Activation of gene expression by SREBF (SREBP) (Homo sapiens)

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17, 20, 3651130623195, 6, 9, 366, 9, 12, 364, 9, 14, 16, 31...9, 3666152599, 331, 42129366, 96274, 6, 12, 36713103286, 9, 22342, 9284, 6, 9, 24, 26...3718226, 9, 36Ligands of PPARA[nucleoplasm]SREBF1A,2[nucleoplasm]SREBF1A,2[nucleoplasm]endoplasmic reticulum membraneSREBP1A/2:NF-Y:SP1:IDI1gene [nucleoplasm]SREBP1A/1C Dimer[nucleoplasm]NF-Y [nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]NF-Y [nucleoplasm]SREBF1A,2[nucleoplasm]SREBP1A/1C/2:ELOVL6gene [nucleoplasm]SREBF1A,2[nucleoplasm]SREBP1A/2:MVD gene[nucleoplasm]SREBP1A/2:NF-Y:SP1:PMVKgene [nucleoplasm]SREBP1A/2:NF-Y:SP1:MVKgene [nucleoplasm]SREBF1A,2[nucleoplasm]SREBP1A/2:NF-Y:HMGCRgene [nucleoplasm]PPARA: Fatty AcidComplex (ActivatedPPARA) [nucleoplasm]NF-Y [nucleoplasm]NF-Y [nucleoplasm]Coactivators ofPPARalpha[nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]NF-Y [nucleoplasm]SREBP1A/1C:NF-Y:SP1:FASNgene [nucleoplasm]NF-Y [nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]SREBP1A/1C/2:NF-Y:HMGCS1gene [nucleoplasm]SREBF1A,1C,2 cleavedby S2P [nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]SREBP1A/2:SQLE gene[nucleoplasm]SREBF1A,2[nucleoplasm]SREBP1A/1C/2 Dimer[nucleoplasm]SREBF1A,2[nucleoplasm]SREBP1A/1C Dimer[nucleoplasm]SREBP1A/1C/2 Dimer[nucleoplasm]SREBP1A/2:NF-Y:SP1:CYP51A1gene [nucleoplasm]PPARA:RXRACoactivator Complex[nucleoplasm]Ligands of PPARA[nucleoplasm]PPARA:RXRACoactivator Complex[nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]NF-Y [nucleoplasm]NF-Y [nucleoplasm]Ligands of PPARA[nucleoplasm]SREBF1A,C[nucleoplasm]Activated PPARA:RXRAHeterodimer[nucleoplasm]SREBP1A/1C/2:NF-Y:SP1:FDFT1gene [nucleoplasm]NF-Y [nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]SREBP1A/2:NF-Y:SP1:GGPS1gene [nucleoplasm]SREBP1A/1C/2 Dimer[nucleoplasm]Activated PPARA:RXRAHeterodimer[nucleoplasm]PPARA: Fatty AcidComplex (ActivatedPPARA) [nucleoplasm]Coactivators ofPPARalpha[nucleoplasm]mitochondrial outer membraneSREBP1A/1C Dimer[nucleoplasm]Coactivators ofPPARalpha[nucleoplasm]NF-Y [nucleoplasm]SREBP1A/1C/2 Dimer[nucleoplasm]NF-Y [nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]SREBF1A,C[nucleoplasm]SREBF1A,2[nucleoplasm]SREBF1A,1C,2 cleavedby S2P [nucleoplasm]Activated PPARA:RXRAHeterodimer[nucleoplasm]SREBP1A/1C/2:NF-Y:FDPSgene [nucleoplasm]SREBP1A/1C:ACACAgene [nucleoplasm]SREBP1A/2:NF-Y:SP1:DHCR7gene [nucleoplasm]SREBP1A/2:NF-Y:SC5DLgene [nucleoplasm]SREBF1A,C[nucleoplasm]NF-Y [nucleoplasm]SREBF1A,1C,2 cleavedby S2P [nucleoplasm]SREBF1A,1C,2 cleavedby S2P [nucleoplasm]SREBP1A/1C/2:NF-Y:TM7SF2gene [nucleoplasm]NF-Y [nucleoplasm]SREBF1A,1C,2 cleavedby S2P [nucleoplasm]PPARA: Fatty AcidComplex (ActivatedPPARA) [nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]SREBF1A,2[nucleoplasm]SREBP1A/1C:ACACBgene [nucleoplasm]SREBP1A/1C/2 Dimer[nucleoplasm]NF-Y [nucleoplasm]cytosolSREBP1A/1C:NF-Y:GPAMgene [nucleoplasm]SREBF1A,1C,2 cleavedby S2P [nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]SREBP1A/1C Dimer[nucleoplasm]SREBP1A/1C Dimer[nucleoplasm]SREBF1A,2[nucleoplasm]SREBF1A,2[nucleoplasm]nucleoplasmSREBP1A/1C/2 Dimer[nucleoplasm]SREBF1A,C[nucleoplasm]SREBF1A,2[nucleoplasm]NF-Y [nucleoplasm]NF-Y [nucleoplasm]PPARA:RXRACoactivator Complex[nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]SREBF1A,C[nucleoplasm]NF-Y [nucleoplasm]SREBP1A/2:LSS gene[nucleoplasm]SREBP1A/1C/2 