Immunoregulatory interactions between lymphoid and non-lymphoid cells (Homo sapiens)
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Description
<p>Molecules such as KIRs and LILRs form part of a crucial surveillance system that looks out for any derangement, usually caused by cancer or viral infection, in MHC Class I presentation. Somatic cells are also able to report internal functional impairment by displaying surface stress markers such as MICA. The presence of these molecules on somatic cells is picked up by C-lectin NK immune receptors.<p><p>Lymphoid cells are able to regulate their location and movement in accordance to their state of activation, and home in on tissues expressing the appropriate complementary ligands. For example, lymphoid cells may fine tune the presence and concentration of adhesion molecules belonging to the IgSF, Selectin and Integrin class that interact with a number of vascular markers of inflammation.<p><p>Furthermore, there are a number of avenues through which lymphoid cells may interact with antigen. This may be presented directly to a specific T-cell receptor in the context of an MHC molecule. Antigen-antibody complexes may anchor to the cell via a small number of lymphoid-specific Fc receptors that may, in turn, influence cell function further. Activated complement factor C3d binds to both antigen and to cell surface receptor CD21. In such cases, the far-reaching influence of CD19 on B-lymphocyte function is tempered by its interaction with CD21.Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=198933</div>
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| AMICA1 [plasma membrane] | Protein | Q86YT9 (Uniprot-TrEMBL)  | |
| AMICA1 | Protein | Q86YT9 (Uniprot-TrEMBL) | |
| Antigen peptide bound class I MHC | Complex | REACT_11766 (Reactome) | |
| Antigen-bound
antibody bound to lymphoid Fc gamma receptors | Complex | REACT_11822 (Reactome) | |
| Antigen-bound Ig G Antibody | Complex | REACT_11894 (Reactome) | In view of the highly variable nature of antibody proteins, this biological object is an approximate and fragmented representation of an IgM/IgD antibody, given the limitations of Ig chain enumeration in UniProt. A single mRNA transcript is alternatively spliced to give either IgM or IgD. Thus unactivated B cells contain both classes of antibody. |
| B2M(21-119) [plasma membrane] | Protein | P61769 (Uniprot-TrEMBL) | |
| C3d complexed with antigen | Complex | REACT_11562 (Reactome) | |
| C3d fragment
[extracellular region] | Protein | P01024 (Uniprot-TrEMBL) | |
| CD160 [plasma membrane] | Protein | O95971 (Uniprot-TrEMBL) | |
| CD160 | Protein | O95971 (Uniprot-TrEMBL) | |
| CD19 [plasma membrane] | Protein | P15391 (Uniprot-TrEMBL) | |
| CD200 [plasma membrane] | Protein | P41217 (Uniprot-TrEMBL) | |
| CD200 bound to CD200R | Complex | REACT_11641 (Reactome) | |
| CD200 | Protein | P41217 (Uniprot-TrEMBL) | |
| CD200R1 [plasma membrane] | Protein | Q8TD46 (Uniprot-TrEMBL) | |
| CD200R1 | Protein | Q8TD46 (Uniprot-TrEMBL) | |
| CD226 [plasma membrane] | Protein | Q15762 (Uniprot-TrEMBL) | |
| CD226 bound to Nectin 2 | Complex | REACT_11703 (Reactome) | |
| CD226:PVR | Complex | REACT_11602 (Reactome) | |
| CD226 | Protein | Q15762 (Uniprot-TrEMBL) | |
| CD247-1 [plasma membrane] | Protein | P20963-1 (Uniprot-TrEMBL) | |
| CD34-1 [plasma membrane] | Protein | P28906-1 (Uniprot-TrEMBL) | |
| CD3D [plasma membrane] | Protein | P04234 (Uniprot-TrEMBL) | |
| CD3E [plasma membrane] | Protein | P07766 (Uniprot-TrEMBL) | |
| CD3G [plasma membrane] | Protein | P09693 (Uniprot-TrEMBL) | |
| CD40 complexed with CD40L | Complex | REACT_11386 (Reactome) | |
| CD40-1 [plasma membrane] | Protein | P25942-1 (Uniprot-TrEMBL) | |
| CD40-1 | Protein | P25942-1 (Uniprot-TrEMBL) | |
| CD40LG(1-261) [plasma membrane] | Protein | P29965 (Uniprot-TrEMBL) | |
| CD40LG(1-261) | Protein | P29965 (Uniprot-TrEMBL) | |
| CD81 [plasma membrane] | Protein | P60033 (Uniprot-TrEMBL) | |
| CD8A [plasma membrane] | Protein | P01732 (Uniprot-TrEMBL) | |
| CD8B [plasma membrane] | Protein | P10966 (Uniprot-TrEMBL) | |
| CD96(22-569) [plasma membrane] | Protein | P40200 (Uniprot-TrEMBL) | |
| CD96(22-569) | Protein | P40200 (Uniprot-TrEMBL) | |
| CD96:PVR | Complex | REACT_11952 (Reactome) | |
| CDH1(155-882) [plasma membrane] | Protein | P12830 (Uniprot-TrEMBL) | |
| CDH1(155-882) | Protein | P12830 (Uniprot-TrEMBL) | |
| CRTAM bound to NECL2 | Complex | REACT_11356 (Reactome) | |
| CRTAM(1-393) [plasma membrane] | Protein | O95727 (Uniprot-TrEMBL) | |
| CRTAM(1-393) | Protein | O95727 (Uniprot-TrEMBL) | |
| CXADR [plasma membrane] | Protein | P78310 (Uniprot-TrEMBL) | |
| CXADR bound to JAML | Complex | REACT_11619 (Reactome) | |
| CXADR | Protein | P78310 (Uniprot-TrEMBL) | |
| Complex of CD19,
CD81, CD225 and CD21 with C3d-bound Antigen | Complex | REACT_11584 (Reactome) | |
| Complex of CD19, CD81, CD225 and CD21 | Complex | REACT_11777 (Reactome) | |
| E-cadherin bound to KLRG1 | Complex | REACT_11260 (Reactome) | |
| FCGR2B [plasma membrane] | Protein | P31994 (Uniprot-TrEMBL) | |
| FCGR3A [plasma membrane] | Protein | P08637 (Uniprot-TrEMBL) | |
| GLYCAM1 [plasma membrane] | Protein | Q8IVK1 (Uniprot-TrEMBL) | |
| HCST(1-93) [plasma membrane] | Protein | Q9UBK5 (Uniprot-TrEMBL) | |
| HLA Bw4 interacting with KIR3DL1 | Complex | REACT_11950 (Reactome) | |
| HLA class I
histocompatibility antigen, A-1 alpha chain precursor [plasma membrane] | Protein | P30443 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-11 alpha chain [plasma membrane] | Protein | P13746 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-2 alpha chain [plasma membrane] | Protein | P01892 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-23 alpha chain [plasma membrane] | Protein | P30447 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-24 alpha chain [plasma membrane] | Protein | P05534 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-25 alpha chain [plasma membrane] | Protein | P18462 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-26 alpha chain [plasma membrane] | Protein | P30450 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-29 alpha chain [plasma membrane] | Protein | P30512 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-3 alpha chain precursor [plasma membrane] | Protein | P04439 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-30 alpha chain [plasma membrane] | Protein | P16188 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-31 alpha chain [plasma