Focal adhesion (Rattus norvegicus)

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1-17+pERKWnt Signaling+p+p+p+p+pITGBLamellipodia+p+pCell Cycle+p+pRegulation of+pIntegrin beta+p+pReceptor Tyrosine KinasesActinPolymerization+psignaling systemCytokine-cytokine receptor interactionsactin cytoskeletonPIP2Apoptosis-pDNAPIP3+pCell Survival+pITGA-pStress Fiber/FA+pCell Proliferation+pECM-receptor interactionsPhosphatidylinositiol+pPKCMEK+pCell MotilityformationRAFFilopodia-p+p+pDNA+p+p+p+pformationIntegrin alphaFA turnover+pVegfcCavPik3cgBirc4ItgavCav2Pik3r4Ha-RasPtenPik3cbFlnaCol1a1Itga7Ccnd3Raf1PdgfrbCol4a4Ctnnb1Col4a2Rock1Cav3Bcl2Lamc3VclItgamActg1Col5a2Mapk9Pik3r2Pak2Actn1Flt1HgfArhgap5Ccnd2ItgaeItgb8Crk1Itgb2Tnk1ActbItga2Pik3cdSrcTnxbMap2k2Pik3caCol11a1Mapk12BlkFigfRap1aFn1Birc2Mapk7BrafMapk8Itga9Map2k5Thbs4Col11a2Col5a1MylkTnnArafZyxShc1IlkRapgef1ItgaxLamb3Ccnd1Ptk6Rock2Pdpk1ChadErbb2PdgfraPip5k1cElk1Lamc1Itgb7Sepp1Itga11Diap1Itgb5Col5a3Map2k3Rac2Akt3Mapk1Pak3Lamb2Pak4Map2k1Mylk2ParvbPeloGrb2Itga8Igf1MetCol2a1Itgb3Pik3r1EgfrItgb6Sos1VaspTnrSrmsJunItga10Col4a6Tnk2Mapk4Rac1Itgb4Ptk2Shc3HckPdgfbItgadCol6a2Thbs2FgrCol4a1VwfItga3Spp1Rac3Bcar1RelnTxkItga5Myl6Itga4Lama5BadIgf1rLOC235580VegfaLama3Lamc2Pak6Pak7KdrTncBrafPdgfcItga6FynPgfThbs3Akt1Ppp1r12aBirc3Akt2CrkEgfCompItga2bIbspFarp2PxnPdgfdCol3a1Cdc42RhoaThbs1Tesk2Map2k6Lama2VegfbLamb1Lama4Rap1bCapn1RhobPik3r5Dock1Styk1VtnItgalGsk3bItgb1Pak1PdgfaMapk6Vav1Tln1Col1a2Lama1


Description

Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. Source: KEGG http://www.genome.jp/kegg/pathway/hsa/hsa04510.html

Comments

GenMAPP notes 
http://www.genome.ad.jp/kegg/pathway/hsa/hsa04510.html
GenMAPP remarks 
Adapted from KEGG (right click for notes)

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Bibliography

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  1. Turner CE; ''Paxillin and focal adhesion signalling.''; Nat Cell Biol, 2000 PubMed Europe PMC Scholia
  2. Lee JW, Juliano R; ''Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.''; Mol Cells, 2004 PubMed Europe PMC Scholia
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  4. Schlaepfer DD, Mitra SK; ''Multiple connections link FAK to cell motility and invasion.''; Curr Opin Genet Dev, 2004 PubMed Europe PMC Scholia
  5. Nicholson KM, Anderson NG; ''The protein kinase B/Akt signalling pathway in human malignancy.''; Cell Signal, 2002 PubMed Europe PMC Scholia
  6. Comoglio PM, Boccaccio C, Trusolino L; ''Interactions between growth factor receptors and adhesion molecules: breaking the rules.''; Curr Opin Cell Biol, 2003 PubMed Europe PMC Scholia
  7. Stupack DG, Cheresh DA; ''Get a ligand, get a life: integrins, signaling and cell survival.''; J Cell Sci, 2002 PubMed Europe PMC Scholia
  8. Guo W, Giancotti FG; ''Integrin signalling during tumour progression.''; Nat Rev Mol Cell Biol, 2004 PubMed Europe PMC Scholia
  9. Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z; ''The mechanism of action of the tumour suppressor gene PTEN.''; Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2003 PubMed Europe PMC Scholia
  10. Burridge K, Wennerberg K; ''Rho and Rac take center stage.''; Cell, 2004 PubMed Europe PMC Scholia
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History