DimerNFYC [nucleoplasm]SREBF1-1(1-490)[nucleoplasm]NFYC [nucleoplasm]SREBF1-1(1-490)[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]HMGCS1NFYA [nucleoplasm]SREBF2(1-484)[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]SREBF2(1-484)[nucleoplasm]SREBF1-3[nucleoplasm]NFYB [nucleoplasm]HMGCR geneNFYA [nucleoplasm]NCOA1 [nucleoplasm]CHD9 [nucleoplasm]PMVK gene[nucleoplasm]MVD gene[nucleoplasm]SREBP1A/2:NF-Y:SP1:GGPS1geneSP1(1-785)FDFT1 gene[nucleoplasm]MVK gene[nucleoplasm]NF-YNFYB [nucleoplasm]GGPS1SREBF1-1(1-490)[nucleoplasm]CREBBP(2-2442)[nucleoplasm]FASNNFYB [nucleoplasm]PPARA [nucleoplasm]RXRA [nucleoplasm]SREBP1A/2:NF-Y:SP1:DHCR7geneSREBF2(1-484)[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]NFYA [nucleoplasm]EPA [nucleoplasm]NF-YACACB geneNFYA [nucleoplasm]SREBF2(1-484)[nucleoplasm]HELZ2 [nucleoplasm]CHD9 [nucleoplasm]ELOVL6 gene[nucleoplasm]SREBP1A/2:NF-Y:SC5DLgeneNFYB [nucleoplasm]SREBF1-3[nucleoplasm]RXRA [nucleoplasm]PPARA:RXRACoactivator ComplexSREBP1A/2:SQLE geneSREBF1-1(1-490)[nucleoplasm]EPA [nucleoplasm]HMGCR-1PMVKLSSALA [nucleoplasm]NFYB [nucleoplasm]NFYC [nucleoplasm]SREBF2(1-484)[nucleoplasm]NFYA [nucleoplasm]NCOA1 [nucleoplasm]NFYB [nucleoplasm]NFYA [nucleoplasm]Palm [nucleoplasm]IDI1 geneSREBP1A/1C:NF-Y:SP1:FASNgeneNFYC [nucleoplasm]MVD geneTM7SF2 gene[nucleoplasm]NFYA [nucleoplasm]SC5DL gene[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]CYP51A1 gene[nucleoplasm]NFYA [nucleoplasm]SREBF1-1(1-490)[nucleoplasm]CYP51A1 geneLINA [nucleoplasm]NFYC [nucleoplasm]SP1(1-785)SREBP1A/2:NF-Y:SP1:MVKgeneTM7SF2 geneNFYC [nucleoplasm]FDFT1GPAM gene[nucleoplasm]SMARCD3[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]SC5DL geneDHCR7DHCR7 geneSREBP1A/2:NF-Y:SP1:PMVKgenePPARA:RXRACoactivator ComplexAA [nucleoplasm]NFYB [nucleoplasm]NCOA6 [nucleoplasm]SREBF2(1-484)[nucleoplasm]NFYA [nucleoplasm]TBL1XR1[nucleoplasm]SMARCD3[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]SP1(1-785)[nucleoplasm]GPAM(1-828)CREBBP(2-2442)[nucleoplasm]TGS1 [nucleoplasm]SREBF1-1(1-490)[nucleoplasm]LINA [nucleoplasm]HMGCS1 geneCARM1(2-608)[nucleoplasm]NCOA2 [nucleoplasm]NFYA [nucleoplasm]TGS1 [nucleoplasm]SREBF2(1-484)[nucleoplasm]SREBP1A/2 DimerSREBF1-1(1-490)[nucleoplasm]CARM1(2-608)[nucleoplasm]FASN geneMVK geneACACB gene[nucleoplasm]SREBF1-3[nucleoplasm]NFYC [nucleoplasm]AA [nucleoplasm]SREBF1-3[nucleoplasm]NFYA [nucleoplasm]NFYA [nucleoplasm]MED1 [nucleoplasm]HMGCR gene[nucleoplasm]NFYB [nucleoplasm]SREBP1A/2:NF-Y:SP1:IDI1geneSP1(1-785)[nucleoplasm]FDPS geneSP1(1-785)[nucleoplasm]CHD9 [nucleoplasm]NFYB [nucleoplasm]SREBP1A/1C DimerRXRA [nucleoplasm]NCOA2 [nucleoplasm]TBL1XR1[nucleoplasm]ACACBSREBP1A/1C/2:NF-Y:SP1:FDFT1geneHELZ2 [nucleoplasm]ALA [nucleoplasm]SREBF2(1-484)[nucleoplasm]DHCR7 gene[nucleoplasm]SREBP1A/1C:ACACAgeneNFYB [nucleoplasm]FDPSSREBF1-1(1-490)[nucleoplasm]NCOA6 [nucleoplasm]SREBF2(1-484)[nucleoplasm]ACACALINA [nucleoplasm]MED1 [nucleoplasm]NFYB [nucleoplasm]SREBF1-3[nucleoplasm]SP1(1-785)[nucleoplasm]TM7SF2ACACA geneSREBF1-1(1-490)[nucleoplasm]NCOA2 [nucleoplasm]SREBP1A/1C:ACACBgeneNFYC [nucleoplasm]SREBF1-1(1-490)[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]NFYC [nucleoplasm]NFYB [nucleoplasm]NFYC [nucleoplasm]PPARA [nucleoplasm]SQLE gene[nucleoplasm]TBL1XR1[nucleoplasm]SREBF2(1-484)[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]SREBP1A/2:MVD geneALA [nucleoplasm]NFYC [nucleoplasm]SMARCD3[nucleoplasm]Palm [nucleoplasm]ELOVL6 geneCYP51A1NFYA [nucleoplasm]SREBP1A/1C/2:NF-Y:TM7SF2geneNCOA1 [nucleoplasm]PMVK geneNFYA [nucleoplasm]SREBF1-3[nucleoplasm]SREBF1-3[nucleoplasm]NFYC [nucleoplasm]SREBF1-3[nucleoplasm]SREBF2(1-484)[nucleoplasm]FDFT1 geneMED1 [nucleoplasm]SREBP1A/1C/2:NF-Y:HMGCS1geneELOVL6SREBF2(1-484)[nucleoplasm]AA [nucleoplasm]NFYA [nucleoplasm]SREBP1A/1C/2:NF-Y:FDPSgeneMVKNFYB [nucleoplasm]SP1(1-785)[nucleoplasm]Palm [nucleoplasm]NFYC [nucleoplasm]SREBF1-1(1-490)[nucleoplasm]SQLESREBF1-1(1-490)[nucleoplasm]LSS geneTGS1 [nucleoplasm]NFYB [nucleoplasm]FASN gene[nucleoplasm]TBL1X [nucleoplasm]NFYC [nucleoplasm]CREBBP(2-2442)[nucleoplasm]NFYB [nucleoplasm]SREBF2(1-484)[nucleoplasm]CARM1(2-608)[nucleoplasm]SP1(1-785)[nucleoplasm]NFYC [nucleoplasm]SREBP1A/2:NF-Y:HMGCRgeneSP1(1-785)[nucleoplasm]SREBF2(1-484)[nucleoplasm]SREBF1-3[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]SREBF2(1-484)[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]GGPS1 geneHMGCS1 gene[nucleoplasm]HELZ2 [nucleoplasm]PPARA:RXRACoactivator ComplexNFYC [nucleoplasm]NCOA6 [nucleoplasm]PPARA [nucleoplasm]NFYB [nucleoplasm]SP1(1-785)[nucleoplasm]TBL1X [nucleoplasm]GGPS1 gene[nucleoplasm]SREBF2(1-484)[nucleoplasm]IDI1ACACA gene[nucleoplasm]SREBF1-3[nucleoplasm]LSS gene[nucleoplasm]NFYA [nucleoplasm]GPAM geneSP1(1-785)[nucleoplasm]NFYC [nucleoplasm]SREBF2(1-484)[nucleoplasm]NFYB [nucleoplasm]TBL1X [nucleoplasm]IDI1 gene[nucleoplasm]SREBF2(1-484)[nucleoplasm]SREBF1-3[nucleoplasm]SREBP1A/2:NF-Y:SP1:CYP51A1geneSREBP1A/1C:NF-Y:GPAMgeneSREBP1A/2:LSS geneFDPS gene[nucleoplasm]EPA [nucleoplasm]MVD(2-400)SQLE geneSREBP1A/1C/2:ELOVL6geneSC5DSREBF1-1(1-490)[nucleoplasm]NFYA [nucleoplasm]6666666383866, 162, 6, 22, 266666


Description

After transiting to the nucleus SREBPs (SREBP1A/1C/2, SREBFs) bind short sequences, sterol regulatory elements (SREs), in the promoters of target genes (reviewed in Eberle et al. 2004, Weber et al. 2004). SREBPs alone are relatively weak activators of transcription, with SREBP1C being significantly weaker than SREBP1A or SREBP2. In combination with other transcription factors such as SP1 and NF-Y the SREBPs are much stronger activators. SREBP1C seems to more specifically target genes involved in fatty acid synthesis while SREBP2 seems to target genes involved in cholesterol synthesis (Pai et al. 1998).Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=2426168

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
123263view09:02, 9 July 2022EgonwIt was there twice
123261view08:50, 9 July 2022EgonwReplaced an old Ensembl identifier
114667view16:13, 25 January 2021ReactomeTeamReactome version 75
114381view12:04, 9 January 2021EgonwUpdated Ensembl identifier
113058view10:58, 2 November 2020ReactomeTeamReactome version 74
112290view15:12, 9 October 2020ReactomeTeamReactome version 73
103006view15:08, 31 January 2019Mkutmonupdated outdated Ensembl identifiers
101249view11:14, 1 November 2018ReactomeTeamreactome version 66
100788view20:41, 31 October 2018ReactomeTeamreactome version 65
100330view19:18, 31 October 2018ReactomeTeamreactome version 64
99875view16:02, 31 October 2018ReactomeTeamreactome version 63
99432view14:36, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93743view13:33, 16 August 2017ReactomeTeamreactome version 61
93257view11:18, 9 August 2017ReactomeTeamreactome version 61
87078view14:22, 18 July 2016MkutmonOntology Term : 'transcription pathway' added !