membrane] | Protein | P16189 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-32 alpha chain [plasma membrane] | Protein | P10314 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-33 alpha chain [plasma membrane] | Protein | P16190 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-34 alpha chain [plasma membrane] | Protein | P30453 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-36 alpha chain [plasma membrane] | Protein | P30455 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-43 alpha chain [plasma membrane] | Protein | P30456 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-66 alpha chain [plasma membrane] | Protein | P30457 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-68 alpha chain [plasma membrane] | Protein | P01891 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-69 alpha chain [plasma membrane] | Protein | P10316 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-74 alpha chain [plasma membrane] | Protein | P30459 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, A-80 alpha chain [plasma membrane] | Protein | Q09160 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, Cw-1 alpha chain [plasma membrane] | Protein | P30499 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, Cw-12 alpha chain [plasma membrane] | Protein | P30508 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, Cw-14 alpha chain [plasma membrane] | Protein | P30510 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, Cw-15 alpha chain [plasma membrane] | Protein | Q07000 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, Cw-16 alpha chain [plasma membrane] | Protein | Q29960 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, Cw-17 alpha chain [plasma membrane] | Protein | Q95604 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, Cw-18 alpha chain [plasma membrane] | Protein | Q29865 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, Cw-2 alpha chain [plasma membrane] | Protein | P30501 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, Cw-3 alpha chain precursor [plasma membrane] | Protein | P04222 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, Cw-4 alpha chain precursor [plasma membrane] | Protein | P30504 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, Cw-5 alpha chain precursor [plasma membrane] | Protein | Q9TNN7 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, Cw-6 alpha chain precursor [plasma membrane] | Protein | Q29963 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] | Protein | P10321 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, Cw-8 alpha chain [plasma membrane] | Protein | P30505 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, E alpha chain precursor [plasma membrane] | Protein | P13747 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, alpha chain F precursor [plasma membrane] | Protein | P30511 (Uniprot-TrEMBL) | |
| HLA class I
histocompatibility antigen, alpha chain G precursor [plasma membrane] | Protein | P17693 (Uniprot-TrEMBL) | |
| HLA-A3 interacting with KIR3DL2 | Complex | REACT_11887 (Reactome) | |
| HLA-A3 | Complex | REACT_11726 (Reactome) | |
| HLA-Bw4 | Complex | REACT_11642 (Reactome) | |
| HLA-C
group-I-interacting KIRs | Protein | REACT_11748 (Reactome) | |
| HLA-C Cw3 (group 1) | Complex | REACT_11404 (Reactome) | |
| HLA-C Cw4 (group 2) | Complex | REACT_11388 (Reactome) | |
| HLA-C group 1
interacting with KIR2DL2/3 | Complex | REACT_11577 (Reactome) | |
| HLA-C group 1
interacting with KIR2DS2 | Complex | REACT_11521 (Reactome) | |
| HLA-C group 2
interacting with KIR2DL1 | Complex | REACT_11338 (Reactome) | |
| HLA-C group 2
interacting with KIR2DS1 | Complex | REACT_11864 (Reactome) | |
| HLA-E interacting with KLRC1:KLRD1 | Complex | REACT_11770 (Reactome) | |
| HLA-E | Complex | REACT_11603 (Reactome) | |
| HLA-G interacting with KIR2DL4 | Complex | REACT_11741 (Reactome) | |
| HLA-G | Complex | REACT_11699 (Reactome) | |
| ICAM 1-4 | Protein | REACT_11859 (Reactome) | |
| ICAM1 [plasma membrane] | Protein | P05362 (Uniprot-TrEMBL) | |
| ICAM2(22-275) [plasma membrane] | Protein | P13598 (Uniprot-TrEMBL) | |
| ICAM3 [plasma membrane] | Protein | P32942 (Uniprot-TrEMBL) | |
| ICAM4 [plasma membrane] | Protein | Q14773 (Uniprot-TrEMBL) | |
| IFITM1 [plasma membrane] | Protein | P13164 (Uniprot-TrEMBL) | |
| IGHV(1-?)
[extracellular region] | Protein | A2KUC3 (Uniprot-TrEMBL) | |
| IGHV7-81(1-?)
[extracellular region] | Protein | Q6PIL0 (Uniprot-TrEMBL) | |
| IGKC(1-106)
[extracellular region] | Protein | P01834 (Uniprot-TrEMBL) | |
| IGKV1-5(23-?)
[extracellular region] | Protein | P01602 (Uniprot-TrEMBL) | |
| IGKV4-1(21-?)
[extracellular region] | Protein | P06312 (Uniprot-TrEMBL) | |
| IGKVA18(21-?)
[extracellular region] | Protein | A2NJV5 (Uniprot-TrEMBL) | |
| IGLC1(1-105)
[extracellular region] | Protein | P0CG04 (Uniprot-TrEMBL) | |
| IGLC2(?-106)
[extracellular region] | Protein | P0CG05 (Uniprot-TrEMBL) | |
| IGLC3(?-106)
[extracellular region] | Protein | P0CG06 (Uniprot-TrEMBL) | |
| IGLC6(?-106)
[extracellular region] | Protein | P0CF74 (Uniprot-TrEMBL) | |
| IGLC7(?-106)
[extracellular region] | Protein | A0M8Q6 (Uniprot-TrEMBL) | |
| IGLV(23-?)
[extracellular region] | Protein | A2NXD2 (Uniprot-TrEMBL) | |
| IGLV1-36(1-?)
[extracellular region] | Protein | Q5NV67 (Uniprot-TrEMBL) | |
| IGLV1-40(1-?)
[extracellular region] | Protein | Q5NV69 (Uniprot-TrEMBL) | |
| IGLV1-44(1-?)
[extracellular region] | Protein | Q5NV81 (Uniprot-TrEMBL) | |
| IGLV10-54(1-?)
[extracellular region] | Protein | Q5NV86 (Uniprot-TrEMBL) | |
| IGLV11-55(1-?)
[extracellular region] | Protein | Q5NV87 (Uniprot-TrEMBL) | |
| IGLV2-11(1-?)
[extracellular region] | Protein | Q5NV84 (Uniprot-TrEMBL) | |
| IGLV2-18(1-?)
[extracellular region] | Protein | Q5NV65 (Uniprot-TrEMBL) | |
| IGLV2-23(1-?)
[extracellular region] | Protein | Q5NV89 (Uniprot-TrEMBL) | |
| IGLV2-33(1-?)
[extracellular region] | Protein | Q5NV66 (Uniprot-TrEMBL) | |
| IGLV3-12(1-?)
[extracellular region] | Protein | Q5NV85 (Uniprot-TrEMBL) | |
| IGLV3-16(1-?)
[extracellular region] | Protein | Q5NV64 (Uniprot-TrEMBL) | |
| IGLV3-22(1-?)
[extracellular region] | Protein | Q5NV75 (Uniprot-TrEMBL) | |
| IGLV3-25(1-?)
[extracellular region] | Protein | Q5NV90 (Uniprot-TrEMBL) | |
| IGLV3-27(1-?)
[extracellular region] | Protein | Q5NV91 (Uniprot-TrEMBL) | |
| IGLV4-3(1-?)
[extracellular region] | Protein | Q5NV61 (Uniprot-TrEMBL) | |
| IGLV4-60(1-?)
[extracellular region] | Protein | Q5NV79 (Uniprot-TrEMBL) | |
| IGLV4-69(1-?)