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CompareRevisionActionTimeUserComment
116964view10:24, 16 May 2021EweitzModified title
104997view04:48, 28 June 2019Khanspersremoved KEGG comments
104996view04:47, 28 June 2019KhanspersModified description
82988view00:44, 17 November 2015Mkutmonfixed special characters in literature references
82978view23:50, 16 November 2015Mkutmonfixed outdated identifiers
79682view13:00, 4 April 2015EgonwAdded a mssing Entrez identifier.
79470view11:26, 23 March 2015FehrhartReplaced a batch of gene names with their Entrez gene IDs
79468view10:28, 23 March 2015Fehrhart
79467view10:15, 23 March 2015Fehrhart
79466view09:53, 23 March 2015Fehrhart
79254view16:22, 17 March 2015MaintBotReplaced a batch of gene names with their Entrez gene IDs.
71837view19:43, 18 October 2013MaintBotremoved data source from nodes without identifier
69967view21:08, 11 July 2013MaintBotupdating to 2013 schema
67251view10:26, 26 June 2013Christine ChichesterOntology Term : 'cell adhesion signaling pathway' added !
41718view02:38, 2 March 2011MaintBotRemoved redundant pathway information and comments
35639view20:22, 12 February 2010KhanspersAdded lit refs
34096view19:18, 9 December 2009MaintBotAutomatic update of empty xrefs
21075view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Focal adhesion KEGG]] moved to [[Pathway:WP188]]: Moved to stable identifier
8062view13:46, 7 January 2008MaintBot[[Pathway:Rat:Focal adhesion KEGG]] moved to [[Pathway:Rattus norvegicus:Focal adhesion KEGG]]: Renaming species
7653view16:07, 18 December 2007MaintBotfixed category names
7224view12:41, 4 November 2007MaintBotAdded categories to GPML
6542view22:20, 22 May 2007169.230.77.174gpml file for [[Rat:Focal_adhesion_KEGG]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ActbGeneProductActb (Entrez Gene)
Actg1GeneProductActg1 (Entrez Gene)
Actn1GeneProductActn1 (Entrez Gene)
Akt1GeneProductAkt1 (Entrez Gene)
Akt2GeneProductAkt2 (Entrez Gene)
Akt3GeneProductAkt3 (Entrez Gene)
ArafGeneProductAraf (Entrez Gene) ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
Arhgap5GeneProductArhgap5 (Entrez Gene)
BadGeneProductBad (Entrez Gene)
Bcar1GeneProductBcar1 (Entrez Gene)
Bcl2GeneProductBcl2 (Entrez Gene)
Birc2GeneProductBirc2 (Entrez Gene)
Birc3GeneProductBirc3 (Entrez Gene)
Birc4GeneProductBirc4 (Entrez Gene)
BlkGeneProductBlk (Entrez Gene)
BrafGeneProductBraf (Entrez Gene)
Capn1GeneProductCapn1 (Entrez Gene)
Cav2GeneProductCav2 (Entrez Gene) CAV2; caveolin 2
Cav3GeneProductCav3 (Entrez Gene) CAV3; caveolin 3
CavGeneProductCav (Entrez Gene) CAV1; caveolin 1 caveolae protein 22kD
Ccnd1GeneProductCcnd1 (Entrez Gene)
Ccnd2GeneProductCcnd2 (Entrez Gene)
Ccnd3GeneProductCcnd3 (Entrez Gene)
Cdc42GeneProductCdc42 (Entrez Gene)
ChadGeneProduct29195 (Entrez Gene) chondroadherin
Col11a1GeneProduct25654 (Entrez Gene) collagen, type XI, alpha 1
Col11a2GeneProduct294279 (Entrez Gene)
Col1a1GeneProductCol1a1 (Entrez Gene)
Col1a2GeneProduct84352 (Entrez Gene)
Col2a1GeneProduct25412 (Entrez Gene) collagen, type II, alpha 1
Col3a1GeneProduct84032 (Entrez Gene) collagen, type III, alpha 1
Col4a1GeneProduct290905 (Entrez Gene) collagen, type IV, alpha 1
Col4a2GeneProduct306628 (Entrez Gene)
Col4a4GeneProduct301562 (Entrez Gene) collagen, type IV, alpha 4
Col4a6GeneProduct
Col5a1GeneProduct85490 (Entrez Gene) collagen, type V, alpha 1