87077view14:21, 18 July 2016MkutmonOntology Term : 'sterol regulatory element-binding protein signaling pathway' added !
86336view09:15, 11 July 2016ReactomeTeamreactome version 56
83318view10:46, 18 November 2015ReactomeTeamVersion54
81757view09:58, 26 August 2015ReactomeTeamVersion53
76917view08:18, 17 July 2014ReactomeTeamFixed remaining interactions
76622view11:59, 16 July 2014ReactomeTeamFixed remaining interactions
75953view10:01, 11 June 2014ReactomeTeamRe-fixing comment source
75655view10:55, 10 June 2014ReactomeTeamReactome 48 Update
75010view13:52, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74843view10:07, 30 April 2014ReactomeTeamReactome46
74654view08:42, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AA [nucleoplasm]MetaboliteCHEBI:15843 (ChEBI)
ACACA gene [nucleoplasm]ProteinENSG00000132142 (ENSEMBL)
ACACA geneENSG00000132142 (ENSEMBL)
ACACAProteinQ13085 (Uniprot-TrEMBL)
ACACB gene [nucleoplasm]ProteinENSG00000076555 (ENSEMBL)
ACACB geneENSG00000076555 (ENSEMBL)
ACACBProteinO00763 (Uniprot-TrEMBL)
ALA [nucleoplasm]MetaboliteCHEBI:27432 (ChEBI)
CARM1(2-608) [nucleoplasm]ProteinQ86X55 (Uniprot-TrEMBL)
CHD9 [nucleoplasm]ProteinQ3L8U1 (Uniprot-TrEMBL)
CREBBP(2-2442) [nucleoplasm]ProteinQ92793 (Uniprot-TrEMBL)
CYP51A1 gene [nucleoplasm]ProteinENSG00000067064 (ENSEMBL)
CYP51A1 geneENSG00000067064 (ENSEMBL)
CYP51A1ProteinQ16850 (Uniprot-TrEMBL)
DHCR7 gene [nucleoplasm]ProteinENSG00000172893 (ENSEMBL)
DHCR7 geneENSG00000172893 (ENSEMBL)
DHCR7ProteinQ9UBM7 (Uniprot-TrEMBL)
ELOVL6 gene [nucleoplasm]ProteinENSG00000170522 (ENSEMBL)
ELOVL6 geneENSG00000170522 (ENSEMBL)
ELOVL6ProteinQ9H5J4 (Uniprot-TrEMBL)
EPA [nucleoplasm]MetaboliteCHEBI:28364 (ChEBI)
FASN gene [nucleoplasm]ProteinENSG00000169710 (ENSEMBL)
FASN geneENSG00000169710 (ENSEMBL)
FASNProteinP49327 (Uniprot-TrEMBL)
FDFT1 gene [nucleoplasm]ProteinENSG00000079459 (ENSEMBL)
FDFT1 geneENSG00000079459 (ENSEMBL)
FDFT1ProteinP37268 (Uniprot-TrEMBL)
FDPS gene [nucleoplasm]ProteinENSG00000160752 (ENSEMBL)
FDPS geneENSG00000160752 (ENSEMBL)
FDPSProteinP14324 (Uniprot-TrEMBL)
GGPS1 gene [nucleoplasm]ProteinENSG00000152904 (ENSEMBL)
GGPS1 geneENSG00000152904 (ENSEMBL)
GGPS1ProteinO95749 (Uniprot-TrEMBL)
GPAM gene [nucleoplasm]ProteinENSG00000119927 (ENSEMBL)
GPAM geneENSG00000119927 (ENSEMBL)
GPAM(1-828)ProteinQ9HCL2 (Uniprot-TrEMBL)
HELZ2 [nucleoplasm]ProteinQ9BYK8 (Uniprot-TrEMBL)
HMGCR gene [nucleoplasm]ProteinENSG00000113161 (ENSEMBL)
HMGCR geneENSG00000113161 (ENSEMBL)
HMGCR-1ProteinP04035-1 (Uniprot-TrEMBL)
HMGCS1 gene [nucleoplasm]ProteinENSG00000112972 (ENSEMBL)
HMGCS1 geneENSG00000112972 (ENSEMBL)
HMGCS1ProteinQ01581 (Uniprot-TrEMBL)
IDI1 gene [nucleoplasm]ProteinENSG00000067064 (ENSEMBL)
IDI1 geneENSG00000067064 (ENSEMBL)
IDI1ProteinQ13907 (Uniprot-TrEMBL)
LINA [nucleoplasm]MetaboliteCHEBI:17351 (ChEBI)
LSS gene [nucleoplasm]ProteinENSG00000160285 (ENSEMBL)
LSS geneENSG00000160285 (ENSEMBL)
LSSProteinP48449 (Uniprot-TrEMBL)
MED1 [nucleoplasm]ProteinQ15648 (Uniprot-TrEMBL) MED1 is a component of each of the various Mediator complexes, that function as transcription co-activators. The MED1-containing compolexes include the DRIP, ARC, TRIP and CRSP compllexes.