[extracellular region] | Protein | Q5NV92 (Uniprot-TrEMBL) | |
| IGLV5-37(1-?)
[extracellular region] | Protein | Q5NV68 (Uniprot-TrEMBL) | |
| IGLV5-45(1-?)
[extracellular region] | Protein | Q5NV82 (Uniprot-TrEMBL) | |
| IGLV7-43(1-?)
[extracellular region] | Protein | Q5NV80 (Uniprot-TrEMBL) | |
| IGLV7-46(1-?)
[extracellular region] | Protein | Q5NV83 (Uniprot-TrEMBL) | |
| IGLV8-61(1-?)
[extracellular region] | Protein | Q5NV62 (Uniprot-TrEMBL) | |
| ITGA4(40-1038) [plasma membrane] | Protein | P13612 (Uniprot-TrEMBL) | |
| ITGAL [plasma membrane] | Protein | P20701 (Uniprot-TrEMBL) | |
| ITGB1 [plasma membrane] | Protein | P05556 (Uniprot-TrEMBL) | |
| ITGB2 [plasma membrane] | Protein | P05107 (Uniprot-TrEMBL) | |
| ITGB7 [plasma membrane] | Protein | P26010 (Uniprot-TrEMBL) | |
| Ig heavy chain V-I
region EU [extracellular region] | Protein | P01742 (Uniprot-TrEMBL) | |
| Ig heavy chain V-I
region HG3 [extracellular region] | Protein | P01743 (Uniprot-TrEMBL) | |
| Ig heavy chain V-I
region Mot [extracellular region] | Protein | P06326 (Uniprot-TrEMBL) | |
| Ig heavy chain V-I
region ND [extracellular region] | Protein | P01744 (Uniprot-TrEMBL) | |
| Ig heavy chain V-I
region SIE [extracellular region] | Protein | P01761 (Uniprot-TrEMBL) | |
| Ig heavy chain V-I
region WOL [extracellular region] | Protein | P01760 (Uniprot-TrEMBL) | |
| Ig heavy chain V-II
region ARH-77 [extracellular region] | Protein | P06331 (Uniprot-TrEMBL) | |
| Ig heavy chain V-II
region COR [extracellular region] | Protein | P01815 (Uniprot-TrEMBL) | |
| Ig heavy chain V-II
region DAW [extracellular region] | Protein | P01816 (Uniprot-TrEMBL) | |
| Ig heavy chain V-II
region HE [extracellular region] | Protein | P01818 (Uniprot-TrEMBL) | |
| Ig heavy chain V-II
region MCE [extracellular region] | Protein | P01817 (Uniprot-TrEMBL) | |
| Ig heavy chain V-II
region NEWM [extracellular region] | Protein | P01825 (Uniprot-TrEMBL) | |
| Ig heavy chain V-II
region OU [extracellular region] | Protein | P01814 (Uniprot-TrEMBL) | |
| Ig heavy chain V-II
region SESS [extracellular region] | Protein | P04438 (Uniprot-TrEMBL) | |
| Ig heavy chain V-II
region WAH [extracellular region] | Protein | P01824 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region BRO [extracellular region] | Protein | P01766 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region BUR [extracellular region] | Protein | P01773 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region BUT [extracellular region] | Protein | P01767 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region CAM [extracellular region] | Protein | P01768 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region DOB [extracellular region] | Protein | P01782 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region GA [extracellular region] | Protein | P01769 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region GAL [extracellular region] | Protein | P01781 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region HIL [extracellular region] | Protein | P01771 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region JON [extracellular region] | Protein | P01780 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region KOL [extracellular region] | Protein | P01772 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region LAY [extracellular region] | Protein | P01775 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region NIE [extracellular region] | Protein | P01770 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region POM [extracellular region] | Protein | P01774 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region TEI [extracellular region] | Protein | P01777 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region TIL [extracellular region] | Protein | P01765 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region TRO [extracellular region] | Protein | P01762 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region TUR [extracellular region] | Protein | P01779 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region WAS [extracellular region] | Protein | P01776 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region WEA [extracellular region] | Protein | P01763 (Uniprot-TrEMBL) | |
| Ig heavy chain V-III
region ZAP [extracellular region] | Protein | P01778 (Uniprot-TrEMBL) | |
| Ig kappa chain V
region EV15 [extracellular region] | Protein | P06315 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region AG [extracellular region] | Protein | P01593 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region AU [extracellular region] | Protein | P01594 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region BAN [extracellular region] | Protein | P04430 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region Bi [extracellular region] | Protein | P01595 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region CAR [extracellular region] | Protein | P01596 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region DEE [extracellular region] | Protein | P01597 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region Daudi [extracellular region] | Protein | P04432 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region EU [extracellular region] | Protein | P01598 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region Gal [extracellular region] | Protein | P01599 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region HK101 [extracellular region] | Protein | P01601 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region Hau [extracellular region] | Protein | P01600 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region Ka [extracellular region] | Protein | P01603 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region Kue [extracellular region] | Protein | P01604 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region Lay [extracellular region] | Protein | P01605 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region Mev [extracellular region] | Protein | P01612 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region Ni [extracellular region] | Protein | P01613 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region OU [extracellular region] | Protein | P01606 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region Rei [extracellular region] | Protein | P01607 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region Roy [extracellular region] | Protein | P01608 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region Scw [extracellular region] | Protein | P01609 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region WAT [extracellular region] | Protein | P80362 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region WEA [extracellular region] | Protein | P01610 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region Walker [extracellular region] | Protein | P04431 (Uniprot-TrEMBL) | |
