direct feedback phosphorylation.''; PubMed Europe PMC Scholia
Kondoh K, Nishida E.; ''Regulation of MAP kinases by MAP kinase phosphatases.''; PubMed Europe PMC Scholia
Raabe T, Rapp UR.; ''Ras signaling: PP2A puts Ksr and Raf in the right place.''; PubMed Europe PMC Scholia
Riese DJ, van Raaij TM, Plowman GD, Andrews GC, Stern DF.; ''The cellular response to neuregulins is governed by complex interactions of the erbB receptor family.''; PubMed Europe PMC Scholia
Samatar AA, Poulikakos PI.; ''Targeting RAS-ERK signalling in cancer: promises and challenges.''; PubMed Europe PMC Scholia
Matallanas D, Birtwistle M, Romano D, Zebisch A, Rauch J, von Kriegsheim A, Kolch W.; ''Raf family kinases: old dogs have learned new tricks.''; PubMed Europe PMC Scholia
Roy M, Li Z, Sacks DB.; ''IQGAP1 is a scaffold for mitogen-activated protein kinase signaling.''; PubMed Europe PMC Scholia
Catalanotti F, Reyes G, Jesenberger V, Galabova-Kovacs G, de Matos Simoes R, Carugo O, Baccarini M.; ''A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal.''; PubMed Europe PMC Scholia
Geng F, Zhang J, Wu JL, Zou WJ, Liang ZP, Bi LL, Liu JH, Kong Y, Huang CQ, Li XW, Yang JM, Gao TM.; ''Neuregulin 1-ErbB4 signaling in the bed nucleus of the stria terminalis regulates anxiety-like behavior.''; PubMed Europe PMC Scholia
Sweeney C, Lai C, Riese DJ, Diamonti AJ, Cantley LC, Carraway KL.; ''Ligand discrimination in signaling through an ErbB4 receptor homodimer.''; PubMed Europe PMC Scholia
Rajakulendran T, Sahmi M, Lefrançois M, Sicheri F, Therrien M.; ''A dimerization-dependent mechanism drives RAF catalytic activation.''; PubMed Europe PMC Scholia
Terai K, Matsuda M.; ''Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.''; PubMed Europe PMC Scholia
Marks JL, Gong Y, Chitale D, Golas B, McLellan MD, Kasai Y, Ding L, Mardis ER, Wilson RK, Solit D, Levine R, Michel K, Thomas RK, Rusch VW, Ladanyi M, Pao W.; ''Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma.''; PubMed Europe PMC Scholia
Rodriguez-Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD, Downward J.; ''Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.''; PubMed Europe PMC Scholia
Gentry LR, Martin TD, Reiner DJ, Der CJ.; ''Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame.''; PubMed Europe PMC Scholia
Nakamura A, Arita T, Tsuchiya S, Donelan J, Chouitar J, Carideo E, Galvin K, Okaniwa M, Ishikawa T, Yoshida S.; ''Antitumor activity of the selective pan-RAF inhibitor TAK-632 in BRAF inhibitor-resistant melanoma.''; PubMed Europe PMC Scholia
Lito P, Saborowski A, Yue J, Solomon M, Joseph E, Gadal S, Saborowski M, Kastenhuber E, Fellmann C, Ohara K, Morikami K, Miura T, Lukacs C, Ishii N, Lowe S, Rosen N.; ''Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.''; PubMed Europe PMC Scholia
Stowe IB, Mercado EL, Stowe TR, Bell EL, Oses-Prieto JA, Hernández H, Burlingame AL, McCormick F.; ''A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1.''; PubMed Europe PMC Scholia
Hu J, Stites EC, Yu H, Yu H, Germino EA, Meharena HS, Stork PJS, Kornev AP, Taylor SS, Shaw AS.; ''Allosteric activation of functionally asymmetric RAF kinase dimers.''; PubMed Europe PMC Scholia
Kainulainen V, Sundvall M, Määttä JA, Santiestevan E, Klagsbrun M, Elenius K.; ''A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis.''; PubMed Europe PMC Scholia
Chaikuad A, Tacconi EM, Zimmer J, Liang Y, Gray NS, Tarsounas M, Knapp S.; ''A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.''; PubMed Europe PMC Scholia
Cheng QC, Tikhomirov O, Zhou W, Carpenter G.; ''Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment.''; PubMed Europe PMC Scholia
Bourne HR, Sanders DA, McCormick F.; ''The GTPase superfamily: conserved structure and molecular mechanism.''; PubMed Europe PMC Scholia
Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, Luttrell LM.; ''The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.''; PubMed Europe PMC Scholia
Coggeshall KM, McHugh JC, Altman A.; ''Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes.''; PubMed Europe PMC Scholia
Vigil D, Cherfils J, Rossman KL, Der CJ.; ''Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?''; PubMed Europe PMC Scholia
Catling AD, Schaeffer HJ, Reuter CW, Reddy GR, Weber MJ.; ''A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function.''; PubMed Europe PMC Scholia
Chitnis MM, Yuen JS, Protheroe AS, Pollak M, Macaulay VM.; ''The type 1 insulin-like growth factor receptor pathway.''; PubMed Europe PMC Scholia
Suire S, Hawkins P, Stephens L.; ''Activation of phosphoinositide 3-kinase gamma by Ras.''; PubMed Europe PMC Scholia
Chen C, Lewis RE, White MA.; ''IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds.''; PubMed Europe PMC Scholia
Bradshaw JM.; ''The Src, Syk, and Tec family kinases: distinct types of molecular switches.''; PubMed Europe PMC Scholia
Gripp KW, Aldinger KA, Bennett JT, Baker L, Tusi J, Powell-Hamilton N, Stabley D, Sol-Church K, Timms AE, Dobyns WB.; ''A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair.''; PubMed Europe PMC Scholia
Hu J, Yu H, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor SS, Shaw AS.; ''Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF.''; PubMed Europe PMC Scholia
Lavoie H, Therrien M.; ''Regulation of RAF protein kinases in ERK signalling.''; PubMed Europe PMC Scholia
Morris EJ, Jha S, Restaino CR, Dayananth P, Zhu H, Cooper A, Carr D, Deng Y, Jin W, Black S, Long B, Liu J, Dinunzio E, Windsor W, Zhang R, Zhao S, Angagaw MH, Pinheiro EM, Desai J, Xiao L, Shipps G, Hruza A, Wang J, Kelly J, Paliwal S, Gao X, Babu BS, Zhu L, Daublain P, Zhang L, Lutterbach BA, Pelletier MR, Philippar U, Siliphaivanh P, Witter D, Kirschmeier P, Bishop WR, Hicklin D, Gilliland DG, Jayaraman L, Zawel L, Fawell S, Samatar AA.; ''Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.''; PubMed Europe PMC Scholia
Shin SY, Rath O, Choo SM, Fee F, McFerran B, Kolch W, Cho KH.; ''Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway.''; PubMed Europe PMC Scholia
Montagut C, Sharma SV, Shioda T, McDermott U, Ulman M, Ulkus LE, Dias-Santagata D, Stubbs H, Lee DY, Singh A, Drew L, Haber DA, Settleman J.; ''Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma.''; PubMed Europe PMC Scholia
Teis D, Wunderlich W, Huber LA.; ''Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction.''; PubMed Europe PMC Scholia
Feng SM, Muraoka-Cook RS, Hunter D, Sandahl MA, Caskey LS, Miyazawa K, Atfi A, Earp HS.; ''The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation.''; PubMed Europe PMC Scholia
Cseh B, Doma E, Baccarini M.; ''"RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway.''; PubMed Europe PMC Scholia
Ohren JF, Chen H, Pavlovsky A, Whitehead C, Zhang E, Kuffa P, Yan C, McConnell P, Spessard C, Banotai C, Mueller WT, Delaney A, Omer C, Sebolt-Leopold J, Dudley DT, Leung IK, Flamme C, Warmus J, Kaufman M, Barrett S, Tecle H, Hasemann CA.; ''Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.''; PubMed Europe PMC Scholia
Heldin CH, Westermark B.; ''Mechanism of action and in vivo role of platelet-derived growth factor.''; PubMed Europe PMC Scholia
Salzano M, Rusciano MR, Russo E, Bifulco M, Postiglione L, Vitale M.; ''Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates Raf-1 at serine 338 and mediates Ras-stimulated Raf-1 activation.''; PubMed Europe PMC Scholia
Boga SB, Deng Y, Zhu L, Nan Y, Cooper AB, Shipps GW, Doll R, Shih NY, Zhu H, Sun R, Wang T, Paliwal S, Tsui HC, Gao X, Yao X, Desai J, Wang J, Alhassan AB, Kelly J, Patel M, Muppalla K, Gudipati S, Zhang LK, Buevich A, Hesk D, Carr D, Dayananth P, Black S, Mei H, Cox K, Sherborne B, Hruza AW, Xiao L, Jin W, Long B, Liu G, Taylor SA, Kirschmeier P, Windsor WT, Bishop R, Samatar AA.; ''MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.''; PubMed Europe PMC Scholia