MVD gene [nucleoplasm]ProteinENSG00000167508 (ENSEMBL)
MVD geneENSG00000167508 (ENSEMBL)
MVD(2-400)ProteinP53602 (Uniprot-TrEMBL)
MVK gene [nucleoplasm]ProteinENSG00000110921 (ENSEMBL)
MVK geneENSG00000110921 (ENSEMBL)
MVKProteinQ03426 (Uniprot-TrEMBL)
NCOA1 [nucleoplasm]ProteinQ15788 (Uniprot-TrEMBL)
NCOA2 [nucleoplasm]ProteinQ15596 (Uniprot-TrEMBL)
NCOA6 [nucleoplasm]ProteinQ14686 (Uniprot-TrEMBL)
NF-YComplexREACT_26721 (Reactome) NF-Y is a ubiquitous heterotrimeric transcription factor comprising subunits NF-Y A, NF-Y B, and NF-Y C. It binds the sequence CCAAT.
NFYA [nucleoplasm]ProteinP23511 (Uniprot-TrEMBL)
NFYB [nucleoplasm]ProteinP25208 (Uniprot-TrEMBL)
NFYC [nucleoplasm]ProteinQ13952 (Uniprot-TrEMBL)
PMVK gene [nucleoplasm]ProteinENSG00000163344 (ENSEMBL)
PMVK geneENSG00000163344 (ENSEMBL)
PMVKProteinQ15126 (Uniprot-TrEMBL)
PPARA [nucleoplasm]ProteinQ07869 (Uniprot-TrEMBL)
PPARA:RXRA Coactivator ComplexComplexREACT_20439 (Reactome)
Palm [nucleoplasm]MetaboliteCHEBI:15756 (ChEBI)
RXRA [nucleoplasm]ProteinP19793 (Uniprot-TrEMBL)
SC5DL gene [nucleoplasm]ProteinENSG00000109929 (ENSEMBL)
SC5DL geneENSG00000109929 (ENSEMBL)
SC5DProteinO75845 (Uniprot-TrEMBL)
SMARCD3 [nucleoplasm]ProteinQ6STE5 (Uniprot-TrEMBL)
SP1(1-785) [nucleoplasm]ProteinP08047 (Uniprot-TrEMBL)
SP1(1-785)ProteinP08047 (Uniprot-TrEMBL)
SQLE gene [nucleoplasm]ProteinENSG00000104549 (ENSEMBL)
SQLE geneENSG00000104549 (ENSEMBL)
SQLEProteinQ14534 (Uniprot-TrEMBL)
SREBF1-1(1-490) [nucleoplasm]ProteinP36956-1 (Uniprot-TrEMBL)
SREBF1-3 [nucleoplasm]ProteinP36956-3 (Uniprot-TrEMBL)
SREBF2(1-484) [nucleoplasm]ProteinQ12772 (Uniprot-TrEMBL)
SREBP1A/1C DimerComplexREACT_148003 (Reactome)
SREBP1A/1C/2 DimerComplexREACT_117119 (Reactome)
SREBP1A/1C/2:ELOVL6 geneComplexREACT_148436 (Reactome)
SREBP1A/1C/2:NF-Y:FDPS geneComplexREACT_148195 (Reactome)
SREBP1A/1C/2:NF-Y:HMGCS1 geneComplexREACT_148333 (Reactome)
SREBP1A/1C/2:NF-Y:SP1:FDFT1 geneComplexREACT_148107 (Reactome)
SREBP1A/1C/2:NF-Y:TM7SF2 geneComplexREACT_148435 (Reactome)
SREBP1A/1C:ACACA geneComplexREACT_148537 (Reactome)
SREBP1A/1C:ACACB geneComplexREACT_148190 (Reactome)
SREBP1A/1C:NF-Y:GPAM geneComplexREACT_148505 (Reactome)
SREBP1A/1C:NF-Y:SP1:FASN geneComplexREACT_116518 (Reactome)
SREBP1A/2 DimerComplexREACT_119740 (Reactome)
SREBP1A/2:LSS geneComplexREACT_148445 (Reactome)
SREBP1A/2:MVD geneComplexREACT_148564 (Reactome)
SREBP1A/2:NF-Y:HMGCR geneComplexREACT_148301 (Reactome)
SREBP1A/2:NF-Y:SC5DL geneComplexREACT_148446 (Reactome)
SREBP1A/2:NF-Y:SP1:CYP51A1 geneComplexREACT_148151 (Reactome)
SREBP1A/2:NF-Y:SP1:DHCR7 geneComplexREACT_148543 (Reactome)
SREBP1A/2:NF-Y:SP1:GGPS1 geneComplexREACT_147937 (Reactome)
SREBP1A/2:NF-Y:SP1:IDI1 geneComplexREACT_148432 (Reactome)
SREBP1A/2:NF-Y:SP1:MVK geneComplexREACT_148095 (Reactome)
SREBP1A/2:NF-Y:SP1:PMVK geneComplexREACT_148481 (Reactome)
SREBP1A/2:SQLE geneComplexREACT_148275 (Reactome)
TBL1X [nucleoplasm]ProteinO60907 (Uniprot-TrEMBL)
TBL1XR1 [nucleoplasm]ProteinQ9BZK7 (Uniprot-TrEMBL)
TGS1 [nucleoplasm]ProteinQ96RS0 (Uniprot-TrEMBL)
TM7SF2 gene [nucleoplasm]ProteinENSG00000149809 (ENSEMBL)
TM7SF2 geneENSG00000149809 (ENSEMBL)
TM7SF2ProteinO76062 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
ACACA geneREACT_147714 (Reactome)
ACACAArrowREACT_147816 (Reactome)
ACACB geneREACT_147803 (Reactome)
ACACBArrowREACT_147743 (Reactome)
CYP51A1 geneREACT_147786 (Reactome)
CYP51A1ArrowREACT_147899 (Reactome)
DHCR7 geneREACT_147715 (Reactome)
DHCR7ArrowREACT_147864 (Reactome)
ELOVL6 geneREACT_147877 (Reactome)
ELOVL6ArrowREACT_147888 (Reactome)
FASN geneREACT_147842 (Reactome)
FASNArrowREACT_115784 (Reactome)
FDFT1 geneREACT_147835 (Reactome)
FDFT1ArrowREACT_115945 (Reactome)
FDPS geneREACT_147735 (Reactome)
FDPSArrowREACT_147807 (Reactome)
GGPS1 geneREACT_147815 (Reactome)
GGPS1ArrowREACT_147826 (Reactome)