| Ig kappa chain V-I
region Wes [extracellular region] | Protein | P01611 (Uniprot-TrEMBL) | |
| Ig kappa chain V-II
region Cum [extracellular region] | Protein | P01614 (Uniprot-TrEMBL) | |
| Ig kappa chain V-II
region FR [extracellular region] | Protein | P01615 (Uniprot-TrEMBL) | |
| Ig kappa chain V-II
region GM607 [extracellular region] | Protein | P06309 (Uniprot-TrEMBL) | |
| Ig kappa chain V-II
region MIL [extracellular region] | Protein | P01616 (Uniprot-TrEMBL) | |
| Ig kappa chain V-II
region RPMI 6410 [extracellular region] | Protein | P06310 (Uniprot-TrEMBL) | |
| Ig kappa chain V-II
region TEW [extracellular region] | Protein | P01617 (Uniprot-TrEMBL) | |
| Ig kappa chain V-III
region B6 [extracellular region] | Protein | P01619 (Uniprot-TrEMBL) | |
| Ig kappa chain V-III
region CLL [extracellular region] | Protein | P04207 (Uniprot-TrEMBL) | |
| Ig kappa chain V-III
region GOL [extracellular region] | Protein | P04206 (Uniprot-TrEMBL) | |
| Ig kappa chain V-III
region HAH [extracellular region] | Protein | P18135 (Uniprot-TrEMBL) | |
| Ig kappa chain V-III
region HIC [extracellular region] | Protein | P18136 (Uniprot-TrEMBL) | |
| Ig kappa chain V-III
region IARC/BL41 [extracellular region] | Protein | P06311 (Uniprot-TrEMBL) | |
| Ig kappa chain V-III
region NG9 [extracellular region] | Protein | P01621 (Uniprot-TrEMBL) | |
| Ig kappa chain V-III
region POM [extracellular region] | Protein | P01624 (Uniprot-TrEMBL) | |
| Ig kappa chain V-III
region SIE [extracellular region] | Protein | P01620 (Uniprot-TrEMBL) | |
| Ig kappa chain V-III
region Ti [extracellular region] | Protein | P01622 (Uniprot-TrEMBL) | |
| Ig kappa chain V-III
region VG [extracellular region] | Protein | P04433 (Uniprot-TrEMBL) | |
| Ig kappa chain V-III
region VH [extracellular region] | Protein | P04434 (Uniprot-TrEMBL) | |
| Ig kappa chain V-III
region WOL [extracellular region] | Protein | P01623 (Uniprot-TrEMBL) | |
| Ig kappa chain V-IV
region B17 [extracellular region] | Protein | P06314 (Uniprot-TrEMBL) | |
| Ig kappa chain V-IV
region JI [extracellular region] | Protein | P06313 (Uniprot-TrEMBL) | |
| Ig kappa chain V-IV
region Len [extracellular region] | Protein | P01625 (Uniprot-TrEMBL) | |
| Ig kappa chain V-IV
region STH [extracellular region] | Protein | P83593 (Uniprot-TrEMBL) | |
| Ig lambda chain
V-III region LOI [extracellular region] | Protein | P80748 (Uniprot-TrEMBL) | |
| Ig lambda chain
V-III region SH [extracellular region] | Protein | P01714 (Uniprot-TrEMBL) | |
| Ig lambda chain
V-VII region MOT [extracellular region] | Protein | P01720 (Uniprot-TrEMBL) | |
| Ig lambda chain V
region 4A [extracellular region] | Protein | P04211 (Uniprot-TrEMBL) | |
| Ig lambda chain V-I
region BL2 [extracellular region] | Protein | P06316 (Uniprot-TrEMBL) | |
| Ig lambda chain V-I
region EPS [extracellular region] | Protein | P06888 (Uniprot-TrEMBL) | |
| Ig lambda chain V-I
region HA [extracellular region] | Protein | P01700 (Uniprot-TrEMBL) | |
| Ig lambda chain V-I
region MEM [extracellular region] | Protein | P06887 (Uniprot-TrEMBL) | |
| Ig lambda chain V-I
region NEW [extracellular region] | Protein | P01701 (Uniprot-TrEMBL) | |
| Ig lambda chain V-I
region NEWM [extracellular region] | Protein | P01703 (Uniprot-TrEMBL) | |
| Ig lambda chain V-I
region NIG-64 [extracellular region] | Protein | P01702 (Uniprot-TrEMBL) | |
| Ig lambda chain V-I
region VOR [extracellular region] | Protein | P01699 (Uniprot-TrEMBL) | |
| Ig lambda chain V-I
region WAH [extracellular region] | Protein | P04208 (Uniprot-TrEMBL) | |
| Ig lambda chain V-II
region BO [extracellular region] | Protein | P01710 (Uniprot-TrEMBL) | |
| Ig lambda chain V-II
region BOH [extracellular region] | Protein | P01706 (Uniprot-TrEMBL) | |
| Ig lambda chain V-II
region BUR [extracellular region] | Protein | P01708 (Uniprot-TrEMBL) | |
| Ig lambda chain V-II
region MGC [extracellular region] | Protein | P01709 (Uniprot-TrEMBL) | |
| Ig lambda chain V-II
region NEI [extracellular region] | Protein | P01705 (Uniprot-TrEMBL) | |
| Ig lambda chain V-II
region NIG-58 [extracellular region] | Protein | P01713 (Uniprot-TrEMBL) | |
| Ig lambda chain V-II
region NIG-84 [extracellular region] | Protein | P04209 (Uniprot-TrEMBL) | |
| Ig lambda chain V-II
region TOG [extracellular region] | Protein | P01704 (Uniprot-TrEMBL) | |
| Ig lambda chain V-II
region TRO [extracellular region] | Protein | P01707 (Uniprot-TrEMBL) | |
| Ig lambda chain V-II
region VIL [extracellular region] | Protein | P01711 (Uniprot-TrEMBL) | |
| Ig lambda chain V-II
region WIN [extracellular region] | Protein | P01712 (Uniprot-TrEMBL) | |
| Ig lambda chain V-IV
region Bau [extracellular region] | Protein | P01715 (Uniprot-TrEMBL) | |
| Ig lambda chain V-IV
region Hil [extracellular region] | Protein | P01717 (Uniprot-TrEMBL) | |
| Ig lambda chain V-IV
region Kern [extracellular region] | Protein | P01718 (Uniprot-TrEMBL) | |
| Ig lambda chain V-IV
region MOL [extracellular region] | Protein | P06889 (Uniprot-TrEMBL) | |
| Ig lambda chain V-IV
region X [extracellular region] | Protein | P01716 (Uniprot-TrEMBL) | |
| Ig lambda chain V-V
region DEL [extracellular region] | Protein | P01719 (Uniprot-TrEMBL) | |
| Ig lambda chain V-VI
region AR [extracellular region] | Protein | P01721 (Uniprot-TrEMBL) | |
| Ig lambda chain V-VI
region EB4 [extracellular region] | Protein | P06319 (Uniprot-TrEMBL) | |
| Ig lambda chain V-VI
region NIG-48 [extracellular region] | Protein | P01722 (Uniprot-TrEMBL) | |
| Ig lambda chain V-VI
region SUT [extracellular region] | Protein | P06317 (Uniprot-TrEMBL) | |
| Ig lambda chain V-VI
region WLT [extracellular region] | Protein | P06318 (Uniprot-TrEMBL) | |
| IgH heavy chain
V-III region VH26 precursor [extracellular region] | Protein | P01764 (Uniprot-TrEMBL) | |
| Integrin alpha4beta7:MADCAM1 | Complex | REACT_11447 (Reactome) | |
| Integrin alpha4beta7 | Complex | REACT_11974 (Reactome) | |
| Integrin alphaLbeta2 (LFA-1) | Complex | REACT_11837 (Reactome) | |
| KIR2DL1 [plasma membrane] | Protein | P43626 (Uniprot-TrEMBL) | |
| KIR2DL1 | Protein | P43626 (Uniprot-TrEMBL) | |
| KIR2DL2 [plasma membrane] | Protein | P43627 (Uniprot-TrEMBL) | |
| KIR2DL3 [plasma membrane] | Protein | P43628 (Uniprot-TrEMBL) | |
| KIR2DL4 [plasma membrane] | Protein | Q99706 (Uniprot-TrEMBL) | |
| KIR2DL4 | Protein | Q99706 (Uniprot-TrEMBL) | |
| KIR2DS1 [plasma membrane] | Protein | Q14954 (Uniprot-TrEMBL) | |
| KIR2DS1 complexed with DAP12 | Complex | REACT_11752 (Reactome) | |