Luo X, Feng L, Jiang X, Xiao F, Wang Z, Feng GS, Chen Y.; ''Characterization of the topology and functional domains of RKTG.''; PubMed Europe PMC Scholia
Prior IA, Lewis PD, Mattos C.; ''A comprehensive survey of Ras mutations in cancer.''; PubMed Europe PMC Scholia
Baldock D, Graham B, Akhlaq M, Graff P, Jones CE, Menear K.; ''Purification and characterization of human Syk produced using a baculovirus expression system.''; PubMed Europe PMC Scholia
Herbst RS.; ''Review of epidermal growth factor receptor biology.''; PubMed Europe PMC Scholia
Roskoski R.; ''MEK1/2 dual-specificity protein kinases: structure and regulation.''; PubMed Europe PMC Scholia
Brunet A, Pagès G, Pouysségur J.; ''Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1).''; PubMed Europe PMC Scholia
Crosier PS, Ricciardi ST, Hall LR, Vitas MR, Clark SC, Crosier KE.; ''Expression of isoforms of the human receptor tyrosine kinase c-kit in leukemic cell lines and acute myeloid leukemia.''; PubMed Europe PMC Scholia
Chen RH, Sarnecki C, Blenis J.; ''Nuclear localization and regulation of erk- and rsk-encoded protein kinases.''; PubMed Europe PMC Scholia
Muraoka-Cook RS, Caskey LS, Sandahl MA, Hunter DM, Husted C, Strunk KE, Sartor CI, Rearick WA, McCall W, Sgagias MK, Cowan KH, Earp HS.; ''Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1.''; PubMed Europe PMC Scholia
Zeng F, Xu J, Harris RC.; ''Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells.''; PubMed Europe PMC Scholia
Lemmon MA, Schlessinger J.; ''Cell signaling by receptor tyrosine kinases.''; PubMed Europe PMC Scholia
Relou IA, Bax LA, van Rijn HJ, Akkerman JW.; ''Site-specific phosphorylation of platelet focal adhesion kinase by low-density lipoprotein.''; PubMed Europe PMC Scholia
Whittaker SR, Theurillat JP, Van Allen E, Wagle N, Hsiao J, Cowley GS, Schadendorf D, Root DE, Garraway LA.; ''A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.''; PubMed Europe PMC Scholia
Schulze WX, Deng L, Mann M.; ''Phosphotyrosine interactome of the ErbB-receptor kinase family.''; PubMed Europe PMC Scholia
Schlessinger J.; ''Ligand-induced, receptor-mediated dimerization and activation of EGF receptor.''; PubMed Europe PMC Scholia
Matsubayashi Y, Fukuda M, Nishida E.; ''Evidence for existence of a nuclear pore complex-mediated, cytosol-independent pathway of nuclear translocation of ERK MAP kinase in permeabilized cells.''; PubMed Europe PMC Scholia
Blank U, Rivera J.; ''The ins and outs of IgE-dependent mast-cell exocytosis.''; PubMed Europe PMC Scholia
Cherfils J, Zeghouf M.; ''Regulation of small GTPases by GEFs, GAPs, and GDIs.''; PubMed Europe PMC Scholia
McGillicuddy LT, Fromm JA, Hollstein PE, Kubek S, Beroukhim R, De Raedt T, Johnson BW, Williams SM, Nghiemphu P, Liau LM, Cloughesy TF, Mischel PS, Parret A, Seiler J, Moldenhauer G, Scheffzek K, Stemmer-Rachamimov AO, Sawyers CL, Brennan C, Messiaen L, Mellinghoff IK, Cichowski K.; ''Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis.''; PubMed Europe PMC Scholia
Chadee DN, Kyriakis JM.; ''A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation.''; PubMed Europe PMC Scholia
Paatero I, Jokilammi A, Heikkinen PT, Iljin K, Kallioniemi OP, Jones FE, Jaakkola PM, Elenius K.; ''Interaction with ErbB4 promotes hypoxia-inducible factor-1α signaling.''; PubMed Europe PMC Scholia
King PD, Lubeck BA, Lapinski PE.; ''Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis.''; PubMed Europe PMC Scholia
Cantwell-Dorris ER, O'Leary JJ, Sheils OM.; ''BRAFV600E: implications for carcinogenesis and molecular therapy.''; PubMed Europe PMC Scholia

