IL1 and megakaryocytes in obesity (Homo sapiens)
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Description
Schematic of the effects of interleukin (IL)1-beta/IL1R1 on megakaryocyte and platelet function. A high fat diet will cause megakaryocytes to produce platelets with an increase in both inflammatory and thrombotic genes.
IL1-beta in circulation as a result of increased body weight will bind IL1R1 on megakaryocytes. This interaction leads to the activation of the nuclear factor (NF)kB, PI3K/Akt, and mitogen activated protein kinase (MAPK) (ERK and p38) pathways. As a result, there is an increase in megakarycoyte maturation, including increased adhesion, increases in ploidy, and increases in mRNA production of inflammatory and thrombotic genes. IL1-beta can also bind IL1R1 on platelets and either enhance aggregation induced by agonists or promote adhesion and heterotypic aggregate formation.
Quality Tags
Ontology Terms
Bibliography
- Beaulieu LM, Lin E, Mick E, Koupenova M, Weinberg EO, Kramer CD, Genco CA, Tanriverdi K, Larson MG, Benjamin EJ, Freedman JE; ''Interleukin 1 receptor 1 and interleukin 1β regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans.''; Arterioscler Thromb Vasc Biol, 2014 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
CCL2 | GeneProduct | 6347 (Entrez Gene) | |
CCR3 | GeneProduct | 1232 (Entrez Gene) | |
ERK pathway | Pathway | ||
FCER1A | GeneProduct | 2205 (Entrez Gene) | |
HBEGF | GeneProduct | 1839 (Entrez Gene) | |
ICAM1 | GeneProduct | 3383 (Entrez Gene) | |
IFNG | GeneProduct | 3458 (Entrez Gene) | |
IL18 | GeneProduct | 3606 (Entrez Gene) | |
IL1B | GeneProduct | 3553 (Entrez Gene) | |
IL1R1 | GeneProduct | 3554 (Entrez Gene) | |
IRAK1 | GeneProduct | 3654 (Entrez Gene) | |
MMP9 | GeneProduct | 4318 (Entrez Gene) | |
MYD88 | GeneProduct | 4615 (Entrez Gene) | |
NFKB1 | GeneProduct | 4790 (Entrez Gene) | |
NLRP3 | GeneProduct | 114548 (Entrez Gene) | |
PAR1 | GeneProduct | 2149 (Entrez Gene) | |
PIK3CA | GeneProduct | 5290 (Entrez Gene) | |
PLA2G7 | GeneProduct | 7941 (Entrez Gene) | |
S100A9 | GeneProduct | 6280 (Entrez Gene) | |
SELENBP1 | GeneProduct | 8991 (Entrez Gene) | |
TIMP1 | GeneProduct | 7076 (Entrez Gene) | |
TIMP2 | GeneProduct | 7077 (Entrez Gene) | |
TLR1 | GeneProduct | 7096 (Entrez Gene) | |
TLR2 | GeneProduct | 7097 (Entrez Gene) | |
Thrombin | GeneProduct | 2147 (Entrez Gene) | |
p38/MAPK pathway | Pathway | WP400 (WikiPathways) |
Annotated Interactions
No annotated interactions