Col5a2GeneProductCol5a2 (Entrez Gene)
Col5a3GeneProduct60379 (Entrez Gene)
Col6a2GeneProductCol6a2 (Entrez Gene)
CompGeneProduct25304 (Entrez Gene)
Crk1GeneProduct
CrkGeneProductCrk (Entrez Gene)
Ctnnb1GeneProduct84353 (Entrez Gene)
Diap1GeneProduct307483 (Entrez Gene)
Dock1GeneProduct309077 (Entrez Gene) DOCK1; dedicator of cyto-kinesis
EgfGeneProduct25313 (Entrez Gene)
EgfrGeneProductEgfr (Entrez Gene)
Elk1GeneProductElk1 (Entrez Gene)
Erbb2GeneProductErbb2 (Entrez Gene)
Farp2GeneProduct316639 (Entrez Gene)
FgrGeneProductFgr (Entrez Gene)
FigfGeneProduct360457 (Entrez Gene)
FlnaGeneProductFlna (Entrez Gene)
Flt1GeneProductFlt1 (Entrez Gene)
Fn1GeneProductFn1 (Entrez Gene)
FynGeneProductFyn (Entrez Gene) FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
Grb2GeneProductGrb2 (Entrez Gene) GRB2; growth factor receptor-bound protein 2
Gsk3bGeneProductGsk3b (Entrez Gene)
Ha-RasGeneProduct
HckGeneProductHck (Entrez Gene)
HgfGeneProduct24446 (Entrez Gene)
IbspGeneProductIbsp (Entrez Gene)
Igf1GeneProduct24482 (Entrez Gene)
Igf1rGeneProductIgf1r (Entrez Gene)
IlkGeneProductIlk (Entrez Gene) ILK; integrin-linked kinase [EC:2.7.1.-]
Itga10GeneProduct310683 (Entrez Gene)
Itga11GeneProduct315744 (Entrez Gene)
Itga2GeneProductItga2 (Entrez Gene)
Itga2bGeneProductItga2b (Entrez Gene)
Itga3GeneProduct360606 (Entrez Gene)
Itga4GeneProduct311144 (Entrez Gene)
Itga5GeneProduct315346 (Entrez Gene)
Itga6GeneProductItga6 (Entrez Gene)
Itga7GeneProductItga7 (Entrez Gene)
Itga8GeneProductItga8 (Entrez Gene)
Itga9GeneProductItga9 (Entrez Gene)
ItgadGeneProductItgad (Entrez Gene)
ItgaeGeneProductItgae (Entrez Gene)
ItgalGeneProductItgal (Entrez Gene)
ItgamGeneProductItgam (Entrez Gene)
ItgavGeneProduct296456 (Entrez Gene)
ItgaxGeneProduct499271 (Entrez Gene)
Itgb1GeneProductItgb1 (Entrez Gene)
Itgb2GeneProductItgb2 (Entrez Gene)
Itgb3GeneProductItgb3 (Entrez Gene)
Itgb4GeneProductItgb4 (Entrez Gene)
Itgb5GeneProductItgb5 (Entrez Gene)
Itgb6GeneProductItgb6 (Entrez Gene)
Itgb7GeneProductItgb7 (Entrez Gene)
Itgb8GeneProduct362800 (Entrez Gene)
JunGeneProductJun (Entrez Gene)
KdrGeneProductKdr (Entrez Gene)
LOC235580GeneProduct
Lama1GeneProduct316758 (Entrez Gene)
Lama2GeneProduct309368 (Entrez Gene)
Lama3GeneProductLama3 (Entrez Gene)
Lama4GeneProduct294569 (Entrez Gene)
Lama5GeneProductLama5 (Entrez Gene)
Lamb1GeneProduct298941 (Entrez Gene)
Lamb2GeneProductLamb2 (Entrez Gene)
Lamb3GeneProductLamb3 (Entrez Gene)
Lamc1GeneProduct117036 (Entrez Gene)
Lamc2GeneProductLamc2 (Entrez Gene)
Lamc3GeneProduct311862 (Entrez Gene)
Map2k1GeneProductMap2k1 (Entrez Gene) MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
Map2k2GeneProductMap2k2 (Entrez Gene) MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
Map2k3GeneProductMap2k3 (Entrez Gene) MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
Map2k5GeneProductMap2k5 (Entrez Gene) MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
Map2k6GeneProductMap2k6 (Entrez Gene) MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
Mapk12GeneProductMapk12 (Entrez Gene) MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
Mapk1GeneProductMapk1 (Entrez Gene) MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
Mapk4GeneProductMapk4 (Entrez Gene) MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
Mapk6GeneProductMapk6 (Entrez Gene) MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