History

View all...

Revision	Action	Time	User	Comment
114761	view	16:25, 25 January 2021	ReactomeTeam	Reactome version 75
113205	view	11:27, 2 November 2020	ReactomeTeam	Reactome version 74
112429	view	15:37, 9 October 2020	ReactomeTeam	Reactome version 73
101333	view	11:22, 1 November 2018	ReactomeTeam	reactome version 66
100871	view	20:55, 31 October 2018	ReactomeTeam	reactome version 65
100412	view	19:28, 31 October 2018	ReactomeTeam	reactome version 64
99961	view	16:13, 31 October 2018	ReactomeTeam	reactome version 63
99516	view	14:46, 31 October 2018	ReactomeTeam	reactome version 62 (2nd attempt)
99158	view	12:41, 31 October 2018	ReactomeTeam	reactome version 62
93933	view	13:46, 16 August 2017	ReactomeTeam	reactome version 61
93520	view	11:25, 9 August 2017	ReactomeTeam	reactome version 61
88127	view	10:15, 26 July 2016	Ryanmiller	Ontology Term : 'kinase mediated signaling pathway' added !
88126	view	10:15, 26 July 2016	Ryanmiller	Ontology Term : 'signaling pathway' added !
86618	view	09:22, 11 July 2016	ReactomeTeam	reactome version 56
83142	view	10:09, 18 November 2015	ReactomeTeam	Version54
81486	view	13:01, 21 August 2015	ReactomeTeam	Version53
76963	view	08:24, 17 July 2014	ReactomeTeam	Fixed remaining interactions
76668	view	12:03, 16 July 2014	ReactomeTeam	Fixed remaining interactions
75998	view	10:05, 11 June 2014	ReactomeTeam	Re-fixing comment source
75701	view	11:04, 10 June 2014	ReactomeTeam	Reactome 48 Update
75057	view	13:56, 8 May 2014	Anwesha	Fixing comment source for displaying WikiPathways description
74701	view	08:46, 30 April 2014	ReactomeTeam	New pathway

External references

DataNodes

View all...