| KIR2DS2 [plasma membrane] | Protein | P43631 (Uniprot-TrEMBL) | |
| KIR2DS2 complexed with DAP12 | Complex | REACT_11717 (Reactome) | |
| KIR3DL1 [plasma membrane] | Protein | P43629 (Uniprot-TrEMBL) | |
| KIR3DL1 | Protein | P43629 (Uniprot-TrEMBL) | |
| KIR3DL2 [plasma membrane] | Protein | P43630 (Uniprot-TrEMBL) | |
| KIR3DL2 | Protein | P43630 (Uniprot-TrEMBL) | |
| KLRC1 [plasma membrane] | Protein | P26715 (Uniprot-TrEMBL) | |
| KLRC1 | Protein | P26715 (Uniprot-TrEMBL) | |
| KLRD1 [plasma membrane] | Protein | Q13241 (Uniprot-TrEMBL) | |
| KLRD1 | Protein | Q13241 (Uniprot-TrEMBL) | |
| KLRG1 [plasma membrane] | Protein | Q96E93 (Uniprot-TrEMBL) | |
| KLRG1 | Protein | Q96E93 (Uniprot-TrEMBL) | |
| KLRK1 [plasma membrane] | Protein | P26718 (Uniprot-TrEMBL) | |
| L-selectin
interacting with known ligands | Complex | REACT_11760 (Reactome) | |
| L-selectin ligands | Protein | REACT_11759 (Reactome) | |
| LFA-1:ICAM 1-4 | Complex | REACT_11942 (Reactome) | |
| LILR set | Protein | REACT_11576 (Reactome) | |
| LILR-interacting MHC Class I molecules | Complex | REACT_11528 (Reactome) | |
| Ligand interacting with NKG2D | Complex | REACT_11751 (Reactome) | |
| Lymphoid-expressed Fc-gamma receptors | Protein | REACT_11814 (Reactome) | |
| MADCAM1-1 [plasma membrane] | Protein | Q13477-1 (Uniprot-TrEMBL) | |
| MADCAM1-1 | Protein | Q13477-1 (Uniprot-TrEMBL) | |
| MHC Class I
interacting with CD160 | Complex | REACT_11275 (Reactome) | |
| MHC Class I
interacting with LILRs | Complex | REACT_11656 (Reactome) | |
| MHC Class I
molecules interacting with CD160 | Complex | REACT_11830 (Reactome) | |
| MICA(1-194) [plasma membrane] | Protein | Q5SS58 (Uniprot-TrEMBL) | |
| MICB(1-318) [plasma membrane] | Protein | Q29980 (Uniprot-TrEMBL) | |
| NKG2D complexed with DAP10 | Complex | REACT_11468 (Reactome) | |
| NKG2D ligand | Protein | REACT_11351 (Reactome) | |
| PVR [plasma membrane] | Protein | P15151 (Uniprot-TrEMBL) | |
| PVRL2 [plasma membrane] | Protein | Q92692 (Uniprot-TrEMBL) | |
| PVRL2 | Protein | Q92692 (Uniprot-TrEMBL) | |
| PVR | Protein | P15151 (Uniprot-TrEMBL) | |
| RAET1E [plasma membrane] | Protein | Q8TD07 (Uniprot-TrEMBL) | |
| SELL [plasma membrane] | Protein | P14151 (Uniprot-TrEMBL) | |
| SELL | Protein | P14151 (Uniprot-TrEMBL) | |
| T-cell receptor
alpha chain V region HPB-MLT precursor [plasma membrane] | Protein | P04436 (Uniprot-TrEMBL) | |
| T-cell receptor
alpha chain V region PY14 precursor [plasma membrane] | Protein | P01737 (Uniprot-TrEMBL) | |
| T-cell receptor complex with CD8 | Complex | REACT_11534 (Reactome) | |
| TCR interacting with
antigen-bearing MHC Class I | Complex | REACT_11723 (Reactome) | |
| TCRA [plasma membrane] | Protein | P04437 (Uniprot-TrEMBL) | |
| TCRB [plasma membrane] | Protein | P04435 (Uniprot-TrEMBL) | |
| TRAC(?-142) [plasma membrane] | Protein | P01848 (Uniprot-TrEMBL) | |
| TRBC1(?-177) [plasma membrane] | Protein | P01850 (Uniprot-TrEMBL) | |
| TRBV12-3 [plasma membrane] | Protein | P01733 (Uniprot-TrEMBL) | |
| TYROBP [plasma membrane] | Protein | O43914 (Uniprot-TrEMBL) | |
| ULBP1 [plasma membrane] | Protein | Q9BZM6 (Uniprot-TrEMBL) | |
| ULBP3 [plasma membrane] | Protein | Q9BZM4 (Uniprot-TrEMBL) | |
| VCAM1 [plasma membrane] | Protein | P19320 (Uniprot-TrEMBL) | |
| VCAM1 | Protein | P19320 (Uniprot-TrEMBL) | |
| VLA-4:VCAM-1 | Complex | REACT_11750 (Reactome) | |
| VLA-4 | Complex | REACT_11798 (Reactome) | |
| cd21(1-?) [plasma membrane] | Protein | O15181 (Uniprot-TrEMBL) | |
| class I MHC B13 [plasma membrane] | Protein | P30461 (Uniprot-TrEMBL) | |
| class I MHC B14 [plasma membrane] | Protein | P30462 (Uniprot-TrEMBL) | |
| class I MHC B15 [plasma membrane] | Protein | P30464 (Uniprot-TrEMBL) | |
| class I MHC B18 [plasma membrane] | Protein | P30466 (Uniprot-TrEMBL) | |
| class I MHC B27 [plasma membrane] | Protein | P03989 (Uniprot-TrEMBL) | |
| class I MHC B35 [plasma membrane] | Protein | P30685 (Uniprot-TrEMBL) | |
| class I MHC B37 [plasma membrane] | Protein | P18463 (Uniprot-TrEMBL) | |
| class I MHC B38 [plasma membrane] | Protein | Q95365 (Uniprot-TrEMBL) | |
| class I MHC B39 [plasma membrane] | Protein | P30475 (Uniprot-TrEMBL) | |
| class I MHC B40 [plasma membrane] | Protein | Q04826 (Uniprot-TrEMBL) | |
| class I MHC B41 [plasma membrane] | Protein | P30479 (Uniprot-TrEMBL) | |
| class I MHC B42 [plasma membrane] | Protein | P30480 (Uniprot-TrEMBL) | |
| class I MHC B44 [plasma membrane] | Protein | P30481 (Uniprot-TrEMBL) | |
| class I MHC B45 [plasma membrane] | Protein | P30483 (Uniprot-TrEMBL) | |
| class I MHC B46 [plasma membrane] | Protein | P30484 (Uniprot-TrEMBL) | |
| class I MHC B47 [plasma membrane] | Protein | P30485 (Uniprot-TrEMBL) | |
| class I MHC B49 [plasma membrane] | Protein | P30487 (Uniprot-TrEMBL) | |
| class I MHC B50 [plasma membrane] | Protein | P30488 (Uniprot-TrEMBL) | |
| class I MHC B51 [plasma membrane] | Protein | P18464 (Uniprot-TrEMBL) | |
| class I MHC B52 [plasma membrane] | Protein | P30490 (Uniprot-TrEMBL) | |
| class I MHC B53 [plasma membrane] | Protein | P30491 (Uniprot-TrEMBL) | |
| class I MHC B54 [plasma membrane] | Protein | P30492 (Uniprot-TrEMBL) | |
| class I MHC B55 [plasma membrane] | Protein | P30493 (Uniprot-TrEMBL) | |
| class I MHC B56 [plasma membrane] | Protein | P30495 (Uniprot-TrEMBL) | |
| class I MHC B57 [plasma membrane] | Protein | P18465 (Uniprot-TrEMBL) | |
| class I MHC B58 [plasma membrane] | Protein | P10319 (Uniprot-TrEMBL) | |
| class I MHC B59 [plasma membrane] | Protein | Q29940 (Uniprot-TrEMBL) | |
| class I MHC B67 [plasma membrane] | Protein | Q29836 (Uniprot-TrEMBL) | |
| class I MHC B7 [plasma membrane] | Protein | P01889 (Uniprot-TrEMBL) | |
| class I MHC B73 [plasma membrane] | Protein | Q31612 (Uniprot-TrEMBL) | |
| class I MHC B78 [plasma membrane] | Protein | P30498 (Uniprot-TrEMBL) | |
| class I MHC B8 [plasma membrane] | Protein | P30460 (Uniprot-TrEMBL) | |
| class I MHC B81 [plasma membrane] | Protein | Q31610 (Uniprot-TrEMBL) | |
| class I MHC B82 [plasma membrane] | Protein | Q29718 (Uniprot-TrEMBL) |
Annotated Interactions
| View all... |
| Source | Target | Type | Database reference | Comment |
|---|---|---|---|---|
| AMICA1 | REACT_11154 (Reactome) | |||
| Antigen peptide bound class I MHC | REACT_11080 (Reactome) | |||
| Antigen-bound
antibody bound to lymphoid Fc gamma receptors | Arrow | REACT_11087 (Reactome) | ||
| Antigen-bound Ig G Antibody | REACT_11087 (Reactome) | |||
| C3d complexed with antigen | REACT_11121 (Reactome) | |||
| CD160 | REACT_11106 (Reactome) | |||
| CD200 bound to CD200R | Arrow | REACT_11188 (Reactome) | ||
| CD200R1 | REACT_11188 (Reactome) | |||