GPAM geneREACT_147903 (Reactome)
GPAM(1-828)ArrowREACT_147810 (Reactome)
HMGCR geneREACT_147894 (Reactome)
HMGCR-1ArrowREACT_115997 (Reactome)
HMGCS1 geneREACT_147710 (Reactome)
HMGCS1ArrowREACT_115739 (Reactome)
IDI1 geneREACT_147783 (Reactome)
IDI1ArrowREACT_147880 (Reactome)
LSS geneREACT_147766 (Reactome)
LSSArrowREACT_147844 (Reactome)
MVD geneREACT_147898 (Reactome)
MVD(2-400)ArrowREACT_147863 (Reactome)
MVK geneREACT_147804 (Reactome)
MVKArrowREACT_147902 (Reactome)
NF-YREACT_147699 (Reactome)
NF-YREACT_147710 (Reactome)
NF-YREACT_147715 (Reactome)
NF-YREACT_147735 (Reactome)
NF-YREACT_147752 (Reactome)
NF-YREACT_147783 (Reactome)
NF-YREACT_147786 (Reactome)
NF-YREACT_147804 (Reactome)
NF-YREACT_147815 (Reactome)
NF-YREACT_147835 (Reactome)
NF-YREACT_147842 (Reactome)
NF-YREACT_147859 (Reactome)
NF-YREACT_147861 (Reactome)
NF-YREACT_147894 (Reactome)
NF-YREACT_147903 (Reactome)
PMVK geneREACT_147861 (Reactome)
PMVKArrowREACT_147771 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115739 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115945 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115997 (Reactome)
REACT_115739 (Reactome) The HMGCS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115784 (Reactome) The FASN gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115945 (Reactome) The FDFT1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115997 (Reactome) The HMGCR gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147699 (Reactome) SREBP2 (SREBF2) binds and transactivates an unusual sterol regulatory element in the promoter of the TM7SF2 gene (Schiavoni et al. 2010). NF-Y binds the promoter and is important for activation by SREBP2. SREBP1A and SREBP1C can also bind the TM7SF2 promoter (Reed et al. 2008, Rome et al. 2008).
REACT_147710 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the HMGCS1 gene (Maeda et al. 1998, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008). SREBP1A and SREBP2 activate HMGCS1 equally (Pai et al. 1998).
REACT_147714 (Reactome) SREBP1A (SREBF1A) or SREBP1C bind two sites in the promoter of the ACACA gene (Magana et al. 1997, Rome et al. 2008). Each site is required for activation of transcription.
REACT_147715 (Reactome) SREBP1A (SREBF1A) and SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the DHCR7 gene (Reed et al. 2008).
REACT_147725 (Reactome) The SQLE gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147728 (Reactome) The TM7SF2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147735 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the FDPS gene (Ericsson et al. 1996, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008, Rome et al. 2008, Ishimoto et al. 2010). The binding of NF-Y synergistically enhances the binding of SREBP1 (Ericsson et al. 1996). SREBP1A activates FDPS more strongly than does SREBP2 or SREBP1C (Amemiya-Kudo et al. 2002).
REACT_147743 (Reactome) The ACACB gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147752 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the SQLE gene (Reed et al. 2008). The promoter also contains a consensus binding site for NF-Y (Nagai et al. 2002).
REACT_147766 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the LSS gene (Pai et al. 1998, Rome et al. 2008). SREBP1A and SREBP2 activate LSS equally (Pai et al. 1998).
REACT_147771 (Reactome) The PMVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147783 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the IDI1 gene (Reed et al. 2008).
REACT_147786 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the CYP51A1 gene (Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP1A and SREBP2 activate CYP51A1 equally (Pai et al. 1998).
REACT_147803 (Reactome) SREBP1A (SREBF1A) or SREBP1C, together with SP1, bind and transactivate promoter II of the ACACB gene in human HepG2 cells (Oh et al. 2003).