Name	Type	Database reference
ADP	Metabolite	CHEBI:16761 (ChEBI)
ATP	Metabolite	CHEBI:15422 (ChEBI)
Activated RAF1 complex MEK1	Complex	REACT_4256 (Reactome)
Activated RAF1 complex MEK2	Complex	REACT_4223 (Reactome)
Activated RAF1 complex MEK	Complex	REACT_3953 (Reactome)
Activated RAF1 complex	Complex	REACT_4906 (Reactome)
GTP	Metabolite	CHEBI:15996 (ChEBI)
HRAS GTP	Complex	REACT_24217 (Reactome)
HRAS	Protein	P01112 (Uniprot-TrEMBL)
KRAS	Protein	P01116 (Uniprot-TrEMBL)
MAP2K1	Protein	Q02750 (Uniprot-TrEMBL)
MAP2K2	Protein	P36507 (Uniprot-TrEMBL)
MAPK1	Protein	P28482 (Uniprot-TrEMBL)
MAPK1	Protein	P28482 (Uniprot-TrEMBL)
MAPK3	Protein	P27361 (Uniprot-TrEMBL)
MAPK3	Protein	P27361 (Uniprot-TrEMBL)
MEK1 ERK-1	Complex	REACT_5539 (Reactome)
MEK1		REACT_2607 (Reactome)
MEK2 ERK-2	Complex	REACT_5435 (Reactome)
MEK	Protein	REACT_2275 (Reactome)
NRAS	Protein	P01111 (Uniprot-TrEMBL)
RAS RAF 14-3-3	Complex	REACT_3642 (Reactome)
RAS RAF	Complex	REACT_3036 (Reactome)
Ras GTP p-Raf1	Complex	REACT_24177 (Reactome)
YWHAB	Protein	P31946 (Uniprot-TrEMBL)
p-MEK1	Protein	REACT_3339 (Reactome)
p-Raf1	Complex	REACT_4612 (Reactome)
p-S,T-MAP2K2	Protein	P36507 (Uniprot-TrEMBL)
p-S,T-MAP2K2	Protein	P36507 (Uniprot-TrEMBL)
p-S218,S222-MAP2K1	Protein	Q02750 (Uniprot-TrEMBL)
p-S218,S222-MAP2K1	Protein	Q02750 (Uniprot-TrEMBL)
p-S259,S621-RAF1	Protein	P04049 (Uniprot-TrEMBL)
p-S259,S621-RAF1	Protein	P04049 (Uniprot-TrEMBL)
p-S259,Y340,Y341,S621-RAF1	Protein	P04049 (Uniprot-TrEMBL)
p-T161-CDK1	Protein	P06493 (Uniprot-TrEMBL)
p-T185,Y187-MAPK1	Protein	P28482 (Uniprot-TrEMBL)
p-T185,Y187-MAPK1	Protein	P28482 (Uniprot-TrEMBL)
p-T202,Y204-MAPK3	Protein	P27361 (Uniprot-TrEMBL)
p-T202,Y204-MAPK3	Protein	P27361 (Uniprot-TrEMBL)
p21 RAS GTP	Complex	REACT_4782 (Reactome)
phospho-ERK-1 MEK1	Complex	REACT_2796 (Reactome)
phospho-ERK-1 dimer	Complex	REACT_3152 (Reactome)
phospho-ERK-1 dimer	Complex	REACT_3932 (Reactome)
phospho-ERK-2 MEK2	Complex	REACT_3199 (Reactome)
phospho-ERK-2 dimer	Complex	REACT_3688 (Reactome)
phospho-ERK-2 dimer	Complex	REACT_5046 (Reactome)
unidentified protein tyrosine kinase		REACT_4938 (Reactome)

Annotated Interactions

View all...