| CD200 | REACT_11188 (Reactome) | |||
| CD226 bound to Nectin 2 | Arrow | REACT_11094 (Reactome) | ||
| CD226:PVR | Arrow | REACT_11239 (Reactome) | ||
| CD226 | REACT_11094 (Reactome) | |||
| CD226 | REACT_11239 (Reactome) | |||
| CD40 complexed with CD40L | Arrow | REACT_11241 (Reactome) | ||
| CD40-1 | REACT_11241 (Reactome) | |||
| CD40LG(1-261) | REACT_11241 (Reactome) | |||
| CD96(22-569) | REACT_11207 (Reactome) | |||
| CD96:PVR | Arrow | REACT_11207 (Reactome) | ||
| CDH1(155-882) | REACT_11212 (Reactome) | |||
| CRTAM bound to NECL2 | Arrow | REACT_11097 (Reactome) | ||
| CRTAM(1-393) | REACT_11097 (Reactome) | |||
| CXADR bound to JAML | Arrow | REACT_11154 (Reactome) | ||
| CXADR | REACT_11154 (Reactome) | |||
| Complex of CD19,
CD81, CD225 and CD21 with C3d-bound Antigen | Arrow | REACT_11121 (Reactome) | ||
| Complex of CD19, CD81, CD225 and CD21 | REACT_11121 (Reactome) | |||
| E-cadherin bound to KLRG1 | Arrow | REACT_11212 (Reactome) | ||
| HLA Bw4 interacting with KIR3DL1 | Arrow | REACT_11223 (Reactome) | ||
| HLA-A3 interacting with KIR3DL2 | Arrow | REACT_11124 (Reactome) | ||
| HLA-A3 | REACT_11124 (Reactome) | |||
| HLA-Bw4 | REACT_11223 (Reactome) | |||
| HLA-C
group-I-interacting KIRs | REACT_11210 (Reactome) | |||
| HLA-C Cw3 (group 1) | REACT_11140 (Reactome) | |||
| HLA-C Cw3 (group 1) | REACT_11176 (Reactome) | |||
| HLA-C Cw4 (group 2) | REACT_11077 (Reactome) | |||
| HLA-C Cw4 (group 2) | REACT_11210 (Reactome) | |||
| HLA-C group 1
interacting with KIR2DL2/3 | Arrow | REACT_11210 (Reactome) | ||
| HLA-C group 1
interacting with KIR2DS2 | Arrow | REACT_11176 (Reactome) | ||
| HLA-C group 2
interacting with KIR2DL1 | Arrow | REACT_11140 (Reactome) | ||
| HLA-C group 2
interacting with KIR2DS1 | Arrow | REACT_11077 (Reactome) | ||
| HLA-E interacting with KLRC1:KLRD1 | Arrow | REACT_11119 (Reactome) | ||
| HLA-E | REACT_11119 (Reactome) | |||
| HLA-G interacting with KIR2DL4 | Arrow | REACT_11141 (Reactome) | ||
| HLA-G | REACT_11141 (Reactome) | |||
| ICAM 1-4 | REACT_11173 (Reactome) | |||
| Integrin alpha4beta7:MADCAM1 | Arrow | REACT_11199 (Reactome) | ||
| Integrin alpha4beta7 | REACT_11199 (Reactome) | |||
| Integrin alphaLbeta2 (LFA-1) | REACT_11173 (Reactome) | |||
| KIR2DL1 | REACT_11140 (Reactome) | |||
| KIR2DL4 | REACT_11141 (Reactome) | |||
| KIR2DS1 complexed with DAP12 | REACT_11077 (Reactome) | |||
| KIR2DS2 complexed with DAP12 | REACT_11176 (Reactome) | |||
| KIR3DL1 | REACT_11223 (Reactome) | |||
| KIR3DL2 | REACT_11124 (Reactome) | |||
| KLRC1 | REACT_11119 (Reactome) | |||
| KLRD1 | REACT_11119 (Reactome) | |||
| KLRG1 | REACT_11212 (Reactome) | |||
| L-selectin
interacting with known ligands | Arrow | REACT_11230 (Reactome) | ||
| L-selectin ligands | REACT_11230 (Reactome) | |||
| LFA-1:ICAM 1-4 | Arrow | REACT_11173 (Reactome) | ||
| LILR set | REACT_11127 (Reactome) | |||
| LILR-interacting MHC Class I molecules | REACT_11127 (Reactome) | |||
| Ligand interacting with NKG2D | Arrow | REACT_11178 (Reactome) | ||
| Lymphoid-expressed Fc-gamma receptors | REACT_11087 (Reactome) | |||
| MADCAM1-1 | REACT_11199 (Reactome) | |||
| MHC Class I
interacting with CD160 | Arrow | REACT_11106 (Reactome) | ||
| MHC Class I
interacting with LILRs | Arrow | REACT_11127 (Reactome) | ||
| MHC Class I
molecules interacting with CD160 | REACT_11106 (Reactome) | |||
| NKG2D complexed with DAP10 | REACT_11178 (Reactome) | |||
| NKG2D ligand | REACT_11178 (Reactome) | |||
| PVRL2 | REACT_11094 (Reactome) | |||
| PVRL2 | REACT_11097 (Reactome) | |||
| PVR | REACT_11207 (Reactome) | |||
| PVR | REACT_11239 (Reactome) | |||
| REACT_11077 (Reactome) | A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual). There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G. In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1. | |||
| REACT_11080 (Reactome) | T cells distinguish foreign material from self through presentation of fragments of the antigen by the MHC cell surface receptors. Only if an MHC molecule presents an appropriate antigenic peptide will a cellular immune response be triggered. The orchestration of recognition and signaling events, from the initial recognition of antigenic peptides to the lysis of the target cell, is performed in a localized environment on the T cell, called the immunological synapse, and requires the coordinated activities of several T-Cell Receptor (TCR)-associated molecules. This particular reaction depicts the interaction of the TCR with MHC Class I molecules on somatic cell, requiring the support of CD3 and CD8 proteins. | |||
| REACT_11087 (Reactome) | Most cells of the immune system express receptors for the Fc region of IgG. This heterogeneous family of molecules plays a critical role in immunity, by linking the humoral to the cellular responses. NK cells and B cells have been shown to express exclusively Fc-gamma RIIIa and RIIb respectively. | |||
| REACT_11094 (Reactome) | NK cells express adhesion molecules that allow interaction with their tumour targets, promoting their lysis. For instance, the activating receptor CD226 is known to be involved in cytotoxic lymphocyte formation, as well as platelet adhesion to the endothelium. The cytoplasmic domain of CD226 contains binding motifs for members of the band 4.1 family of proteins, and for members of the membrane-associated guanylate kinase homolog (MAGUK) family. These proteins connect the CD226 receptor to the cytoskeleton and may promote clustering with LFA-1 integrin (also discussed in this pathway), which is known to participate in CD226's signaling cascade. CD226 plays a role in transendothelial migration, where it facilitates adherence to endothelial cells and migration between cell junctions. Nectin-2 binds CD226. It is ubiquitously expressed in cells of various tissues, especially in epithelial cells, neurons and fibroblasts. Like many other nectin and Necl proteins, nectin-2 serves as a viral entry receptor for alpha-herpesviruses including herpes simplex virus (HSV-1 and HSV-2). The other CD226 ligand, Necl-5, was initially identified as a receptor for poliovirus. CD96, another ligand for Necl-5, is strongly upregulated in activated NK cells. CRTAM is similarly up-regulated, and has been shown to to bind Necl-2, promoting NK cell cytotoxicity towards otherwise poorly immunogenic targets. | |||