Mapk7GeneProductMapk7 (Entrez Gene) MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
Mapk8GeneProductMapk8 (Entrez Gene)
Mapk9GeneProductMapk9 (Entrez Gene)
MetGeneProductMet (Entrez Gene)
Myl6GeneProduct362816 (Entrez Gene)
MylkGeneProduct288057 (Entrez Gene)
Mylk2GeneProductMylk2 (Entrez Gene)
Pak1GeneProductPak1 (Entrez Gene)
Pak2GeneProductPak2 (Entrez Gene)
Pak3GeneProductPak3 (Entrez Gene)
Pak4GeneProduct292756 (Entrez Gene)
Pak6GeneProduct296078 (Entrez Gene)
Pak7GeneProduct311450 (Entrez Gene)
ParvbGeneProduct362973 (Entrez Gene)
PdgfaGeneProduct25266 (Entrez Gene)
PdgfbGeneProductPdgfb (Entrez Gene)
PdgfcGeneProductPdgfc (Entrez Gene)
PdgfdGeneProductPdgfd (Entrez Gene)
PdgfraGeneProductPdgfra (Entrez Gene)
PdgfrbGeneProductPdgfrb (Entrez Gene)
Pdpk1GeneProductPdpk1 (Entrez Gene)
PeloGeneProduct294754 (Entrez Gene)
PgfGeneProduct94203 (Entrez Gene)
Pik3caGeneProductPik3ca (Entrez Gene)
Pik3cbGeneProductPik3cb (Entrez Gene)
Pik3cdGeneProduct366508 (Entrez Gene)
Pik3cgGeneProduct298947 (Entrez Gene)
Pik3r1GeneProductPik3r1 (Entrez Gene)
Pik3r2GeneProductPik3r2 (Entrez Gene)
Pik3r4GeneProduct363131 (Entrez Gene)
Pik3r5GeneProduct497931 (Entrez Gene)
Pip5k1cGeneProductPip5k1c (Entrez Gene)
Ppp1r12aGeneProductPpp1r12a (Entrez Gene)
PtenGeneProductPten (Entrez Gene)
Ptk2GeneProductPtk2 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
Ptk6GeneProduct366275 (Entrez Gene)
PxnGeneProductPxn (Entrez Gene)
Rac1GeneProductRac1 (Entrez Gene)
Rac2GeneProductRac2 (Entrez Gene)
Rac3GeneProduct
Raf1GeneProduct24703 (Entrez Gene) RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
Rap1aGeneProductRap1a (Entrez Gene) RAP1A; RAP1A member of RAS oncogene family
Rap1bGeneProductRap1b (Entrez Gene) RAP1B; RAP1B member of RAS oncogene family
Rapgef1GeneProductRapgef1 (Entrez Gene)
RelnGeneProductReln (Entrez Gene)
RhoaGeneProductRhoa (Entrez Gene)
RhobGeneProductRhob (Entrez Gene)
Rock1GeneProductRock1 (Entrez Gene)
Rock2GeneProductRock2 (Entrez Gene)
Sepp1GeneProductSepp1 (Entrez Gene) SEPP1; selenoprotein P plasma
Shc1GeneProductShc1 (Entrez Gene) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
Shc3GeneProductShc3 (Entrez Gene) SHC3; neuronal Sh
Sos1GeneProductSos1 (Entrez Gene) SOS1; son of sevenless homolog 1 (Drosophila)
Spp1GeneProductSpp1 (Entrez Gene)
SrcGeneProductSrc (Entrez Gene) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
SrmsGeneProductSrms (Entrez Gene)
Styk1GeneProduct500340 (Entrez Gene)
Tesk2GeneProductTesk2 (Entrez Gene)
Thbs1GeneProductThbs1 (Entrez Gene)
Thbs2GeneProductThbs2 (Entrez Gene)
Thbs3GeneProduct295242 (Entrez Gene)
Thbs4GeneProduct29220 (Entrez Gene)
Tln1GeneProductTln1 (Entrez Gene)
TncGeneProductTnc (Entrez Gene)
Tnk1GeneProduct303247 (Entrez Gene)
Tnk2GeneProductTnk2 (Entrez Gene)
TnnGeneProduct304913 (Entrez Gene)
TnrGeneProductTnr (Entrez Gene)
TnxbGeneProductTnxb (Entrez Gene)
TxkGeneProductTxk (Entrez Gene)
VaspGeneProduct361517 (Entrez Gene) VASP; vasodilator-stimulated phosphoprotein
Vav1GeneProductVav1 (Entrez Gene)
VclGeneProduct305679 (Entrez Gene) VCL; vinculin
VegfaGeneProductVegfa (Entrez Gene)
VegfbGeneProductVegfb (Entrez Gene)
VegfcGeneProductVegfc (Entrez Gene)
VtnGeneProduct25567 (Entrez Gene)
VwfGeneProduct116669 (Entrez Gene)
ZyxGeneProductZyx (Entrez Gene) ZYX; zyxin

Annotated Interactions

No annotated interactions
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