REACT_147804 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the MVK gene (Reed et al. 2008).
REACT_147807 (Reactome) The FDPS gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147810 (Reactome) The GPAM gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147815 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the GGPS1 gene (Reed et al. 2008).
REACT_147816 (Reactome) The ACACA gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147826 (Reactome) The GGPS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147835 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y and SP1, bind and transactivate the promoter of the FDFT1 gene (Inoue et al. 1998, Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP2 activates FDFT1 more strongly than does SREBP1A (Pai et al. 1998).
REACT_147842 (Reactome) SREBP1A (SREBF1A) or SREBP1C, together with NF-Y and SP1, bind and transactivate the promoter of the FASN gene (Bennett et al. 1995, Pai et al. 1998, Xiong et al. 2000, Amemiya-Kudo et al. 2002, Shin et al. 2007, Choi et al. 2008, Rome et al. 2008). NF-Y is required for response to cholesterol (Xiong et al. 2000). SREBP1A activates FASN more strongly than does SREBP1C or SREBP2 (Pai et al. 1998, Amemiya-Kudo et al. 2002).
REACT_147844 (Reactome) The LSS gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147859 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y, bind and transactivate the promoter of the SC5DL gene (Reed et al. 2008, Rome et al. 2008).
REACT_147861 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the PMVK gene (Reed et al. 2008).
REACT_147863 (Reactome) The MVD gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147864 (Reactome) The DHCR7 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147875 (Reactome) The SC5D gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147877 (Reactome) As inferred from mouse, SREBP1A/1C/2 (SREBF1A/1C/2) binds and transactivates the promoter of the ELOVL6 gene.
REACT_147880 (Reactome) The IDI1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147888 (Reactome) The ELOVL6 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147894 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y, bind and transactivate the promoter of the HMGCR gene (Vallett et al. 1996, Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP2 activates HMGCR slightly more than does SREBP1A (Pai et al. 1998). SREBP1A/2 binds 2 main sites and 2 auxiliary sites in the HMGCR promoter (Vallett et al. 1996).
REACT_147898 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the MVD gene (Rome et al. 2008).
REACT_147899 (Reactome) The CYP51A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147902 (Reactome) The MVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147903 (Reactome) SREBP1A (SREBF1A) or SREBP1C bind and transactivate promoter II of the GPAM gene (Harada et al. 2012). Promoter II is active in lipogenic tissues. As inferred from mouse, NF-Y also binds the GPAM promoter with SREBP1A/1C.
SC5DArrowREACT_147875 (Reactome)
SC5DL geneREACT_147859 (Reactome)
SP1(1-785)REACT_147715 (Reactome)
SP1(1-785)REACT_147783 (Reactome)
SP1(1-785)REACT_147786 (Reactome)
SP1(1-785)REACT_147803 (Reactome)
SP1(1-785)REACT_147804 (Reactome)
SP1(1-785)REACT_147815 (Reactome)
SP1(1-785)REACT_147835 (Reactome)
SP1(1-785)REACT_147842 (Reactome)
SP1(1-785)REACT_147861 (Reactome)
SQLE geneREACT_147752 (Reactome)
SQLEArrowREACT_147725 (Reactome)
SREBP1A/1C DimerREACT_147714 (Reactome)
SREBP1A/1C DimerREACT_147803 (Reactome)
SREBP1A/1C DimerREACT_147842 (Reactome)
SREBP1A/1C DimerREACT_147903 (Reactome)
SREBP1A/1C/2 DimerREACT_147699 (Reactome)
SREBP1A/1C/2 DimerREACT_147710 (Reactome)
SREBP1A/1C/2 DimerREACT_147735 (Reactome)
SREBP1A/1C/2 DimerREACT_147835 (Reactome)