| REACT_11097 (Reactome) | NK cells express adhesion molecules that allow interaction with their tumour targets, promoting their lysis. For instance, the activating receptor CD226 is known to be involved in cytotoxic lymphocyte formation, as well as platelet adhesion to the endothelium. The cytoplasmic domain of CD226 contains binding motifs for members of the band 4.1 family of proteins, and for members of the membrane-associated guanylate kinase homolog (MAGUK) family. These proteins connect the CD226 receptor to the cytoskeleton and may promote clustering with LFA-1 integrin (also discussed in this pathway), which is known to participate in CD226's signaling cascade. CD226 plays a role in transendothelial migration, where it facilitates adherence to endothelial cells and migration between cell junctions. Nectin-2 binds CD226. It is ubiquitously expressed in cells of various tissues, especially in epithelial cells, neurons and fibroblasts. Like many other nectin and Necl proteins, nectin-2 serves as a viral entry receptor for alpha-herpesviruses including herpes simplex virus (HSV-1 and HSV-2). The other CD226 ligand, Necl-5, was initially identified as a receptor for poliovirus. CD96, another ligand for Necl-5, is strongly upregulated in activated NK cells. CRTAM is similarly up-regulated, and has been shown to to bind Necl-2, promoting NK cell cytotoxicity towards otherwise poorly immunogenic targets. | |||
| REACT_11106 (Reactome) | CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic NK cells. MHC class I molecules bind to CD160 receptors on circulating NK lymphocytes and this triggers their cytotoxic activity and cytokine production. NK cells stimulated by IL-15 secrete soluble CD160 protein that binds to MHC-I molecules, resulting in the inhibition of the cytotoxic CD8+ T lymphocyte activity and of the CD160-mediated NK cell cytotoxicity. | |||
| REACT_11119 (Reactome) | After interaction with its ligand HLA-E, which is expressed on normal cells, the C-type lectin inhibitory receptor CD94/NKG2A suppresses activation signaling processes. CD94/NKG2A receptors continuously recycle from the cell surface through endosomal compartments and back again in a process that requires energy and the cytoskeleton. This steady state process appears to be largely unaffected by exposure to ligand. | |||
| REACT_11121 (Reactome) | CD19 is a lymphocyte cell surface molecule that functions as a general response regulator or rheostat, which defnes signalling thresholds. These responses are infuenced by signals transduced through a CD19-CD21 cell surface receptor complex, where the binding of complement C3d to CD21 links humoral immune responses with the innate immune system. The CD19-CD21 complex is composed of at least four non-covalently associated proteins: CD19, CD21(complement receptor 2),CD81 and CD225. | |||
| REACT_11124 (Reactome) | A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual). There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G. In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1. | |||
| REACT_11127 (Reactome) | Leukocyte immunoglobulin (Ig)-like receptors [LILRs, also known as Ig-like transcripts (ILTs)] are a family of inhibitory and stimulatory receptors encoded within the leukocyte receptor complex and are expressed by immune cell types of both myeloid and lymphoid lineage. Several members of the LILR family recognize major histocompatibility complex class I. The immunomodulatory role of LILR receptors indicates that they may exert an influence on signaling pathways of both innate and adaptive immune systems. Signaling mechanisms are employed that are similar to the ones adopted by the closely related killer cell inhibitory receptors (KIRs). ITIMs recruit inhibitory phosphatases that dephosphorylate ITIM and ITAM domains in order to influence intracellular signaling cascades. In contrast, activating LILRs, which lack any signaling domains of their own, rely on association with an adaptor protein such as FceRI-gamma to transmit their signal through its intracellular ITAMs. | |||
| REACT_11140 (Reactome) | A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual). There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G. In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1. | |||
| REACT_11141 (Reactome) | A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual). There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G. In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1. | |||
| REACT_11154 (Reactome) | JAM members, such as JAML, bind coxsackie and adenovirus receptor (CXADR) on epithelial and endothelial cells. | |||
| REACT_11161 (Reactome) | Integrins play a central role in mediating lymphocyte
adhesion to a number of surfaces. LFA-1 interacts with ICAMs 1-3 that are typically expressed on other immune system cells. ICAM-4 also interacts with LFA-1, and is known to be expressed on telencepahlic neurons.VCAM-1 regulates lymphocyte adhesion to activated endothelial cells via Very Late Antigen-4 (VLA-4). To function in a circulating mode, leukocytes express LFA-1 and VLA-4 in a low ligand binding capacity. When leukocytes reach sites of imflammation, these integrins are switched to a higher binding state to guide the complex process of transmigration, tethering, rolling, arrest, adhesion and shape change. Signal cascades between LFA-1 and VLA-4 may cross-talk affecting binding affinities in a reciprocal fashion. | |||
| REACT_11173 (Reactome) | Integrins play a central role in mediating lymphocyte
adhesion to a number of surfaces. LFA-1 interacts with ICAMs 1-3 that are typically expressed on other immune system cells. ICAM-4 also interacts with LFA-1, and is known to be expressed on telencepahlic neurons.VCAM-1 regulates lymphocyte adhesion to activated endothelial cells via Very Late Antigen-4 (VLA-4). To function in a circulating mode, leukocytes express LFA-1 and VLA-4 in a low ligand binding capacity. When leukocytes reach sites of imflammation, these integrins are switched to a higher binding state to guide the complex process of transmigration, tethering, rolling, arrest, adhesion and shape change. Signal cascades between LFA-1 and VLA-4 may cross-talk affecting binding affinities in a reciprocal fashion. | |||
| REACT_11176 (Reactome) | A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual). There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G. In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1. | |||
| REACT_11178 (Reactome) | NKG2D is an activating immunoreceptor. By engaging NKG2D, HlA Class I-like molecules such as MICA, MICB, ULBP1-4 and RAE-1 provide powerful costimulation for NK cells and T-cells and can determine the magnitude and outcome of certain effector functions. NKG2D ligands are upregulated on the surfaces of cells under conditions of stress, for example infection or tumorigenesis, and therefore act as molecular flags to the immune system that something is wrong. | |||