Source	Target	Type	Database reference	Comment
	ADP	Arrow	REACT_136 (Reactome)
	ADP	Arrow	REACT_1727 (Reactome)
	ADP	Arrow	REACT_1836 (Reactome)
	ADP	Arrow	REACT_2247 (Reactome)
	ADP	Arrow	REACT_525 (Reactome)
	ADP	Arrow	REACT_545 (Reactome)
ATP			REACT_136 (Reactome)
ATP			REACT_1727 (Reactome)
ATP			REACT_1836 (Reactome)
ATP			REACT_2247 (Reactome)
ATP			REACT_525 (Reactome)
ATP			REACT_545 (Reactome)
Activated RAF1 complex MEK1			REACT_545 (Reactome)
Activated RAF1 complex MEK2			REACT_1727 (Reactome)
Activated RAF1 complex MEK			REACT_1727 (Reactome)
Activated RAF1 complex MEK			REACT_545 (Reactome)
	Activated RAF1 complex	Arrow	REACT_1727 (Reactome)
	Activated RAF1 complex	Arrow	REACT_525 (Reactome)
	Activated RAF1 complex	Arrow	REACT_545 (Reactome)
Activated RAF1 complex			REACT_143 (Reactome)
HRAS GTP			REACT_23877 (Reactome)
MAPK1			REACT_495 (Reactome)
MAPK3			REACT_1780 (Reactome)
MEK1 ERK-1			REACT_136 (Reactome)
MEK1			REACT_1836 (Reactome)
MEK2 ERK-2			REACT_2247 (Reactome)
MEK			REACT_143 (Reactome)
RAS RAF 14-3-3			REACT_525 (Reactome)
	RAS RAF	Arrow	REACT_359 (Reactome)
RAS RAF			REACT_996 (Reactome)
			REACT_1019 (Reactome)	MEK2 dissociates from phospho-ERK2, allowing phospho-ERK2 to dimerise with another phospho-ERK2.
			REACT_1289 (Reactome)	Two phospho-ERK1 molecules dimerise and enter the nucleus, where they may phosphorylate downstream targets.
			REACT_136 (Reactome)	MEK1 phosphorylates the critical Tyrosine and Threonine on ERK1, converting two ATP to ADP. Phosphorylation of ERK-1 activates its kinase activity.
			REACT_143 (Reactome)	MEK-1/2 have a proline rich domain (P) and critical Serine residues (MEK-1 S218/222, MEK-2 unknown, S) upon which the molecules may be phosphorylated. MEK1/2 are found in the cytoplasm of unstimulated cells. MEK-1/2 bind to active Raf-1 via the proline-rich domain. Active Raf-1 is able to phosphorylate target Serine and Threonine residues in the presence of ATP.
			REACT_1727 (Reactome)	Active Raf-1 phosphorylates MEK-1/2 on Serine residues, converting ATP to ADP. The MEK-1/2 kinase is now active.
			REACT_1740 (Reactome)	MEK1 dissociates from phospho-ERK1, allowing phospho-ERK1 to dimerise with another phospho-ERK1.
			REACT_1780 (Reactome)	In the cytoplasm activated MEK1 (Serine phosphorylated) may encounter monomeric, inactive ERK1. ERK1 in its inactive form is not phosphorylated on a critical Threonine (T) and a critical Tyrosine (Y).
			REACT_1836 (Reactome)	At the beginning of this reaction, 2 molecules of 'ATP', and 1 molecule of 'MEK1' are present. At the end of this reaction, 1 molecule of 'phospho_MEK1', and 2 molecules of 'ADP' are present. This reaction takes place in the 'cytosol' and is mediated by the 'protein serine/threonine kinase activity' of 'phospho-Cdc2 (Thr 161)'.
			REACT_1866 (Reactome)	Phospho-ERK-1 dimer is translocated from cytosol to nucleoplasm.
			REACT_2158 (Reactome)	Inactive Raf-1 is associated in the cytoplasm with 14-3-3. 14-3-3 binds to Raf-1 via the Ser259 phosphorylation site (S1). This interaction stabilises the inactive conformation of Raf-1 in which the Ras-binding Cysteine-rich domain (CRD) is obscured. The Raf-1 molecule contains an additional p21ras-binding domain (RBD), a second serine phosphorylation site at S621 (S2) and two tyrosine phosphorylation sites (at 340, Y1 and 341, Y2).
			REACT_2196 (Reactome)	Two phospho-ERK2 molecules dimerise and enter the nucleus, where they may phosphorylate downstream targets.