SREBP1A/1C/2 DimerREACT_147877 (Reactome)
SREBP1A/1C/2:ELOVL6 geneArrowREACT_147877 (Reactome)
SREBP1A/1C/2:ELOVL6 geneArrowREACT_147888 (Reactome)
SREBP1A/1C/2:ELOVL6 geneREACT_147888 (Reactome)
SREBP1A/1C/2:NF-Y:FDPS geneArrowREACT_147735 (Reactome)
SREBP1A/1C/2:NF-Y:FDPS geneArrowREACT_147807 (Reactome)
SREBP1A/1C/2:NF-Y:FDPS geneREACT_147807 (Reactome)
SREBP1A/1C/2:NF-Y:HMGCS1 geneArrowREACT_115739 (Reactome)
SREBP1A/1C/2:NF-Y:HMGCS1 geneArrowREACT_147710 (Reactome)
SREBP1A/1C/2:NF-Y:HMGCS1 geneREACT_115739 (Reactome)
SREBP1A/1C/2:NF-Y:SP1:FDFT1 geneArrowREACT_115945 (Reactome)
SREBP1A/1C/2:NF-Y:SP1:FDFT1 geneArrowREACT_147835 (Reactome)
SREBP1A/1C/2:NF-Y:SP1:FDFT1 geneREACT_115945 (Reactome)
SREBP1A/1C/2:NF-Y:TM7SF2 geneArrowREACT_147699 (Reactome)
SREBP1A/1C/2:NF-Y:TM7SF2 geneArrowREACT_147728 (Reactome)
SREBP1A/1C/2:NF-Y:TM7SF2 geneREACT_147728 (Reactome)
SREBP1A/1C:ACACA geneArrowREACT_147714 (Reactome)
SREBP1A/1C:ACACA geneArrowREACT_147816 (Reactome)
SREBP1A/1C:ACACA geneREACT_147816 (Reactome)
SREBP1A/1C:ACACB geneArrowREACT_147743 (Reactome)
SREBP1A/1C:ACACB geneArrowREACT_147803 (Reactome)
SREBP1A/1C:ACACB geneREACT_147743 (Reactome)
SREBP1A/1C:NF-Y:GPAM geneArrowREACT_147810 (Reactome)
SREBP1A/1C:NF-Y:GPAM geneArrowREACT_147903 (Reactome)
SREBP1A/1C:NF-Y:GPAM geneREACT_147810 (Reactome)
SREBP1A/1C:NF-Y:SP1:FASN geneArrowREACT_115784 (Reactome)
SREBP1A/1C:NF-Y:SP1:FASN geneArrowREACT_147842 (Reactome)
SREBP1A/1C:NF-Y:SP1:FASN geneREACT_115784 (Reactome)
SREBP1A/2 DimerREACT_147715 (Reactome)
SREBP1A/2 DimerREACT_147752 (Reactome)
SREBP1A/2 DimerREACT_147766 (Reactome)
SREBP1A/2 DimerREACT_147783 (Reactome)
SREBP1A/2 DimerREACT_147786 (Reactome)
SREBP1A/2 DimerREACT_147804 (Reactome)
SREBP1A/2 DimerREACT_147815 (Reactome)
SREBP1A/2 DimerREACT_147859 (Reactome)
SREBP1A/2 DimerREACT_147861 (Reactome)
SREBP1A/2 DimerREACT_147894 (Reactome)
SREBP1A/2 DimerREACT_147898 (Reactome)
SREBP1A/2:LSS geneArrowREACT_147766 (Reactome)
SREBP1A/2:LSS geneArrowREACT_147844 (Reactome)
SREBP1A/2:LSS geneREACT_147844 (Reactome)
SREBP1A/2:MVD geneArrowREACT_147863 (Reactome)
SREBP1A/2:MVD geneArrowREACT_147898 (Reactome)
SREBP1A/2:MVD geneREACT_147863 (Reactome)
SREBP1A/2:NF-Y:HMGCR geneArrowREACT_115997 (Reactome)
SREBP1A/2:NF-Y:HMGCR geneArrowREACT_147894 (Reactome)
SREBP1A/2:NF-Y:HMGCR geneREACT_115997 (Reactome)
SREBP1A/2:NF-Y:SC5DL geneArrowREACT_147859 (Reactome)
SREBP1A/2:NF-Y:SC5DL geneArrowREACT_147875 (Reactome)
SREBP1A/2:NF-Y:SC5DL geneREACT_147875 (Reactome)
SREBP1A/2:NF-Y:SP1:CYP51A1 geneArrowREACT_147786 (Reactome)
SREBP1A/2:NF-Y:SP1:CYP51A1 geneArrowREACT_147899 (Reactome)
SREBP1A/2:NF-Y:SP1:CYP51A1 geneREACT_147899 (Reactome)
SREBP1A/2:NF-Y:SP1:DHCR7 geneArrowREACT_147715 (Reactome)
SREBP1A/2:NF-Y:SP1:DHCR7 geneArrowREACT_147864 (Reactome)
SREBP1A/2:NF-Y:SP1:DHCR7 geneREACT_147864 (Reactome)
SREBP1A/2:NF-Y:SP1:GGPS1 geneArrowREACT_147815 (Reactome)
SREBP1A/2:NF-Y:SP1:GGPS1 geneArrowREACT_147826 (Reactome)
SREBP1A/2:NF-Y:SP1:GGPS1 geneREACT_147826 (Reactome)
SREBP1A/2:NF-Y:SP1:IDI1 geneArrowREACT_147783 (Reactome)
SREBP1A/2:NF-Y:SP1:IDI1 geneArrowREACT_147880 (Reactome)
SREBP1A/2:NF-Y:SP1:IDI1 geneREACT_147880 (Reactome)
SREBP1A/2:NF-Y:SP1:MVK geneArrowREACT_147804 (Reactome)
SREBP1A/2:NF-Y:SP1:MVK geneArrowREACT_147902 (Reactome)
SREBP1A/2:NF-Y:SP1:MVK geneREACT_147902 (Reactome)
SREBP1A/2:NF-Y:SP1:PMVK geneArrowREACT_147771 (Reactome)
SREBP1A/2:NF-Y:SP1:PMVK geneArrowREACT_147861 (Reactome)
SREBP1A/2:NF-Y:SP1:PMVK geneREACT_147771 (Reactome)
SREBP1A/2:SQLE geneArrowREACT_147725 (Reactome)
SREBP1A/2:SQLE geneArrowREACT_147752 (Reactome)
SREBP1A/2:SQLE geneREACT_147725 (Reactome)
TM7SF2 geneREACT_147699 (Reactome)
TM7SF2ArrowREACT_147728 (Reactome)
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