| REACT_11188 (Reactome) | While not ubiquitously distributed, CD200 is expressed on a wide range of cell types including thymocytes, B-cells, activated T-cells, follicular dendritic cells,
endothelium, CNS neurons in the central nervous system, cells in reproductive organs, keratinocytes and renal glomeruli. CD200R is a myeloid-inhibitory receptor, despite the absence of classical ITIMs in the cytoplasmic portion of the protein. Interestingly, CD200 is also expressed on neurons within the CNS and would be predicted to modulate activation of microglia through CD200R. | |||
| REACT_11199 (Reactome) | Mucosal addressin cell adhesion molecule (MADCAM1) is present in the endothelium of mucosa, and binds alpha-4 beta-7 integrin and L-selectin, regulating both the passage and retention of leukocytes in mucosal tissues. MADCAM1 has been shown to be present as a homodimer. | |||
| REACT_11207 (Reactome) | NK cells express adhesion molecules that allow interaction with their tumour targets, promoting their lysis. For instance, the activating receptor CD226 is known to be involved in cytotoxic lymphocyte formation, as well as platelet adhesion to the endothelium. The cytoplasmic domain of CD226 contains binding motifs for members of the band 4.1 family of proteins, and for members of the membrane-associated guanylate kinase homolog (MAGUK) family. These proteins connect the CD226 receptor to the cytoskeleton and may promote clustering with LFA-1 integrin (also discussed in this pathway), which is known to participate in CD226's signaling cascade. CD226 plays a role in transendothelial migration, where it facilitates adherence to endothelial cells and migration between cell junctions. Nectin-2 binds CD226. It is ubiquitously expressed in cells of various tissues, especially in epithelial cells, neurons and fibroblasts. Like many other nectin and Necl proteins, nectin-2 serves as a viral entry receptor for alpha-herpesviruses including herpes simplex virus (HSV-1 and HSV-2). The other CD226 ligand, Necl-5, was initially identified as a receptor for poliovirus. CD96, another ligand for Necl-5, is strongly upregulated in activated NK cells. CRTAM is similarly up-regulated, and has been shown to to bind Necl-2, promoting NK cell cytotoxicity towards otherwise poorly immunogenic targets. | |||
| REACT_11210 (Reactome) | A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual). There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G. In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1. | |||
| REACT_11212 (Reactome) | The lectin-like NK cell receptor KLRG1 binds to cadherins on epithelial cells and transmits inhibitory signals to the leukocyte. | |||
| REACT_11223 (Reactome) | A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). KIRs are not only variably expressed on the level of single NK cells but they are also highly polymorphic and polygenic (i.e. the gene content of the KIR cluster varies from individual to individual). There are 15 functional KIR genes known to date, 11 encoding receptors with two immunoglobulin domains (KIR2D genes) and 4 with three domains (KIR3D genes). Inhibitory KIR genes are characterized by long cytoplasmic tails featuring immunoreceptor tyrosine-based inhibitory motifs (ITIM), which upon engagement transmit inhibitory signals leading to the general shutdown of NK cell effector functions. There are six inhibitory KIRs with clearly defined specificities, all of the inhibitory kind and all for HLA class I allotypes: KIR2DL2 and KIR2DL3 for HLA-C group 1, KIR2DL1 for HLA-C group 2, KIR3DL1 for HLA-B (Bw4 epitope), KIR3DL2 with HLA-A3 and KIR2DL4 with HLA-G. In contrast, stimulatory KIR have short cytoplasmic tails lacking ITIM, but have a charged amino acid in the transmembrane region that provides a docking site for the activating adapter molecule DAP12. KIR2DS1 is known to bind HLA-C group 2 and KIR2DS2 binds HLA-C group 1. | |||
| REACT_11230 (Reactome) | L-selectin plays a major role in leukocyte traffic through lymph node high endothelial venules. Both MAdCAM and GlyCAM-1 are major L-selectin ligands produced by these venules and mediate leukocyte rolling, particularly in lymphocytes. They are also expressed in mammary tissue and play an important role in the transfer of immune cells into milk secretions. The adhesive properties of CD34 and its potential role in homing lymphocytes to lymphoid tissues mimics the mechanims leukocytes adopt to travel to inflammatory sites. | |||
| REACT_11239 (Reactome) | NK cells express adhesion molecules that allow interaction with their tumour targets, promoting their lysis. For instance, the activating receptor CD226 is known to be involved in cytotoxic lymphocyte formation, as well as platelet adhesion to the endothelium. The cytoplasmic domain of CD226 contains binding motifs for members of the band 4.1 family of proteins, and for members of the membrane-associated guanylate kinase homolog (MAGUK) family. These proteins connect the CD226 receptor to the cytoskeleton and may promote clustering with LFA-1 integrin (also discussed in this pathway), which is known to participate in CD226's signaling cascade. CD226 plays a role in transendothelial migration, where it facilitates adherence to endothelial cells and migration between cell junctions. Nectin-2 binds CD226. It is ubiquitously expressed in cells of various tissues, especially in epithelial cells, neurons and fibroblasts. Like many other nectin and Necl proteins, nectin-2 serves as a viral entry receptor for alpha-herpesviruses including herpes simplex virus (HSV-1 and HSV-2). The other CD226 ligand, Necl-5, was initially identified as a receptor for poliovirus. CD96, another ligand for Necl-5, is strongly upregulated in activated NK cells. CRTAM is similarly up-regulated, and has been shown to to bind Necl-2, promoting NK cell cytotoxicity towards otherwise poorly immunogenic targets. | |||
| REACT_11241 (Reactome) | CD40 is a member of the Tumour Necrosis Factor receptor family and its ligand CD40L is a type II transmembrane protein of the TNF superfamily. The latter is expressed preferentially on T-cells and platelets. In the immune system, CD40-CD40L interaction affects some key processes such as immune cell activation, differentiation, proliferation, and apoptosis. CD40-CD40L interaction also upregulates costimulatory molecules (ICAM-1, VCAM-1, E-selectin, LFA-3, B7.1, B7.2, class II MHC, and CD40 itself). | |||
| SELL | REACT_11230 (Reactome) | |||
| T-cell receptor complex with CD8 | REACT_11080 (Reactome) | |||
| TCR interacting with
antigen-bearing MHC Class I | Arrow | REACT_11080 (Reactome) | ||
| VCAM1 | REACT_11161 (Reactome) | |||
| VLA-4:VCAM-1 | Arrow | REACT_11161 (Reactome) | ||
| VLA-4 | REACT_11161 (Reactome) |