			REACT_2247 (Reactome)	MEK2 phosphorylates the critical Tyrosine and Threonine on ERK2, converting two ATP to ADP. Phosphorylation of ERK-2 activates its kinase activity.
			REACT_23877 (Reactome)	A key event for Ras transformation involves the direct physical association between Ras and the Raf-1 kinase. This interaction promotes both Raf translocation to the plasma membrane and activation of Raf kinase activity.
			REACT_359 (Reactome)	Activated p21ras (the GTP-bound form) is associated with the plasma membrane. Inactive Raf-1 is associated in the cytoplasm with 14-3-3. 14-3-3 binds to Raf-1 via the Ser259 phosphorylation site (S1). This interaction stabilises the inactive conformation of Raf-1 in which the Ras-binding Cysteine-rich domain (CRD) is obscured. The Raf-1 molecule contains an additional p21ras-binding domain (RBD), a second serine phosphorylation site at S621 (S2) and two tyrosine phosphorylation sites (at 340, Y1 and 341, Y2). Raf-1 binds activated p21ras via the RBD. This displaces 14-3-3 from Ser259 and unmasks the CRD.
			REACT_487 (Reactome)	Phospho-ERK-2 dimer is translocated from cytosol to nucleoplasm.
			REACT_495 (Reactome)	In the cytoplasm activated MEK2 (Serine phosphorylated) may encounter monomeric, inactive ERK2. ERK2 in its inactive form is not phosphorylated on a critical Threonine (T183) and a critical Tyrosine (Y185).
			REACT_525 (Reactome)	An unidentified protein tyrosine kinase located in the plasma membrane phosphorylates tyrosine residues at 340 and 341 (Y1, Y2 in diagram) of Raf-1. This serves to further stabilise the active 'open' Raf-1 conformation. While the kinase has not been definitively identified, Src is a plausible candidate: coexpression of Raf-1 and Src in Sf9 cells resulted in phosphorylation of Y340/Y341 and enzymatic activationof Raf-1; Raf-1 interacts with Src and co-immunoprecipitates with Src/Fyn in NIH-3T3 cells.
			REACT_545 (Reactome)	Active Raf-1 phosphorylates MEK-1/2 on Serine residues, converting ATP to ADP. The MEK-1/2 kinase is now active.
			REACT_996 (Reactome)	14-3-3 has been displaced from Ser259. 14-3-3 may now bind its higher affinity Ser621 (S2) site. This stabilises an 'open' Raf-1 conformation that is catalytically active, and bound to p21ras via both p21ras-binding domains, CRD and RBD.
	YWHAB	Arrow	REACT_359 (Reactome)
YWHAB			REACT_2158 (Reactome)
YWHAB			REACT_996 (Reactome)
	p-MEK1	Arrow	REACT_1836 (Reactome)
p-MEK1		TBar	REACT_136 (Reactome)
p-Raf1			REACT_359 (Reactome)
	p-S,T-MAP2K2	Arrow	REACT_1019 (Reactome)
	p-S,T-MAP2K2	Arrow	REACT_1727 (Reactome)
p-S,T-MAP2K2			REACT_495 (Reactome)
	p-S218,S222-MAP2K1	Arrow	REACT_1740 (Reactome)
	p-S218,S222-MAP2K1	Arrow	REACT_545 (Reactome)
p-S218,S222-MAP2K1			REACT_1780 (Reactome)
p-S259,S621-RAF1			REACT_2158 (Reactome)
p-S259,S621-RAF1			REACT_23877 (Reactome)
p-T161-CDK1			REACT_1836 (Reactome)
	p-T185,Y187-MAPK1	Arrow	REACT_1019 (Reactome)
	p-T202,Y204-MAPK3	Arrow	REACT_1740 (Reactome)
p21 RAS GTP			REACT_359 (Reactome)
	phospho-ERK-1 MEK1	Arrow	REACT_136 (Reactome)
	phospho-ERK-2 MEK2	Arrow	REACT_2247 (Reactome)
unidentified protein tyrosine kinase			REACT_525 (Reactome)

RAF/MAP kinase cascade (Homo sapiens)

From WikiPathways

Description

Try the New WikiPathways

Quality Tags

Ontology Terms

Bibliography

History

External references

DataNodes

Annotated Interactions

Views

Personal tools

search

Download

Activity

Tools

Community Portals

Toolbox